Intelligent Drug Delivery System of Intelligent High Polymer Materials

Μέγεθος: px

Εμφάνιση ξεκινά από τη σελίδα:

Download "Intelligent Drug Delivery System of Intelligent High Polymer Materials"

Κόσμος Βάμβας
7 χρόνια πριν
Προβολές:

1 19 2Π PROGRESS IN CHEMISTRY Vol. 19 No. 2Π3 Mar., ,2 1, ( ; ; ) : O631 ; TB381 : A : X(2007) 02Π Intelligent Drug Delivery System of Intelligent High Polymer Materials Dai Yani 1,2 Li Ping 1,3 3 3 Wang Aiqin 3 (1. The Second Hospital of Lanzhou University, Lanzhou , China ; 2. Pharmacy College of Lanzhou University, Lanzhou , China ; 3. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou , China) Abstract The application and development in intelligent drug delivery systems of synthetic intelligent high polymer materials,semisynthetic high polymer materials,and natural intelligent high polymer materials are reviewed. The prospects in intelligent drug delivery system of intelligent high polymer materials are discussed. Key words intelligent high polymer materials ; intelligent drug delivery systems ; synthetic intelligent high polymer materials ; semisynthetic high polymer materials ; natural intelligent high polymer materials 1 5 ], : 21 ph : 3 [1 : , : (No. LZUYX200625) 3 3 e2mail com

2 2Π ,, PHEMA 2 2 (MAA2 ( g2eg), ) ph Eeckman [15 ] N2 (NIPAAm) 4, ( intelligent drug delivery (LCST) 37 4 LCST system,idds) ( self- regulated drug delivery system,srdds) : (PNIPAAm2co2AAm) ; N2 2N2 2N2 ( PNIPAAm2co2, ; MVA) ; N2 2N2 ( ph ( PNIPAAm2co2NVA) ; ),, N2 222 ( PNIPAAm2 ; co2vpl) [6 ] 10 % ph Na 2 SO 4 11 ] N2, [7 ( PNIPA) (MAA) 222 (HEMA) (AA) Na 2 SO 4 (PVA) (MMA) ( PEG), ( PNIPAAm2co2MVA) ( PNIPAAm2co 2NVA) ( PAAm) ( PVP) 80 % 90 % (DMAEMA) N2 Smart Plug TM [16 ] ( IPN) [12,13 ] 014 mm 1 mm, 9 mm 2 mm, Huang [17 ] N2 2 ( PNIPAAm2co2allylamine) N2 : 2 ( PNIPAAm2co2AA) He [14 ] N2, ph PNIPAAm2co2allylamine 222 ( PHEMA) PEO2PPO2PEO G(AO8) (BSA) : N2 2, 222 ( HEMA), PNIPAAm2co2AA

3 364 19, (ph = 210) 20 % ph = 714 C 80 % 60 % 80 % ph,3, (ph ) [18 Ramkissoon- Ganorkar 20 ] ph N2 2 1 : 2 (PNIPAAm2co2BMA2co2AA), C ; ; ph, [20 ] 1 phπ Fig. 1 Mechanism of protein drug release from phπthermo2sensitive beads made of polymers with increasing molecular weight(mw) [20 ] PEO ph EUD, 2 p K a ( Eudragit,EUD L100 or EUD S100) ph,, EUD L100 ph = 6, EUD S100 ph = 7 Carelli [21 ] ph 2. 2 ( PEO) ( PACA) 2 Eudragit ( EUD L100 or EUD S100) 1 1 (WΠW) ph ph EUD p K a (p K a > 6) PEO EUD PEO2EUD ; ph EUD (PLA) ( PLGA) p K a, 2 ( PLA2PEG) 2

4 2Π3 365, Ertl [28 ] D, L2 Yoo [22 ], (PLGA) PLGA ( H2PLGA) ( PLGA), : 20 % 35 % ; 160h 40 % 75 %, PLGA H2PLGA 1 % PLGA P2 Dong Marinina [29 ] [23 ] (D,L2, )Π ( PLGAΠMMT) (VCR) PLGAΠMMT (VBL) VCR ZnSO 4 Π,MMT VCR ; VBL 310nm, MMT Zhang [30 ] N2, (NIPAAm) :MMT (PGCL) ; MMT, ( OVA), Caco22 HT229 NIPAAmΠPGCL % 117 % 11 % 55 %, MMT OVA 3, PLGAΠMMT Π PLGAΠMMT [24 Jong 26 ] (PLA) ( CMC) ( EC) (MC),D L2 (HPMC), 2D2 ( dextran2d2 33 lactate) 2L2 ( dextran2l2lactate) ],, Bilati [27 ] D,L2 ( PLGA) [34 ] w(1)πoπw(2) (FITC2BSA),BSA > 80 % D,, Liang [35 ] L2 (MC),pH : Π w(1) CaCl 2 Na 2 HPO 4 NaCl 100 % ; Π, Π 017molΠL [31

5 NaCl 32 ph : (BSA) Π (95 % 98 %) (chitosan) ph = 112, 215 %,BSA (20 %) ; ph = 714, 86 % 41 ] Π [42 ( ) ],, Karavas [36 ] [43 ] (CS) 2 ( 2GP), Π ph (FELOΠPVP) 10 90, 37, Π (PVPΠHPMC) ph VB12, PVPΠ ph HPMC : ph = 410,, 70min 65 % ;ph = 714 Wakerly [37 ] 57 % ph = h 20 % min 42 % ;ph = h 50 % 37 Sangalli [38 ] CSΠGP ph HPMC, Bayramoglu [44 ] ph,hpmc ( IPN) (AIBN) 222 4, ( 22 ph = ) 714,10h 80 %, [39, 100mg 2

6 2Π3 367 [45 ] 4. 2, [46 ] Lin [49 ] ph (BSA), : (alginate)πn, O2 (NOCC) CaCl 2 ( molΠL) ; 1 %BSA (WΠV) alginateπnocc,, CaCl 2 (012molΠL) 30min 37 ; [47 ], CaCl 2 ( PLGA) ph = mm mm Zeta ; 10u kg - 1,14 16h :alginate NOCC 1 1 (W ( P < 01 05) W) ; alginate2nocc 1514 %, PLGA 77 % ph = 112 ph = 714 : ph = % ; ph = 714 PLGA, Zheng [48 ] 80 % ;24h 82 % 87 % (alginate)2 (chitosan)2 alginateπnocc (PLGA) (BSA), 6,alginateΠchitosan Zahoor [50 ] PLGA WΠO ( INH) 31 9 m,bsa 81 % (RIF) ( PZA), INH PZA 87 % PLGA 61 % 65 % 70 % 90 %,RIF 80 % 90 %, PLGA PLGA 23515nm 8015 % BSA Π, m, m,24h 24 % 8 %, PLGA 48 % 52 %,24h 15 5 % 2 % ;,, 15

7 ,,, Liu [51 ] Π (alginateπhpmc), 2, 8h, 2 [52 ] 4. 3 Fig. 2 Concept of dual2stimuli2responsive drug release by IPN2 structured hydrogel [52 ] ph DNA Kurisawa [52 ] DNA,,DNA ( IPN) DNA 2, DNA 5 ; ( ) [53, 2 ] Π,,, ph ph ; ( ),, ( ) 21 DNA (DDS), Kushibiki [54 ] ( [ 1 ] Kasbyap N, Kumar N, Kumar M N V R. Critical Review in ) Therapeutic Drug Carrier Systems, 2005, 22 (2) :

8 2Π3 369 [ 2 ] (Huang J), (Wang X L), (Chen X Z). (Journal of Nanjing University of Chemical Technology), 2000, 22(6) : [ 3 ] (Li Y), (Zhu L Y), (Zhu J H). ( Polymer Materials Science and Engineering), 2003, 19(5) : [ 4 ] Ye P, Xu Z K, Wu J, et al. Biomaterials, 2006, 27 : [ 5 ] Mequanint K, Patel A, Bezuidenhout D. Biomacromolecules, 2006, 7 : [ 6 ] ( Zhang Z P). (Shanxi Chemical Industry), 2004, 24(4) : [ 7 ] Verestiuc L, Ivanov C, Barbu E, et al. Int. J. Pharm., 2004, 269(1) : [ 8 ] Matsumoto A, Yoshida R, Kataoka K. Biomacromolecules, 2004, 5 (3) : [ 9 ] (Liu L P), (Li P), (Wu Z Z). (Journal of Chongqing University), 2002, 25 (10) : [10] (Zhu L Y), (Zhu J H), (Chen W M). (Journal of Sichuan University, 2002), 34 (5) : [11] (Chen L), (Han YL), (Zhao Y P). (Journal of Tianjin Polytechnic University), 2004, 23(4) : [12] Sutton D, Durand R, Shuai X T. Journal of Applied Polymer Science, 2006, 100 : [13] Godwin A, Bolina K, Clochard M, et al. Journal of Pharmacy and Pharmacology, 2001, 53 : [14] He H Y, Cao X, Lee L J. Journal of Controlled Release, 2004, 95 : [15] Eeckman F, Moes A J, Amighi K. International Journal of Pharmaceutics, 2004, 273 : [16] Kojima T, Dogru M, Ishida R, et al. Am. J. Ophthalmology, 2006, 141 (2) : [17] Huang G, Gao J, Hu Z B, et al. J. Control. Release, 2004, 94 : [18] Ramkissoon- Ganorkar C, Baudys M, Kim S W. J. Biomater. Sci. Polym. Ed., 2000, 2 : [19] Ramkissoon- Ganorkar C, Gutowka A, Liu F, et al. Pharm. Res., 1999, 16 : [20] Ramkissoon- Ganorkar C, Liu F, Kim S W, et al. J. Control. Release, 1999, 59 : [21] Carelli V, Colo G D, Nannipieri E. International Journal of Pharmaceutics, 2000, 202 : [22] Yoo H S, Park T G. Polym. Prepr., 2000, 41(1) : [23] Dong Y C, Feng S S. Biomaterials, 2005, 26 : [24] Jong S J, Eerdenbrugh B V, Nostrum C F V, et al. J. Control. Release, 2001, 71 : [25] Jong SJ, Smedt S C D, Demeester J, et al. J. Control. Release, 2001, 72 : [26] Hennink W E, Jong SJ, Bos G W, et al. Int. J. Pharm., 2004, 277 : [27] Bilati U, Allemann E, Doelker E. J. Microencapsul., 2005, 22 (2) : [28] Ertl B, Platzer P, Wirth M, et al. J. Control. Release, 1999, 61 (3) : [29] Marinina J, Shenderova A, Mallery S R, et al. J. Pharm. Res., 2000, 17(6) : [30] Zhang X Z, Lewis P J, Chu C C. Biomaterials, 2005, 26 : [31] (Li B H), (Zhang L J), (Deng Y F). ( Practical Journal of Medicine and Pharmacy), 2004, 21(8) : [32] (Ma F J ). ( Chinese Journal of Clinical Pharmacy), 2006, 15(1) : [33] Chavanpatil M D, Jain P, Chaudhari S, et al. International Journal of Pharmaceutics, 2006, 316 (1Π2) : [34] Fundueanu G, Constantin M, Esposito E, et al. Biomaterials, 2005, 26 : [35] Liang H F, Hong M H, Ho R M, et al. Biomacromolecules, 2004, 5 : [36] Karavas E, Georgarakis E, Bikiaris D. European Journal of Pharmaceutics and Biopharmaceutics, 2006, 63(2) : [37] Wakerly Z, Fell J, Attwood D, et al. Int. J. Pharmaceutics, 1997, 153 : [38] Sangalli M E, Maroni A, Zema L, et al. J. Controlled Release, 2001, 73 : [39] (Li P), (Wang A Q), (Zhang J L). ( Chinese Journal of Hospital Pharmacy), 1996, 16(12) : [40] (Li P), ( Yao N), (Zhang J L). ( Chinese Journal of Pharmaceuticals), 1999, 30 (3) : [41] (Li P), (Ren S L), ( Zhang Y). (Chinese Journal of Biochemical Pharmaceutics), 2001, 22(3) : [42] (Ma N), (Wang Q), (Sun S L). (Progress in Chemistry), 2004, 16(4) : [43] (Zhang J), (Zhu L Y), (Zhang S B). (Journal of Sichuan University), 2006, 38 (1) : [44] Bayramoglu G, Aric M Y. Macromol. Symp., 2003, 203 : [45] (Pan Y), (Xu H), (Zhao H Y). (Acta Pharmaceutica Sinica), 2002, 37(5) : [46] Marco W, Wim E H, Wim J. Pharm. Res., 2000, 17 (10) : [47] (Pan Y), (Li YJ), ( Gao P). (Acta Pharmaceutica Sinica), 2003, 38(6) : [48] Zheng C H, Gao J Q, Zhang Y P. Biochemical and Biophysical Research Communications, 2004, 323 : [49] Lin Y H, Liang H F, Chung C K, et al. Biomaterials, 2005, 26 : [50] Zahoor A, Sharma S, Khuller G K. International Journal of Antimicrobial Agents, 2005, 26 : [51] Liu Z D, Li J W, Nie S F, et al. International Journal of Pharmaceutics, 2006, 315 (1Π2) : [52] Kurisawa M, Yui N. Journal of Controlled Release, 1998, 54 : [53] (Zhou Y H), (Huang M Z). (Journal of Beijing University of Chemical Technology), 2003, 30(5) : [54] Kushibiki T, Tomoshige R, Iwanaga K. Journal of Controlled Release, 2006, 112 :

Σχετικά έγγραφα

Advance in Nanorealgar Studies

21 5 2009 5 PROGRESS IN CHEMISTRY Vol. 21 No. 5 May, 2009 1 1 2 3 (1. 430074 ; 2. 430074),,, ;,, : O61316 ; R284 : A : 10052281X(2009) 0520934206 Advance in Nanorealgar Studies Ye Xiaochuan 1 Yang Xiangliang