Alzheimer s disease AD AD

DOI:10.16636/j.cnki.jinn.2013.z1.025 Journal of International Neurology and Neurosurgery 3 Lehti Maki T Dastidar P Jokela H et al. Effect of long term hormone replace -ment therapy on atherosclerosis progression in post menopausal women relates to functional apolipoprotein E genotype. Clin Endocrinol Metab 2 0 0 2 8 7 9 4 1 4 7-4 1 5 3. 1 3 Giassakisi G Veletza S Papanas N et al. Apolipoprotein E and First -ever Ischaemic Stroke in Greek Hospitalized Pa- 4. ApoE tients. J Int Med Res 2 0 0 7 3 5 1 1 2 7-1 3 3.. 2012 32 5 1802-1804. 1 4 Kokubo Y Chowdhury AH Date C et al. Age -dependent 5. association of apolipoprotein E genotype with stroke subtypes in. 2 0 1 2 a Japanese rural population. Stroke 2 0 0 0 3 1 9 3 9 1 3 4-3 6. 6 Paternoster L Martínez González NA Lewis S et al. Association Between Apolipoprotein E Genotype and Carotid Intima - Media Thickness May Suggest a Specific Effect on Large Artery Atherothrombotic Stroke. Stroke 2 0 0 8 3 9 1 4 8-5 4. 7 Szolnoki Z Somogyvari F Kondacs A et al. Evaluation of the interactions of common genetic mutations in stroke subtypes. J Neurol 2 0 0 2 2 4 9 1 0 1 3 9 1-1 3 9 7.. 2 0 1 2 1 4 3 1 9 5-1 9 8. 9 Schilling S Destfano AL Sachdev PS et al. APOE genotype and MRI markers of cerebrovascular disease Systematic review and meta -analysis. Neurology 2 0 1 3 8 1 3 2 7 7 1-2 1 7-2 1. 1 2 Chiou LL Ching KL Ruey TL et al. Association Of Apolipoprotein E Polymorphism With Ischemic Stroke Subtypes In TAIWAN. Kaohsiung J Med Sci 2007 23 10 491-497. 1 2 9 9-1 3 0 6. 1 5 Biffi A Sonni A Anderson CD et al. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol 2 0 1 0 6 8 6 9 3 4-9 4 3. 1 6 Pezzini A Padovani A. Cerebral amyloid angiopathy -related hemorrhages. J Neurol Sci 2 0 0 8 2 9 2 2 6 0-2 6 3. 1 7 Sullivan PM Mace BE Estrada JC et al. Human apolipoprotein E4 targeted replacement mice show increased preva- 8. E lence of intracerebral hemorrhage associated with vascular amyloid deposition. 3 0 3-3 1 1. Stroke Cerebrovasu Dis 2 0 0 8 1 7 5 1 8 Tzourio C Arima H Harrap S et al. etheicity and the risk of cerebral hemorrhage. 2 0 0 8 7 0 1 6 1 3 2 2-1 3 2 8. ApoE genotype Neurology 2 9 2-3 0 0. 1 9 Biffi A Soaai A Anderson CD et al. Variants at APOE iffluence 1 0. E. 2013 42 2 172-174. risk of deep and lobar intracerebral hemorrhage. Neurol 2 0 1 0 6 8 6 9 3 4-9 4 3. Ann 1 1 Tascilar N Dursun A Ankarali H et al. Relationship of 2 0 Biffi A Christopher D Anderson MD et al. APOE Genotype apoe polymorphism with lipoprotein a apoa apob and lipid levels in atherosclerotic infarct. J Neurolog Sci 2 0 0 9 Predicts Extent of Bleeding and Outcome in Lobar Intracerebral Hemorrhage. Lancet Neurol 2011 10 8 702-709. MicroRNA 215000 mirna mirna MicroRNA MicroRNA Alzheimer s disease AD AD 2013-06 - 21 2013-08 - 07 1987-462

2 013 4 0 5-6 senile plaque SP neurofibrillary tangles NFTs SP amyloid precursor protein APP β 1 beta amyloid cleaving 2007 Lukiw 2 enzyme 1 BACE1 γ AD mirnas Lukiw β amyloid β -protein Aβ NFTs mirna Tau 1 AD mirna mirna 21 ~ 23 RNA mrna 3 untranslated regions UTR AD mirna AD mrna mirna 5 AD mirna 2 ~ 8 mirna mir -29 mir -15 mir -107 mir -181 mir -146 mrna seed region mirna APP BACE1 MAPT microtubule -associated mir -9 mir -101 mir -106 mirna protein tau AD DNA AD mirna mirna 1 1 AD mirna 1 microrna AD microrna AD AD mir-181 ATM DNA mir-146 DNA / RANTES IRAK1 mir-101 APP APP APP Aβ COX2 MAGL2 Tau Tau mir-15 Bcl-2 ERK1 Tau Tau mir-29 BIM BMF HRK Puma BACE1 Aβ Aβ mir-107 BACE1 Aβ Aβ Dicer mirna mirna cofilin CDK6 mir-106 Rb1 p21 APP P73 APP APP Aβ Tau /Tau P62 Aβ 2 AD mirna 2. 1 mir -181 mir -181 4 mir -181 a mir - mir -181 a mir -181 b 42 β mir -181 c mirna 4 mir -181 c 181 b mir -181 c mir -181 d DNA mir -181 c AD ataxia telangiectasia mutated ATM DNA mir -181 d AD 3 5 463

Journal of International Neurology and Neurosurgery AD DNA 2. 4 mir -29 mir -181 c mir -29 3 mir -29 a mir -29 b DNA mir -29 c 2. 2 mir -146 mir - mir -146 mir -146 a mir -146 b AD mir -146 a Bim Bmf Hrk Puma Bcl -2 mir -146 b C 6 mir -146 a mir -29 b Bcl -2 mir -146 b AD IL -1 C AD NF -κb mir - 13 146 a 7 AD mir -29 b NF -κb 8 mir - BACE1 146 a mir -146 b β mir -146 a AD mir -146 a RANTES I- RAK1 6 mir -146 a mir -29 b 29 c BACE1 AD Aβ AD 14 15 9 2. 5 mir -15 mir -146 mir-15 mir-15 a mir-15 b mir-16 AD mir-195 mir-424 mir-497 mir-503 mir-646 2. 3 mir -101 APP mir -101 3 UTR mir -101 AD 16 AD tau mir -101 mir -101 APP AD APP 1 ERK1 mir -101 Aβ 10 mir -15 ERK1 mir -101 COX -2 ERK1 / 2 AD mir -15 a NFTs mirna 11 mir -101 APP tau 17 COX -2 Tau AD AD mir -101 mir -15 tau MGI2 MGI2 tau AD tau 2. 6 mir -107 tau NFTs AD mir -107 mir -107 / 103 mir -107 / 12 mir -101 103 mir -15 APP COX -2 Tau AD 464 29 b mir -29 b mir -29 b mir -29 c BACE1 3 UTR β mir -29 mir -15 Bcl -2 tau mir -107 18 mir -15

2 013 4 0 5-6 2 Lukiw WJ. Micro -RNA speciation in fetal adult and Alzhei- mir -107 AD MCI mer s disease hippocampus. Neuroreport 2 0 0 7 1 8 3 BACE1 mrna 19 2 9 7-3 0 0. 3 Geekiyanage H Chan C. MicroRNA -1 3 7 / 1 8 1 c regulates mir -107 serine palmitoyltransferase and in turn amyloid β novel targets in sporadic Alzheimer s disease. J Neurosci 2 0 1 1 AD β 20miR -107 AD 3 1 4 1 1 4 2 0-1 4 3 0. 4 Schonrock N Ke YD Humphreys D et al. Neuronal microrna deregulation in response to Alzheimer s disease amy- AD 2. 7 mir -106 loid -beta. PLoS One 2 0 1 0 5 6 e1 1 0 7 0. mir -106 mir -17 5 Wang Y Yu Y Tsuyada A et al. Transforming growth factor -β regulates the sphere -initiating stem cell -like feature in mir -17 mir -18 mir -20 mir -93 mir -106 mir -106 a mir -106 b 21 breast cancer through mirna -1 8 1 and ATM. Oncogene 2 0 1 1 3 0 1 2 1 4 7 0-1 4 8 0. mir -106 a APP 3 UTR APP mir -106 a APP mir -106 a mir106 b 6 Cui JG Li YY Zhao Y et al. Differential regulation of interleukin -1 receptor -associated kinase -1 IRAK -1 and I- RAK -2 by microrna -1 4 6 a and NF -kappab in stressed hu- APP mir -106 b man astroglial cells and in Alzheimer disease. J Biol Chem APP AD 22 mir - 2 0 1 0 2 8 5 5 0 3 8 9 5 1-3 8 9 6 0. 106 b 1 retinoblastoma protein 1 p21 22 mary human brain cells. Exp Neurol 2 0 1 2 2 3 5 2 7 Lukiw WJ. NF -кb -regulated micro RNAs mirnas in pri- 21 p73 p73 tau AD p73 1 0 Vilardo E Barbato C Ciotti M et al. MicroRNA -1 0 1 regulates tau p73 amyloid precursor protein expression in hippocampal neurons. J Biol Chem 2 0 1 0 2 8 5 2 4 1 8 3 4 4-1 8 3 5 1. tau mir -106 a 1 1 Yokota O Terada S Ishizu H et al. Cyclooxygenase -2 in mir106 b AD Aβ the hippocampus is up -regulated in Alzheimer s disease but not in variant Alzheimer s disease with cotton wool plaques 3 in humans. Neurosci Lett 2 0 0 3 3 4 3 3 1 7 5-1 7 9. mirna AD 1 2 Sachdeva M Wu H Ru P et al. MicroRNA -1 0 1 -mediated AD mirna AD mirna Akt activation and estrogen -independent growth. gene 2 0 1 1 3 0 7 8 2 2-8 3 1. Onco- 1 3 Kole AJ Swahari V Hammond SM et al. mir -2 9 b is activated during neuronal maturation and targets BH3 -only genes RNA mirna AD to restrict apoptosis. Genes Dev 2 0 1 1 2 5 2 1 2 5-1 3 0. 1 Lewis BP Burge CB Bartel DP. Conserved seed pairing often flanked by adenosines indicates that thousands of human genes are microrna targets. Cell 2 0 0 5 1 2 0 1 1 5-2 0. 465 4 8 4-4 9 0. AD mir -106 b 8 Granic I Dolga AM Nijholt IM et al. Inflammation and NF -kappab in Alzheimer s disease and diabetes. J Alzheimers Dis 2 0 0 9 1 6 4 8 0 9-8 2 1. mir -106 b p73 9 Lee YJ Han SB Nam SY et al. Inflammation and Alzheimer s disease. Arch Pharm Res 2 0 1 0 3 3 1 0 1 5 3 9-1 5 5 6. 1 4 Hébert SS Horré K Nicola L et al. Loss of microrna cluster mir -2 9 a / b -1 in sporadic Alzheimer s disease correlates with increased BACE1 / beta -secretase expression. Proc Natl Acad Sci U S A 2 0 0 8 1 0 5 1 7 6 4 1 5-6 4 2 0. 1 5 Zong Y Wang H Dong W et al. mir -2 9 c regulates BACE 1 protein expression. Brain Res 2 0 1 1 1 3 9 5 1 0 8-1 1 5.

Journal of International Neurology and Neurosurgery 1 6 Cimmino A Calin GA Fabbri M et al. mir -1 5 and mir - 1 6 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 2 0 0 5 1 0 2 3 9 1 3 9 4 4-1 3 9 4 9. 1 7 Hébert SS Papadopoulou AS Smith P et al. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet 2 0 1 0 1 9 2 0 3 9 5 9-3 9 6 9. 1 8 Finnerty JR Wang WX Hébert SS et al. The mir -1 5 / 1 0 7 group of microrna genes evolutionary biology cellular functions and roles in human diseases. J Mol Biol 2 0 1 0 4 0 2 3 4 9 1-5 0 9. 1 9 Nelson PT Wang WX. MiR -1 0 7 is reduced in Alzheimer s disease brain neocortex validation study. J Alzheimers Dis 2 0 1 0 2 1 1 7 5-7 9. 2 0 Bonda DJ Lee HP Kudo W et al. Pathological implications of cell cycle re -entry in Alzheimer disease. Expert Rev Mol Med 2 0 1 0 1 2 e1 9. 2 1 Hébert SS Horré K Nicola L et al. MicroRNA regulation of Alzheimer s Amyloid precursor protein expression. Neurobiol Dis 2 0 0 9 3 3 3 4 2 2-4 2 8. 2 2 Wang PY Li YJ Zhang S et al. Regulating A5 4 9 cells growth by ASO inhibiting mirna expression. Mol Cell Biochem 2 0 1 0 3 3 9 1-2 1 6 3-1 7 1. 2 2 Kim YK Yu J Han TS et al. Functional links between clustered micrornas suppression of cell -cycle inhibitors by microrna clusters in gastric cancer. Nucleic Acids Res 2 0 0 9 3 7 5 1 6 7 2-1 6 8 1. 2 3 Patel N Hoang D Miller N et al. MicroRNAs can regulate human APP levels. Mol Neurodegener 2 0 0 8 3 1 0. 2 4 Sampath D Calin GA Puduvalli VK et al. Specific activation of microrna1 0 6 b enables the p7 3 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation. Blood 2 0 0 9 1 1 3 1 6 3 7 4 4-3 7 5 3. 2 5 Meenhuis A van Veelen PA de Looper H et al. MiR - 1 7 / 2 0 / 9 3 / 1 0 6 promote hematopoietic cell expansion by targeting sequestosome 1 -regulated pathways in mice. Blood 2 0 1 1 1 1 8 4 9 1 6-9 2 5. β 110001 β Aβ β β normal brain aging β beta amyloid Aβ AD NBA Alzheimer s disease AD 1 mild cognitive impairment MCI 4 Aβ Aβ deposition 5 2 3 Aβ 2013-05 - 29 2013-09 - 20 1989 - E-mail lixingqiangsyy@ yeah. net 1963 - E-mail ypengcao@ yahoo. com 466