8~12 h. TC-SGTZ index BMI HEM-907

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1 13 6 Vol13 No Life Science Research Dec 2009 a,b,c, d b*,, e, a a b c d e : (Metabolic syndrome, MS), 2005~2008, (1959~1961 ) ( ), (1955~1957 ) ( ) (1963~1965 ) ( ), 3 4 MS, SAS91 MS MS 463, 1030%; MS 403, 1104%; MS 609, 900% MS 1 326, 1406% MS 149, 272% MS, MS > > >,,, : ; ; ; : R151 : A : (2009) The Impact of Malnutrition Caused of Famine on the Adult Metabolic Syndrome GUAN Yun-liang a b c WANG Yong-hong d LI Ting-yu b* PENG Bin e ZHAO Yong a a Department of Nutrition and Food Hygiene Public Health School b Children s Hospital Children Nutrition Research Centre of Chongqing City c Editorial Department of Journal of Chongqing Medical University d Medical Examination Center the First Affiliated Hospital e Department of Health Statistics Chongqing Medical University Chongqing China Abstract The influence of the malnutrition which caused by the early-life food shortage malnutrition on the MS in people adulthoods was studied And the causes of the adult chronic diseases were explored and thus to provide the scientific reference for making better nutrition-improving policies for women and children cases from the Personal Medical Examination Database data between 2005 and first half of 2008 of the Medical Examination Center in the First Affiliated Hospital of Chongqing Medical University were adopted cases Group that were born during the Great Leap Forward famine 1959~ 1961 were chosen as the famine-affected population cases Group born prior to the famine 1955~1957 and cases Group born after the famine 1963~1965 were chosen as the nonfamine-affected population BMI glucose values blood pressure and cholesterol levels were compared between these three groups as the partial judgment for MS criteria SAS version 91 was used to analyze the occurrence of MS 463 cases from Group were diagnosed as MS accounting for 1030% of Group : : : JC : Tel guanguan522@163com * Tel tyli@vipsinacom

2 cases from Group were diagnosed as MS accounting for 1104% of Group 609 cases from Group were diagnosed as MS accounting for 900% of Group Comparison between groups was statistically significant There were male MS patients make a morbidity of 1406% while 149 female MS patients were diagnosed make a morbidity of 272% The early-life malnutrition in the famine period had influenced the occurrence of MS in people s adulthood The factors due to the severity for causing MS are as followed in descending order dyslipidmias overweight hypertension and hyperglycemia There is also a clear gender difference that the morbidity of male is significantly higher than that of female thus this difference is meaningful to statistics Therefore scientific supply and reasonable formula for the diets of the pregnant women wet nurses and infants are very important and can be used to improve the life quality of the entire population Key words earlier period of life malnutrition metabolic syndrome chronic disease Life Science Research ~511 Metabolic syndrome MS 1959~ [1] ~ ~ MS 2 12 MS 121 [2,3] MS [4,5] Barker [6~9] Barker 3 d [10~20] 1959~ ~12 h 1958~ TC-SGTZ [21] 1997 Body mass index BMI 01 kg 001 m MS HEM-907 Barker MS ~ Chinese

3 6 : 507 diabetes society CDS MS 13 CDS 4 SAS91 [22] 3 1 Body mass index BMI 250 kg / m 2 2 Logistic P < mmol / L 2 h 2 78 mmol / L 3 / 140 / mmhg / kpa % mmol / L 3678% 1955~ High density lipoprotein HDL < 09 mmol / L ~ ~1965 < 10 mmol / L Table 1 The research object distribution according to of gender and birth time group Group Birth year Male n % Female n % Total Before the famine Middle of famine After the famine 1955~ ~ ~ MS 23 MS ± MS MS > 2 BMI > > 3 Group 2 MS (x ± s) Table 2 Indicator mean different gender and MS born group each single(x ± s) Every single indicator of MS BMI kg / m 2 Systolic pressure mmhg Diastolic pressure mmhg Blood glucose mmol / L Triglyceride mmol / L High-density lipoprotein mmol / L Male 2445 ± ± ± ± ± ± 030 x ± s Female 2271 ± ± ± ± ± ± 036 BMI kg / m 2 Systolic pressure mmhg Diastolic pressure mmhg Blood glucose mmol / L Triglyceride mmol / L High-density lipoprotein mmol / L 2462 ± ± ± ± ± ± ± ± ± ± ± ± 033 BMI kg / m 2 Systolic pressure mmhg Diastolic pressure mmhg Blood glucose mmol / L Triglyceride mmol / L High-density lipoprotein mmol / L 2458 ± ± ± ± ± ± ± ± ± ± ± ± mmhg 0133 kpa

4 Group 3 MS Table 3 The each single indicator overweight situation of different gender and MS born group Every single indicator of MS Systolic pressure overproof Diastolic pressure overproof Pressure overproof Triglyceride overproof High-density lipoprotein overproof Specific overweight n % Male Female Total Systolic pressure overproof Diastolic pressure overproof Pressure overproof Triglyceride overproof High-density lipoprotein overproof Systolic pressure overproof Diastolic pressure overproof Pressure overproof Triglyceride overproof High-density lipoprotein overproof (Metabolic abnor- 2801% 2 MA mality, MA) 1980% 3 MA MA % 4 MA 1 MA % 4 4 MA Table 4 MA distribution of different gender and group (n, %) Sex Group 0 item 1 item 2 item 3 item 4 item Male Female Total MS 5 MS MS % MS % MS % MS % 272% 5

5 6 : MA MS 27 MS 6 MS Logistic MS MS MS MA MS MS > BMI Logistic > > 5 MS Table 5 Respondents MS analysis situation(n, %) Group Male Female Gender comparison in each group Total χ 2 P < < < χ 2 = P = χ 2 = P = χ 2 = P = Notes vs χ 2 = P = vs χ 2 = P = vs χ 2 = P = MA MS Table 6 MA distributionin in the diagnosis of MS(n, %) Item 1 item 2 item 3 item Total Blood pressure overproof MS Logistic Table 7 MS sicken Logistic regression factor and risk factors for assignment Factor Data assignment Unit Sex BMI Blood glucose Systolic pressure Diastolic pressure Triglyceride High-density lipoprotein 0 indicate male 1 indicate female 0 indicate 25 1 indicate < 25 0 indicate 61 1 indicate < 61 0 indicate indicate < indicate indicate < indicate 17 1 indicate < 17 Male: 0 indicate < 09 1 indicate 09 Female: 0 indicate < 10 1 indicate 10 kg / m 2 mol / L mmhg kpa mmhg kpa mmol / L mmol / L 8 MS Logistic Table 8 MS illness risk factors for Logistic regression analysis results of single factor Factor Regression coefficient Standard error Wald chi-square P value OR value 95% CI vs vs Sex BMI Blood glucose Systolic pressure Diastolic pressure Triglyceride High-density lipoprotein < < < < < < < ~ ~ ~ ~ ~ ~ ~ ~ ~04964

6 ~3 3 MS 5 MS % MS % MS % 50 MS [22] 50 MS MS 1955~1957 > 1959~1961 > 1963~1965 MS 1104% Logistic MS MS 3 6 MS MS (References): [1] Third report of the national cholesterol education program NCEP expert on detection Evaluation and treatment of high blood cholesterol in adults adult treatment panel final report[j] Circulation [2] YO S NICKLAS T BARANOWSKI T et al Comparison of dietary intakes associated with metabolic syndrome risk factors in young adults The Bogalusa Heart Stndy[J] Am J Clin Nutr [3] [J] HU Yisong ZHAI Feng-ying HE Yu-na et al Relationship between metabolic syndrome and dietary nutrients[j] Public Health and Preventive Medicine [4] RICCARDI G RIVELLESE A A Dietary treatment of the metabolic syndrome-the optimal diet[j] British Journal of Nutrition Suppl 1 Sl43-S148 [5]

7 6 : 511 [J] GU Hai-bo TENG Ya-ping SHI Hai-hong et al Strengthening the effect on food intervention to metoblic index of metaboylic syndrome patient[j] Modern Hospital [6] BARKER D J P OSMOND C Infant mortality childhood nutrition and ischaemic heart disease in England and Walse [J] Lancet [7] BARKER D J P WINTER P D OSMOND C et al Weight in infancy and death from ischaemic heart disease[j] Lancet [8] BARKER D J P BULL A R OSMOND C et al Fetal and placental size and risk of hypertension in adult life[j] BMJ [9] GODFREY K M BARKER D J Fetal nutrition and adult disease[j] Am J Clin Nutr Suppl 1344s-1352s [10] MARJO R J ULLA S VANESSA K et al Early life factors and blood pressure at age 31 years in the 1996 Northern Finland birth cohort[j] Hypertension [11] ALAN B JIM V O CORINE D et al Further evidence of relation between prenatal famine and major affective disorder [J] Am J Psychiatry [12] RICHARD N HANS W H EZRA S Prenatal exposure to wartime famine and development of antisocial personality disorder in early adulthood[j] JAMA [13] RICH-EDWARDS J W COLDITZ G A STAMPFER M J et al Birth weight and the risk for type 2 diabetes mellitus in adult women[j] Ann Intern Med [14] JIE M CATHERINE L ZHANG K L et al Effects of infants birth weight and maternal body mass index in pregnancy on components of insulin resistance syndrome in China[J] Ann Intern Med [15] RAVELL I van der MEULEN J H OSMOND C et al Obesity at the age of 50 in men and women exposed to famine prenatally[j] Am J Clin Nutr [16] HALES C N BARKER D J CLARK P M et al Fetal and infant growth and impaired glucose tolerance at age 64 [J] BMJ [17] LITHELL H O MCKEIGUE P M BERGLUND L et al Relation of size at birth to non insulin dependent diabetes and insulin concentrations in men aged 50~60 years[j] BMJ [18] mccanee D R PETTITT D J HANSON R L et al Birth weight and non-insulin dependent diabetes thrifty genotype thrifty phenotype or surviving small baby genotype?[j] BMJ [19] FORSEN T ERIKSSON J TUOMILEHTO J et al The fetal and childhood growth of persons who develop type 2 diabetes [J] Ann Intern Med [20] NEWSORNE C A SHLELL A W FAU C H et al Is birth weight related to later glucose and insulin metabolism? A systematic review[j] Diabet Med [21] [J] WANG Z The most grieved disaster of new Republic of China great famine in three years[j] Wan Xia Data Collection [22] [J] Chinese Diabetes Society of Chinese Medical Association Suggestions for metabolic sysdrome [J] Chinese Journal of Diabetes

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