Effects of barley flake on metabolism of glucose and lipids in the patients with impaired fasting glucose

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1 JOURNAL OF HYGIENE RESEARCH Vol. 42 No. 5 Sep OGTT AUC HOMA-IR FBG INS μu /L / FBG INS 9. 26% P < % P = TC LDL-C 7. 20% P < % P = HbAlc HOMA-IR TG Apo-B OGTT AUC P < P < HDL- C Apo-A ALP SOD S Q591 R A Effects of barley flake on metabolism of glucose and lipids in the patients with impaired fasting glucose BI Mingxin NIU Yucun LI Xue LI Ying SUN Changhao Department of Nutrition and Food Hygiene College of Public Health Harbin Medical University Harbin China Abstract Objective To investigate the effects of barley flake BF on the glucoselipid metabolism in patients with impaired fasting glucose IFG. Methods 100 patients with IFG were divided into the oat meal OM control group and barley flake experimental group for three months intervention according to randomized controlled trail RCT. Biochemical indicators glucose-lipid metabolism related enzymes the area under curve AUC of blood glucose and insulin after oral glucose tolerance test OGTT were assessed before and after intervention. In addition the homeostasis model assessment of insulin resistance HOMA-IR was calculated by FBG INS μu /L / Results At the end of the three month active intervention the mean fasting blood glucose FBG and insulin INS in the patients with BF treatment decreased by 9. 26% P < and % P = separately compared with that in patients with OM treatment meanwhile total cholesterol TC and low density lipoprotein cholesterol LDL-C in patients with BF treatment also decreased by 7. 20% P < and 863 No. 2010AA No. 2012BAI02B00 bimingxin2006@ yahoo. cn 1 Sun2002changhao@ yahoo. com

2 % P = respectively. Glycosylated hemoglobin HbAlc HOMA-IR total glyceride TG Apo-B the AUC of blood glucose and insulin after OGTT were also significantly decreased separately P < or < However statistically significant differences failed to be found in HDL-C Apo-A ALP and SOD between these two groups. Conclusion BF had favorable effect on improvement of glucose-lipid metabolism in the patients with impaired fasting glucose. Key words barley flake impaired fasting glucose glucose and lipid metabolism β β β β IGT 8% ~ 1 11% / WHO ! ~ 6. 9 mmol /L β- β β- β- 7 1 β TC LDL-C 8 β- 50 g 1 Table g The nutrients of oat meal and barley flake per 100 g /kcal /g /g /g /g β- /g /g /g min 10 min BMI BMI = kg / 2 m

3 x 珋 ± s N % FBG HbAlc INS TC TG HDL-C LDL-C SOD ALP P < HOMA-IR = μu /L / OGTT min t BMI SPSS Table 2 2 The basic characteristics of the two groups of subjects n = 50 / BMI /cm /cm ± / ± ± ± ± / ± ± ± 5. 9 P /% /mmhg /mmhg ± ± ± ± ± ± ± ± 8. 9 P OGTT 3 3 P < P < FBG P = AUC P < HbAlc P = % P < % P < P < AUC AUC % AUC FBG 9. 26% P < INS P = P < % P < AUC HOMA-IR P < AUC % P < INS 3 INS IFG % P = TC P = P = LDL-C P < P < Apo-B P = TC LDL-C 7. 20% P < P < β % P = TG P = P = β P = % HDL-C Apo-A ALP 13 SOD % P < OGTT FBG INS OGTT 1. 8 g β-

4 Table 3 3 The results of glucose lipids and other indicators in the two groups before and after the intervention n = 50 x 珔 ± s FBG / HbAlc / % INS / 10-6 U /L HOMA-IR TC / TG / ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 0. 1 P < ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± P 1 < < < < P 2 < < < HDL-C / LDL-C / Apo-A / g /L Apo-B / g /L ALP / U /L SOD / mg /L ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± P < ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± P < < P < Table 4 4 OGTT The results of OGTT and insulin in the two groups before and after intervention n = 50 珔 x ± s OGTT 0 min 30 min 60 min 90 min 120 min ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± P < ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± P 1 < < < < < P 2 < < < < < min 30 min 60 min 90 min 120 min ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± P < < ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 1. 9 P < < < < P 2 < < < < β g β- β g

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