Research of postpartum depression and progesterone estradiol change before and after childbirth

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1 E 2 P EPDS ELISA 2 P 5 - HT % 2 P < EPDS 5 - HT r = ~ P < E 2 P HT R A doi /j. issn Research of postpartum depression and progesterone estradiol change before and after childbirth CHEN Jing 1 XIA Guang - yuan 1 TANG Wen - quan 2 WEI Hua 3 ZOU Tao 1 1 Psychological Department of Affiliated Hospital of Guiyang Medical College Guiyang China 2 Neurology Department of central Hospital of Yunyang County Chongqing China 3 Henan Nursing Vocational College Anyang China Abstract Objective To explore the impact of serum estradiol E 2 progesterone P on the postpartum depression about a week before and after childbirth. Methods Selection 395 cases of maternal who saw a doctor in guiyang medical college affiliated hospital as the research object in March September 2012 using the Edinburgh postnatal depression scale EPDS to assess the postpartum depression and uses the biotin method of double antibody sandwich enzyme - linked immunosorbent ELISA determination of maternal serum estradiol E 2 progesterone P serotonin 5 - HT level. Results 1Depression detected the number of 48 cases detection rate of % a week after childbirth. 2Female serum progesterone level difference after childbirth between depression with and without depression group was statistically significant P < The correlation analysis showed that the postpartum EPDS scores and prenatal serum estradiol level prenatal postpartum serum progesterone level and postnatal progesterone estradiol declines were positively correlated and negatively correlated with postpartum 5 - HT estradiol levels r = ~ P <

2 http / /www. psychjm. net. cn Conclusion Maternal serum progesterone estradiol level declined obviously after delivery female progesterone and estradiol dramatic drops were important biological factors on postpartum depression. Key words Estradiol E 2 Progesterone P Serotonin 5 - HT Postpartum depression PPD EPDS l3 EPDS < 13 α ml ELISA 2 E 2 P 5 - HT 1. 4 SPSS hydroxytryptamine Excel HT 5 t Pearson 5 - HT 6-7 α = HT E 2 P 5 - HT % 2. 2 E E 2 1 E ± pg /m ± pg /ml P 9 < E ± pg /ml ± pg /ml 1 2 P > E ± pg /ml ± pg /ml Edinburgh Postnatal Depression Scale EPDS P < E x ± s pg /ml EPSD < E 2 E 2 E ± ± ± ± ± ± t P EPDS Cox 2 l0 4 0 ~ 3 0 ~ E - mail zoutaozou@ tom. com 1 E 2 386

3 48h 72h k E 2 E P F a - F b P ± nmol /L ± k E 2 = a - b nmol /L P < = P ± nmol /L h 72h 3 P ± = k E 2 < k E 2 < 0 E ± nmol /L P < k E nmol /L ± nmol /L f a - f b k E 2 = P < a - b 2 2 P P x ± s nmol /L P P ± ± ± ± ± ± t P P x ± s nmol /L 72h 48h k P 2. 3 EPDS k P = F a - F b = a - b HT r = - 48h 72h 3 k P f a - f b = a - b k P = k P < k P < 0 P P HT 5 - HT ± ng /ml ± ng /ml t = P = ~ P < EPDS 5 - HT r 5 - HT E 2 E 2 E 2 P 5 - HT a E a a E a E a a a a P a a a a - - P a a a a a - P a a a a a a a P < P % 78. 8% 5 387

4 http / /www. psychjm. net. cn E 2 P 5 - HT R 2 F P B Beta t p EPDS HT % 5 - HT 11. 0% ~ 35. 0% HIAA 3. 5% ~ 33% HT HT HT HT HT 5 - HT mrna HT HT P < EPDS 5 - HT 5 - HT E HT HT 2 GABA HT HT 14 GABA γ - - HPG - 20 P < EPDS - - HP- 388

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