The Effect of Aerobic Exercise on Blood Glucose, Lipid Profile and Apo B-100 in Patients with Type II Diabetes

Μέγεθος: px

Εμφάνιση ξεκινά από τη σελίδα:

Download "The Effect of Aerobic Exercise on Blood Glucose, Lipid Profile and Apo B-100 in Patients with Type II Diabetes"

Πορφύριος Αθανασιάδης
6 χρόνια πριν
Προβολές:

1 Journal of Ardabil University of Medical Sciences Vol.13, No.2, Summer 2013, Page The Effect of Aerobic Exercise on Blood Glucose, Lipid Profile and B-100 in Patients with Type II Diabetes Esfarjani F* 1, Rashidi F 1, Marandi SM 1 1 Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran * Corresponding Author: Tel: Fax: F.esfarjani@yahoo.com Received: 31 Oct 2011 Accepted: 1 Jan 2013 ABSTRACT Background & Objectives: Elevated apolipoprotein B-100 and decreased Plasma due to hypertriglyceridemia are common abnormalities in insulin-resistant subjects that increase the risk of cardiovascular disease. The aim of this study was to investigate the effects of 8 weeks progressive aerobic exercise (AE) on blood glucose, lipid and lipoprotein profile, and aerobic power in adults with type 2 diabetes. Methods: Twenty nine women with type 2 diabetes (mean age 43.4 ± 1.7 years and blood glucose range of 150 to 230 mg/dl) were divided into a control (n=14) and exercise (n=15) groups. Exercise group participated in an aerobic training program 3 times per week for 8 weeks. The intensity of aerobic exercise was 60 75% of HR max. The control subjects were asked not to alter their physical activity patterns. All subjects underwent anthropometric, lipid profile and aerobic power evaluation, at the baseline and 48 hours after last session training. Following a 12 h overnight fasting, a venous blood sample was drawn for the analysis of total cholesterol (TC), triglycerides (TG), high density lipoprotein (), low-density lipoprotein (), and (apob100). Paired t test and analysis of covariance (ANCOVA) were used to analyze the data. Results: Significant improvement was observed in FBS, aerobic power, percent body fat, () B-100 and triglycerides (p< 0.05) for the exercise compared with the control group after training. No significant difference was observed in TC, and between two groups. Conclusion: According to our findings moderate intensity physical exercise can be effective in preventing the atherosclerosis via significant improvement in blood sugar, cardiovascular endurance, B-100 and triglyceride in patients with type 2 diabetes. Key words: Aerobic Training; Blood Glucose; Lipid Profile; B-100; Type II Diabetes

2 APO B * 1 1 F.esfarjani@yahoo.com : 91/10/12 : : :. * 90/8/9 : B-100 : /4 29 : 8. (N = 15) (N =14) mg/dl. % B-100 t.. α<0/05 8 B100 :.(p<0/05). : B B-100 : [4] d-.[1]. B/E % [1 2].[3].[1]. IRCT N1 *

3 %43 %19. A-I.[1].[6] B-100 V B-100 [2] B-100.[6] V.[6] B-100.[2].[6]..[7 8]..[8] %1.[5].[1].[5].[1].[1 5]. -C..[1].[1].[1].[1 3 4]

4 : B TG TC B. (ROCSH).. 1 CE-120. = 0 / ( 4) 0 / ( 4 2 ) + 0 /02963 (Age) + 1 / 4072 : 4 %18 %1 %20.[9] %37 0/6.[5 10].[ ] (%40-60) (%15-20).[11].[11 12] B- 100 B- [6] 100 RCT mg/dl 34 1 Randomized Controlled Trials

5 1392 t [13] VO2max ( ml /kg/min)=132/ 85-0/ 0769(bodyweight) - 0/3877(age) + 6/ 315(sex) - 3/ 2649(time) - 0/1565(heart rate) 16 SPSS α<0/ BMI (Kg) (cm) ( ) 30 /6 76 / / 9 44 / 2 n=14 30 /5 75 / / 1 42 / 7 n=15 t -. B100.(2) : % [ ] 48.. ( ) 0/005 0/272 0/03 0/401 0/619 0/02.2 F 9/36 1/25 2/47 0/72 0/25 4/ / / /31 377/37 16/ /87 (mg/dl) (mg/dl) (mg/dl) (mg/dl) (mg/dl) B100 (mg/dl)

6 %30 28.[14].[17]. GLUT4.[18]. GLUT-4 [8].[8 16] GLUT4 *0/002 0/77 *0/02 0/57 *0/02 0/14 0/86 0/23 *0/04 0/75 0/46 0/38 0/43 0/85 *0/03 0/71.[8 5] GLUT4 8 B100.(p<0/05) 8. %9/2.(3 ) 8 (FBS) mg/dl 8 (%16/2) 155/2 185/ %20 (2009).. %18/2 (2009) [16] % T 3/722 0/253 2/67 0/65 2/82 1/12 0/180 1/18 1/96 0/270 0/88 1/23 0/96 0/165 2/95 0/86 30/2±5/6 29/9±5/1 29/1±4/1 25/8±4/76 155/2±55/4 204/4±78/2 197/35±52/1 202/8 ±40/6 193/2±46/4 204/4± 76/6 111/7±46/5 115/4±32/7 48/1±6/6 42/3±8/1 94±10/1 95±9/4 31/3±5/3 29/3±4/9 26/6±5/5 24/3±4/1 185/8±53/2 190/7±69/4 199/2±35/3 188/6 ±33/6 212 ±99/1 200/4± 68/6 113/8±31/7 109/9±29/5 47±11/8 43/80±4/1 98±11/9 96±8/9 10 (%) (ml.kg- 1.min -1 ) ( mg/dl) (mg/dl) (mg/dl) (mg/dl) (mg/dl) (mg/dl) B100 * 1 Arara 2 Bweir

7 [19].[20].[5] ( ). %6/ %50.[16] 8 197/3±52/6 199/2±35/3.. 4/23 4/32.[17] 8.[16] [21] [3]. GLUT4 %22.[12] B (IR).[8].[18 10]. %3/5...[5]. (TG) 8 193/2±46/4 mg/dl 212/4±76/4..[3] %18/9.[9]

8 [23].[22 23].[22] 8 %9/2..[22] B-100.[22] B-100 %4 B-100 %3/9.[22] B B-100. APO B B [2] B-100..[19]. [9] [22] [16] (%17/3).[3].[21]. LCAT [19]. 106/7±46/5 108/8±31/7 [23] [3] [9] [21].[4]..[22] 4 [23] /3

9 B References 1- Verges B. Lipid modification in type 2 diabetes: the role of and. Fundam Clin Pharmacol Dec; 23(6): Rabbani N, Rabbani N, Chittari MV, Bodmer CW, Zehnder D, Ceriello A, et al. Increased glycation and oxidative damage to apolipoprotein B100 of cholesterol in patients with type 2 diabetes and effect of metformin. Diabetes Apr; 59(4): Zois CE, Tokmakidis SP, Volaklis KA, Kotsa K, Touvra AM, Douda E, et al. Lipoprotein profile, glycemic control and physical fitness after strength and aerobic training in post-menopausal women with type 2 diabetes. Eur J Appl Physiol Aug; 106(6): Iborra RT, Ribeiro IC, Neves MQ, Charf AM, Lottenberg SA, Negrao CE, et al. Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus. Scand J Med Sci Sports Dec; 18(6): Agosti V,Graziano S, Artiaco L, Sorrentino G. Biological mechanisms of stroke prevention by physical activity in type 2 diabetes. Acta Neurol Scand Apr; 119(4): Watts GF, Ooi EM, Chan DC. Therapeutic regulation of apob100 metabolism in insulin resistance in vivo. Pharmacol Ther Sep; 123(3): Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, et al. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation Jun; 119(25): Wang Y, Simar D, Fiatarone Singh M. Adaptations to exercise training within skeletal muscle in adults with type 2 diabetes or impaired glucose tolerance: a systematic review. Diabetes Metab Res Rev Jan; 25(1): Sigal RJ, Kenny GP, Boule NG, Wells GA, Prudhomme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med Sep; 147(6): Sanz C, Gautier JF, Hanaire H. Physical exercise for the prevention and treatment of type 2 diabetes. Diabetes Metab Nov; 36(5): Mogensen M, Vind BF, Hojlund K, Beck-Nielsen H, Sahlin K. Maximal lipid oxidation in patients with type 2 diabetes is normal and shows an adequate increase in response to aerobic training. Diabetes Obes Metab Sep; 11(9): Teixeira-Lemos E, Nunes S, Teixeira F, Reis F. Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol Jan; 28(10): Osho O, Akinbo S, Osinubi A, Olawale O. Effect of Progressive Aerobic and Resistance Exercises on the Pulmonary functions of Individuals with Type 2 Diabetes in Nigeria. Int J Endocrinol Metab Jan; 10(1):

10 Bweir S, Al-Jarrah M, Almalty AM, Maayah M, Smirnova IV, Novikova L. Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes. Diabetol Metab Syndr Dec; 10(1): Robergs RA, Keteyian SJ. Fundamentals of Exercise Physiology for Fitness, Performance, and Health. 2 nd ed. Mc Graw-Hill, 2003: Arora E, Shenoy S, Sandhu JS. Effects of resistance training on metabolic profile of adults with type 2 diabetes. Indian J Med Res May; 129(5): Gordon LA, Morrison EY, McGrowder DA, Young R, Fraser YT, Zamora EM, et al. Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. BMC Complement Altern Med May; 13(8): Cho K, Kim YB. Molecular mechanism of insulin resistance in obesity and type 2 diabetes. Korean J Intern Med Jun; 25(2): Mougios V. Exercise Biochemistry, 1 st ed. Human Kinetics, 2006 Jun; Plotnikoff RC, Courneya K, Trinh L, Karunamuni N, Sigal R. Aerobic physical Activity and resistance training: an application of the theory of planned behavior among Adults with type 2 diabetes in a random, national sample of Canadians. Int J behav Nutri physl Act Dec; (5): Balducci S, Nicolucci D, Fernando E, Cavallo S. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis Oct; 20(8): Kawano M, Shono N, Yoshimura T, Yamaguchi M, Hirano T, Hisatomi A. Improved cardiorespiratory fitness correlates with changes in the number and size of small dense : randomized controlled trial with exercise training and dietary instruction. Intern Med Jan; 48(1): Wooten JS, Biggerstaff KD, Ben-Ezra V. Responses of and particle size and distribution to omega-3 fatty acid supplementation and aerobic exercise. J Appl Physiol Sep; 107(3):

Σχετικά έγγραφα

: Archive of SID. LDL t. Apo B Apo B-100 : LDL LDL HDL LDL LDL. . IRCT N1 *

: Archive of SID. LDL t. Apo B Apo B-100 : LDL LDL HDL LDL LDL. . IRCT N1 * 133... 2 B-100 1 1 * 1 1 F.esfarjani@yahoo.com : 0311-6687572 : 09133163919 :. * 91/10/12 : [4] d-.[1]. B/E %28 90/8/9 : 2 4.[1 2] B-100 :. 8. 2 43/4 29 : 8. (N = 15) (N =14) 150-230 mg/dl. %75 60 60 40