2014 6 1 3 International Breast Cancer Symposium, June 2014, Vol. 1, No. 3 197 dxy.cnmedlive.cn Yeo B, Turner NC, Jones A. Clinical Review: An update on the medical management of breast cancer. BMJ. 2014 Jun 9;348:g3608. 2014 6 9 ICR 3 BMJ 2008 HER2 HER2 PubMed 2013 [1] 1 [2] 1 30 Cancer Research UK [1] 2008 [3,4] 1 1.1 NHS 4773 [2] B 1.2 1.2.1 [5] 1mm [6] 1.2.2 SLNB SLNB ALND ALND ALND SLNB ALND [7] SLN ALNDZ0011 [8] 800 SLNB 27% ALND 6.3 SLNBALND SLNB ALND 1 2 SLN ALND [9] [10] SLN ALND 1.3
198 2014 6 1 3 International Breast Cancer Symposium, June 2014, Vol. 1, No. 3 HER2 Adjuvant Online PREDICT Ki-67 [11] 2 2 B A Oncotype DX 21 3Mammaprint 70 NICE Oncotype DX A B 2 3 [12] A BHER2 A BHER2 HER2 HER2 HER2 50% HER2 HER2 3 Oncotype DX 11 5 10 7%95%[CI]5%10% T Ki-67 21 HER2 21 70
2014 6 1 3 International Breast Cancer Symposium, June 2014, Vol. 1, No. 3 199 2 2.1 5 80% 5 41% 31% [13] 10000 2 ATAC BIG1-98 5 5 5.8 2.9%9.6% 12.6%P0.001 [14] 2 D [15] 23 [14] 2.2 5 5 [16] 5 5 42% 0.57P0.001 [17] 5 5 ATLAS 7000 [18] 10 5 617 711P0.002331 397P 0.01 5 20000 [19] 4925 2.1% 4.1% 5 514 3.1% 1.6% [18] 6953 ATTom [20] ATLAS ATTom 10 10 10 [20] 10 2.3 [21] Oncotype DX TAILORx NCT00310180 MINDACT NCT00433589 [22] 1% MINDACT 2.4 HER2 15% HER2 [23] HER2 3 1 218 321 0.64P0.000159 900.66P0.0115 [24,25] 3% [26] HER2 20% 30%HER2 HER2 HER2 HER2 2.5 36 [27] 11000 18.4% 21.9%P0.0015.9% 8.8% P0.001 3 HER2 [28]
200 2014 6 1 3 International Breast Cancer Symposium, June 2014, Vol. 1, No. 3 [29] HER2 / 4 A 2.2 0.5 [30] HER2 [31] 4.1 mtor [32] mtor 10.6 4.1 P0.001 [33] HER2 mtor IIII 4.2 HER2 HER2 4.3 HER2 HER2 4 25.1 20.3 P0.046 [34] [35] HER2 III 800 HER3 HER2 HER2 6.1 18.5 12.4 P0.001 [36] 0.66P0.0008 [37] 4 HER2 HER2 HER2 ACLEOPATRA [36] HER2 48%BEMILIA [39] T-DM1 T DM1 T-DM1 T-DM1 HER2 - [38] III EMILIA T-DM1 9.6 6.4 P0.00130.9 25.1 P 0.001 [39] HER2 3 [39] 5 60%80% [40,41] [42] RANK [43] 2000 [44] D
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