doi:10.3969 / j.issn.1000-3606.2011.06.025 587 -α(tnf-α) 1.2 ( ) TNF-α 1 ; 2 TNF-α 2005 2007 ; 3 (RA) (AS) ; 4 ; 5 ; (Ps) 6 ; 7 (JIA) [1-6] 1.3 JIA JIA 0.8 mg / (kg ) 1 ~ 2 : 2 1.6 mg / kg 3 JIA 1 JIA 0.8 mg/kg JIA 1 [78] JIA 2 [9] JIA 50 mg 1.4 JIA 1 1.1 (MRI X ) (ILAR)2001 JIA [ ( ESR) C [ JIA JIA (RF) (CRP) RF CCP ] JIA RF JIA JIA JIA] 4 ~ 18 2 ~ 4 ACR [ACR Pedi 30 / 50 / 70]) [10] 6 : (MTX) 10 ~ 15 mg / m 2 ( (CHAQ) ) 1 12 ( ) 5 / ; 0.25 mg / (kg d)] 4 3 6 3 30% [ 30% ( ACR Pedi 30 ) : 6 30% 5 3 / DAS28 [11] RF ( CCP ) JIA ( ) ( ) JIA ( ESR CRP : 3 30% Wallace [12] JIA (ID) (CRM) JIA (CR) (ERA) ( ) (RF ) JIA JIA JIA(SoJIA) JIA : 1 MTX (
588 29 ); 2 EBV CMV JIA JIA ; 3 ; 4ESR CRP ; 5 [20] ( 1 ~ 8 ) ID 6 CRM CR 10% ~36% ID 12 1% ~ 6% ID TNF JIA 1 3 1 X 1 TNF JIA ( ) 2.2.1 40 JIA TNF [13] 12 1.5 T-Spot 3 3 PPD ACR Pedi 30 ; 6 ACR Pedi 30 : 1 1.6 1 ; 2 EBV CMV HBsAg HBV TNF ) ; 3 ; 2 JIA (ALT AST 2 ( ); 3 1.7 DMARDs DMARDs JIA ( JIA 3 ~ 6 1 X ); 6 MTX 12 ACR Pedi 70 (62%) JIA (45%) [14] 1.8 1 3 ~ 6 1 X : X X ( CT ) PPD HBV / HCV (HCV) JIA TNF ( ) [1416-18] [19] (HBV) JIA 2 ; 4 ; 5 TNF ; 7 6 ~ 12 3 2.2.2 HBV (HBsAg) 2 HBV TNF 2.1 [ 21] HBV HBV JIA HCV HBV (IFN) : 1 28% ~ 39% [1516] HBV HCV ; 2 T ; 3HBsAg HBV (ALT AST 2 2.2 ) ; 4HBsAg TNF-α HBV ; 5HBsAg HBV ; 6
589 HBsAg 1 10 TNF HBV DNA 2.2.3 2.4 TNF TNF JIA [1416-182022] TNF [1826] TNF JIA : 2.3 [1417182026-32] TNF TNF DNA [17192023] 2 000 TNF (FDA) TNF 1999 2008 TNF 48 TNF [24] [33] 20 α (IFN-α) TNF-α (JIA 15 3 TNF 6 1 1 ) (IBD) ; ( 11 / 10 ) 5 ; 80% TNF 30 (1 ~ 7 ) 2.5 (MAS) 11 MAS (1998 2009 ) 18 JIA TNF 22 725 MAS [37] MAS 6 [16-1835-37] TNF MAS 18 4 7 7 2.6 [25] 4 ~ 17 ( 0.02% 17 MRI 0.015%) ( 0.014%) 4 ~17 FDA [38] 0.01% 0.002 6% 2 3.8 [25] FDA JIA 21 8 [141719] JIA 1 FDA TNF 2.7 TNF [2123] 3 TNF TNF 3.1 2 ~ 4
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