systems biology metabonomics R A doi /j. issn
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1 Global Traditional Chinese Medicine November 2015 Vol. 8 No. 11 R A doi /j. issn Application of metabonomics in the study of disease integrating with syndrome and Chinese compound medicine GUO Yu WEI Wei YANG Jian-qin. Dongzhimen Hospital of Beijing University of Chinese Medicine Beijing China Corresponding author YANG Jian-qin @ qq. com Abstract As a branch of systems biology metabonomics is a holistic study method based on the overall viewpoint. In the study of modern traditional Chinese compound medicine this method not only accords with guiding concepts in traditional Chinese medicine TCM such as holistic view dynamic view and syndrome differentiation but also combines TCM with modern scientific and advanced technology which is widely used in studies related to disease integrating with syndrome and has prominent advantages in integrality and dynamics. Key words Metabonomics Traditional Chinese compound medicine Disease and syndrome combination Review 1-3 systems biology metabonomics ZZ guoyu_2013@ yeah. net @ qq. com
2 Global Traditional Chinese Medicine November 2015 Vol. 8 No Zheng Xiaofen 15 1 H-NMR PCA 7 O- 8 Wang Ping 16 UPLC-HDMS OPLS- 2 DA UPLC /Q-TOF MS PLS- DA NMR PCA β
3 Global Traditional Chinese Medicine November 2015 Vol. 8 No. 11 Xue Liming Liu Yuetao 19 UPLC /Q-TOF MS OPLS-DA β Liu Pei 28 UHPLC / Q-TOF-MS PLS-DA Liang Xiaoping 20 UPLC /TOF-MS PCA PLS-DA Liu Xiaojie 29 1 H-NMR PLS-DA chronic 21 LS /MS unpredictable mild stress CUMS PCA PLS N- β- / N- B4 Gao Xiaoxia Dai Weidong GC /MS PCA UFLS /MS-IT-TOF PCA CUMS 1 Su Zhiheng 31 UPLC /Q- TOF-MS PLS-DA chronic variable stress CVS GC /MS PCA PLS-DA 3. 3 Gou Xiaojun 24 GC /MS PCA PLS-DA 31 UPLC /Q-TOF-MS PCA 25 GC /MS PCA PLS-DA PLS-DA OPLS-DA PLS-DA Zhang Huawei 26 LC /Q-TOF-MS PLS-DA 27 1 H-NMR PCA PLS-DA Sun Shujun 32 GC /MS
4 Global Traditional Chinese Medicine November 2015 Vol. 8 No precision medicine chinmedomics 43 molecular diver plotting of correlation between marker metabolites and serum constituents PCMS functional gastrointestinal disorders FGIDs Hu C Xu G. Metabolomics and traditional Chinese medicine 40 J. Trends in Analytical Chemistry J S- Pi2-2 α Wang X Sun H Zhang A et al. Potential role ofmetabolomics apporoaches in the area of traditional Chinese medicine as pillars of the bridge between Chinese and Western medicine J. 41 Journal of pharmaceutical and biomedical analysis Transgelin J
5 Global Traditional Chinese Medicine November 2015 Vol. 8 No J J. J of liver fibrosis induced by CCl in rats and intervention effects of J Xia Yu Xue Decoction J. Journal of pharmaceutical and bio- 8. medical analysis J J J Nicholson J K Connelly J Lindon J C et al. Metabonomics a platform for studying drug toxicity and gene function J. Nature reviews Drug discovery J study of postmenopausal osteoporosis and intervention effects of J er-xian decoction in ovariectomized rats J. International journal 13. of molecular sciences J Liu P Duan J Guo J et al. Plasma metabolic profiling of normal 14. J. and dysmenorrhea syndrome rats and the effects of Xiang-Fu-Si Zheng X F Tian J Liu P et al. Analysis of the restorative effect of Bu-zhong-yi-qi-tang in the spleen-qi deficiency rat model using 1 H-NMR-based metabonomics J. Journal of ethnopharmacology Wang P Sun H Lv H et al. Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS J. Journal of pharmaceutical and biomedical analysis J. Journal of ethnopharmacology model of depression induced by chronic variable stress in rats J Liu Y T Peng J B Jia H M et al. UPLC-Q/ TOF MS standardized Chinese formula Xin-Ke-Shu for the treatment of atherosclerosis in a rabbit model J. Phytomedicine Liang X Chen X Liang Q et al. Metabonomic study of Chinese medicine Shuanglong formula as an effective treatment for myocardial infarction in rats J. Journal of proteome research Nature J J Dai W Wei C Kong H et al. Effect of the traditional Chinese medicine tongxinluo on endothelial dysfunction rats studied by u- sing urinary metabonomics based on liquid chromatography mass spectrometry J. Journal of pharmaceutical and biomedical analysis Gou X Tao Q Feng Q et al. Urinary metabonomics characterization 26 Zhang H Fu P Ke B et al. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang J. Journal of ethnopharmacology Xue L Wang Y Liu L et al. A 1HNMR-based metabonomics Wu Decoction intervention J. Pharmaceutical biology Liu X J Zhou Y Z Li Z F et al. Anti depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress a plasma metabonomics study based on NMR spectroscopy J. Journal of Pharmacy and Pharmacology Gao X Zheng X Li Z et al. Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry J Su Z H Li S Q Zou G A et al. Urinary metabonomics study of anti-depressive effect of Chaihu-Shu-Gan-San on an experimental J. Journal of pharmaceutical and biomedical analysis J Sun S Dai J Wang W et al. Metabonomic Evaluation of ZHENG Differentiation and Treatment by Fuzhenghuayu Tablet in Hepatitis-B-Caused Cirrhosis J. Evidence-based Complementary and Alternative Medicine Nicholson J K Lindon J C. Systems biology metabonomics J. 35 Xie B G Zhang Z R Gong T et al. Application of metabonomic strategy to discover an unreported active ingredient in LiuWeiDi- Huang pills suppressing beta-glucuronidase J. Analytical &
6 Global Traditional Chinese Medicine November 2015 Vol. 8 No Bioanalytical Chemistry J J Xu W Wang H Chen G et al. 1 H NMR-based metabonomics study on the toxicity alleviation effect of other traditional Chinese medicines in Niuhuang Jiedu tablet to realgar As 2 S 2 J. Journal of ethnopharmacology Wan J B Bai X Cai X J et al. Chemical differentiation of Da- Cheng-Qi-Tang a Chinese medicine formula prepared by traditional and modern decoction methods using UPLC / Q-TOFMSbased metabolomics approach J. Journal of pharmaceutical and biomedical analysis Based Complementary and Alternative Medicine J Wei W Li X Hao J et al. Proteomic analysis of functional dyspepsia in stressed rats treated with traditional Chinese medicine Wei Kangning J. Journal of gastroenterology and hepatology Taylor J King R D Altmann T et al. Application of metabolomics to plant genotype discrimination using statistics and machine learning J. Bioinformatics S2 S241-S J J Liu P Liu S Tian D et al. The applications and obstacles of metabonomics in traditional chinese medicine J. Evidence R A doi /j. issn The Review on analysis technique in the evaluation of quality of traditional Chinese medicine NAN Yang XU Peng DING Hong et al. College of pharmacy Heilongjiang university of Chinese medicine Haerbin China Corresponding author MA Wei-wei mawei - wei@ 163. com Abstract Traditional Chinese medicine TCM is widely used in all over the world and more RFQXJ nancy _ sina. com mawei_wei@ 163. com
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