SYNkinase Catalogue. September Kinase Inhibitor Library Arrays. 1 Multi-Target Arrays. 2 Pathway and Family Specific Arrays

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1 SYNkinase Catalogue September 2014 Kinase Inhibitor Library Arrays Pre-made Inhibitor Array Options 1 Multi-Target Arrays 2 Pathway and Family Specific Arrays 9 Custom Array Options 16

2 Abl Kinase Inhibitor Library Arrays High quality, research relevant kinase inhibitor library arrays. SYNkinase multi-target inhibitor libraries are available in either 100 μl of 10mM or 100 μl of 20mM DMSO inhibitor solution per well. SYNkinase pathway specific inhibitor arrays are available as 100 μl of 10mM DMSO inhibitor solution per well. These arrays are available with to six wells per inhibitor on each plate. SYNkinase Library Arrays Abl PYK2, FAK PYK2, FAK Half-Plate Library (47 Inhibitors) BTK BTK FAK, PYK2 JAK1,3 Src, Abl Syk FAK, PYK2 JAK1,3 Src, Abl Syk Single Plate Library (95 Inhibitors),1 LCK, RAF TYK2,1 LCK, RAF TYK2 Double Plate Library (190 Inhibitors) PI3K Array (11 Inhibitors) SYNkinase libraries are made in REMP plates with individually foil sealed wells. Thermo Matrix plates are available for an additional fee. PI3K Pathway Array (9 Inhibitors) Cytoplasmic PTK Panel (11 Inhibitors) RTK Panel (13 Inhibitors) Ser/Thr Kinase Array (16 Inhibitors) Ras-Raf Panel (9 Inhibitors) JAK-STAT Family Array (12 Inhibitors) JAK-STAT Array (8 Inhibitors) 1

3 47 Kinase Inhibitor Library SYN-2104 Plate Wells by Target CHK1 PI3K, p110 α/β/δ/γ S6K c-met, Flt-1/3/4, Tie2, 2, AXL, Ret, Kit Akt1,, PKA EGFR c-kit PI3Kδ TRK Bcr-Abl, Src, c-kit Akt1/2/3 (p38map), p38α/β Pim TrkA 1/2/3 ALK FAK MEK1/2 PLK TYK2 BCR-ABL, 2, FGFR1, Src, PDGFRα Aurora A FGFR1 c-met PYK2 1/2/3, c-kit B-RAF, -2, Raf-1 Bcl-2 FLT3, FMS, ckit, PDGFR B-RAF 1/2/3,FGFR, c-fms VEGF, FGFR1 BCR-ABL GSK-3 PDK1 ROCK c-kit, PDGFRβ, 1/2/3 c-kit, PDGFRβ, 2 (Flk-1) PERK RSK BCR-Abl, Src FLT3, PDGFR 2

4 47 Kinase Inhibitor Library Inhibitor name, Catalog and CAS # SYN-1174 PF A3 SYN-1104 TG A5 SYN-1200 BKM120 1-A7 SYN-1177 PF A9 SYN-1138 Cabozantinib 1-A11 SYN-1110 A B1 SYN-1042 Gefitinib 1-B3 SYN-1053 Masatinib 1-B5 SYN-1045 IC B7 SYN-1183 GNF B9 SYN-1036 Dasatinib 1-B11 SYN-1162 MK C1 SYN-1052 Lapatinib 1-C3 SYN-1073 SB C5 SYN-1113 SMI-4a 1-C7 SYN-1044 GW C9 SYN-1055 Motesanib 1-C11 SYN-1199 LDK378 1-D1 SYN-1064 PF D3 SYN-1031 CI D5 SYN-1019 (R)-BI D7 SYN-1198 GDC D9 SYN-1116 Ponatinib 1-D11 SYN-1092 Tozasertib 1-E1 SYN-1176 PD E3 SYN-1060 PF E5 SYN-1063 PF E7 SYN-1013 Tivozanib 1-E9 SYN-1082 Sorafenib 1-E11 SYN-1001 ABT F1 SYN-1003 Quizartinib 1-F3 SYN-1181 PP242 1-F5 SYN-1161 PLX F7 SYN-1058 Pazopanib 1-F9 SYN-1085 SU F11 SYN-1046 Imatinib mesylat 1-G1 SYN-1075 SB G3 SYN-1026 BX795 1-G5 SYN-1071 GSK429286A 1-G7 SYN-1014 Axitinib 1-G9 SYN-1086 Sunitinib 1-G11 SYN-1070 Purvalanol B 1-H1 SYN-1112 Mubritinib 1-H3 SYN-1201 GSK H5 SYN-1020 BI-D H7 SYN-1025 Bosutinib 1-H9 SYN-1088 Tandutinib 1-H11 3

5 95 Kinase Inhibitor Library SYN-2103 Plate Wells by Target Control AXL FGFR1/2/3 JAK3 (p38map), p38α PI3Kα/δ PLK TRK c-kit, PDGFRβ, 1/2/3 c-met, FGFR1/2/3, PDGFRβ Akt1,, PKA Bcl-2 FGFR1 JNK MEK1/2 PI3Kδ PYK2 TrkA BCR-Abl, Src 1/2/3 Akt1/2/3 BCR-ABL CHK1 FLT3, FMS, ckit, PDGFR c-kit MEK1/2 PI3K, p110α B-RAF TYK2 c-met, Flt-1/3/4, Tie2, 2, AXL, Ret, Kit BCR-ABL, 2, FGFR1, Src, PDGFRα ALK BTK CK2 GSK-3 Lck MEK1 PDK1 PI3Kα/γ/δ ROCK 1/2/3, c-kit Bcr-Abl, Src, c-kit 1/2/3, PDGFRβ, KIT, RET, Raf-1 ASK c-src EGFR LIMK c-met PERK PI3K, p110β RSK 2 FGFR1/3, FLT3, FMS, 1-4 B-RAF, -2, Raf-1 Aurora A/B 1/2/4/6 (p38map) 1c-MET PI3Kγ PIK fyve S6K 3 2, 3 (Flt-4) VEGF, FGFR1 Aurora A/B/C Aurora A 1/2/4/6/9 4/6 FAK FGFR1, 2 JAK1/2 (p38map), p38α/β (p38map) c-met, Mps1, TTK PI3K, p110α/β/δ/γ PI3Kα/δ/γ Pim PKC Syk TIE-2 1/2/3, FGFR, c-fms Flt3, KIT, PDGFRα 1/2/3, FGFR1/2/3, PDGFRα/β Flt-1/3, PDGFRβ, 2, CSF-1R c-kit, PDGFRβ, 2 (Flk-1) FLT3, PDGFR 4

6 95 Kinase Inhibitor Library Inhibitor name, Catalog and CAS # SYN-1183 GNF A10 SYN-1014 Axitinib 1-A11 SYN-1149 MK A12 SYN-1131 R428 1-A2 SYN-1070 Purvalanol B 1-A3 SYN-1152 NVP-BGJ398 1-A4 SYN-1032 Tofacitinib 1-A5 SYN-1087 TAK A6 SYN-1181 PP242 1-A7 SYN-1041 GDC A8 SYN-1019 (R)-BI A9 SYN-1110 A B1 SYN-1044 GW B10 SYN-1025 Bosutinib 1-B11 SYN-1055 Motesanib 1-B12 SYN-1001 ABT B2 SYN-1080 BMS B3 SYN-1176 PD B4 SYN-1028 CC B5 SYN-1190 AS B6 SYN-1185 Rapamycin 1-B7 SYN-1045 IC B8 SYN-1063 PF B9 SYN-1162 MK C1 SYN-1198 GDC C10 SYN-1138 Cabozantinib 1-C11 SYN-1116 Ponatinib 1-C12 SYN-1046 Imatinib mesylate 1-C2 SYN-1174 PF C3 SYN-1003 Quizartinib 1-C4 SYN-1053 Masatinib 1-C5 SYN-1031 CI C6 SYN-1186 XL388 1-C7 SYN-1067 PIK-75 1-C8 SYN-1161 PLX C9 SYN-1199 LDK378 1-D1 SYN-1013 Tivozanib 1-D10 SYN-1036 Dasatinib 1-D11 SYN-1169 Regorafenib 1-D12 SYN-1164 GCI D2 SYN-1109 CX D3 SYN-1075 SB D4 SYN-1007 AMG-47a 1-D5 SYN-1016 Selumetinib 1-D6 SYN-1026 BX795 1-D7 SYN-1068 PIK-90 1-D8 SYN-1071 GSK429286A 1-D9 SYN-1119 S-99 1-E1 SYN-1133 JNJ E10 SYN-1029 CHIR E11 SYN-1082 Sorafenib 1-E12 SYN-1062 PD Analog1 1-E2 SYN-1042 Gefitinib 1-E3 SYN-1112 Mubritinib 1-E4 SYN-1024 BMS-5 1-E5 SYN-1139 Crizotinib 1-E6 SYN-1201 GSK E7 SYN-1089 TGX221 1-E8 SYN-1020 BI-D E9 SYN-1034 CYC116 1-F1 SYN-1165 SAR F10 SYN-1038 E F11 SYN-1085 SU F12 SYN-1040 Alvocidib 1-F2 SYN-1052 Lapatinib 1-F3 SYN-1196 LY F4 SYN-1072 RWJ F5 SYN-1060 PF F6 SYN-1009 AS F7 SYN-1094 YM F8 SYN-1177 PF F9 SYN-1081 SNS G1 SYN-1058 Pazopanib 1-G10 SYN-1091 Intedanib 1-G11 SYN-1086 Sunitinib 1-G12 SYN-1010 AT G2 SYN-1064 PF G3 SYN-1035 Momelotinib 1-G4 SYN-1073 SB G5 SYN-1129 Foretinib 1-G6 SYN-1200 BKM120 1-G7 SYN-1113 SMI-4a 1-G8 SYN-1121 R406 1-G9 SYN-1092 Tozasertib 1-H1 SYN-1056 Amuvatinib 1-H10 SYN-1002 Linifanib 1-H11 SYN-1088 Tandutinib 1-H12 SYN-1180A Palbociclib Isethionate 1-H2 SYN-1134 BMS H3 SYN-1104 TG H4 SYN-1079 SD169 1-H5 SYN-1187 MPI H6 SYN-1202 GDC H7 SYN-1021 Bisindoylmaleimide X 1-H8 SYN-1008 AMG-Tie2-1 1-H9 5

7 Control Control SYN-2102 Plate Wells by Target Akt1,, PKA Akt Akt Akt Akt1/2/3 Akt1/2/3 ALK ALK ASK Aurora A/B, /3, Abl Aurora A/B Aurora A/B/C, Abl,TrkA, c-ret, FGFR1 Aurora A/B, 1/2 Aurora A/B/C Aurora A AXL Bcl-2 Bcr-Abl, Lyn BCR-ABL BCR-ABL, c-src BCR-ABL BTK c-src 1/2/4/6 1/2/4/6/9 4/6 4/6 CHK1/2 CHK1 CHK1 CHK1 CK2 EGFR EGFR EGFR ErbB2, FAK FGFR1, 2 2 FGFR 1/2/3 FGFR1 FGFR, FLT3, FMS, ckit, PDGFR c-fms FMS GSK-3 JAK1/2 FMS JAK1 JAK1/2 JAK1/2 JAK3 JNK-1 JNK c-kit c-kit Lck LIMK LIMK (p38map) MEK1/2 MEK1/2 MEK1/2 MEK1/2 MEK MEK (p38map) (p38map) (p38map) (p38map) (p38map) (p38map) (p38map), p38α (p38map), p38α MEK1 c-met, RON c-met c-met c-met c-met c-met c-met c-met c-met, Mps1, TTK C 1/2 PDK1 PDK1 PERK PIK fyve Pim Pim1, FLT3 Pim PKC PKC PKCβ PLK PYK2 PYK2 B-RAF B-RAF B-RAF ROCK ROCK ROCK-II RSK S6K S6K Syk Syk TIE-2 TRK TrkA TYK TYK2 TYK 1/2/3, c-kit -2 2, RAF 3 1/2/3, FGFR, c-fms 1/2/4, FGFR, c-fms Flt3, KIT, PDGFRα c-kit, PDGFRβ, 1/2/3 BCR-Abl, Src c-met, Flt-1/3/4, Tie2, 2, AXL,Ret, Kit Bcr-Abl, Src, c-kit 2 (KDR)/ 3 (Flt-4) 1/2/3, FGFR1/2/3, PDGFRα/β Flt-1/3, PDGFRβ, 2(KDR), CSF-1R c-met, FGFR1/2/3, DGFRβ 1/2/3 BCR-ABL, 2, FGFR1, Src, PDGFRα 1/2/3, PDGFRβ, KIT, RET, Raf-1 PI3Kα PI3Kα PI3Kα/δ PI3Kα/δ/γ PI3Kα/δ/β PI3Kδ PI3Kδ PI3K δ/γ PI3Kγ PI3Kγ/δ PI3Kα/δ/γ PI3Kα/γ/δ pan-pi3k pan-pi3k pan-pi3k PI3K, p110 α/β/δ/γ PI3K, p 110δ PI3K, p110β PI3K, p110α p110 α/β/δ/γ PI3K p110 α/γ/δ/β, p110 α/β/δ/γ, C1/2 PI3K α/β/δ/γ, PI3Kα/β/γ, PI3Kα/β/γ, PI3K, PI3K, PI3K, 190 Kinase Inhibitor Library 6

8 190 Kinase Inhibitor Library (Plate #1) Inhibitor name, Catalog and CAS # SYN-1159 TAE684 1-A2 SYN-1131 R428 1-A3 SYN-1040 Alvocidib 1-A4 SYN-1173 SCH A5 SYN-1012 AV A6 SYN-1033 CP A7 SYN-1154 JNJ A8 SYN-1120 Ruxolitinib 1-A9 SYN-1191 XL019 1-A10 SYN-1024 BMS-5 1-A11 SYN-1087 TAK A12 SYN-1110 A B1 SYN-1119 S-99 1-B2 SYN-1001 ABT B3 SYN-1010 AT B4 SYN-1189 SAR B5 SYN-1100 Afatinib 1-B6 SYN-1064 PF B7 SYN-1049 Ki B8 SYN-1196 LY B9 SYN-1032 Tofacitinib 1-B10 SYN-1101 R B11 SYN-1123 VX745 1-B12 SYN-1005 Akt-I-1 1-C1 SYN-1011 AT C2 SYN-1057 Nilotinib 1-C3 SYN-1151 BS194 1-C4 SYN-1174 PF C5 SYN-1142 BMS C6 SYN-1176 PD C7 SYN-1003 Quizartinib 1-C8 SYN-1015 AZ C9 SYN-1147 Bentamapimod 1-C10 SYN-1072 RWJ C11 SYN-1190 AS C12 SYN-1006 Akt-I-2 1-D1 SYN-1034 CYC116 1-D2 SYN-1046 Imatinib mesylate 1-D3 SYN-1180 Palbociclib HCl 1-D4 SYN-1017 AZD D5 SYN-1052 Lapatinib 1-D6 SYN-1152 NVP-BGJ398 1-D7 SYN-1075 SB D8 SYN-1156 CEP D9 SYN-1028 CC D10 SYN-1073 SB D11 SYN-1195 AZD D12 SYN-1160 AZD-26 1-E1 SYN-1081 SNS E2 SYN-1061 PD E3 SYN-1180A Palbociclib Isethionate 1-E4 SYN-1109 CX E5 SYN-1140 Neratinib 1-E6 SYN-1135 Brivanib 1-E7 SYN-1112 Mubritinib 1-E8 SYN-1136 NVP-BSK805 1-E9 SYN-1125 AMG-25 1-E10 SYN-1073A SB HCl 1-E11 SYN-1170 GSK E12 SYN-1043 GSK F1 SYN-1048 JNJ F2 SYN-1179 Bafetinib 1-F3 SYN-1097 PHA F4 SYN-1042 Gefitinib 1-F5 SYN-1141 Pelitinib 1-F6 SYN-1084 SU F7 SYN-1158 GPLG F8 SYN-1107 TG-89 1-F9 SYN-1053 Masatinib 1-F10 SYN-1076 SB F11 SYN-1031 CI F12 SYN-1162 MK G1 SYN-1095 Danusertib 1-G2 SYN-1164 GCI G3 SYN-1070 Purvalanol B 1-G4 SYN-1030 Canertinib 1-G5 SYN-1153 TAK G6 SYN-1134 BMS G7 SYN-1117 Baricitinib 1-G8 SYN-1103 TG G9 SYN-1007 AMG-47a 1-G10 SYN-1078 SD-06 1-G11 SYN-1188 CH G12 SYN-1199 LDK378 1-H1 SYN-1092 Tozasertib 1-H2 SYN-1062 PD Analog1 1-H3 SYN-1080 BMS H4 SYN-1039 Erlotinib 1-H5 SYN-1090 Vandetanib 1-H6 SYN-1197 BLZ H7 SYN-1035 Momelotinib 1-H8 SYN-1104 TG H9 SYN-1023 BMS-3 1-H10 SYN-1079 SD169 1-H11 SYN-1059 PD H12 7

9 190 Kinase Inhibitor Library (Plate #2) Inhibitor name, Catalog and CAS # 8 SYN-1060 PF A2 SYN-1181 PP242 2-A3 SYN-1041 GDC A4 SYN-1127 XL147 2-A5 SYN-1067 PIK-75 2-A6 SYN-1137 XL765 2-A7 SYN-1172 Ruboxistaurin 2-A8 SYN-1071 GSK429286A 2-A9 SYN-1183 GNF A10 SYN-1013 Tivozanib 2-A11 SYN-1036 Dasatinib 2-A12 SYN-1016 Selumetinib 2-B1 SYN-1143 AMG-1 2-B2 SYN-1185 Rapamycin 2-B3 SYN-1202 GDC B4 SYN-1068 PIK-90 2-B5 SYN-1065 PI103 2-B6 SYN-1194 PF B7 SYN-1019 (R)-BI B8 SYN-1083 SR B9 SYN-1044 GW B10 SYN-1168 Takeda-6d 2-B11 SYN-1038 E B12 SYN-1155 SGX523 2-C1 SYN-1129 Foretinib 2-C2 SYN-1050 KU C3 SYN-1009 AS C4 SYN-1114 GNE C5 SYN-1018 BEZ C6 SYN-1094 YM C7 SYN-1063 PF C8 SYN-1020 BI-D C9 SYN-1130 Bayer-18 2-C10 SYN-1058 Pazopanib 2-C11 SYN-1091 Intedanib 2-C12 SYN-1111 AMG-51 2-D1 SYN-1187 MPI D2 SYN-1026 BX795 2-D3 SYN-1099 ZSTK474 2-D4 SYN-1115 GNE D5 SYN-1126 GSK D6 SYN-1182 CX D7 SYN-1163 PF D8 SYN-1177 PF D9 SYN-1198 GDC D10 SYN-1056 Amuvatinib 2-D11 SYN-1002 Linifanib 2-D12 SYN-1144 AMG E1 SYN-1167 AZD E2 SYN-1027 BX912 2-E3 SYN-1175 IPI E4 SYN-1145 NIBR-17 2-E5 SYN-1150 RG E6 SYN-1113 SMI-4a 2-E7 SYN-1069 PLX E8 SYN-1132 S6K-18 2-E9 SYN-1128 RO495 2-E10 SYN-1058A Pazopanib HCl 2-E11 SYN-1149 MK E12 SYN-1022 BMS-2 2-F1 SYN-1166 AZD F2 SYN-1201 GSK F3 SYN-1045 IC F4 SYN-1200 BKM120 2-F5 SYN-1178 BGT F6 SYN-1193 SGI F7 SYN-1077 SB F8 SYN-1121 R406 2-F9 SYN-1004 AG F10 SYN-1014 Axitinib 2-F11 SYN-1055 Motesanib 2-F12 SYN-1139 Crizotinib 2-G1 SYN-1157 MLN G2 SYN-1146 CH G3 SYN-1108 LY G4 SYN-1089 TGX221 2-G5 SYN-1178A BGT-226 free base 2-G6 SYN-1021 Bisindoylmaleimide X 2-G7 SYN-1161 PLX G8 SYN-1122 Tamatinib fosdium 2-G9 SYN-1133 JNJ G10 SYN-1025 Bosutinib 2-G11 SYN-1116 Ponatinib 2-G12 SYN-1047 JNJ H1 SYN-1186 XL388 2-H2 SYN-1066 PIK-93 2-H3 SYN-1105 TG H4 SYN-1098 PIK H5 SYN-1148 GNE H6 SYN-1037 Dianilinopyrimidine_01 2-H7 SYN-1124 GSK-25 2-H8 SYN-1008 AMG-Tie2-1 2-H9 SYN-1165 SAR H10 SYN-1138 Cabozantinib 2-H11 SYN-1169 Regorafenib 2-H12

10 PI3K Pathway Array SYN-2155 AKT (allosteric) GSK (SYN-1043) [ ] p110γ TG (SYN-1105) [ ] AKT1 (kinase) A (SYN- 1110) [ ] pan PI3K GSK (SYN-1126) [ ] GSK3 SB (SYN-1075) [ ] pan-akt (kinase) MK-2206 dihydrochloride (SYN-1162) [ ] KU (SYN-1050) [ ] p110δ NIBR-17 (SYN-1145) [ ] p110α NVP-BGT226 (SYN-1178) [ ] 9

11 Cytoplasmic PTK Panel SYN-2156 Abl PD (SYN-1176) [ ] PYK2, FAK Tofacitinib (SYN-1032) [ ] BTK FAK, PYK2 PF (SYN-1163) [ ] CGI1746 (SYN-1164) [ ] Src, Abl R406 (SYN-1121) [ ] Momelotinib (SYN-1035) [ ] JAK1,3 Bosutinib (SYN-1025) [ ] Syk GDC046 (SYN-1198) [ ],1 CGI1746 (SYN-1164) [ ] TYK2 AMG-47a (SYN-1007) [ ] LCK, RAF Dasatinib (SYN-1036) [ ] 10

12 Ras-Raf Panel SYN-2153 B-raf PLX4720 (SYN-1069) [ ] MEK1,2,5 - MKK3,4,6,7 AS (SYN-1190) [ ] c-raf/lck AMG-47a (SYN-1007) [ ] RSK SR3677 (SYN-1083) [ ] EGFR Lapatinib (SYN-1052) [ ] S6K PF (SYN-1177) [ ] GSK3 SB (SYN-1075) [ ] MEK1,2,5 PD (SYN-1059) [ ] R1487 (SYN-1101) [ ] 11

13 Ser/Thr Kinase Array SYN-2157 ASK S-99 (SYN-1119) [ ] GSK3 SB (SYN-1075) [ ] RSK SR3677 (SYN-1083) [ ] PKCα CX6258 (SYN-1182) [ ] LIMK1/2 BMS-3 (SYN-1023) [ ] S6K1 PF (SYN-1177) [ ] AURK Tozasertib (SYN-1092) [ ] R1487 (SYN-1101) [ ] TBK1 BX795 (SYN- 1026) [ ] B-Raf PLX4720 (SYN-1069) [ ] MEK1,2,5 - MKK3,4,6,7 Crizotinib (SYN-1139) [ ] CHK2 CX-4945 (SYN-1109) [ ] (family) BS194 (SYN- 1151) [ ] PKC LY Hydrochloride (SYN-1172) [ ] c-raf AMG-47a (SYN-1007) [ ] CHK1 XL388 (SYN-1186) [ ] 12

14 RTK Panel SYN-2152 AXL R428 (SYN-1131) [ ] FGFR MK-2461 (SYN-1149) [ ] ALK NVP-TAE684 (SYN-1159) [ ] Tie-2 AMG-Tie2-1 (SYN-1008) [ ] EGFR Lapatinib (SYN-1052) [ ] TRK GNF-5837 (SYN-1183) [ ] c-fms Ki20227 (SYN-1049) [ ] TrkA GW (SYN-1044) [ ] c-met Ki20227 (SYN-1049) [ ] Regorafenib (SYN-1169) [ ] c-kit, PDGFR FGFR3 Masitinib (SYN-1053) [ ] -2 JNJ (SYN-1133) [ ] -3 SAR (SYN-1165) [ ] 13

15 JAK-STAT Family Array SYN-2150 JAK1/3 Tofacitinib (SYN-1032) [ ] BI-D1870 (SYN-1020) [ ] Bayer-18 (SYN-1130) [ ] JAK1/2 GPLG0634 (SYN-1158) [ ] TYK2 GDC046 (SYN-1198) [ ] LY (SYN-1196) [ ] RO495 (SYN- 1128) [ ] NVP-BSK805 (SYN-1136) [ ] Pan JAK Baricitinib phosphate salt (SYN-1117) [ ] XL019 (SYN-1191) [ ] /1 Momelotinib (SYN-1035) [ ] AZ-960 (SYN-1015) [ ] 14

16 JAK-STAT Array (small) SYN-2151 Pan JAK Baricitinib phosphate salt (SYN-1117) [ ] /1 JAK1/2 Momelotinib (SYN-1035) [ ] BI-D1870 (SYN-1020) [ ] JAK1/3 Tofacitinib (SYN-1032) [ ] TYK2 NVP-BSK805 (SYN-1136) [ ] AZ-960 (SYN-1015) [ ] Bayer-18 (SYN-1130) [ ] GDC046 (SYN-1198) [ ] 15

17 Custom Libraries SYNkinase s partnership with a state of the art robotics facility means we can manufacture custom arrays with a lead time as short as three days. Select from over 200 high purity kinase inhibitors to design the perfect array for your research. You pick the inhibitors, their positions and concentrations, then we ll take care of the rest. Just look for the Array Ready* compounds on pages X-Y. All SYNkinase library arrays are manufactured using REMP 96 well plates with individually foil sealed wells to minimize any chance of cross contamination during use. For more information on custom libraries, or to start building your own right away, visit us at SYNkinase.com Custom Dilutions Anything You Can Imagine Pixel Art 16

18 BIOMOL GmbH Waidmannstr Hamburg Germany Fon: +49 (0) Fax: +49 (0)