Biological characteristics of different sources of mesenchymal stem cells. doi: /j.issn

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1 Chinese Journal of Tissue Engineering Research August 6, 2015 Vol.19, No.32 ( ) 1 2 CD90 CD73 CD105 CD44 3, ( ) :R394.2 :B : (2015) PubMed. [J] (32): doi: /j.issn Biological characteristics of different sources of mesenchymal stem cells Fang Hong-song, Zhou Jian-lin, Peng Hao, Deng Shuang, Weng Jin-qing, Liu Feng, Chen Sen, Zhou Guan-jin (Department of Bone and Joint Surgery, Renmin Hospital of Wuhan University, Wuhan , Hubei Province, China) Abstract BACKGROUND: Mesenchymal stem cells, under in vivo or in vitro specific induction conditions, can differentiate into the cartilage, muscle, tendons and so on. Clinical trials concerning mesenchymal stem cells mainly include tissue repair (such as bone, cartilage and joint repair) and treatment of heart, liver, spinal cord injury and nervous system diseases. OBJECTIVE: To compare the biological characteristics of mesenchymal stem cells from different sources. METHODS: PubMed and CNKI databases were retrieved for articles related to sources of mesenchymal stem cells and biological characteristics of mesenchymal stem cells published from 1987 to The retrieved articles were summarized and analyzed in the following aspects: cell surface marker, proliferation, differentiation, migration, and function, so as to explore the merits and demerits of mesenchymal stem cells from different sources. RESULTS AND CONCLUSION: A difference in the proliferation ability and surface markers is found between different sources of mesenchymal stem cells. Immunological competence of mesenchymal stem cells from different sources may be correlated with their activation status, species differences, tissue sources and culture Fang Hong-song, Master, Associate chief physician, Department of Bone and Joint Surgery, Renmin Hospital of Wuhan University, Wuhan , Hubei Province, China Accepted: ISSN CN /R CODEN: ZLKHAH 5243

2 conditions, resulting the immunological competence of mesenchymal stem cells from different sources is not exact the same. In-depth understanding of the factors and mechanisms by which influence the migration of mesenchymal stem cells from different sources can enhance the migration ability of different sources of mesenchymal stem cells, and increase their efficiency in wound healing, tissue repair and regeneration treatment. Subject headings: Mesenchymal Stem Cells; Cell Proliferation; Cell Differentiation; Antigens, Surface Funding: the National Natural Science Foundation of China, No Fang HS, Zhou JL, Peng H, Deng S, Weng JQ, Liu F, Chen S, Zhou GJ. Biological characteristics of different sources of mesenchymal stem cells. Zhongguo Zuzhi Gongcheng Yanjiu. 2015;19(32): Introduction [1] 1987 Friedenstein [2] ( ) [3-4] 40 [5-6] [7-8] CD10 CD13 CD29 CIM4 CD90 CD1 CD14 CD34 CD45 [9-10] CD105 CD73 CD44 CD71 CD90 CD166 (STRO-1) β [11] Tantrawatpan [12] Teotia [13] Data and methods PubMed mesenchymal stem cells; bone marrow; umbilical cord; placenta; amniotic fluid Results 2.1 [14-15] [16] CD90 CD73 CD105 CD44 CD45 CD11b CD34 [17] CD29 CD44 CD49e CD73 CD90 CD34 CD45 CD271 P.O. Box 10002, Shenyang

3 [18] Lee [19] CD90CD166 [20] SD CD11b CD29 CD106 CD90 CD45 CD49d SD 36 hpcr Oct-4 Nanog [21] [22] 2 CD29 CD44CD34 CD106 [23] CD90 CD73 CD105 90% T B TT T TT BB G 0 /G 1 () IgA IgM IgG 2 2 HLA-1 ( ) α [2] 10 β1e2 2 CD8 + T 10 [24-25] BN [26] G 0 G % 91.2% [27] 10 [28] [29] d 80% d 80% 8 10 d 80% d 80% Roura [30] 3 [31] ISSN CN /R CODEN: ZLKHAH 5245

4 () (Von Kossa ) ( O ) 1 [44] 3 O 3 3 Von Kossa µm [32-33] [34-35] [36-37] [38-39] [40] [41] Li [42-44] ( 1) 3 Clinical application and prospect of mesenchymal stem cells [45] [46] 5246 P.O. Box 10002, Shenyang

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