,**1 The Japanese Society for AIDS Research The Journal of AIDS Research,* - HAART Symposium - Strategies for Better Results of HAART Satoshi KIMURA HIVAIDS Takuma SHIRASAKA HAART * HAART HIV HAART HAART STI HAART HAART HAART HIV 0 HAART HIVAIDS + +330 HIV HIV Highly active antiretroviral therapy HAART HIV : *,2132,+.,-,**1., DHHS HIV,,/ +* HIV +330 Hit HIV early and Hard HIV 3+ +
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The Journal of AIDS Research Vol. 3 No.,,**1 HIV 0 HIV HIV + Report of the NIH panel to define principles of therapy of HIV infection. MMWR.1 (RR-/) :+.+, +332., Guidelines for the Use of Antiretroviral Agents in HIV- Infected Adults and Adolescents. Department of Health and Human Services (DHHS).,**0 * * - Hammer SM et al. : Treatment for Adult HIV Infection. Recommendations of the International AIDS Society USA Panel. JAMA,30 (1) :2,12.-,,**0.. HIV +* HIV,**0 + / HIV +1 HIV,**0 - HAART Highly active antiretroviral therapy HAART + CD. CD.,**mL HIV CD. -/*ml CD.,**-/*mL CD. HIV-RNA HAART : 331,**+ 2 HAART,**0 2 2/ HAART CD. HIV-RNA AIDS : 2/ +3 +00.3./.*.1 P*.*/ CD. +** 3- +- HAART : +3 +3 *.34/,,01*.* +2. HIV-+ RNA cml4,*+* / +4++* - +4/+* 1 HIV-+ RNA+**5*** /143 CD. cellsmm - 0,mL +/*2 CD.,** 1-41 +00 +-3,1.*41,00 114/,2+*0 HIV-+ RNA cml4-.+* / +42+* - 14/+* 0 HIV-+ RNA+**5*** /.42 CD. cellsmm - *3mL +203 CD.,** 0+4. *P*.*+ 3- -
S Kimura et al : Symposium : Strategies for Better Results of HAART HAART +** 3, 0 HIV-RNA **,*** copiesml +*, ++ 2-2 HAART AIDS AIDS 1/ +- AIDS ++* 0 P*.*/ AIDS AIDS / - AIDS, ATL, HCV AIDS, AIDS HIV + efavirenz : HAART HIV,, - + Egger M, May M, Chene G, Phillips AN, Ledergerber B, Dabis F, Costagliola D, D Arminio Monforte A, de Wolf F, Reiss P, Lundgren JD, Justice AC, Staszewski S, Leport C, Hogg RS, Sabin CA, Gill MJ, Salzberger B, Sterne JA : ART Cohort Collaboration. Prognosis of HIV-+-infected patients starting highly active antiretroviral therapy : a collaborative analysis of prospective studies. Lancet -0* : ++3+,3,,**,., Cooksley CD, Hwang LY, Waller DK, Ford CE : HIVrelated malignancies : community-based study using linkage of cancer registry and HIV registry data. Int J STD AIDS +* : 13/2*,, +333. - Chiao EY, Krown SE : Update on non-acquired immunodeficiency syndrome-defining malignancies. Curr Opin Oncol +/ : -23-31,,**-. HAART +2. 3..
The Journal of AIDS Research Vol. 3 No.,,**1 +, -. / HIV-RNA+*** copiesml, IAS USA + DHHS, European - +. Hirsch MS, et al. : Clin Infect Dis -1 : ++-+,2,,**-.,. Available at : http : //www.aidsinfo.nih.gov. Oct.,**0. -. Vandamme AM, et al. : Antivir Ther 3 : 2,32.2,,**.. Stanford HIV RT and Protease Seqence Detabase : http : //HIV db. stanford. edu/ HIV-+ HIV HAART, DHHS 0+0 -/ / 3/ /
S Kimura et al : Symposium : Strategies for Better Results of HAART HAART, HAART RNA,. - HIV, -TC M+2.V M+2.V Stanford http : // HIVdb.stanford.edu SNPs + efavirenz cytochrome P./*,B0 efavirenz EFV EFV EFV cytochrome P./*,B0 CYP,B0 CYP,B0 *+ *0 *0 *+ *0 EFV + CYP,B0 *0*0./ EFV 0** mgday CYP,B0 *0*0 EFV CYP,B0 *0*0 EFV.** mg.** mg,** mg EFV EFV CYP,B0 *0*0 ** HIV CYP, B0 EFV CYP,B0 *0*0 0 EFV *0 EFV EFV CYP,B0 30 0
The Journal of AIDS Research Vol. 3 No.,,**1 CYP,B0 EFV +*+. CYP,B0 *0*0 EFV, abacavir, nevirapine HLA HIV abacavir ABC nevirapine NVP ABC + +* /2 HLA-B/1 ABC HLA B/1 ABC ABC B/1 ABC HLA B/1 ABC ABC NVP NVP HLA Cw2 B+. NVP B+. NVP NVP Cw2., vs +* p*.*-, HLA-Cw2 NVP NVP NVP HLA-Cw2 + Tsuchiya K Gatanaga H, Tachikawa N, Teruya K, Kikuchi Y, Yoshino M, Kuwahara T, Shirasaka T, Kimura S, Oka S : Homozygous CYP,B0 *0 (Q+1,H and K,0,R) correlates with high plasma efavirenz concentrations in HIV-+ patients treated with standard efavirenz-containing regimens. Biochem Biophys Res Commun -+3 : +-,,+-,0,,**.., Gatanaga H, Yazaki H, Tanuma J, Honda M, Genka I, Teruya K, Tachikawa N, Kikuchi Y, Oka S : HLA-Cw2 primarily associated with hypersensitivity to nevirapine. AIDS,+ :,0.,0/,,**1. 31 1
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