TGF - β1 30% 1. 2 β - catenin Wnt PHC DAB PHC. β - catenin TGF - β1 PHC SPSS α = 0.

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1 Journal of Ningxia Medical University TGF - β TGF - β1 Hepatocellular carcinoma PHC 45 PHC TGF - β % 26. 7% P < TGF - β1 40% 20% P < TGF - β1 HBsAg χ 2 P TGF - β1 P < TGF - β1 PHC PHC TGF - β1 R A Wnt AFP % Hepatocellular carcinoma PHC 1 Wnt 2001 TGF - β1 4 I II % III IV % 1. 2 TGF - β1 TGF - β1 2 - PHC 3 PV DAB TGF - β1 PHC PHC PHC 3μm 1 TGF - β DAB B CT PHC TGF - β ~ ± % % % 4. 4% HBsAg % > 10% NZ TGF - β1 30% 1. 5 SPSS17. 0 χ 2 Fisher s α = 0. 05

2 P < /45 χ 2 = P = 2. 3 TGF - β1 PHC 45 PHC % HBsAg 26. 7% 12 / % 23 /45 P < HBsAg AFP χ 2 = P = P < % 9 /45 40% P > TGF - β1 40% 18 / 45 PHC 2. 2 TGF - β1 TGF - β1 AFP HBsAg P < P > TGF - β1 PHC TGF - β1 n χ2 P χ2 P / < I II III IV /cm < HBsAg AFP TGF - β1 2 χ 2 = P = PHC TGF - β1 Wnt / TGF - β PHC PHC 6-7 Wnt

3 10. TGF - β1 915 Wnt 3 Song BC Chung YH Kim JA et al. Transforming growth factor - beta1 as a useful serologic marker of APC Tcf /Lef small hepatocellular carcinoma J. Cancer Tcf /Lef 4. CyclinD1 c - myc J β - 5 Maruyama K Ochiai A Akimoto S et al. Cytoplasmic catenin beta - catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer J. Oncolo- gy Wnt HBV PHC the Wnt /beta - catenin /TCF pathway by in vivo interferon - alpha2b IFN - alpha2b treatment in preneoplastic HBV PHC rat livers J. Growth Factors DNA Ozawa M Baribault H and Kemler R. The cytoplasmic HBV domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related TGF - β1 Wnt in different species J. EMBO J TGF - β Tcf /Lef1 Wnt 8 Polakis P. The oncogenic activation of beta - catenin TGF - β J. Curr Opin Genet Dev χ 2 = P = TGF - β1 HBV PHC 11 Lai J Gao ZL Yang L et al. Correlation of genetic polymorphisms of beta - catenin to hepatitis B virus - re- hepatocellular carcinoma J. Ai Zheng 2009 TGF - β1 lated PHC 12 Park NH and Chung YH. Molecular mechanisms of Wnt / TGF - β hepatitis B virus - associated hepatocellular carcinoma J. Korean J Hepatol Ozturk M. Genetic aspects of hepatocellular carcinogenesis J. Semin Liver Dis TGF - β1 14 Nishita M Hashimoto MK Oqata S. et al. Interaction between Wnt and TGF - beta signalling pathways dur- 1 Kim YD Park CH Kim HS et al. Genetic alterations of Wnt signaling pathway - associated genes in hepatocellular carcinoma J. J Gastroenterol Hepatol Shirai Y Kawata S Tamura S et al. Elevated levels of plasma transforming growth factor - beta in patients with hepatocellular carcinoma J. Jpn J Cancer Res Parody JP Alvarez ML Quiroga AD et al. Attenuation of Smad4 9 Tien LT Ito M Nakao M et al. Expression of beta - 11 Wnt TGF - β catenin in hepatocellular carcinoma J. World J Gastroenterol Poy F Lepourcelet M Schivdasani RA et al. Structure TGF - β1 of a human Tcf4 - beta - catenin complex J. Nat Struct Biol ing formation of Spemann 's organizer J. Nature Takaku K Oshima M Miyoshi H et al. Intestinal tumorigenesis in compound mutant mice of both Dpc4 Smad4 and Apc genes J. Cell

4 J T J J T J β T Effects of Aerobic and Exhausted Exercise on the Immune Function in Mice LIU Hong - peng ZHAO Zhi - fang TAO Hong LIU Hong - mei LU Ning - qing ZHOU Xu LI Guang - hua Ningxia Medical University Yinchuan Abstract Objective To investigate the effects of aerobic and exhausted swimming exercise on immune function in mice. Methods Male Kunming mice were chosen and divided randomly into three groups including controls aerobic and exhausted swimming exercise groups. Aerobic and exhausted swimming exercise model was employed to observe the effects of two type of the exercise load on the weight gain the weight of immunity organs the phagocytosis rate of macrophagus in abdominal cavity the content of serum murammidase antibody potency and ear swelling index. Results The weight of immunity organs the phagocytosis rate of macrophagus in abdominal cavity the content of serum murammidase antibody potency and ear swelling index which were significantly higher than those in control group P < Comparing with the group of control and aerobic the body weight the weight of immunity organs the phagocytosis rate of macrophagus in abdominal cavity the content of serum murammidase antibody potency and ear swelling index significantly decreased in exhausted mice P < Conclusion Exhausted exercise can depress the immune function whereas aerobic exercise can enhance the immune function. Key words aerobic exercise exhausted exercise immune function mice 915 Expression of and TGF - β1 in Primary Hepatocellular Carcinoma and their Clinical Significance ZHAO Wei 1 LI Zhao - yu 2 1. Ningxia Med. Univ. Yinchuan The General Hospital of Ningxia Med. Univ. Yinchuan Abstract Objective To exploere the expression of and TGF - β1 in primary liver cancer and their relationship with the clinicopathological parameters. Methods Two - step non - biotin immunohistochemical method was performed to detect the expression of and TGF - β1 protein in 45 PHC tissues and their corresponding normal liver tissues. Results The positive rates of expression in cancer tissues and their adjacent tissues were 51. 1% and 26. 7% P < The positive rates of TGF - β1 expression in cancer tissues and their adjacent tissues were 40% and 20% P < The abnormal expression of and TGF - β1 were all significantly associated with surface antigen HBsAg portal vein tumor thrombus capsule and lymph nodes The expression of and TGF - β1 showed significant correlation P = Conclusion The expression of and TGF - β1 in PHC may co - promote the occurrence development transfer evolution and prognosis in PHC. Key words primary hepatocellular carcinoma TGF - β1 immunohistochemical

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