DCIS MR GE SIGNA HDX 1. 5T T1 T2. Magnetic Resonance Imaging MRI TR / GE Vibrant. 2. 0mL 1.

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1 Journal of Ningxia Medical University MRI MRI Dynamic Contrast - enhanced ImagingDCE - MRI smax% s - 1 Peak High PH Time - to - PeakTpeak ± ± ± Smax P < Ⅰ 2 / % 5 / % 13 / % Ⅱ 4 /850. 0% Ⅱ4 / % 5 / % Ⅲ 2 /825. 0% 3 / % 0 /180% TIC % I I PH Tpeak 1 smax% s - 1 Smax TIC 2PH Tpeak - R A DCIS8 8 1 ADH % - TDLU ~ MR GE SIGNA HDX 1. 5T 8 Magnetic Resonance Imaging MRI T1 T2 T2 5. 0mm 27 GE Vibrant TR / MR TE4. 6ms /2. 2ms 83. 3Hz 2. 0mm GD - DTPA 0. 2mmol kg s mL MRI s 9. 55min NZ yunliushky@hotmail. com 2. 0mL 1. 3 GE ADW4. 4 Functool

2 c % I Region of Interest ROI % II % III DCE - MRI - Time Intensity Curve TIC χ 2 = P = I TIC 1 Smax Smax % s - 1 = SIend - SIprior 100% /SIo Tend - 2 TIC Tprior SIend SIprior - /% 2 Tend Tprior I II III SIend SIprior SIo Peak Heigh PH PH = SImax SIo SImax 3 Time - to - peak Tpeak 3 Tpeak 4 - Ⅰ Ⅱ - TDLU 3 Ⅲ 1. 4 SPSS Smax MRI TIC χ DCE - MRI Smax DCE - MRI ± * ± * ± F = P = ADH DCIS * P < Smax% s - 1 Smax F = P = Smax Smax Smax% s - 1 P = Smax P = Smax% s x 珋 ± s Smax /% s % ADH Smax% s - 1 DCIS Smax% s - 1 PH 2. 2 DCE - MRI - DCE - MRI Tpeak PH - I

3 TIC % I 2. M. PH Tpeak Celis JEMoreira JMGromova I et al. Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia J. Mol Oncol TDLU - 4. J. I MRI J. - Gd - DTPA Buadu LDMurakami JMurayama S et al. Pattems of 10 peripheral enhancement in breast masses correlation of findings on contrast medium enhanced MRI with histologic features and tumor angiogenesis J. J Comput As sist Tomogr II 7.. III 25. 0% I J I II 8. II III J Kvisted KARydland JVainio Jet al. Breast lesions evaluationwith dynamic contrast - enhanced T1 - weight - MR imaging and with T2* - weighted first - pass perfusion MR imaging J. Radiology Rankin S C. MRI of the breast J. Br J Radiol Wang LJiang T Liu XJ et al. Correlation of dynamic contrast - enhanced MR imaging semi - quantita- tive parameters with microvessel density in breast disease J. Chinese Journal of Medical Imaging Tech- 1Tavassoli FA Devilee P. WHO Pathology and Genetics nology Tumours of the Breast and Female Genital OrganM. LyonIARC Press The Application of MRI Dynamic Contrast - enhanced Imaging in the Diagnosis of the Intraductal Hyperplasia Lesions of Breast WANG Xing - juan 1 REN Xiao - lu 1 WANG Xue - mei 1 MA Feng 1 ZHANG Xiao - yu 2 YAN Shao - ning 2 LIU Yun 2 ZHANG Zhi - yuan 2 1. Ningxia Medical University Yinchuan Dept. of Radiology the General Hospital of Ningxia Medical UniversityYinchuan AbstractObjective To investigate the value of dynamic contrast enhanced imaging of MRI in the diagnosis of the intraductal hyperplasia Lesions of Breast. Methods 27 patients with 38 lesions proved by histological results were included and the time - intensity curve type calculate parameters of dynamic Smaxpeak High and Tpeak were analyzed. Results The average Smax% s - 1 of DCTS were ± ADH ± TDLU hyperplasia ± The smax difference among DCTSADH and TDLU hy-

4 perplasia showed statistical significancep < The results showed that T - SI curve of DCIS I type 2 / % II type 4 /850. 0% III type 2 /825. 0% T - SI curve of ADH I type 5 / % II type 4 / % III type 3 / % T - SI curve of TDLU hyperplasia I type 13 / % II type 5 / % III type 0 /18 0% % T - SI curve of the intraductal hyperplasia Lesions of Breast show I type and had no peak heigh PHtime - to - peak Tpeak. Conclusion athe larger lesions' Smax value isthe more malignant lesions tend to The combination of Smax value and T - SI curve type is very useful to improve the diagnostic accuracy of intraductal hyperplasia lesions of breast. bph and Tpeak are not very useful in the diagnosis of intraductal hyperplasia lesions of breast. Key wordsbreastintraductal hyperplasiamritime - intensity curve Onogama SKitadai YTanaka Set al. Regulation of vascular endothelial growth factor VEGF- C and VEGF - D expression by the organ microenvironmentin human colon carcinomaj. Eur J Cancer HMGB1 VEGF - C J The Expression and Significance of HMGB1 and VEGF - C Protein in Human Cervical Squamous Cell Carcinoma WU Wei ZHANG Xue - yuyang Cai - hong ZHANG Yong - mei LI Li - fang LIU Li - li MA Wen - juan Ningxia Medical UniversityYinchuan AbstractObjective To investigate the expression and significance of HMGB1 and VEGF - C in human cervical squamous cell carcinoma CSCC. Methods The expression of HMGB1 and VEGF - C were monitored by immunohistochemical staining in 76 cases with CSCC15 cases with CIN III cervical intraepithelial neoplasiaand 15 cases with normal cervical squamous epithelial tissue samples. The relationships between their expression and the clinical pathological parameters of CSCC were analyzed. Results From normal cervical squamous epithelial tissuecin III to CSCCthe positive rates of HMGB1 showed an increased trendp < The expression of HMGB1 was significantly higher in patients with advanced stage lymphatic metastasis and bigger size of the tumor P < 0. 05in CSCC. From normal cervical squamous epithelial tissuecin III to CSCC the positive rate of VEGF - C showed an increase trendp < The expression of VEGF - C was significantly higher in patients with advanced stagelymphatic metastasisbigger size of the tumor and lower differentiative squamous carcinoma P < 0. 05in CSCC. The expression of HMGB1 was positively correlated with the expression of VEGF - C P < Conclusion HMGB1 and VEGF - C protein were over - expressed in CSCC. Their over - expression might play a critical role in the initiationprogression invasion and lymphatic metastasis of CSCC. Key wordscervical squamous cell carcinomalymphatic metastasishmgb1vegf - C

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