ADI TS2 A

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1 TS2 A Impact of Antibiotics Residues in Animal-Derived Foods on Intestinal Microflora and the Microbiological SUN Xiao-hongWANG Hai-xiangCHEN JuanZHANG Li-shi Department of Nutrition and Food HygieneGuiyang Medical UniversityGuizhou Guiyang China AbstractMany investigations showed that a certain amount of antibiotics was left over in various animal foods. Widespread attention has been paid to the potential risks of antibiotic residues long-termlow doseon human intestinal flora. The main cause of antibiotic residues left over in foodthe potential impacts of antibiotic residues on human intestinal flora and the regulatory approach of microbiologic in the safety assessment of antibiotic residues in international agencies were described in this review. Key wordsanimal-derived FoodsAntimicrobial ResiduesMicrobiological Accessible Daily Intake Safety AssessmentIntestinal Microflora / J sunxh2003@ gmc. edu. cn %

2 472 CHINESE JOURNAL OF FOOD HYGIENE % % 11 Stark % 9. 3% % 22. 2% % 23. 5% 6. 5% 1. 3% Corpet mg / d21 E. coli μg / ml E. coli 2001 Perrin- Guyomard 14 HFA humanflora-associated Perrin-Guyomard HFA ~ ATCC SPF 2008

3 PCR-DGGE SPF PCR-DGGE 0. 3 mg / L 3 mg / L 30 mg / L PCR-DGGE 1 MIC 4 / MRL 3 MRL 100% NOAEL 1988 WHO / FAO JECFA JECFA JECFA 1 4 MIC 12 2 CVMP FDA CVM NOAECs / NOAELs - - NOAEC / NOAEL VICH VICH 2004 NOAEC / CVMP / VICH /467 / 03-FINAL NOAEL MIC MIC 220 g / d = 60 kg 5 2 MIC MIC 50 90%

4 474 CHINESE JOURNAL OF FOOD HYGIENE NOAEC 220 g / d = 1 60 kg NOAEC NOAEC 90% CI MIC EMEA / CVMP JECFA J 1 http/ / www. emea. eu. int / index / indexv. 1. htm http/ / www. inchem. org / pages / jecfa. html 0 ~ 5 μg / kg 0 ~ 50 μg / kgjecfa 0 ~ 5 μg / kg 23 flumequine 0 ~ 37 μg / kg 0 ~ 30 μg / kg JECFA 0 ~ 30 μg / kg 24 7 EMEA / CVMP JECFA μg / kg MRL Antimicrob Agents Chemother CERNIGLIA C EKOTARSKI S. the effects on the human intestinal microflora J Pharmacol Ther CVMP JECFA J. 2 GASKIN H R COLLIER C CANDERSON D B. Antibiotics as growth promotionsmode of actionj. Anim Biotechnol J J J MACFARLANE G TMACFARLANE S. Human colonic microbiotaecologyphysiology and metabolic potential of intestinal bacteriaj. Scand J Gastroenterol Suppl STARK C AADAMSSON IEDLUND Cet al. Effects of omeprazol and amoxicillin on the human oral and gastrointestinal microflora in patients with Hlicobacter pylori infection J. J Antimicrob Chemother EDLUND CNORD C E. Effect of quinolones on intestinal ecologyj. Drugs Suppl GORBACH S L. Perturbation of intestinal microflora J. Veterinary Human Toxicol Suppl NORD C ESILLERSTROM EWAHLUND E. Effect of tigecycline on normal oropharyngeal and intestinal microfloraj. Approaches in the safety evaluations of veterinary antimicrobial agents in food to determine. J Vet 13CORPET D E. Antibiotic residues and drug resistance in human

5 475 intestinal flora J. Antimicrob Agents Chemother PERRIN-GUYOMARD ACOTTIN SCORPET D E et al. Evaluation of residual and therapeutic doses of tetracycline in the human-flora-associated HFAmice modelj. Regul Toxicol Pharmacol PERRIN-GUYOMARD APOUL J MCORPET D E. et al. Impact of residual and therapeutic doses of ciprofloxacin in the human-flora-associated mice mode J. Regul Toxicol Pharmacol PERRIN-GUYOMARD APOUL J MLAURENTIE M et al. Impact of ciprofloxacin in the human-flora-associated HFArat modelcomparison with the HFA mouse model J. Regul Toxicol Pharmacol WHO. Toxicological evaluation of certain veterinary drug residues J in food. Antimicrobial agentthiamphenicolwho food additives series43 Geneva 2000 EB / OL http/ / 18. SPF J SPF Geneva EB / OL http/ / www. J. inchem. org / documents / jecfa / V39je07V53je06. htm FAO / WHO. Evaluation of certain veterinary drug residues in foodr. Thirty-second meeting of the joint FAO / WHO expert committee on food additives. WHO food additives seres FAO / WHO. Evaluation of certain veterinary drug residues in food R. Thirty-sixth meeting of the joint FAO / WHO expert committee on food additives. WHO food additives seres CVMP / VICH /467 /03-FINAL. Studies to evaluate the safety of residues of veterinary drugs in human foodgeneral approach to establish a microbiological EB / OL. VICH Final Draft 17 March GL 36 for implementation at step 7-final 30 April http/ / www. emea. europa. eu / pdfs / vet / vich. www. inchem. org / documents / jecfa / V43jec03. htm. 24WHO. Toxicological evaluation of certain veterinary drug residues in food. Flumequine WHO food additives series 3953

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