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1 vol Mallory-Weiss Boerhaave vol Fujise T, Iwakiri R, Shiraishi R, Wu B, Fujimoto K: Azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling and the effects of the olive oil. Olives and Olive Oil in Health and Disease Prevention, edited by Preedy VR and Watson RR , Academic Press. Oxford UP-TO-DATA p ABC p p Arima S, Sakata Y, Ogata S, Tominaga N, Tsuruoka N, Mannen K, Shiraishi R, Shimoda R, Tsunada S, Sakata H, Iwakiri R, Fujimoto K: Evaluation of hemostasis with soft coagulation using endoscopic hemostatic forceps in comparison with metallic hemoclips for bleeding gastric ulcers: a prospective, randomized trial. J Gastroenterol. 45: , Ario K, Mizuta T, Eguchi Y, Kawaguchi Y, Oza N, Akiyama T, Iwane S, Takahashi H, Yasutake T, Ozaki I, Fujimoto K: Presence of esophageal varices is a risk factor for non-hemorrhagic death of hepatocellular carci-

2 noma patients treated with radiofrequency ablation. Hepatogastroenterology. 57: , Fujimoto K, Hongo M: The Japan Maintenance Study Group Risk factors for relapse of erosive GERD during long-term maintenance treatment with proton pump inhibitor: a prospective multicenter study in Japan. J. Gastroenterol. 45: , Hongo M, Fujimoto K: The Japan Maintenance Study Group. Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan. J Gastroenterol. 45: , Kitajima Y, Eguchi Y, Ishibashi E, Nakashita S, Aoki S, Toda S, Mizuta T, Ozaki I, Ono N, Eguchi T, Arai K, Iwakiri R, Fujimoto K: Age-related fat deposition in multifidus muscle could be a marker for nonalcoholic fatty liver disease. J Gastroenterol. 45: , Kusano K, Inokuchi A, Fujimoto K, Miyamoto H, Tokunaga O, Kuratomi Y, Shimazu R, Mori D, Yamasaki F, Kidera K, Tsunetomi K, Miyazaki J: Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy. J Gastroenterol. 45: , Mannen K, Tsunada S, Hara M, Yamaguchi K, Sakata Y, Fujise T, Noda T, Shimoda R, Sakata H, Ogata S, Iwakiri R, Fujimoto K: Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions. J Gastroenteol. 45: 30-36, Nakashima M, Hamajima H, Xia J, Iwane S, Kawaguchi Y, Eguchi Y, Mizuta T, Fujimoto K, Ozaki I, Matsuhashi S: Regulation of tumor suppressor PDCD4 by novel protein kinase C isoforms Biochem. Biophys. Acta. 1803: , Shiraishi R, Iwakiri R, Fujise T, Kuroki T, Kakimoto T, Takashima T, Sakata Y, Tsunada S, Nakashima Y, Yanagita T, Fujimoto K: Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow. J. Gastroenterol. 45: , α a C β Takahashi H, Ono N, Euchar Y, Euchar T, Katarina Y, Kawaguchi Y, Makeshift S, Ozaki I, Mizuta T, Toda S, Kudos S, Miyoshi A, Miyazaki K, Fujimoto K., 2010: Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease: a pilot study. Liver Int 30: , Takahashi H, Mizuta T, Kawazoe S, Eguchi Y, Kawaguchi Y, Otuka T, Oeda S, Ario K, Iwane S, Akiyama T, Ozaki I, Fujimoto K., 2010: Efficacy and safety of radiofrequency ablation for elderly hepatocellular carcinoma patients. Hepatol Res. 40: , Takashima T. Yamaguchi K, Mhara M, Fukuda T, Kuroki T, Furushima C, Wakeshima R, Iwakiri R, Fujimoto K, Inoue N., 2010: Brief questioning by nursing staffs before endoscopic examination may always pick up clinical symptoms of endoscopic reflux esophagitis. J. Clin. Biochem. Nutr. 46: , 2010.

3 Plummer-Vinson Tominaga N, Shimoda R, Iwakiri R, Tsuruoka N, Sakata Y, Hara H, Hayashi S, Morita S, Hamasaki Y, Matsushima T, Miyazaki K, Node K, Fujimoto K: Low serum albumin level is risk factor for patients with percutaneous endoscopic gastrostomy. Intern. Med. 49: , The GI Forefront GERD Frontiers in Gastroenterology NSAIDs Pharma Media GERD Barrett GI Research GI Research Arima S. : Endoscopic hemostasis using high-frequency soft coagulation for bleeding gastric ulcer: comparison with hemoclips in a prospective, randomized study. The 3rd International Gastrointestinal Consensus Symposium: JGA Keynote Program. 2009, 2, 20. Digestion 81: 156, 2010 (Symposium). Ο Eguchi Y, Mizuta T, Kawaguchi Y, Ozaki I, Ono N, Eguchi T, Fujimoto K.: Visceral fat accumulation is the first and second hit pathogenesis for development of nonalcoholic fatty liver disease. The Second International Forum of Japanese Society of Gastroenterology. 2010, 4, : A61 (Plenary Oral Presentation). Ο Higuchi K, Umegaki E, Nagahara A, Kato M, Kimura K, Ota T, Takahhashi S, Yamamoto S, Shiotani A, Watanabe T, Arakawa T, Hiraishi H, Kanke K, Hokimoto S, Fujimoto K, Ogawa H.: Risk factors for gastroin-

4 testinal bleeding in patients with drug eluting stents placement: a pilot case control study in Japanese multicenter. 111st Annual Meeting of the American Gastroenterological Association, DDW. 2010, 5, 1-6. Kusano M, Fujimoto K.: Heartburn symptoms are stronger than dyspepsia symptoms in motivating general population to seek medical attention. 111st Annual Meeting of the American Gastroenterological Association, DDW. 2010, 5, 1-6 Ο Kuwashiro T, Mizuta T, Isoda H, Oeda S, Iwane S, Kawaguchi Y, Eguchi Y, Ozaki I, Fujimoto K.: Insulin resistance is a main exacerbated factor of health-related quality of life (QOL) in chronic hepatitis C patients. 18th United European Gastroenterology Week, EUGW. 2010, 10, Gut 2010: 58 (suppliii): A323. Mannen K, Miyahara K, Yamazoto T, Tsuruoka N, Tominaga N, Fujise T, Noda T, Sonoda R, Sakata Y, Shimoda R, Sakata H, Ogata S, Iwakiri R, Fujimoto K.: Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 1121 lesions. 18th United European Gastroenterology Week, EUGW. 2010, 10, Gut 2010: 58 (suppl III): A262. Nakano R, Iwakiri R, Tsuruoka N, Yamaguchi K, Shiraishi R, Fujimoto K.: Factors associated with the efficacy of granulocyte and monocyte/macrophage adsorptive apheresis (GCAP) for patients with ulcerative colitis. 18th United European Gastroenterology Week, EUGW. 2010, 10, Gut 2010: 58 (suppl III): A303. Nomoto N, Yonemitsu N, Aoki S, Uchihashi K, Matsunobu A, Toda S, Fujimoto K.: Adipose tissue-derived stromal cells promote the invasion growth of gastric adenocarcinoma cells, which accelerate the myofibroblastic differentiation of the stromal cells in order to develop a cancer-associated cell type. 111st Annual Meeting of the American Gastroenterological Association, DDW. 2010, 5, 1-6. Shiraishi R, Iwakiri R, Fujise T, Kuroki T, Kakimoto T, Sakata Y, Tsunada S, Sonoda R, Nakashima Y, Yanagida T, Fujimoto K.: Suppressive effects of conjugated linoleic acid on colon carcinogenesis with azoxymethane and long term beef tallow feeding: different mechanisms between free fatty acid form and triglyceride form. 18th United European Gastroenterology Week, EUGW. 2010, 10, Gut 2010: 58 (suppl III): A127. Takashima T, Shiraishi R, Oda Y, Tsuruoka N, Nakano R, Shirahama N, Yamaguchi K, Shimoda R, Tsunada S, Sakata H, Iwakiri R, Fujimoto K.: Helicobacter pylori infection and endoscopic reflux esophagitis did not affect quality of life (QOL) with gastrointestinal symptoms in healthy Japanese volunteers. 12th World Congress of the International Society for Diseases of the Esophagus. 2010, Diseases of the Esophagus. 23 (Suppl I): 31A. Tominaga N, Arima S, Ogata S, Tsuruoka N, Mannen K, Sakata Y, Shimoda R, Tsunada S, Sakata H, Iwakiri R, Fujimoto K.: Prospective randomized trial for evaluation of hemostasis with soft coagulation for bleeding gastric ulcers. 111st Annual Meeting of the American Gastroenterological Association, DDW. 2010, 5, 1-6. Tominaga K, Fujiwara Y, Shimoyama Y, Umegaki E, Iwakiri R, Higuchi K, Kusano M, Fujimoto K, Arakawa T.: Rikkunshito improves PPI-refractory NERD: a prospective randomized multi-center trial in Japan. 111st Annual Meeting of the American Gastroenterological Association, DDW. 2010, 5, 1-6. Tominaga N, Shimoda R, Nakano R, Shirahama N, Tsuruoka N, Mannen K, Sakata Y, Tsunada S, Sakata H, Iwakiri R, Fujimoto K.: Prognostic factors for one-year survival in patients with percutaneous endoscopic gastrostomy. 111st Annual Meeting of the American Gastroenterological Association, DDW. 2010, 5, 1-6. Tsuruoka N, Fujimoto K, Fujiwara Y, Akiyama J, Ando T, Inamori M, Tanaka J, Shimatani T, Manabe N, Fu-

5 ruta K, Shimoyama Y, Kinjo F, Deguchi R, Kusano M.: Risk factors for low responders to proton pump inhibitor (PPI) treatment in reflux esophagitis (RE) and non erosive reflux esophagitis (NERD)-Japan FSSG Society. 111st Annual Meeting of the American Gastroenterological Association, DDW. 2010, 5, 1-6. Tsuruoka N, Tominaga N, Shirahama N, Nakano R, Shimoda R, Tsunada S, Sakata H, Iwakiri R, Fujimoto K.: NSAIDs accelerated a risk of colonic diverticular hemorrhage: a case-control study. 111st Annual Meeting of the American Gastroenterological Association, DDW. 2010, 5, 1-6. PPI GERD ALT β Suppl A C ALT metabolic factors direct PEG Suppl A A J-FOCUS

6 functional dyspepsia A GERD NERD LERD Suppl A NSAIDs NSAIDs Suppl A

7 Brunner s adenoma C NASH OGIB Blind loop syndrome

8 C Peg INF + Ribavirin INF-β + Ribavirin C C CIIP

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