chronic kidney disease CKD A Survey and Analysis of Chinese Patent Medicine for Outpatients with Chronic Kidney Disease SU Guobin LIU

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1 CJITWM August 2011 Vol. 31 No chronic kidney disease CKD CKD Logistic CKD % 41 / % 24 / % 5 / % 14 / % 7 / % 2 /41 Logistic Enter P < A Survey and Analysis of Chinese Patent Medicine for Outpatients with Chronic Kidney Disease SU Guobin LIU Xu-sheng WENG Jun-xiong et al Department of Nephropathy Peking University Third Hospital Beijing ABSTRACT Objective To investigate the current state of oral administration of Chinese patent medicine in treatment of chronic kidney disease CKD in the Western medicine hospitals. Methods Outpatients of Department of Nephropathy Peking University Third Hospital with diagnosed CKD confirmed by CKD diagnosis standard were surveyed by questionnaire in May The following patients' information was collected using the Questionnaire of the Current State of Oral Administration of Chinese Patent Medicine at CKD Clinics. 1 The present symptoms tongue figure pulse figure were syndrome typed referring to The Diagnosis Syndrome Typing and Efficacy Assessment of Chronic Renal Failure 2006 by Chinese Society of Renal Diseases Chinese Society of Traditional Chinese Medicine. 2 Names of Chinese patent medicines and Western medicines patients use presently the dose and dosage names of hospitals responsible for prescriptions. 3 Patients' basic diseases including diabetes hypertension hyperuricemia and so on at present. Irrational applications of Chinese patent medicines were classified according to the drug instruction and Guiding Principle of Clinical Application of Chinese Patent Medicines issued by State Administration of Traditional Chinese Medicine. The irrationality was analyzed. Correlated factors such as age sex deficiency in origin syndrome sthenia in superficiality syndrome the nature and grade of hospitals responsible for prescriptions total numbers of Chinese patent medicines and primary dis- No Tel wangt@ bjmu. edu. cn

2 CJITWM August 2011 Vol. 31 No eases etc. were analyzed using Logistic regression model. These factors might result in irrational application of Chinese patent medicines. Results 102 questionnaires were handed out with 78 effective ones. Of them 41 patients 41 /78 accounting for 52. 6% were taking Chinese patent medicines. Of the 41 patients irrational application happened to 24 patients 24 /41 accounting for 58. 5% absolute discrepancy of medicines and syndromes to 5 5 /41 accounting for 12. 2% repeated medication to 7 7 /41 accounting for 17. 1% and interaction to 2 2 /41 accounting for 4. 9%. Logistic regression model was analyzed. Variables were screened by Enter method. The number of Chinese patent medicines had statistic significance P < Conclusions The occurrence rate of irrational application of Chinese patent medicines in CKD outpatients in Western medicine hospitals was higher. They were mainly manifested as absolute discrepancy of medicines and syndromes and repeated medication. Increased numbers of Chinese patent medicines in recipes would increase the occurrence rate of irrational application of Chinese patent medicines. KEYWORDS chronic kidney disease Chinese patent medicine survey of the current state chronic kidney disease CKD CKD CKD CKD CKD 2 CKD CKD CKD 2 glomerular fil- 3 tration rate GFR < 60 ml / min m CKD CKD CKD

3 CJITWM August 2011 Vol. 31 No % 5 / % 2 / % 5 / % 1 / % 3 /41 5 CKD % 22 / CKD ± % % 22 /41 5 SPSS CKD x ± s 58. 5% 24 /41 t χ 2 2 /5 Logistic 1 /5 2 /5 α = 0. 05α < % 14 / / % 7 /41 CKD 41 1 / % 41 / /7 1 / ~ / % % 2 / % 11 /41 CKD 1 CKD1 1 /2 7. 3% 3 / % 10 / % 18 / % 7 / % 3 / % 5 / % 5 / % 11 / % 17 / % 3 / % 4 / % 8 / % 4 / % 38 / % 32 / % 5 /41 11 /14 1 /14 1 /7 1 /7 2 CKD 1 / % 31 / % 1 /7 1 /2 7 P = P < P = P = CKD % 34 /41 CKD

4 CJITWM August 2011 Vol. 31 No Logistic Enter P > B > 0 OR > 1 P = Logistic B S. E Wals χ 2 P OR CKD CKD 1 CKD 1. 1 CKD CKD 4 CKD CKD CKD 2 CKD CKD CKD CKD CKD

5 CJITWM August 2011 Vol. 31 No /6 1 /3 ~ 1 /2 2 /3 3 9 CKD CKD PAF 10 CKD 1 K /DOQI clinical practice guidelines for chronic kidney disease evaluation classification and stratification J. Am J Kidney Dis Suppl 1 S1-S J He LQ. The diagnosis differentiation and efficacy assess ment of chronic renal failure trial J. Shanghai J Tradit Chin Med M. 11 CKD State Administration of Traditional Chinese Medicine of the People's Republic China. Guiding principle of clinical appli CKD ~ 5 8 CKD cation of Chinese patent medicines trial M

6 CJITWM August 2011 Vol. 31 No Stevens LA Levey AS. Chronic kidney disease in the elderly how to assess risk. J. N Engl J Med J Sun W Wei MG. How to rationally use traditional Chinese patent medicine for chronic kidney disease patients One J. China Licensed Pharm D Huang WZ. The interaction of Chinese herbs and chemical Zhang E. Correlation study on Chinese medicine syndromes medicine J. Adverse Drug React J and clinical factors of chronic kidney disease stage 4 D. 11. Beijing Univ Chin Med J D Lei SH Liu K. Measurements to avoid adverse reaction caused Feng DH. Correlation study on Chinese medicine syn- by unreasonable use of traditional Chinese medicine patents dromes and clinical factors of chronic kidney disease stage 3 D. Heibei Univ Chin Med J Li Y Luo CL Jia Y. Analysis of current exploration of Chinese patent medicine for nephrology J. Chin Med Modern Distance Educ China J Zhang BH Gao SQ Fu DX. A review of adverse drug reaction of traditional Chinese patent medicines in Beijing Hospital from 2004 to 2007 J. Chin Gen Pract J. J. J Sichuan Tradit Chin Med M. Huang ZS editor. Chinese materia medica M. Beijing People's Medical Publishing House MEDLINE CA AJ JST Ulrich's PD IC CABI WHO WPRIM / ISSN CN /R 2-52 M cjim@ cjim. cn http / /www. cjim. cn

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