P < P < C

Μέγεθος: px

Εμφάνιση ξεκινά από τη σελίδα:

Download "P < P < C"

Αιγιδιος Κόρακας
7 χρόνια πριν
Προβολές:

1 CJITWMDecember 2013Vol. 33No ankylosing spondylitis AS AS A 22 + B C 27 SASP D 21 SASP + 12 AS BAS-G AS BASFI AS BASDAI Schober ESR CRPASAS20 ASAS50 ASAS70 BASDAI50 BAS-G BASFI BASDAI Schober ESR CRP P < P < A C P < P < B P < P < C A BAS-G BASFI BASDAI Schober ESR CRP P < P < D B BASFI BAS- DAI Schober ESR P < P < ASAS20 ASAS50 ASAS70 BASDAI50 P < AS AS SASP Treatment of Ankylosing Spondylitis by Modified Bushen Zhuanggu Recipe a Clinical Observation ZHANG Nan ZHANG Ying-ze TAO Qing-wen and YAN Xiao-ping Beijing China Department of Rheumatology China-Japan Friendship Hospital ABSTRACT Objective To observe the clinical effect and safety of modified Bushen Zhuanggu Recipe BZR in treating ankylosing spondylitis AS. Methods Recruited were 96 AS outpatients of Shen deficiency induced cold-dampness syndrome SDCDS or Shen deficiency dampness-heat syndrome SDDHS at clinics of China-Japan Friendship Hospital from May 2010 to May They were randomly assigned to the traditional Chinese medicine TCM treatment group and the Western medicine WM treatment group in the ratio of 1 1. Those in the TCM treatment group were syndrome typed as the SDCDS group group A22 casestreated by Bushen Zhuanggu Quhan Decoction + WM placebos and the SDDHS group group B26 cases treated by Bushen Zhuanggu Qinghua Decoction + WM placebos. Those in the WM treatment group were syndrome typed as SDCDS group group C27 cases treated by SASP + TCM placebos and the SDDHS group group D21 casestreated by SASP + TCM placebos. Totally 12 weeks consisted of one therapeutic course. BAS-G BASFI BASDAIspine painpain at nighttcm symptom scoredistance between occipital and walldistance between finger and ground thoracic activityspine activityschober test ESRCRP were observed as the observing indices ASAS20 ASAS50ASAS70BASDAI50and criteria of TCM were explored for clinical evaluation and safety evaluation. Results In No Tel yanxiaoping1688@ 126. com DOI /CJIM

2 CJITWMDecember 2013Vol. 33No. 12 comparison with the same group before treatment BAS-G BASFI BASDAI spine pain at nighttcm syndrome score distance between finger and ground Schober test ESRand CRP were improved after treatment P < P < In group A and C thoracic activity and spine activity were getting better P < P < In group B distance between occipital and wall and spine activity were getting better P <0. 01 P < In comparison with group C BAS-G BASFI BASDAI spine pain distance between finger and ground thoracic activity spine activityschober testesrcrp were getting better in group A after treatment P < P < In comparison with group DBASFI BASDAIspine pain pain at night distance between finger and grounddistance between occipital and wallspine activityschober test and ESR were getting better in group B after treatment P <0. 01 P < The total effective rateasas20asas50 ASAS70 and BASDAI50 were higher in the TCM treatment group than in the WM treatment group P < Conclusion Modified BZR was more effective than SASP method in relieving clinical symptoms and signstcm syndrome scoresand inflammatory activity indicators of AS patients. KEYWORDS Bushen zhuanggu Recipe ankylosing spondylitis Shen deficiency induced cold-dampness syndrome Shen deficiency dampness-heat syndrome efficacy observation ankylosing spondylitis AS AS 2 NSAIDs 1 SASP MTX Lef 3 SASP MTX AS 48 1 AS A B C 27 D ~ ± ~ ~ ± ~ P > A 20 g 20 g 2 30 g 12 g 12 g 12 g 16 ~ 55 X Ⅱ AS g 10 g 20 g 20 g 12 g 10 g B 20 g 10 g 12g 15 g

3 CJITWMDecember 2013Vol. 33No g 30 g 20 g 20 g 12 g 12 g 10 g ml 4 2 C D cm > 5 cm< 5 cm salicylazosulfapyridinesasp cm g cm 1 g ml the Bath Ankylosing Spondylitis Indices of disease activity BASDAI 3 AS the Bath Ankylosing Spondylitis Indices of functional statusbas- FI 4 AS the Bath Ankylosing Spondylitis Indices of overall well-being BAS-G SASP > 40 < 40 Schober 5 cm 10 cm cm > 4 cm < 4 cm 5. 3 Assessment in Ankylosing Spondyli- International Working Group CriteriaASAS 20% 5 tis 50% 70% ASAS20 ASAS50 ASAS AS AS AS disease activity index BAS- DAI 50% BASDAI50 7 ASAS % % ASAS % % 1 0 ASAS % Schober 70% 4 6 ESR C VAS VAS CRP BASFI BASDAI 8 cm 0 cm> 0 cm ESR CRP 70% ESR CRP 50% ESR CRP 30% 0 cm AS

4 CJITWMDecember 2013Vol. 33No. 12 ESR CRP < 30% 5. 4 BASFI BASDAI 1 B % Schober ESR P < C % ASAS20 ASAS50 ASAS70 BAS- P < P < DAI50 4 ASAS C A BAS-G BASFI BAS- DAI P < P < D B P < P < SPSS A C x ±s Schober ESR CRP t /Wilcoxon P < P < B χ 2 P < Schober ESR CRP P < P < D Schober 1 ESR CRP P < C A Schober ESR CRP P < D B P < ASAS50 ASAS70 BASDAI50 P < x ±s BAS-G BASFI BASDAI A ± ± ± ± ± ± ± 1. 3 **Δ 1. 6 ± 1. 4 **Δ 2. 5 ± 1. 5 **Δ 3. 6 ± 1. 6 **ΔΔ 2. 1 ± 2. 0 * ± ** C ± ± ± ± ± ± ± 0. 8 * 2. 2 ± 1. 5 * 3. 8 ± 1. 2 * 4. 5 ± 1. 6 * 2. 5 ± 2. 5 * ± * B ± ± ± ± ± ± ± 1. 4 * 2. 4 ± 1. 4 **ΔΔ 2. 7 ± 1. 4 **ΔΔ 1. 5 ± 1. 5 **ΔΔ 2. 3 ± 2. 2 * Δ ± **Δ D ± ± ± ± ± ± ± 1. 9 * 4. 0 ± 2. 5 * 4. 5 ± 2. 0 * 3. 6 ± 2. 0 * 3. 2 ± 2. 6 * ± * * P < ** P < Δ P < ΔΔ P < 0. 2 x ±s Schober ESR mm /h CRP mg /L A ± ± ± ± ± ± ± ± ± 8. 6 **Δ 3. 5 ± 2. 0 * Δ ± 7. 9 **Δ 6. 6 ± 2. 9 **Δ ± **Δ 4. 0 ± 7. 0 * Δ C ± ± ± ± ± ± ± ± ± * Δ 2. 7 ± 1. 3 * ± * Δ 4. 4 ± 1. 8 * ± * 9. 5 ± * B ± ± ± ± ± ± ± ± 3. 5 * Δ ± **Δ 3. 9 ± ± **Δ 5. 1 ± 2. 0 **ΔΔ ± * Δ 7. 4 ± 9. 9 * D ± ± ± ± ± ± ± ± ± * 3. 6 ± ± ± 2. 7 * ± * 4. 6 ± 6. 6 * * P ** P Δ P ΔΔ P 0. 3 % BASDAI50 % * * P < ASAS20 ASAS50 ASAS70 ASAS20 ASAS50 ASAS70 BASDAI * * * * * P < 0. 05

5 CJITWMDecember 2013Vol. 33No C 3 B 1 C 2 4 A 2 B 1 C 1 1 AS 9 AS 10 AS BAS-G BASFI BASDAI Schober ESR CRP AS P < P < P > BASFI BASDAI P < Schober ESR AS P < BAS-G CRP AS SASP P > AS AS AS 1Calin A. SpondylarthropathiesM. Orlando Grune and AS Stratton Inc M Garrett S Jenkinson TKennedy LGet al. A new approach to defining disease status in ankylosing spondylitis the Bath ankylosing spondylitis disease activity index J. J Rheumatol Calin A Garrett S Whitelock H et al. A new approach to defining functional ability in ankylosing spondylitis the development of the Bath ankylosing spondylitis functional index J. J Rhematol Jones SD Steiner AGarrett SLet al. The Bath ankylosing spondylitis patient global score BAS-G J. Br J Rheumatol

6 CJITWMDecember 2013Vol. 33No M. 9. CR CT Brandt J Listing J Sieper J et al. Development and preselection of criteria for short term improvement after anti- TNF-ɑ treatment in ankylosing spondylitis J. Ann Rheum Dis M J M J 檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴 Rg1 Rg1 Rb1 8 檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴檴

Σχετικά έγγραφα

Παναγόπουλοσ Παναγιώτησ Ρευματολογικό κλινικό Ναυτικό Νοςοκομεύο Αθηνών

Παναγόπουλοσ Παναγιώτησ Ρευματολογικό κλινικό Ναυτικό Νοςοκομεύο Αθηνών Δείκτεσ ενεργότητασ ςτην ΑΣ Παρακολούθηςη ενεργότητασ Α και αποτελεςματικότητασ θεραπεύασ Assessment of SpondyloArthritis Society,