Supplementary figures for MED13 dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.
|
|
|
- Μέδουσα Γιαννόπουλος
- 5 χρόνια πριν
- Προβολές:
Transcript
1 Supplementary figures for MED13 dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver. Content: Figure S1. Cardiac overexpression of MED13 increases metabolic gene expression in white adipose tissue. Figure S. Regulation of liver metabolite production by cardiac expression of MED13 in the fed state. Figure S3. Cardiac overexpression of MED13 alters metabolic gene expression. Figure S4. MED13cTg hearts maintain the ability to adapt to fasting. Figure S5. Circulating factor(s) regulate enhanced WAT and liver metabolism and contribute to the lean phenotype of MED13cTg mice. Supplementary Table 1. Acylcarnitines in liver from fed and fasted and MED13cTg mice. SupplementaryTable. Acyl-CoAs in liver from fed and fasted and MED13cTg mice. SupplementaryTable 3. Acylcarnitines in heart from fed and fasted and MED13cTg mice. Supplementary Table 4. Acyl-CoAs in heart from fed and fasted and MED13cTg mice. SupplementaryTable 5. Acylcarnitines in serum from fed and fasted and MED13cTg mice. Supplemental figure legends
2 Supplementary Figure 1 A Fatty acid transport and oxidation Outer Mitochondrial Membrane / Cytoplasm Inner Mitochondrial Membrane Mitochondrial Matrix FFA ATP Acyl-CoA synthetase AMP (ACSL3) Acylcarnitine Carnitine palmitoyltransferase 1 (CPT1B) Carnitine palmitoyltransferase (CPTB) Fatty acid transporter (Slc7a) Acyl-CoA FADH (ACADVL) -Enoyl CoA FADH Acyl CoA Trifunctional protein (HADHA) Acyl-CoA,4-Dienoyl-CoA reductase + 3,-trans-enoyl-CoA isomerase NADP (ECH1) -Enoyl-CoA -Enoyl-CoA hydratase (ECHS1) 3-Hydroxyacyl-CoA 3-Ketoacyl CoA (plasma membrane) FFA 3-Hydroxyacyl-CoA FADH Malate Malate Fumarase Fumarate Pyruvate Citrate synthase Oxaloacetate (MDH) Succinate (SDHA) Succinate Pyruvate complex (DLAT, PDHX) GTP Krebs Cycle Succinyl CoA synthetase (SUCLA) Citrate Aconitase Succinyl CoA cis-aconitate Aconitase Isocitrate Isocitrate (IDH3A, IDH3G, IDH) α-ketoglutarate α-ketoglutarate complex (DLST) 3-Ketoacyl-CoA thiolase B Fold change over Fatty acid oxidation genes ACSL13 CPT1b CPT ACADVL HADHA Ecl1 ECHS1 HADH Fold change over 6 4 DLAT PDHX Krebs cycle genes IDH3A IDH3G IDH DLST SUCLA SDHA MDH
3 Supplementary Figure A Concentration in liver (μm) C Liver ceramides (pmol/ml) D Heart ceramides (pmol/ml) C14 C14 Lactate Pyruvate * C16 * * # C16 C18 * C18 Succinate * Fumarate C:1 C:1 Malate C C C C fed fasted fed fasted α-ketoglutarate Citrate C3 C3 * # *# C4:1 C4:1 B Concentration in heart (μm) C4 C C5 C5 Lactate C6:1 # C6:1 Pyruvate C6 C6 Succinate * d18:1/c16 d18:1/c16 Fumarate d18:1/c18 d18:1/c18 Malate d18:1/c d18:1/c α-ketoglutarate d18:1/c d18:1/c fed fasted fed fasted d18:1/c3 d18:1/c3 Citrate d18:1/c4:1 d18:1/c4:1 d18:1/c4 d18:1/c4 d18:1/c6:1 fed fasted fed fasted d18:1/c6:1 fed fasted fed fasted * d18:1/c6 d18:1/c6
4 SupplementaryFigure 3 A Fatty acid transport and oxidation Outer Mitochondrial Membrane / Cytoplasm Inner Mitochondrial Membrane Mitochondrial Matrix FFA ATP Acyl-CoA synthetase AMP (ACSL1) Acylcarnitine Carnitine palmitoyltransferase 1 (CPT1B) Carnitine palmitoyltransferase (CPT) FADH -Enoyl CoA FADH NADP Acyl CoA -Enoyl-CoA Fatty acid transporter Acyl-CoA Trifunctional protein (HADHA) (ADADM, ACADSB) -Enoyl-CoA hydratase (ECHS1) 3-Hydroxyacyl-CoA 3-Ketoacyl CoA (plasma membrane) Acyl-CoA,4-Dienoyl-CoA reductase + 3,-trans-enoyl-CoA isomerase FFA 3-Hydroxyacyl-CoA (HADH) FADH Malate Malate Fumarase Fumarate Succinate Pyruvate Citrate synthase Oxaloacetate (SDHA) Succinate Pyruvate complex (DLAT1, PDHX, PDHa1) GTP Krebs Cycle Succinyl CoA synthetase Citrate (SUCLA, SUCLG) Aconitase (ACO) Succinyl CoA cis-aconitate Aconitase (ACO) Isocitrate Isocitrate (IDH3A) α-ketoglutarate α-ketoglutarate complex (OGDH) 3-Ketoacyl-CoA thiolase B Fold change over D Glucose (mg/dl) F Malonyl CoA (μm) Fatty acid oxidation genes ACSL1 CPT1b CPT HADHA ACADM ACADSB ECHS1 HADH FFA (μm) Triglycerides (μm) Fold change over DLAT1 PDHX Krebs cycle genes Ketones (μm) PDH1a ACO IDH3A OGDH SUCLA 18 p= SUCLG SDHA C E Fold Change over F p=. Nppa F p=.1 p=.5 F F F G G G p=.13 Nppb F Chemical Shift (ppm) fed fasted fed fasted C4
5 Supplementary Figure 4 A B Heart Acyl-CoAs CoA acetyl propionyl succinyl itaconyl glutaryl Medium Chain C1:3 C1: C1:1 decanoyl Long Chain C1:1 lauroyl myristoyl C15/C14:1-OH C14-OH C16:3 C16: C16:1 palmitoyl C17:1 linolenoyl linoleoyl oleoyl stearoyl C19: C19:1 C19 Very Long Chain C:5 C: C:1 -. C1:3 C1: C1:1 C1 C:6 C:5 C:4 C:3 C: C:1.. Liver Acyl-CoAs CoA acetyl propionyl succinyl itaconyl glutaryl Medium Chain C1:3 C1: C1:1 decanoyl Long Chain C1:1 lauroyl myristoyl C15/C14:1-OH C14-OH C16:3 C16: C16:1 palmitoyl C17:1 linolenoyl linoleoyl oleoyl stearoyl C19: C19:1 C19 Very Long Chain -. C Insulin (ng/ml) p=.31 p=.1.. p=.5 D Adiponectin (μg/ml) E Plasma T4 (μg/dl) p=.34 p=. F Plasma corticosterone (ng/ml) p=. p=.5 G Plasma BNP (pg/ml) p=.4 p=.46 H Plasma ANP (pg/ml) p=.14 p=.5
6 Supplementary Figure 5 Week * * Weight ± SEM (g) 15.5 ± ± ± ±.9 Week 7 Weight ± SEM (g) 18.8 ± ±.4# 16. ±.6* 16. ±.5* Isotypic parabiosis Heterotypic parabiosis Isotypic parabiosis
7 Acylcarnitines in liver from fed and fasted and MED13cTg mice. C6.159 ±..5 ±.4 #.1 ±. *. ±.3 # C5-OH/C3-DC.18 ±.1.71 ±.1 #.94 ± ±.3 # C4-DC/Ci4-DC.48 ±.3.7 ±.4 #.38 ±.4 *.3 ±.5 C8:1.3 ±.7. ±..3 ±..3 ±. C8.6 ±.4.41 ±.3 #.51 ±.5.3 ±.3 # C6-DC/C8-OH.141 ±.1.7 ±.8 #.7 ±.11 *.37 ±.33 # C1:3.5 ±.1. ±.4 #.3 ±.. ±. # C1.4 ±.3.16 ±.3.19 ±.3.17 ±. C8:1-DC.1 ±.1.8 ±.1.6 ±.1 *.13 ±.1 # C1-OH/C8-DC.6 ±.1.6 ±.1.3 ±.1 *.9 ±.1 # C1:1.5 ±.1.3 ±.1 #. ±. *.3 ±. C1.8 ±.1.8 ±.1.5 ±.1 *.8 ±.1 # C14:1.15 ±.4.13 ±.3.6 ±.1 *.1 ±.1 # C14.4 ±.4.6 ±.4.1 ±. *.4 ±. # C16:.8 ±.1.6 ±.1.5 ±.1 *.7 ±.1 C16:1.43 ±.1.49 ±.11.1 ±.1 *.4 ±.4 # C16.16 ±..18 ±.17 #.5 ±.7 *.177 ±.13 # C18:.56 ±.1.86 ±.1.3 ±.4 *.19 ±.9 # C18.69 ±..13 ±.5 #.6 ±.4 *.114 ±.3 #
8 Acyl-CoAs in liver from fed and fasted and MED13cTg mice. CoA ± ± ± ± 37.4 # Acetyl 865. ± ± # ± ± # Propionyl ± ± ± * 34.3 ± 5.89 # Crotonyl 59.5 ± ± ± 4.98 * 1.57 ± 13.4 # C1: ± ± ± ± 4. decanoyl ± ± ± ± C1:1 38. ± ± ± ± 5.15 lauroyl 5.58 ± ± ± 8.65 * 38.7 ± 3.7 # myristoyl 5.69 ± ± ± ± 1.89 C15/C14:1-OH ± ± ± ±.6 C16: ± ± ± ± 17.3 palmitoyl ± ± ± 1.74 * ± 8.59 C17:1 8.8 ± ± ± ±.7 linolenoyl 87. ± ± ± ± 5.3 linoleoyl ± # ± ± 48.3 * ± 6.5 oleoyl ± ± # ± 8.1 * ± stearoyl ± ± ± ± 5.1 # C19: 5.45 ± ± ±.86 * 16.4 ± 4.8 C19: ± ± ± ±.74 C: ± ± ± ± 4.57 C: 1.48 ± ± ± ± 1.4 C: ± ± ± 1.1 * 14.4 ± 3.13 # C ± ± 4.4 # 14.9 ± ± 4.43 C: ± ± ± ± 4.64 C: ± ± ± ± 1.89 C: 63.8 ± ± ± ±.13 # C: ± ± 4.89 # ± 1.49 *.95 ± 5.65 #
9 Acylcarnitines in heart from fed and fasted and MED13cTg mice. C4/Ci4.6 ± ± ±.3 *.515 ±.7 # C6.9 ±.1.98 ±.1.4 ±.1 *.97 ±.1 # C8.31 ±.1.41 ±.1.7 ±. *.41 ±. # C1.36 ±.1.77 ±..7 ±. *.7 ±. # C1-OH/C8-DC.7 ±..13 ±. #.3 ±..11 ±. # C1:1.1 ±.1.39 ±.1.7 ±. *.9 ±. # C1.7 ±.3.14 ±.3.8 ±. *.119 ±.1 # C1:1-OH/C1:1-DC.7 ±..1 ±.. ±. *.1 ±. # C1-OH/C1-DC.1 ±..14 ±.. ±. *.19 ±. # C14:1.136 ±.5.44 ±.6.16 ±. *.8 ±.1 # C14.4 ±.1.54 ±.13. ±.1 *.53 ±.4 # C14:-OH/C1:-DC.9 ±..14 ±..4 ±. *.14 ±. # C14:1-OH/C1:1-DC.5 ±.1.49 ±.1.5 ±. *.54 ±.1 # C14-OH/C1-DC.3 ±.1.36 ±.1.3 ±. *.5 ±. # C16:.191 ± ±.6.16 ±. *.333 ±.5 # C16:1.38 ± ±.. ±.1 *.816 ±.9 # C ± ± ±.1 *.368 ±.33 # C16-OH/C14-DC.54 ±..16 ±.3.7 ±. *.193 ±. # C18:3.56 ±..69 ±.1.6 ±. *.96 ±. # C18:.77 ±. 1.4 ± ±.1 * ±.4 # C18:1.889 ± ± ±.1 *.85 ±.45 # C18.88 ±.1.69 ±.17.3 ±.1 *.784 ±.11 # C:.54 ± ± ±.1 *.598 ±.1 # C:1.7 ± ± ±.1 *.56 ±.9 #
10 Acyl-CoAs in heart from fed and fasted and MED13cTg mice. CoA 71.6 ± ± ± 6.56 * 39.4 ± 7.67 # Acetyl ± ± ± 63. * ± 7.43 # Propionyl 17.1 ± ± ± 3.93 * ±.98 # Succinyl ± ± ± 11.5 * 51.4 ± 6.7 # Itaconyl 4. ± ± ± ±.43 # glutaryl ± ± ± ±.9 # C1:3 5.6 ± ±.46 # 9.5 ± 1.7 * 3.6 ±.55 # C1: 3.54 ± ± ± ± 1.18 C1: ± ± ±.1 * 4.5 ±.43 # decanoyl ± ± ± 3.6 * 5.67 ± 4.85 # C1:1 8.4 ± ± ± 1.63 * 6.41 ± 1.9 # lauroyl 5.5 ± ± ± 3.6 * 59.1 ± 6.34 # myristoyl 76.7 ± ± ±.94 * ± 8.66 # C15/C14:1-OH ± ± ± 1.47 * ± 1.57 # C14-OH 8.6 ± ± ±.49 * 1.45 ±.55 # C16: ± ± ± 1.6 * 7.78 ± 5.14 # C16: ± ± ± 6.9 * ± 19.8 # C16: ± ± ± 8.5 * 41. ± 8.5 # palmitoyl ± ± ± 9.31 * ± # C17: ± ± ±.4 * ± 3.4 # linolenoyl ± ± ± 6.3 * 185. ± # linoleoyl ± ± ± 4. * ± # oleoyl ± ± ± * ± # stearoyl 17. ± ± ± * ± 37.5 # C19: ± ± ± 1.69 * 3.84 ± 3.7 # C19: ± ± ± 6.5 * ± 7. # C ± ± ± 6.46 * ± 1.8 # C: ± ± ±.47 * 7.17 ± 1.19 # C: ± ± ± 3.4 * ± 75.8 # C:1 9.3 ± ± ± * ± # C1:3 9. ± ± ± 1.44 * 1.15 ±.6 # C1: 7.53 ± ± ± 1. * 1.6 ± 3.5 # C1: ± ± ± 3. * 6.33 ± 1. # C1 31. ± ± ± 5.61 * ± 6.73 # C:6 7.5 ± ± ± ± 1.46 C:5 4.7 ± ± ± ±.69 C: ± ± ±.8 * 14.1 ±.6 # C:3.17 ± ± ±. * 5.74 ± 4.5 # C: ± ± ± ± C: ± ± ± ± 6.4
11 Acylcarnitines in serum from fed and fasted and MED13cTg mice. C 3.45 ± ± 4.55 # 1.59 ± ±.6 # C3 1.3 ± ±.49 # ± ±.56 # C4/Ci ± ±.18 # 1.5 ± ±.116 C5:1.4 ±.5.39 ±.4 #.4 ±.5.4 ±.5 # C5.164 ± ±.3.33 ± ±.1 C4-OH.174 ± ±.57 #.7 ± ±.5 # C6.164 ± ± ± ±.6 C5-OH/C3-DC.9 ± ±.1 #.11 ± ±.17 # C4-DC/Ci4-DC.53 ±.6.8 ±.11 #.65 ±.1.68 ±.14 C8:1.3 ±..9 ±. #. ±.3.1 ±. # C8.148 ± ±.3 #.16 ± ±.6 # C1-OH/C8-DC.156 ±.. ±. #.151 ±.49.3 ±.3 # C1:1.37 ±.6.45 ±.7.33 ±.9.48 ±.7 C1:-OH/C1:-DC.19 ±..4 ±.5 #.14 ±..39 ±.5 # C1:1-OH/C1:1-DC.34 ±.9.13 ±.1 #.3 ±.9.1 ±.14 # C1-OH/C1-DC.67 ± ±. #.6 ± ±.14 # C14.5 ± ±.9 #.38 ± ±.15 # C14:3-OH/C1:3-DC.4 ± ±.4 #.48 ± ±.39 # C14:-OH/C1:-DC.8 ±..5 ±.4 #.1 ±..7 ±.3 # C14-OH/C1-DC.65 ±.1.17 ±.16 #.71 ± ±.16 # C16:3.94 ± ±.33 #.98 ±.6.44 ±.9 # C16:-OH/C14:-DC.8 ±.6.37 ±.3 #. ±.6.38 ±.3 #
12 SUPPLEMENTARY FIGURE LEGENDS Figure S1. Cardiac overexpression of MED13 increases metabolic gene expression in white adipose tissue. (A) Schematic of changes in expression of genes involved in fatty acid transport and oxidation and the Krebs cycle. Red indicates increased gene expression in MED13cTg WAT, gene abbreviations are in parentheses and shown in graphical form in Figure 1. (B) Gene expression was also validated by qpcr, n=6. Data are mean + SEM and all genes shown in the graphs are significantly increased in MED13cTg WAT (p<.5), t-test. Related to Figure. Figure S. Regulation of liver metabolite production by cardiac expression of MED13 in the fed state. (A) Krebs cycle intermediary metabolites are unchanged in the fed state and are decreased in both and MED13cTg liver with fasting, but (B) are unchanged in the heart. (C) Ceramide species in the liver and (D) hearts of fed and fasted mice, n=5. Data are mean + SEM, two-way ANOVA followed by Tukey s test, *p<.5 fed vs. fed, #p<.5 fed vs. fasted. Related to Figure 3. Figure S3. Cardiac overexpression of MED13 alters metabolic gene expression. (A) Schematic of changes in expression of genes involved in fatty acid oxidation and the Krebs cycle. Green indicates decreased gene expression in MED13cTg heart, gene abbreviations are in parentheses and shown in graphical form in Figure 4. (B) Fatty acid oxidation and the Krebs cycle gene expression was validated by qpcr. All genes shown in the graphs are significantly decreased in MED13cTg heart (p<.5), t-test. (C) Nppa and Nppb gene expression trended to increase in MED13cTg hearts, irrespective of the fed or fasted state, n=5. (D) Blood glucose, free fatty acids (FFA), triglycerides, and ketones in the postprandial state, n=6. (E) Representative 13C-NMR spectrum of a perfused heart. The enlarged portion of the spectra shows the C4 glutamate peaks that arise from fatty acid oxidation (indicated by F) and glucose oxidation (indicated by G). (F) Malonyl CoA levels in and Med13cTg hearts in the fed and fasted state. Data are mean + SEM, t-test or two-way ANOVA followed by Dunnett s test. Related to Figure 4. Figure S4. MED13cTg hearts maintain the ability to adapt to fasting. (A) Acyl-CoA species in heart and (B) liver are decreased with fasting in MED13cTg mice. (C) Insulin, (D) adiponectin, (E) thyroxine (T4), (F) corticosterone, (G) brain natriuretic peptide (BNP), and (H) atrial natriuretic peptide (ANP) in serum from fed and fasted mice, n=5. Data are mean + SEM, two-way ANOVA followed by Tukey s test, *p<.5 fed vs. fed, #p<.5 fed vs. fasted. Related to Figure 5. Figure S5. Circulating factor(s) regulate enhanced WAT and liver metabolism and contribute to the lean phenotype of MED13cTg mice. Schematic and results of isotypic and heterotypic parabiosis experiments in and MED13cTg mice. Weights are from individual parabiots before surgery and 7 weeks post-surgery, n=6 pair per group. Data are mean ± SEM,
13 two-way ANOVA followed by Dunnett s test, *p<.5 vs., #p<.5 heterotypic parabiots vs. isotypic parabiots. Related to Figure 6. Supplementary Table 1. Acylcarnitines in liver from fed and fasted and MED13cTg mice. Acylcarnitines (µm) measured by metabolomics are mean ± SEM, two-way ANOVA followed by Tukey s test, n=5, *p<.5 fed vs. fed, #p<.5 fed vs. fasted. Supplementary Table. Acyl-CoAs in liver from fed and fasted and MED13cTg mice. Acyl-CoAs (pmol/ml) measured by metabolomics are mean ± SEM, two-way ANOVA followed by Tukey s test, n=5, *p<.5 fed vs. fed, #p<.5 fed vs. fasted. Supplementary Table 3. Acylcarnitines in heart from fed and fasted and MED13cTg mice. Acylcarnitines (µm) measured by metabolomics are mean ± SEM, two-way ANOVA followed by Tukey s test, n=5, *p<.5 fed vs. fed, #p<.5 fed vs. fasted. Supplementary Table 4. Acyl-CoAs in heart from fed and fasted and MED13cTg mice. Acyl-CoAs (pmol/ml) measured by metabolomics are mean ± SEM, two-way ANOVA followed by Tukey s test, n=5, *p<.5 fed vs. fed, #p<.5 fed vs. fasted. SupplementaryTable 5. Acylcarnitines in serum from fed and fasted and MED13cTg mice. Acylcarnitines (µm) measured by metabolomics are mean ± SEM, two-way ANOVA followed by Tukey s test, n=5, *p<.5 fed vs. fed, #p<.5 fed vs. fasted.
Supplementary Table 1. Primer sequences used for RT-qPCR validation of the microarray data. Primer. direction. Forward
Supplementary Table 1. Primer sequences used for RT-qPCR validation of the microarray data Gene Glyceraldehyde 3-phosphate dehydrogenase (Gapdh) Cell death-inducing DFFAlike effector a (Cidea) Peroxisome
ΙΑΤΑΡΑΧΕΣ ΜΕΤΑΒΟΛΙΣΜΟΥ ΛΙΠΑΡΩΝ ΟΞΕΩΝ
Ηµ/νία Εξέτασης : ΙΑΤΑΡΑΧΕΣ ΜΕΤΑΒΟΛΙΣΜΟΥ ΛΙΠΑΡΩΝ ΟΞΕΩΝ Medium Chain Acyl CoA Dehydrogenase C6< 0.24 C8< 0.35 C10< 0.3 C10:1 < 0.22 C8/C2< 0.02 C8/C10 < 3 Long Chain 3 Hydroxyacyl Coa Dehydrogenase C16OH
Table S1: Inpatient Diet Composition
Table S1: Inpatient Diet Composition Diet Components (% of Energy) Inpatient Period Baseline Intervention Protein 15.1 ± 0.0 15.0 ± 0.1 Total fat 30.0 ± 0.0 30.0 ± 0.1 Saturated fat 8.6 ± 0.8 8.4 ± 0.9
Sar1B-mediated Regulation of Triglyceride and Cholesterol
FIGURE S1. Comparing Sar1A- and Sar1B-flag Over-expression on RNA Profiles of McArdle RH7777 cells. RNA was prepared from two Sar1B:H79G-flag cell lines and two control cell lines plus two Sar1B-flag and
Αξιοποίηση Φυσικών Αντιοξειδωτικών στην Εκτροφή των Αγροτικών
Ζώων για Παραγωγή Προϊόντων Ποιότητας» 1 Αξιοποίηση Φυσικών Αντιοξειδωτικών στην Εκτροφή των Αγροτικών Ζώων για Παραγωγή Προϊόντων Ποιότητας Γεωπονικό Πανεπιστήμιο Αθηνών Εργαστήριο Ζωοτεχνίας MIS 380231
MANAGING AUTHORITY OF THE OPERATIONAL PROGRAMME EDUCATION AND INITIAL VOCATIONAL TRAINING ΘΕΡΜΟΡΥΘΜΙΣΗ. ΘΑΝΑΣΗΣ ΤΖΙΑΜΟΥΡΤΑΣ, Ph.D., C.S.C.
MANAGING AUTHORITY OF THE OPERATIONAL PROGRAMME EDUCATION AND INITIAL VOCATIONAL TRAINING ΘΕΡΜΟΡΥΘΜΙΣΗ ΘΑΝΑΣΗΣ ΤΖΙΑΜΟΥΡΤΑΣ, Ph.D., C.S.C.S Ισοζύγιο θερμότητας Σύνολο μηχανισμών που αφορούν τη δυσχέρανση
Supplementary Information for. The effect of standardized food intake on the association between BMI and 1 H-NMR metabolites
Supplementary Information for The effect of standardized food intake on the association between BMI and 1 H-NMR metabolites Bianca A.M. Schutte 1*, Erik B. van den Akker 1,2, Joris Deelen 1, Ondine van
NES: normalized enrichment score (analyzed using KEGG pathway gene sets in the GSEA software); FDR:
Supplementary table1. List of gene sets with simultaneously altered the enrichment upon SAP18 overexpression and knockdown. Gene sets enriched by SAP18 and reduced by shsap18 SAP18 against LacZ shsap18
Μεταβολισμός των Υδατανθράκων
Μεταβολισμός των Υδατανθράκων 1 Συνολική παρουσίαση πρωτεϊνες ADP + P i αμινοξέα ADP + P i πολυσακζαρίτης ADP + P i εξόζες πεντόζες λίπη ADP + P i Λιπαρά οξέα ουρία Κύκλος ουρίας C 2 ADP + P i ADP + P
abs acces acces Sample test results. Actual results may vary. Antioxidants B-Vitamins Minerals Order Today At Results Overview
Order Today At www.accesalabs. Antioxidants B-Vitamins Minerals Vitamin C Pyridoxine - Biotin Vitamin A / Carotenoids Vitamin E / Tocopher α-lipoic A Co T ami B1 cer R bo a n - B2 N acin - B3 Results Overview
LC-MS και εφαρµογές του στη Βιοανάλυση LC-MS και Νεογνικός Έλεγχος Μεταβολικών Νοσηµάτων
και εφαρµογές του στη Βιοανάλυση LC-MS και Νεογνικός Έλεγχος Μεταβολικών Νοσηµάτων Ιωάννης Παπουλίδης, BSc.(Hons), MSc Μοριακός Βιολόγος ιευθυντής ΕΥΡΩΓΕΝΕΤΙΚΗ Α.Ε. ΜΕΤΑΒΟΛΙΚΑ ΝΟΣΗΜΑΤΑ Γενετικές ανωµαλίες
Supplementary Table 1. Primers used for RT-qPCR analysis of striatal and nigral tissue.
Supplementary Table 1. Primers used for RT-qPCR analysis of striatal and nigral tissue. Gene Forward Primer (5-3 ) Reverse Primer (5-3 ) Dopaminergic Markers TH CTG GCC ATT GAT GTA CTG GA ACA CAC ATG GGA
ΑΜΦΙΚΟΙΛΙΑΚΗ ΒΗΜΑΤΟΔΟΤΗΣΗ
ΠΑΝΕΛΛΗΝΙΑ ΣΕΜΙΝΑΡΙΑ ΟΜΑΔΩΝ ΕΡΓΑΣΙΑΣ 2015 ΟΜΑΔΑ ΕΡΓΑΣΙΑΣ ΚΑΡΔΙΑΚΗΣ ΑΝΕΠΑΡΚΕΙΑΣ Από τη βασική έρευνα στην κλινική πράξη ΑΜΦΙΚΟΙΛΙΑΚΗ ΒΗΜΑΤΟΔΟΤΗΣΗ Ξυδώνας Σωτήριος, MD, FESC Καρδιολογικό Τµήµα, Γ.Ν.Α. «Ο
ΟΞΕΙΕΣ ΥΠΕΡΓΛΥΚΑΙΜΙΚΕΣ ΚΑΤΑΣΤΑΣΕΙΣ
ΟΞΕΙΕΣ ΥΠΕΡΓΛΥΚΑΙΜΙΚΕΣ ΚΑΤΑΣΤΑΣΕΙΣ ΚΑΛΛΙΟΠΗ ΚΩΤΣΑ ΛΕΚΤΟΡΑΣ ΕΝΔΟΚΡΙΝΟΛΟΓΙΑΣ ΤΜΗΜΑ ΕΝΔΟΚΡΙΝΟΛΟΓΙΑΣ, ΔΙΑΒΗΤΗ, ΜΕΤΑΒΟΛΙΣΜΟΥ Α ΠΑΘΟΛΟΓΙΚΗ ΚΛΙΝΙΚΗ ΝΟΣΟΚΟΜΕΙΟ ΑΧΕΠΑ ΔΙΑΒΗΤΙΚΗ ΚΕΤΟΞΕΩΣΗ ΥΠΕΡΓΛΥΚΑΙΜΙΚΟ ΥΠΕΡΩΣΜΩΤΙΚΟ
Pentoxifylline ameliorated nonalcoholic fatty liver disease in the hyperglycemia and dyslipidemia mice by the up-regulation of fatty acid β-oxidation.
Pentoxifylline ameliorated nonalcoholic fatty liver disease in the hyperglycemia and dyslipidemia mice by the up-regulation of fatty acid β-oxidation. Jia-Hung Ye 1, Jung Chao 2, Ming-Ling Chang 3, Wen-Huang
Chapter 1. Fingolimod attenuates ceramide induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes
Chapter 1 Fingolimod attenuates ceramide induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes 1 1 1 1 CHAPTER SUMMARY FINGOLIMOD ATTENUATES CERAMIDE PRODUCTION
Supporting Information
Chloromethylhalicyclamine B, a Marine-Derived Protein Kinase CK1δ/ε Inhibitor Germana Esposito, Marie-Lise Bourguet-Kondracki, * Linh H. Mai, Arlette Longeon, Roberta Teta, Laurent Meijer, Rob Van Soest,
ΕΠΙ ΡΑΣΗ ΤΟΥ ΕΥΝΟΥΧΙΣΜΟΥ ΣΕ ΠΑΡΑΓΩΓΙΚΑ ΚΑΙ ΦΥΣΙΟΛΟΓΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ ΑΡΣΕΝΙΚΩΝ ΟΡΝΙΘΙΩΝ
ΓΕΩΠΟΝΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΑΘΗΝΩΝ ΤΜΗΜΑ ΕΠΙΣΤΗΜΗΣ ΖΩΙΚΗΣ ΠΑΡΑΓΩΓΗΣ & Υ ΑΤΟΚΑΛΛΙΕΡΓΕΙΩΝ ΕΡΓΑΣΤΗΡΙΟ ΓΕΝΙΚΗΣ & ΕΙ ΙΚΗΣ ΖΩΟΤΕΧΝΙΑΣ Ι ΑΚΤΟΡΙΚΗ ΙΑΤΡΙΒΗ ΕΠΙ ΡΑΣΗ ΤΟΥ ΕΥΝΟΥΧΙΣΜΟΥ ΣΕ ΠΑΡΑΓΩΓΙΚΑ ΚΑΙ ΦΥΣΙΟΛΟΓΙΚΑ ΧΑΡΑΚΤΗΡΙΣΤΙΚΑ
Ο ρόλος του λιπώδους ιστού
Ο ρόλος του λιπώδους ιστού Γιώργος Βαλσαμάκης Ενδοκρινολόγος Eπιστημονικός συνεργάτης Ενδοκρινολογικήs Μονάδαs Β Μαιευτικής και Γυναικολογικής κλινικής Αρεταίειο Νοσοκομείο Θέματα συζήτησης Α. Ο λιπώδης
Supplementary File. Table S1. Metabolic model.
Supplementary File Table S. Metabolic model. Flux number Reaction Carbon transitions r Glucose --> G6P ABCDEF --> ABCDEF r2 G6P --> F6P ABCDEF --> ABCDEF r3 F6P --> G6P ABCDEF --> ABCDEF r4 F6P --> FBP
Study of the function of PGC-1β in white adipose tissue and its contribution to the development of insulin resistance
Study of the function of PGC-1β in white adipose tissue and its contribution to the development of insulin resistance Natalia Enguix Elena Phd Thesis Barcelona, 2014 Laboratory of Metabolism and Obesity
Ινσουλίνη και γήρανση
Ινσουλίνη και γήρανση Γεώργιος Δ. Δημητριάδης Καθηγητής Παθολογίας Διευθυντής Β Προπαιδευτικής Παθολογικής Κλινικής, Μονάδας Έρευνας και Διαβητολογικού Κέντρου Πανεπιστημίου Αθηνών, ΠΓΝΑ Αττικόν Πρόεδρος
ΠΑΝΕΠΙΣΤΗΜΙΟ ΙΩΑΝΝΙΝΩΝ ΑΝΟΙΚΤΑ ΑΚΑΔΗΜΑΪΚΑ ΜΑΘΗΜΑΤΑ. Φαρμακολογία ΙI. Κυκλοφορικό Διδάσκοντες: Μ. Μαρσέλος, Μ. Κωνσταντή, Π. Παππάς, Κ.
ΠΑΝΕΠΙΣΤΗΜΙΟ ΙΩΑΝΝΙΝΩΝ ΑΝΟΙΚΤΑ ΑΚΑΔΗΜΑΪΚΑ ΜΑΘΗΜΑΤΑ Φαρμακολογία ΙI Κυκλοφορικό Διδάσκοντες: Μ. Μαρσέλος, Μ. Κωνσταντή, Π. Παππάς, Κ. Αντωνίου Άδειες Χρήσης Το παρόν εκπαιδευτικό υλικό υπόκειται σε άδειες
Αιτιοπαθογένεια ΣακχαρώδηΔιαβήτη2
Αιτιοπαθογένεια ΣακχαρώδηΔιαβήτη2 ΧάρηςΒασιλόπουλος, Διευθυντής Τμήματος Ενδοκρινολογίας, Μεταβολισμού και Διαβήτη, Υπεύθυνος Διαβητολογικού κέντρου Π.Γ.Ν.Α. Ο Ευαγγελισμός Ορισμός Σακχαρώδους Διαβήτη
Supplementary Figure 1
NSC N2d N5d TNFRSFa TNFRSFb RIPK RelA Madd I-TRAF/TANK GAPDH γ-actin Supplementary Figure A 2 hrs Day : Cell seeding Day 9: +ng/ml TNF-α Day 9: Fixation B Merge Nestin PH-3 Hoechst Acute TNF-α Control
«Συντήρηση αχλαδιών σε νερό. υπό την παρουσία σπόρων σιναπιού (Sinapis arvensis).»
ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ ΓΕΩΠΟΝΙΚΗ ΣΧΟΛΗ ΤΟΜΕΑΣ ΕΠΙΣΤΗΜΗΣ & ΤΕΧΝΟΛΟΓΙΑΣ ΤΡΟΦΙΜΩΝ ΕΛΕΝΗ Π. ΠΑΠΑΤΣΑΡΟΥΧΑ Πτυχιούχος Τεχνολόγος Τροφίμων της Γεωπονικής Σχολής (Α.Π.Θ.) «Συντήρηση αχλαδιών σε
Guo_Fig. S1. Atg7 +/+ Atg7 -/- FBP_M+6 DHAP_M+3. Glucose Uptake Rate G6P_M+6. nmol/ul cell/hr
Guo_Fig. S1 A C D nmol/ul cell/hr nmol/ul cell/hr Glucose Uptake Rate.3.2.1 *. Lactate Secretion Rate.4.3.2.1. Atg7-/- B Glucose G3P Lac Glucose G6P FBP 3-PG Pyr DHAP cycle Carbon from labeled glucose
ΕΠΙΔΡΑΣΗ ΤΩΝ ΜΑΚΡΟΘΡΕΠΤΙΚΩΝ ΣΥΣΤΑΤΙΚΩΝ ΣΤΗΝ ΑΝΤΙΣΤΑΣΗ ΣΤΗΝ ΙΝΣΟΥΛΙΝΗ ΚΑΙ ΤΙΣ ΑΠΑΙΤΗΣΕΙΣ ΣΕ ΙΝΣΟΥΛΙΝΗ
ΕΠΙΔΡΑΣΗ ΤΩΝ ΜΑΚΡΟΘΡΕΠΤΙΚΩΝ ΣΥΣΤΑΤΙΚΩΝ ΣΤΗΝ ΑΝΤΙΣΤΑΣΗ ΣΤΗΝ ΙΝΣΟΥΛΙΝΗ ΚΑΙ ΤΙΣ ΑΠΑΙΤΗΣΕΙΣ ΣΕ ΙΝΣΟΥΛΙΝΗ ΠΗΝΕΛΟΠΗ ΔΟΥΒΟΓΙΑΝΝΗ Κ Λ Ι Ν Ι Κ Η Δ Ι Α Ι Τ Ο Λ Ο Γ Ο Σ - Δ Ι ΑΤ Ρ Ο Φ Ο Λ Ο Γ Ο Σ M S C, R D Περίληψη
Supporting Information
Supporting Information Wiley-VCH 27 69451 Weinheim, Germany Supplementary Figure 1. Synthetic results as detected by XRD (Cu-Kα). Simulation pattern of MCM-68 Relative Intensity / a.u. YNU-2P Conventional
Electrolyzed-Reduced Water as Artificial Hot Spring Water
/-,**- + +/ 0 +, - + + +, - + +. ++,3 +/. +. Electrolyzed-Reduced Water as Artificial Hot Spring Water Shoichi OKOUCHI +, Daisuke TAKEZAKI +, Hideyuki OHNAMI +, Yuhkoh AGISHI,, Yasuo KANROJI -, and Shigeo
Patrycja Miszczyk, Dorota Wieczorek, Joanna Gałęzowska, Błażej Dziuk, Joanna Wietrzyk and Ewa Chmielewska. 1. Spectroscopic Data.
; doi:10.3390/molecules22020254 S1 of S23 Supplementary Materials: Reaction of 3-Amino-1,2,4-Triazole with Diethyl Phosphite and Triethyl Orthoformate: Acid-Base Properties and Antiosteoporotic Activities
Πρωτογενής πρόληψη των καρδιαγγειακών IFG
Πρωτογενής πρόληψη των καρδιαγγειακών νοσημάτων στον προ-διαβήτη. Έχει θέση; IFG Δρ Σταύρος Μπούσμπουλας Διευθυντής Γ Παθολογικής Κλινικής & Υπεύθυνος Διαβητολογικού Κέντρου Γ.Ν. Νίκαιας Πειραιά Προ-διαβήτης
A strategy for the identification of combinatorial bioactive compounds. contributing to the holistic effect of herbal medicines
1 2 Supplementary information 3 4 A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines 5 6 Fang Long 1, Hua Yang 1, Yanmin Xu,
Supporting Information. Palladium Complexes with Bulky Diphosphine. Synthesis of (Bio-) Adipic Acid from Pentenoic. Acid Mixtures.
Supporting Information Palladium Complexes with Bulky Diphosphine Ligands as Highly Selective Catalysts for the Synthesis of (Bio-) Adipic Acid from Pentenoic Acid Mixtures. Choon Heng Low, James D. Nobbs,*
Simon et al. Supplemental Data Page 1
Simon et al. Supplemental Data Page 1 Supplemental Data Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction Short
Structure-Metabolism-Relationships in the microsomal clearance of. piperazin-1-ylpyridazines
Electronic Supplementary Material (ESI) for MedChemComm. This journal is The Royal Society of Chemistry 2017 Structure-Metabolism-Relationships in the microsomal clearance of piperazin-1-ylpyridazines
Supporting Information
Tissue Level Diet and Sex-by-Diet Interactions Reveal Unique Metabolite and Clustering Profiles Using Untargeted Liquid Chromatography-Mass Spectrometry on Adipose, Skeletal Muscle, and Liver Tissue in
ΑΝΑΠΝΕΥΣΤΙΚΟΙ ΜΥΕΣ & ΦΥΣΙΚΗ ΑΠΟΔΟΣΗ. Γ. Κουτεντάκης 1/2 ΑΝΑΠΝΕΥΣΤΙΚΟΙ ΜΥΕΣ ΕΙΣΠΝΟΗ
ΑΝΑΠΝΕΥΣΤΙΚΟΙ ΜΥΕΣ & ΦΥΣΙΚΗ ΑΠΟΔΟΣΗ Οι αναπνευστικοί μύες έχουν τα ίδια χαρακτηριστικά όπως και οι άλλοι σκελετικοί μύες Γ. Κουτεντάκης 1/2 1 ΤΕΦΑΑ, Πανεπιστήμιο Θεσσαλίας,, 42 Τρίκαλα 2 School of Sports,
Supplementary Materials: A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans
S1 of S11 Supplementary Materials: A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans Eveline Dirinck, Alin C. Dirtu, Govindan Malarvannan, Adrian
CSAE WPS/2009-06 Figure 1: Cut Flower Exports from Kenya, 1995-2007 Table 1: Firms in Areas with and w/out Conflict Panel A - Export Records Variable Observations Mean in No-Conflict
Υγεία και Άσκηση Ειδικών Πληθυσμών ΜΚ0958
Υγεία και Άσκηση Ειδικών Πληθυσμών ΜΚ0958 Διάλεξη 8-9: Παχυσαρκία και Άσκηση Υπεύθυνη Μαθήματος: Χ. Καρατζαφέρη Διδάσκοντες: Χ. Καρατζαφέρη, Γ. Σακκάς, Α. Καλτσάτου 2013-2014 Διάλεξη 8-9 ΤΕΦΑΑ, ΠΘ Σύνδεση
Γεωπονικό Πανεπιςτήμιο Αθηνών Τμήμα Αξιοποίηςησ Φυςικών Πόρων και Γεωργικήσ Μηχανικήσ
Γεωπονικό Πανεπιςτήμιο Αθηνών Τμήμα Αξιοποίηςησ Φυςικών Πόρων και Γεωργικήσ Μηχανικήσ Εργαςτήριο Γεωργικών Καταςκευών ΠΜΣ Ενεργειακά Συςτήματα και Ανανεώςιμεσ Πηγέσ Ενέργειασ Διδακτορική διατριβή Καιιηέξγεηα
Lipid mediator profile in vernix caseosa reflects skin barrier development
Supplementary material Lipid mediator profile in vernix caseosa reflects skin barrier development Antonio Checa 1, Tina Holm 2, Marcus O. D. Sjödin 1, Stacey N. Reinke 1, Johan Alm 3, Annika Scheynius
Technical Information T-9100 SI. Suva. refrigerants. Thermodynamic Properties of. Suva Refrigerant [R-410A (50/50)]
![Technical Information T-9100 SI. Suva. refrigerants. Thermodynamic Properties of. Suva Refrigerant [R-410A (50/50)]](/thumbs/89/98928029.jpg "Technical Information T-9100 SI. Suva. refrigerants. Thermodynamic Properties of. Suva Refrigerant [R-410A (50/50)]")
d Suva refrigerants Technical Information T-9100SI Thermodynamic Properties of Suva 9100 Refrigerant [R-410A (50/50)] Thermodynamic Properties of Suva 9100 Refrigerant SI Units New tables of the thermodynamic
IL - 13 /IL - 18 ELISA PCR RT - PCR. IL - 13 IL - 18 mrna. 13 IL - 18 mrna IL - 13 /IL Th1 /Th2
344 IL - 13 /IL - 18 1 2 1 2 1 2 1 2 1 2 3 1 2 13 18 IL - 13 /IL - 18 10% / OVA /AL OH 3 5% 16 ~ 43 d 44 d ELISA BALF IL - 13 IL - 18 PCR RT - PCR IL - 13 IL - 18 mrna IL - 13 mrna 0. 01 IL - 18 mrna 0.
ΙΔΡΥΜΑ. Θεσσαλονίκη, ύλα
ΑΛΕΞΑΝΔΡΕΙΟ ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΘΕΣΣΑΛΟΝΙΚΗΣ ΣΧΟΛΗ ΤΕΧΝΟΛΟΓΙΑΣ ΓΕΩΠΟΝΙΑΣ, ΤΡΟΦΙΜΩΝ & ΔΙΑΤΡΟΦΗΔ ΗΣ ΤΜΗΜΑ ΔΙΑΤΡΟΦΗΣ & ΔΙΑΙΤΟΛΟΓΙΑΣ ΠΑΡΕΜΒΑΤΙΚΟ ΠΡΟΓΡΑΜΜΑ ΔΙΑΤΡΟΦΙΚΗΣ ΑΓΩΓΗΣ ΣΤΟΝ ΔΗΜΟ ΚΑΒΑΛΑΣ Πτυχιακή
Engineering Tunable Single and Dual Optical. Emission from Ru(II)-Polypyridyl Complexes. Through Excited State Design
Engineering Tunable Single and Dual Optical Emission from Ru(II)-Polypyridyl Complexes Through Excited State Design Supplementary Information Julia Romanova 1, Yousif Sadik 1, M. R. Ranga Prabhath 1,,
!!Διατροφή!και!αθηροσκλήρωση!!ίσως!το! καλύτερο!φάρμακο
!!Διατροφή!και!αθηροσκλήρωση!!ίσως!το! καλύτερο!φάρμακο Dietary!Fats!and!LDLCCholesterol! 0,18 0,14 0,10 β=0.032*& SFA! Change!in! LDLCC! (mmol/l)! 0,06 0,02-0,02-0,06-0,10 β=c0.009*& β=c0.019*& 0 1%
Supporting Information. Multigenerational Disruption of Thyroid Endocrine System in Marine Medaka
Supporting Information Multigenerational Disruption of Thyroid Endocrine System in Marine Medaka after A Life-Cycle Exposure to Perfluorobutane Sulfonate (PFBS) Lianguo Chen,, Chenyan Hu #, Mirabelle M.
Dietary success of a new key fish in an overfished ecosystem: evidence from fatty acid and stable isotope signatures
The following supplement accompanies the article Dietary success of a new key fish in an overfished ecosystem: evidence from fatty acid and stable isotope signatures M. G. van der Bank 1, A. C. Utne-Palm
DuPont Suva 95 Refrigerant
Technical Information T-95 SI DuPont Suva refrigerants Thermodynamic Properties of DuPont Suva 95 Refrigerant (R-508B) The DuPont Oval Logo, The miracles of science, and Suva, are trademarks or registered
Review article Ανασκόπηση
: 38-47 ΠΕΡΙΟΔΙΚΟ ΤΗΣ EΛΛHNIKHΣ KTHNΙΑΤΡΙΚΗΣ ETAIPΕIAΣ 2011, 62(1): 38-47 Review article Ανασκόπηση Aflatoxin effects on animals health and milk composition of the ruminants Kourousekos G. D., DVM, PhD
# Effect of PPAR-α agonist on adipokines expression in rats fed with high-fat diet LI yan#, HUANG bin, CHENG hua, LIANG zhen, LIU shan-ying
PPAR-α # 510120 PPAR-α SD SD 6 4 RT-PCR?? mrna FFA TG HOME-IR FFA 2.37±0.60 1.59±0.30 1.33±0.34 mmol/l p
DuPont Suva 95 Refrigerant
Technical Information T-95 ENG DuPont Suva refrigerants Thermodynamic Properties of DuPont Suva 95 Refrigerant (R-508B) The DuPont Oval Logo, The miracles of science, and Suva, are trademarks or registered
ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ ΣΤΙΣ «ΚΛΙΝΙΚΕΣ ΚΑΙ ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΕΣ ΙΑΤΡΙΚΕΣ ΕΙΔΙΚΟΤΗΤΕΣ»
ΠΑΝΕΠΙΣΤΗΜΙΟ ΠΑΤΡΩΝ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ ΤΜΗΜΑ ΙΑΤΡΙΚΗΣ ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ ΣΤΙΣ «ΚΛΙΝΙΚΕΣ ΚΑΙ ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΕΣ ΙΑΤΡΙΚΕΣ ΕΙΔΙΚΟΤΗΤΕΣ» ΑΡΝΗΤΙΚΗ ΡΥΘΜΙΣΗ ΤΗΣ ΜΕΤΑΒΙΒΑΣΗΣ ΤΟΥ ΣΗΜΑΤΟΣ ΤΗΣ
UDZ Swirl diffuser. Product facts. Quick-selection. Swirl diffuser UDZ. Product code example:
UDZ Swirl diffuser Swirl diffuser UDZ, which is intended for installation in a ventilation duct, can be used in premises with a large volume, for example factory premises, storage areas, superstores, halls,
Υπέρταση και Διατροφή
Υπέρταση και Διατροφή Αντώνης Ζαμπέλας Μονάδα Διατροφής του Ανθρώπου Τμήμα Επιστήμης και Τεχνολογίας Τροφίμων Γεωπονικό Πανεπιστήμιο Αθηνών Συχνότητα εμφάνισης της υπέρτασης στην Ελλάδα. Μελέτη Αττικής
Mean bond enthalpy Standard enthalpy of formation Bond N H N N N N H O O O
Q1. (a) Explain the meaning of the terms mean bond enthalpy and standard enthalpy of formation. Mean bond enthalpy... Standard enthalpy of formation... (5) (b) Some mean bond enthalpies are given below.
Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: -S-aromatic heterocyclic podophyllum derivatives display antitumor activity
Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: -S-aromatic heterocyclic podophyllum derivatives display antitumor activity Jian-Long Li 1,a, Wei Zhao 1,a, Chen Zhou 1,a, Ya-Xuan
Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes
![Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes](/thumbs/92/108867714.jpg "Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes")
SUPPORTING INFORMATION Pyrrolo[2,3-d:5,4-d']bisthiazoles: Alternate Synthetic Routes and a Comparative Study to Analogous Fused-ring Bithiophenes Eric J. Uzelac, Casey B. McCausland, and Seth C. Rasmussen*
Supplemental tables and figures
Supplemental tables and figures Supplemental Table S1. Demographic and clinical parameters by quartiles of white Variables blood cell count. WBC quartiles( 1 9 cells/l) Q1(.6-5.3, n=2587) Q2(5.4-6.3, n=263)
DuPont Suva. DuPont. Thermodynamic Properties of. Refrigerant (R-410A) Technical Information. refrigerants T-410A ENG
Technical Information T-410A ENG DuPont Suva refrigerants Thermodynamic Properties of DuPont Suva 410A Refrigerant (R-410A) The DuPont Oval Logo, The miracles of science, and Suva, are trademarks or registered
Copper-catalyzed formal O-H insertion reaction of α-diazo-1,3-dicarb- onyl compounds to carboxylic acids with the assistance of isocyanide
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 Copper-catalyzed formal O-H insertion reaction of α-diazo-1,3-dicarb- onyl compounds to carboxylic
Science of Sericulture
Science of Sericulture 2012 38 1 0065-0069 ISSN 0257-4799 CN 32-1115 /S E-mail CYKE@ chinajournal. net. cn 215123 25 0 ~ 24 h GSH GSSG GSH + 2GSSG GSH /GSSG S- GST TPX 23% GR 57% GSH TPX GST GSSG 61% GSH
Emulsifying Properties of Egg Yolk as a Function of Diacylglycerol Oil
354 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /-, No.0, -/.-0* (,**0) 38 * * Emulsifying Properties of Egg Yolk as a Function of Diacylglycerol Oil Tomoko Kawakami, Kyoko Ohashi* and Atsuko Shimada Graduate
Αξιοποίηση Φυσικών Αντιοξειδωτικών στην Εκτροφή των Αγροτικών
Ζώων για Παραγωγή Προϊόντων Ποιότητας» 1 Αξιοποίηση Φυσικών Αντιοξειδωτικών στην Εκτροφή των Αγροτικών Ζώων για Παραγωγή Προϊόντων Ποιότητας Γεωπονικό Πανεπιστήμιο Αθηνών Εργαστήριο Ζωοτεχνίας MIS 380231
Το Βιολογικό Ρολόι: Θεµελιώδης Ρυθµιστής της Φυσιολογίας των Οργανισµών
Ιούλιος 2005 Το Βιολογικό Ρολόι: Θεµελιώδης Ρυθµιστής της Φυσιολογίας των Οργανισµών ρ. Α. Προµπονά Εργαστήριο Ρύθµισης της Μεταγραφής από το Βιολογικό Ρολόι Κιρκαδικό Ρολόι Ρυθµοί µε περίοδο ~ 24 ωρών
Supplementary Information 1.
Supplementary Information 1. Fig. S1. Correlations between litter-derived-c and N (percent of initial input) and Al-/Fe- (hydr)oxides dissolved by ammonium oxalate (AO); a) 0 10 cm; b) 10 20 cm; c) 20
SUPPORTING INFORMATION
SUPPORTING INFORMATION Heronamides A C, new polyketide macrolactams from an Australian marine-derived Streptomyces sp. A biosynthetic case for synchronized tandem electrocyclization. Ritesh Raju, Andrew
Metabonomics: Η επιστροφή των μεταβολιτών; Το παράδειγμα του Σακχαρώδη Διαβήτη
Metabonomics: Η επιστροφή των μεταβολιτών; Το παράδειγμα του Σακχαρώδη Διαβήτη Χριστίνα Κωσταρά, Πανεπιστημιακός Υπότροφος Ελένη Μπαϊρακτάρη, Καθηγήτρια Κλινικής Χημείας Εργαστήριο Κλινικής Χημείας, Τμήμα
Ι. ΟΙΚΟΝΟΜΙΔΗΣ 1, Γ. ΠΑΥΛΙΔΗΣ 1, Β. ΛΑΜΠΑΔΙΑΡΗ 2, Φ. ΚΟΥΣΑΘΑΝΑ 2, Ε. ΤΡΙΑΝΤΑΦΥΛΛΙΔΗ 1, Μ. ΒΑΡΟΥΔΗ 1, Γ. ΔΗΜΗΤΡΙΑΔΗΣ 2, Ι.
ΜΕΛΕΤΗ ΤΟΥ ΕΝΔΟΘΗΛΙΑΚΟΥ ΓΛΥΚΟΚΑΛΥΚΑ, ΤΩΝ ΕΛΑΣΤΙΚΩΝ ΙΔΙΟΤΗΤΩΝ ΤΩΝ ΑΡΤΗΡΙΩΝ ΚΑΙ ΤΗΣ ΜΥΟΚΑΡΔΙΑΚΗΣ ΠΑΡΑΜΟΡΦΩΣΗΣ ΣΕ ΔΙΑΒΗΤΙΚΟΥΣ ΑΣΘΕΝΕΙΣ ΚΑΙ ΣΕ ΣΥΓΓΕΝΕΙΣ ΠΡΩΤΟΥ ΒΑΘΜΟΥ Ι. ΟΙΚΟΝΟΜΙΔΗΣ 1, Γ. ΠΑΥΛΙΔΗΣ 1, Β. ΛΑΜΠΑΔΙΑΡΗ
Fe II aq Fe III oxide electron transfer and Fe exchange: effect of organic carbon
Supplementary materials Fe II aq Fe III oxide electron transfer and Fe exchange: effect of organic carbon Timothy Pasakarnis, A Michael L. McCormick, B Gene F. Parkin, A Aaron Thompson C and Michelle M.
Supporting Information
Supporting Information Mitochondria-Targeting Polydopamine Nanocomposites as Chemophotothermal Therapeutics for Cancer Zhuo Wang *,, Yuzhi Chen, Hui Zhang, Yawen Li, Yufan Ma, Jia Huang, Xiaolei Liu, Fang
Si + Al Mg Fe + Mn +Ni Ca rim Ca p.f.u
.6.5. y = -.4x +.8 R =.9574 y = - x +.14 R =.9788 y = -.4 x +.7 R =.9896 Si + Al Fe + Mn +Ni y =.55 x.36 R =.9988.149.148.147.146.145..88 core rim.144 4 =.6 ±.6 4 =.6 ±.18.84.88 p.f.u..86.76 y = -3.9 x
Electronic supplementary information for
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry C. This journal is The Royal Society of Chemistry 2017 Electronic supplementary information for Highly responsive ethylenediamine
Reaction of a Platinum Electrode for the Measurement of Redox Potential of Paddy Soil
J. Jpn. Soc. Soil Phys. No. +*0, p.- +*,**1 Eh * ** Reaction of a Platinum Electrode for the Measurement of Redox Potential of Paddy Soil Daisuke MURAKAMI* and Tatsuaki KASUBUCHI** * The United Graduate
Supporting Information
Supporting Information Molecular Cage Impregnated Palladium Nanoparticles: Efficient, Additive-Free Heterogeneous Catalysts for Cyanation of Aryl Halides. Bijnaneswar Mondal, Koushik Acharyya, Prodip Howlader
Πτυχιακή Εργασία Η ΠΟΙΟΤΗΤΑ ΖΩΗΣ ΤΩΝ ΑΣΘΕΝΩΝ ΜΕ ΣΤΗΘΑΓΧΗ
ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ Πτυχιακή Εργασία Η ΠΟΙΟΤΗΤΑ ΖΩΗΣ ΤΩΝ ΑΣΘΕΝΩΝ ΜΕ ΣΤΗΘΑΓΧΗ Νικόλας Χριστοδούλου Λευκωσία, 2012 ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ
HDL HDL S1P. Micro Channel array Flow Analyzer (MC-FAN) ex vivo S1P S1P HDL MC-FAN HDL HDL S1P. Owen HDL S1P S1P HDL ELISA M (1) mean ±S.D.
HDL HDL - S1P S1P S1P β HDL β HDL HDL MM S1P Owen 2 M HDLM S1P S1P S1P M HDL HDLM S1P ELISA M HDL S1P M HDL (1) M HDLM HDLM M HDL 75gOGTT M 75gOGTT M HDL LDL CRP C- HbA1c 75gOGTT 75gOGTT M M M HDL LDL
Jesse Maassen and Mark Lundstrom Purdue University November 25, 2013
Notes on Average Scattering imes and Hall Factors Jesse Maassen and Mar Lundstrom Purdue University November 5, 13 I. Introduction 1 II. Solution of the BE 1 III. Exercises: Woring out average scattering
Supporting Information
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2018 Supporting Information Crotonols A and B, Two Rare Tigliane Diterpenoid
Potential Dividers. 46 minutes. 46 marks. Page 1 of 11
Potential Dividers 46 minutes 46 marks Page 1 of 11 Q1. In the circuit shown in the figure below, the battery, of negligible internal resistance, has an emf of 30 V. The pd across the lamp is 6.0 V and
ΕΦΑΡΜΟΣΜΕΝΗ ΒΙΟΤΕΧΝΟΛΟΓΙΑ
1 ο Εργαστήριο PyMOL 07/11/14 ΕΦΑΡΜΟΣΜΕΝΗ ΒΙΟΤΕΧΝΟΛΟΓΙΑ Ευάγγελος Τόπακας Username: biotech Password: applbiot1 Εργαστήριο Εφαρμοσμένης Βιοτεχνολογίας Θεματικές ενότητες/υπολογιστικά προγράμματα: - Απεικόνιση
SUPPLEMENTARY INFORMATION
Sensitivity of [Ru(phen) 2 dppz] 2+ Light Switch Emission to Ionic Strength, Temperature, and DNA Sequence and Conformation Andrew W. McKinley, Per Lincoln and Eimer M. Tuite* SUPPLEMENTARY INFORMATION
ΕΦΑΡΜΟΓΗ ΕΥΤΕΡΟΒΑΘΜΙΑ ΕΠΕΞΕΡΓΑΣΜΕΝΩΝ ΥΓΡΩΝ ΑΠΟΒΛΗΤΩΝ ΣΕ ΦΥΣΙΚΑ ΣΥΣΤΗΜΑΤΑ ΚΛΙΝΗΣ ΚΑΛΑΜΙΩΝ
ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙ ΕΥΤΙΚΟ Ι ΡΥΜΑ ΚΡΗΤΗΣ ΤΜΗΜΑ ΦΥΣΙΚΩΝ ΠΟΡΩΝ ΚΑΙ ΠΕΡΙΒΑΛΛΟΝΤΟΣ ΕΦΑΡΜΟΓΗ ΕΥΤΕΡΟΒΑΘΜΙΑ ΕΠΕΞΕΡΓΑΣΜΕΝΩΝ ΥΓΡΩΝ ΑΠΟΒΛΗΤΩΝ ΣΕ ΦΥΣΙΚΑ ΣΥΣΤΗΜΑΤΑ ΚΛΙΝΗΣ ΚΑΛΑΜΙΩΝ ΕΠΙΜΕΛΕΙΑ: ΑΡΜΕΝΑΚΑΣ ΜΑΡΙΝΟΣ ΧΑΝΙΑ
Supplementary Materials
Supplementary Materials Figure S1. Chemical structures of phloracetophenone intermediates (2a, 2c 2g). 2a 2c 2d 2e 2f 2g Figure S2. Chemical structures of geranylacetophenone analogues (3a, 3c, 3e g).
νεογνικός έλεγχος neo screen πληρέστερος Προληπτικός έλεγχος μεταβολικών νοσημάτων Και μοριακός έλεγχος για ασυμπτωματική βαρηκοΐα (μετάλλαξη 35delG)
ο νεογνικός πληρέστερος Και μοριακός έλεγχος για ασυμπτωματική βαρηκοΐα (μετάλλαξη 35delG) έλεγχος Προληπτικός έλεγχος μεταβολικών νοσημάτων neo screen ΕΡΓΑΣΤΗΡΙΟ ΠΡΟΓΕΝΝΗΤΙΚΟΥ ΚΑΙ ΝΕΟΓΝΙΚΟΥ ΕΛΕΓΧΟΥ Aνίχνευση
νεογνικός έλεγχος neo screen πληρέστερος Προληπτικός έλεγχος μεταβολικών νοσημάτων Και μοριακός έλεγχος για ασυμπτωματική βαρηκοΐα (μετάλλαξη 35delG)
ο νεογνικός πληρέστερος Και μοριακός έλεγχος για ασυμπτωματική βαρηκοΐα (μετάλλαξη 35delG) έλεγχος Προληπτικός έλεγχος μεταβολικών νοσημάτων neo screen ΕΡΓΑΣΤΗΡΙΟ ΠΡΟΓΕΝΝΗΤΙΚΟΥ ΚΑΙ ΝΕΟΓΝΙΚΟΥ ΕΛΕΓΧΟΥ Aνίχνευση
Calorie restriction prevents metabolic ageing caused by abnormal SIRT1 function in
Page 1 of 205 Calorie restriction prevents metabolic ageing caused by abnormal SIRT1 function in adipose tissues Cheng Xu 1, Yu Cai 1, Pengcheng Fan 1, Bo Bai 1, Jie Chen 1, Han-Bing Deng 1, Chi-Ming Che
Supplemental Table S1. Tumor specific networks are enriched with somatically mutated genes (taken from the database COSMIC)
Additional file 1 Supplemental Table S1. Tumor specific networks are enriched with somatically mutated genes (taken from the database COSMIC) COSMIC genes in tumor network COSMIC genes not in tumor network
Διευθυντής Τμήμα: Διαβήτη-Παχυσαρκίας-Μεταβολισμού Ιδιωτικό Νοσοκομείο Metropolitan
1 Διευθυντής Τμήμα: Διαβήτη-Παχυσαρκίας-Μεταβολισμού Ιδιωτικό Νοσοκομείο Metropolitan Νεώτερες γνώσεις για το λιπώδη ιστό 2 Τιμητική αμοιβή (Honorarium): - ΑSTRA ΖENECA - BOEHRINGER INGELHEIM - ELPEN -
[11].,, , 316 6, ,., 15.5%, 9.8%, 2006., IDF,, ,500, 2,830.,, ,200.,,, β, [12]. 90% 2,,,,, [13-15].,, [13,
![[11].,, , 316 6, ,., 15.5%, 9.8%, 2006., IDF,, ,500, 2,830.,, ,200.,,, β, [12]. 90% 2,,,,, [13-15].,, [13,](/thumbs/89/98694254.jpg "[11].,, , 316 6, ,., 15.5%, 9.8%, 2006., IDF,, ,500, 2,830.,, ,200.,,, β, [12]. 90% 2,,,,, [13-15].,, [13,")
in vitro αα In Vitro α-glucosidase and α-amylase Inhibitory Effects of Herbal Tea Leaves from Yacon (Smallanthus sonchifolius) 1, 1, 1, 2, 1, 2, 3, 1, 2, 1, 2, 1, 2, 1, 2 1, 2, *, 1 2, 3 Yuto Ueda 1, Shintaro
Electronic Supplementary Information
Electronic Supplementary Material (ESI) for Polymer hemistry This journal is The Royal Society of hemistry 2011 Phosphoric and Phosphoramidic Acids as Bifunctional atalysts for the Ring-pening Polymerization
ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΓΕΩΠΟΝΙΚΩΝ ΕΠΙΣΤΗΜΩΝ ΚΑΙ ΔΙΑΧΕΙΡΙΣΗΣ ΠΕΡΙΒΑΛΛΟΝΤΟΣ
ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΓΕΩΠΟΝΙΚΩΝ ΕΠΙΣΤΗΜΩΝ ΚΑΙ ΔΙΑΧΕΙΡΙΣΗΣ ΠΕΡΙΒΑΛΛΟΝΤΟΣ Πτυχιακή εργασία ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΑΥΞΗΣΗΣ ΤΗΣ ΔΙΑΤΗΡΗΣΙΜΟΤΗΤΑΣ ΤΟΥ ΒΟΔΙΝΟΥ ΚΡΕΑΤΟΣ ΠΑΡΟΥΣΙΑ ΚΥΠΡΙΑΚΩΝ ΟΙΝΩΝ Γεωργία
1. Ηλεκτρικό μαύρο κουτί: Αισθητήρας μετατόπισης με βάση τη χωρητικότητα
IPHO_42_2011_EXP1.DO Experimental ompetition: 14 July 2011 Problem 1 Page 1 of 5 1. Ηλεκτρικό μαύρο κουτί: Αισθητήρας μετατόπισης με βάση τη χωρητικότητα Για ένα πυκνωτή χωρητικότητας ο οποίος είναι μέρος
Supplementary figures
A Supplementary figures a) DMT.BG2 0.87 0.87 0.72 20 40 60 80 100 DMT.EG2 0.93 0.85 20 40 60 80 EMT.MG3 0.85 0 20 40 60 80 20 40 60 80 100 20 40 60 80 100 20 40 60 80 EMT.G6 DMT/EMT b) EG2 0.92 0.85 5
A facile and general route to 3-((trifluoromethyl)thio)benzofurans and 3-((trifluoromethyl)thio)benzothiophenes
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2014 A facile and general route to 3-((trifluoromethyl)thio)benzofurans and 3-((trifluoromethyl)thio)benzothiophenes
Group 2 Methotrexate 7.5 mg/week, increased to 15 mg/week after 4 weeks. Methotrexate 7.5 mg/week, increased to 15 mg/week after 4 weeks
Group 1 Methotrexate 7.5 mg/week, increased to 15 mg/week after 4 weeks Group 2 Methotrexate 7.5 mg/week, increased to 15 mg/week after 4 weeks Sulfasalazine 2000-3000 mg/day Leflunomide 20 mg/day Infliximab
Longitudinal Changes in Component Processes of Working Memory
This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. Research Article: New Research Cognition and Behavior Longitudinal Changes in Component Processes
The toxicity of three chitin synthesis inhibitors to Calliptamus italicus Othoptera Acridoidea
2011 48 4 909 914 * 1 2** 2 2 2 2 2*** 1. 110161 2. 100081 026000 3 Calliptamus italicus L. 3 LC 50 LC 90 1. 34 14. 17 mg / L LC 50 LC 90 2. 09 45. 22 mg / L 50 mg / L 14 d 87% 100% 50 mg / L 50% The toxicity