Drosophila melanogaster. Drosophila melanogaster. Caenorhabditis elegans. Caenorhabditis elegans. Caenorhabditis elegans. Drosophila melanogaster

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1 Type of C14 Abbreviation Protein ID Protein name Species Kingdom Phylum Class peptidase Initiator caspases HsC2 NP_ caspase-2 Homo sapiens Animalia Chordata Mammalia HsC8 AAL caspase-8 Homo sapiens Animalia Chordata Mammalia HsC9 AAD caspase-9 Homo sapiens Animalia Chordata Mammalia HsC10 NP_ caspase-10 Homo sapiens Animalia Chordata Mammalia DmC1 NP_ DREDD DmC2 NP_ DRONC CeC1 AAG CED-3 CeC2 AAC Csp-1 CeC3 AAC Csp-2 Inflammarory caspases HsC1 BAD caspase-1 Homo sapiens Animalia Chordata Mammalia HsC4 NP_ caspase-4 Homo sapiens Animalia Chordata Mammalia HsC5 ABB caspase-5 Homo sapiens Animalia Chordata Mammalia Effector caspases HsC3 CAC caspase-3 Homo sapiens Animalia Chordata Mammalia HsC6 NP_ caspase-6 Homo sapiens Animalia Chordata Mammalia HsC7 NP_ caspase-7 Homo sapiens Animalia Chordata Mammalia DmC3 NP_ Strica DmC4 NP_ DCP1 DmC5 CAA DRICE DmC6 AAD Decay DmC7 AAF Damm

2 E AmC1 AAG CfaC1 CAF CeC4 AAC Csp-3 Amsacta moorei entomopoxvirus Viruses - - Spodoptera frugiperda ascovirus Viruses - - 1a Caspase-14 HsC14 NP_ caspase-14 Homo sapiens Animalia Chordata Mammalia Paracaspase type I HsPCP1 NP_ MALT1 Homo sapiens Animalia Chordata Mammalia CePC1 AAG DrPCP1 XP_ Paracaspase PCP1 Danio reiro Animalia Chordata Actinopterygii DrPCP2 XP_ Paracaspase PCP2 Danio reiro Animalia Chordata Actinopterygii DrPCP3 XP_ Paracaspase PCP3 Danio reiro Animalia Chordata Actinopterygii HvPCP1 XP_ Hydra vulgaris NvPCP1 XP_ Paracaspase 1 NvPCP2 XP_ Paracaspase 2 Paracaspase type II NvPCP3 XP_ Paracaspase 3 ShPCP1 XP_ DdPCP1 AAG Paracsapase 1 DdPCP2 XP_ Paracsapase 2 Stereum hirsutum FP SS1 Dyctiostelium discodeum Dyctiostelium discodeum Fungi Basidiomycota Agaricomycetes Protozoa Amoebozoa Dictyostelia Protozoa Amoebozoa Dictyostelia MbMC1 KUK C14 peptidase 1 Cb C14.1 WP_ C14 peptidase 1 Methanobacterium sp Calothrix sp. PCC 7103 Archaea Euryarchaeota Methanobacteria

3 Ma C14.1 WP_ C14 peptidase 1 LspC14.1 WP_ C14 peptidase 1 Microcystis aeruginosa Leptolyngbya sp. JSC-1 TbMC1 CAD Metacaspase 1 Trypanosoma brucei Protista Euglenozoa Kinetoplastea TbMC2 AAX Metacaspase 2 Trypanosoma brucei Protista Euglenozoa Kinetoplastea TbMC3 AAX Metacaspase 3 Trypanosoma brucei Protista Euglenozoa Kinetoplastea TbMC4 XP_ Metacaspase 4 Trypanosoma brucei Protista Euglenozoa Kinetoplastea Metacaspase type I TbMC5 CAD Metacaspase 5 Trypanosoma brucei Protista Euglenozoa Kinetoplastea ScMC1 EDN YCA1 Saccharomyces cerevisiae YJM789 Fungi Ascomycota Saccharomycotina AnMC1 A2RB75.2 Metacaspase 1 Aspergillus niger Fungi Ascomycota Eurotiomycetes PtMC1 fgenesh1_pg.c_chr_2000 Phaedactylum Metacaspase PtMC3 phatr1_ua_kg.chr_80000 Phaedactylum Metacaspase 3 29 CcMC3 Metacaspase 3 XP_ Chondrus crispus Rodophyta Florideophyceae CcMC1 Metacaspase 1 XP_ Chondrus crispus Rodophyta Florideophyceae PhMC1 AMB Metacaspase 1 Pyropia haitanensis Rhodophyta Bangiophyceae CrMc1 Cre03.g t1.2.p Metacaspase 1 Chlamydomonas reinhardtii Chlorophyta Chlorophyceae CrMc2 Cre12.g t1.1.p Metacaspase 2 Chlamydomonas reinhardtii Chlorophyta Chlorophyceae VcMc1 Vocar.0006s p Metacaspase 1 Volvox carteri Chlorophyta Chlorophyceae VcMc2 Vocar.0015s p Metacaspase 2 Volvox carteri Chlorophyta Chlorophyceae PpMc2 Pp3c17_17780V3.10.p Metacaspase 2 PpMc5 Pp3c24_11630V3.1.p Metacaspase 5 SmMc Metacaspase 1 PaMC1 MA_183122g0010 Metacaspase 1 Picea abies Gymnosperms Pinopsida PaMC5 MA_ g0010 Metacaspase 8 Picea abies Gymnosperms Pinopsida AtMC1 NP_ Metacaspase 1

4 AtMC2 NP_ Metacaspase 2 AtMC3 NP_ Metacaspase 3 VvMC1 AGJ Metacaspase 1 Vitis vinifera VvMC2 AGJ Metacaspase 2 Vitis vinifera VvMC3 AGJ Metacaspase 3 Vitis vinifera VvMC6 AGJ Metacaspase 6 Vitis vinifera OsMC2 LOC_Os03g Metacaspase 2 Oryza sativa Angiosperms Liliopsida OsMC3 LOC_Os03g Metacaspase 3 Oryza sativa Angiosperms Liliopsida OsMC4 LOC_Os03g Metacaspase 4 Oryza sativa Angiosperms Liliopsida OsMC5 LOC_Os03g Metacaspase 5 Oryza sativa Angiosperms Liliopsida OsMC8 LOC_Os11g Metacaspase 8 Oryza sativa Angiosperms Liliopsida ZmMc1 GRMZM2G022799_P01 Metacaspase 1 Zea mays Angiosperms Liliopsida ZmMc4 GRMZM2G120069_P01 Metacaspase 4 Zea mays Angiosperms Liliopsida ZmMc5 GRMZM2G120079_P01 Metacaspase 5 Zea mays Angiosperms Liliopsida ZmMc6 GRMZM2G125314_P01 Metacaspase 6 Zea mays Angiosperms Liliopsida ZmMc7 GRMZM2G132238_P01 Metacaspase 7 Zea mays Angiosperms Liliopsida ZmMc8 GRMZM2G155422_P01 Metacaspase 8 Zea mays Angiosperms Liliopsida ZmMc9 GRMZM2G320206_P01 Metacaspase 9 Zea mays Angiosperms Liliopsida ZmMc10 GRMZM2G337548_P01 Metacaspase 10 Zea mays Angiosperms Liliopsida ZmMc11 GRMZM2G382581_P01 Metacaspase 11 Zea mays Angiosperms Liliopsida CcMC2 XP_ Metacaspase 2 Chondrus crispus Rodophyta Florideophyceae PpMc1 Pp3c1_20330V3.1.p Metacaspase 1 PpMc3 Pp3c21_16610V3.1.p Metacaspase 3

5 Metacaspase type II PpMc4 Pp3c2_20840V3.1.p Metacaspase 4 SmMc Metacaspase 2 SmMc Metacaspase 3 PaMC2 MA_ g0010 Metacaspase 2 Picea abies Gymnosperms Pinopsida PaMC3 MA_ g0010 Metacaspase 3 Picea abies Gymnosperms Pinopsida PaMC4 MA_939400g0010 Metacaspase 4 Picea abies Gymnosperms Pinopsida AtMC4 NP_ Metacaspase 4 AtMC5 AEE Metacaspase 5 AtMC6 AEE Metacaspase 6 AtMC7 AEE Metacaspase 7 AtMC8 NP_ Metacaspase 8 AtMC9 AED Metacaspase 9 VvMC4 AGJ Metacaspase 4 Vitis vinifera VvMC5 AGJ Metacaspase 5 Vitis vinifera OsMC1 LOC_Os01g Metacaspase 1 Oryza sativa Angiosperms Liliopsida OsMC6 LOC_Os05g Metacaspase 6 Oryza sativa Angiosperms Liliopsida OsMC7 LOC_Os05g Metacaspase 7 Oryza sativa Angiosperms Liliopsida ZmMc2 GRMZM2G047274_P01 Metacaspase 2 Zea mays Angiosperms Liliopsida ZmMc3 GRMZM2G066041_P01 Metacaspase 3 Zea mays Angiosperms Liliopsida Metacaspase type III PtMC2 PtMC4 PtMC5 estext_fgenesh1_pg.c_c hr_ estext_phatr1_ua_kg.c_ chr_ estext_phatr1_ua_kg.c_ chr_ Metacaspase 2 Metacaspase 4 Metacaspase 5 EsMC1 CBN Metacaspase 1 Ectocarpus siliculosus