VBD TCD MRA VBD 30 VBD VBD VBD P > VBD TCD

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1 Chin J Cerebrovasc Dis Electronic Edition December 2011 Vol 5 No VBD TCD 18 MRA VBD 30 VBD VBD VBD P < PI RI P > VBD TCD VBD TCD Primary investigation of transcranial Doppler manifestation of vertebrobasilar dolichoectasia ZHANG Xia JI Ping LIU Hui-hui CAO Yong-jun LIU Chun-feng. Department of Neurology the Second Affiliated Hospital of Soochow University Suzhou China Corresponding author LIU Chun-feng liucf20@ hotmail. com Abstract Objective To investigate the transcranial Doppler TCD manifestation and clinical significance of vertebrobasilar dolichoectasia VBD. Methods 18 VBD patients diagnosed by cranial magnetic resonance angiograph MRA underwent intracranial Doppler examinations and 30 patients with no significant differences in age sex clinical symptoms past history were included as matched control. Results Vs and Vm of VBD patients decreased compared with control group P < PI and RI of VBD group had no significant differences compared with control group P < Spectral shapes of some VBD patients showed blunt peak and low-resistant waveform. Conclusions Hemodynamics of VBD patients changed and TCD can be one of screening and auxiliary diagnosis. Key words Vertebrobasilar dolichoectasia Transcranial Doppler liucf20@ hotmail. com

Department of Neurology the Second Affiliated Hospital of Soochow University Suzhou 215004 China Corresponding author LIU Chun-feng E-mail liucf20@ hotmail.

2 Chin J Cerebrovasc Dis Electronic Edition December 2011 Vol 5 No. 6 vertebrobasilar dolichoectasia VBD transcranial Doppler TCD TCD MRI VBD 18 Ubogu EE 1 MRA > mm 10 > mm 10 mm 18 VBD ~ ± MRA 30 P > Philips Medical Systems Achieva 1. 5T SE T1WI + TSE T2WI DWI OM 6 mm FOV Gd-DTPA 10 ~ 15 ml 0. 1 mmol /kg magnetic resonance angiography MRA TR 23 ms TE ms 6 mm Willis Smoker l 2 3

5 mm 10 > 23. 5 mm 10 mm 18 VBD 10 8 46 ~ 74 60. 54 ± 8. 23 10 6 6 1 1 5 9 6 3 2 6 1 MRA 30 P > 0. 05 2.

3 Chin J Cerebrovasc Dis Electronic Edition December 2011 Vol 5 No TCD NICVUE TC8080 TCD vertebral artery VA basilar artery BA Vs Vd Vm resistance index RI Vs - Vd /Vs pulse index PI Vs - Vd /Vm 4. SPSS χ 2 PI RI T P < P > % QSAS VBD VBD P > MRI MRA VBD MRI T1WI T2WI 18 VBD MRA % CPA % CPA % % CPA % CPA % MRA - CT 1

0 χ 2 PI RI T P < 0. 05 1. P > 0. 05 1 1 % QSAS VBD 18 10 55. 56 10 55. 56 0 0. 00 6 33. 33 6 33. 33 1 5. 56 5 27. 78 1 5. 56 VBD 30 17 56.

4 Chin J Cerebrovasc Dis Electronic Edition December 2011 Vol 5 No. 6 1 MRI MRA A MRI B MRA 3. TCD TCD Vs RI PI VBD % 5 7 VBD PI /RI VBD Vd Vs Vm P < PI RI 2 VBD TCD VBD PI VBD Vs Vm PI RI 2

5 Chin J Cerebrovasc Dis Electronic Edition December 2011 Vol 5 No TCD x 珋 ± s LVA RVA Vs cm /s Vm cm /s EDV cm /s PI RI Vs cm /s Vm cm /s EDV cm /s PI RI VBD ± ± ± ± ± ± ± ± ± ± VBD ± 13 a 40 ± 18 a 22 ± ± ± ± 15 a 41 ± 17 a 21 ± ± ± BA Vs cm /s Vm cm /s EDV cm /s PI RI VBD 48 ± ± 9 23 ± ± ± VBD 67 ± 12 a 43 ± 15 a 25 ± ± ± a P < VBD / α- Ehlers-Danlos PHACES 3 Marfan Fabry 4 5 EEC Pompe VBD VBD

07 44 ± 18 30 ± 12 20 ± 9 0. 84 ± 0. 25 0. 55 ± 0. 10 VBD 30 62 ± 13 a 40 ± 18 a 22 ± 11 0. 86 ± 0. 21 0. 56 ± 0. 08 63 ± 15 a 41 ± 17 a 21 ± 13 0. 86 ± 0. 16 0.

6 Chin J Cerebrovasc Dis Electronic Edition December 2011 Vol 5 No. 6 PI RI VBD 9 VBD VBD PI RI 10 PI RI VBD PI PI VBD PI VBD TCD 1 2 VBD VBD TCD VBD VBD VBD Passero 11 VBD 2. 2 / / TCD Vs Vm PI RI EDV

7 Chin J Cerebrovasc Dis Electronic Edition December 2011 Vol 5 No TCD VBD TCD VBD Vs Vm VBD 1 Ubogu EE Zaidat OO. Vertebrobasilar Dolichoeetasia Diagnosed by Magnetic Resonance Angiography and Risk of Stroke and Death a Cohort Study. J Neurol Neurosurg Psychiatry Smoker WR Corbett JJ Gentry LR et al. High-resolution Computed Tomography of the Basilar Artery Clinical pathologic Correlation and Review. Am J Neuroradiol Baccin CE Krings T Alvarez H et al. A Report of Two Cases with Dolichosegm ental Intracranial Arteries as a New Feature of PHACES Syndrome. Childs Nerv Syst Savitz SI Ronthal M Caplan LS. Verbebral Artery Compression of the Medulla. Arch Neurol Schievink WI Torres VE Wiebers Do et al. Intracranial Arterial Doli-choectasia in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol Laforêt P Petiot P Nicolino M et al. Dilative Arteriopathy and Basilar Artery Dolichoectasia Complicating Late-onset Pompe Disease. Neurology CT Ince B Petty GW Brown R D et al. Dolichoectasia of the Intracranial Arteries in Patients with First Ischemic Stroke a Population-based Study. Neurology Pico F Labreuche J Touboul PJ et al. Intracranial arterial dolichoectasia and small-vessel disease in stroke patients. Ann Neurol Passero SG Calchetti B Bartalini S. Intracranial Bleeding in Patients With Vertebrobasilar Dolichoectasia. Stroke J /CD

2 Smoker WR Corbett JJ Gentry LR et al. High-resolution Computed Tomography of the Basilar Artery Clinical pathologic Correlation and Review. Am J Neuroradiol 1986 7 1 61-72.

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