Advance in modern studies on compatibility of Coptidis Rhizoma and Evodiae Fructus
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1 Vol. 40 No. 4 February * Pubmed Advance in modern studies on compatibility of Coptidis Rhizoma and Evodiae Fructus QIU Chao 1 2 CUI Yuan-lu 1 2* QI Xue-jie 2 3 JIANG Heng-li 1 2 WANG Qiang-song Research Institute of Traditional Chinese Medicine Tianjin University of Chinese Medicine Tianjin China 2. Key Laboratory of Modern Chinese Medicine of Tianjin Tianjin China 3. College of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China Abstract In traditional clinical application Coptidis Rhizome and Evodiae Fructus have been combined to treat various stomach heat and cold syndromes gastritis gastric ulcer and the like. With the application of modern instruments and the development of molecular pharmacologic theory their chemical constituents and pharmacological effects have been sufficiently studied. In this paper literatures from Pubmed were adopted with particular emphasis on findings of international counterparts and studies on compatibility of main chemical components in Coptidis Rhizoma and Evodiae Fructus in order to elaborate on the scientific comparability of Coptidis Rhizoma and Evodiae Fructus through chemical analysis and pharmacological and biopharmaceutics studies and introduce the future development trend of the studies. Key words Coptidis Rhizoma Evodiae Fructus compatibility Zuojin pill doi /cjcmm * cuiyl@ tju. edu. cn qiuchao0607@ 163. com 582
2 13 HPLC HPLC Zhao 7 UPLC- DAD 6 1 TLC 2-4 HPLC - 5 LC-MS 6 CE - CE-MS UPLC 6-7 HPLC 8 16 HPLC-MS - 9 HPLC-ESI-MS Gao 10 HPLC PCA 2 Yuan 11 HPLC-MS μg L - 1 Luo 9 HPLC-ESI-MS LC-MS UPLC 2 Gao 6 UPLC Jiang 12 UPLC-QTOF /MS UPLC UPLC-MS SGC-7901 SGC
3 Vol. 40 No. 4 February g kg g kg Hu HTT 5-5-HTT 5-HTT 5-HTT Wang 25 TNF -α mrna 5-3 Hu Wang 18 Wang S180 TNF-α 2. 3 Luo 27 2 Wang 22 5% SMMC CD4 + CD8 + T SMMC-7721 CD8 + TNF-α CD4 + CD8 + T 2 CD8 + T Chao 23 2 HepG2 2-1 AP-1 NF -κb Sui 28 P- P-gp NF-κB AP-1 P-gp HepG2 HepG2 - Wang 29 / RAW LPS NO - PGE 2 COX-2 mrna 2. 2 COX-2 PGE 2 Ca
4 33 Zhao 30 Ca 2 + Ca 2 + Yuan 11 LC-MS Yan 34 NE 5-HT NE - 31 Wang Ma g kg g kg Ⅱ AngⅡ P-gp MCP-1-1 P-gp CCR-2 C-C -2 P-gp AngⅡ ROS P-gp Ko AngⅡ MCP-1 mrna CYP3A1 /3A2 AngⅡ MCP-1 AngⅡ Yan AUC
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