Aflatoxin Biosynthesis
|
|
|
- Φιλομήνα Γαλάνης
- 5 χρόνια πριν
- Προβολές:
Transcript
1 June , 2 Aflatoxin Biosynthesis Kimiko Y67: 1, and Hiromitsu N6@6?>B6 2 1 National Food Research Institute, National Agricultural Research Organization (NARO), Tsukuba, Ibaraki , Japan; 2 Faculty of Agriculture, Tottori University, Koyama, Tottori , Japan; Corresponding author / / 1) 3) AF AF B 1 (AFB 1 ) AF AFB 1 P450 Q 1,P 1,M 1 AFB 1 P450 AFB 1-8,9- DNA 4) AFB 1 AFB 1-8,9- AF 250 AF AF 5), 6) ) AF AF AF AF AF AF 8) AF 9) 12) AF AF AF AF AF AF 2. AF A. flavus A. parasiticus Aspergillus flavus A. flavus A. parasiticus AF AF A. flavus AF 13) A. flavus
2 136 Vol. 52, No. 3 AF AF AF AF 14) AF AF AF AF AF AF AF AF 15 17) 3. AF AFB 1,AFB 2, AFG 1,AFG 2 AF AFM 1,AFM 2 1 AFB 1,AFB 2,AFM 1 difurocoumarocyclopentenone AFG 1,AFG 2, AFM 2 difurocoumaro-d-lactone 1 AF (AFB 1,AFG 1,AFM 1 ) 2 (AFB 2, AFG 2, AFM 2 ) AFM 1, AFM 2 14 AFB 1,AFB 2 AF 15) 17) AF AF 28 AF 37 AF AF AF AF kb A. flavus 8 AF III 16), 17) 2 AF ORF 19) AF aflr AF 1. AF AFM 1,AFM 2 AflR AF 20), 21) 4. A. oryzae A. sojae A. flavus AF FDA GRAS (Generally Recognized As Safe) A. oryzae A. oryzae AF 22), 23) AF AF 24) AF 25) A. oryzae A. sojae A. flavus A. parasiticus
3 June norb cypa aflt pksa hypb1 nor-1 fas-2 fas-1 aflr aflj NI 26 NI 2 NI R (R) adha esta nora ver-1 vera avna hypb2 verb avfa dmta 7 11 NI NI omta orda vbs cypx moxy ordb hypa nada vrda , (27) 8, , 4 hypb1 hypb2 AF vrda R, NI, 3-1. A. flavus A. parasiticus 5. AF acetyl CoA 28 AF AF
4 138 Vol. 52, No DMST HOMST VB (22) (24) G-AF 2 AF 3 17) (1) (4) Acetyl CoA norsolorinic acid (NA) AF 2 fas1 fas2 26) acetyl CoA malonyl CoA C6 hexanoyl CoA Hexanoyl CoA 27), pksa (polyketide synthase) CoA hexanoyltetrahydroxyanthrone (HexAT) 28), 29) HexAT C10 norsolorinic acid (NA) hypb1 19) NA NA NA AF 10) 12) (5) NA averantin (AVN) NA NA reductase NADPH NADH averantin (AVN) 30) AVN NAD(P) NA
5 June AF NA reductase AF AF nor ) Nor-1 AF (13R,14S)-( )-aflatoxin 1 AF AF AF AVN (1 S)-( ) NA 1 (HPLC) AVN NA (1 S)-( )-AVN (1 R)- ( )-AVN 32) NADP (1 S)-( )-AVN NA (1 R)-( )- AVN NA reductase NA AVN AVR (8) AF Emericella heterothallica AVN (1 S)-( )-AVN (1 R)-( )-AVN (6) AVN 5 -hydroxyaverantin (HAVN) AVN (AVN monooxygenase) 5 -hydroxyaverantin (HAVN) 30), 32) avna 33) (1 S)-( )-AVN (1 S, 5 S)-HAVN (1 S, 5 R)-HAVN 2:1 (1 R)-( )-AVN 32) AVN (monooxygenase) AVN 1 5 HAVN Emericella heterothallica 30) AF (7) HAVN 5 -oxoaverantin (OAVN) (1 S, 5 S)-HAVN (1 S, 5 R)-HAVN (HAVN dehydrogenase) (1 S)-5 -oxoaverantin (OAVN) 32) 5 adha 34) NAD NADP OAVN OAVN HAVN dehydrogenase 35) acetyl methionine sulfoxide 60 kda (8) OAVN averufin (AVR) (1 S)-OAVN OAVN (cyclase) (1 S, 5 S)-AVR 32) 158 kda 36) AF (1 S, 5 S)-AVR (1 S)-OAVN (1 S, 5 S)-AVR OAVN 1 S NA reductase (5) AVR 32), 36) OAVN (cyclase) VHOH cyclase (VBS) VHOH cyclase (14) 36) VHOH VB (9) AVR hydroxyversicolorone (HVN) avfa cypx AVR HVN 38), 39) AvfA CypX P450 2 cypx AF avfa AF Cai, (1 S, 5 S)-AVR NADPH hydroxyversicolorone (HVN) 37) AvfA (10) HVN versiconal hemiacetal acetate (VHA) HVN NADPH HVN (monooxygenase) versi-
6 140 conal hemiacetal acetate (VHA) 37) 40) moxy HVN versicolorone (VONE) moxy HVN monooxygenase 39) HVN VONE (12) Vol. 52, No. 3 AF VHA reductase vrda vrda AF 44) vrda aflr AF AF AF (11) VHA versiconal (VHOH) VHA esta VHA (esterase) versiconal (VHOH) 41) (DV) 42) DV AF AF VHA versiconol acetate (VOAc) 43) esta VHA VOAc 41) VOAc (12) Esterase VHA VHOH VOAc versiconol (VOH) esta 30 41) esterase VHOH VHA (12), (13) VHA reductase versicolorol (VONOL) HVN, VHA, VHOH NADPH VHA reductase VONE, VOAc, VOH 43), 44) VONE, VOAc, VOH feeding AF VONE, VOAc, VOH AF 43) VONE VOAc HVN VHA monooxygenase esterase HVN VHA VHOH VONE VOAc VOH VHA reductase 6 37), 43) VONE NADPH versicolorol (VONOL) (14) VHOH versicolorin B (VB) VHOH VHOH cyclase (1 R, 2 S)-versicolorin B (VB) 37), 45) AF vbs (versicolorin B synthetase) 46) VHOH cyclase AF OAVN cyclase VHOH cyclase 1 2 (8) (14) (8) OAVN AVR OAVN cyclase N VHOH VB VHOH cyclase (VBS) 36), 46) VBS vbs VHOH OAVN HAVN AF cyclase vbs 1 1 AF 2 36) AF AF AF HVN, VHA, VHOH (1 R, 2 S) (1 S, 2 R) AF HPLC VHOH cyclase VHOH (1 R, 2 S)-VB 47) VHOH VHOH (1 R, 2 S) (1 S, 2 R) versicolorin C (VC) VHOH (1 R, 2 S)- VB HPLC cyclase
7 June (1 R, 2 S)- (1 R, 2 S)-VB 47) (1 S, 2 R)-VHOH (1 R, 2 S)- VHOH (1 S, 2 R)- VHOH (1 R, 2 S)-VHOH VHOH cyclase VB (1 R, 2 S)- VB AF AF VHOH cyclase VHOH cyclase OAVN (15) VB versicolorin A (VA) (1 R, 2 S)-VB desaturase VA 48) (1 S, 2 R)- VB 47) Desaturase 48) VB AFB 2,AFG 2 tetrahhydrobisfuran versicolorin A (VA) AFB 1,AFG 1 dihydrobisfuran AF feeding VB 4 AF VA AFB 1 AFG 1 48) Desaturase verb 49) verb 1 AF (AFB 1,AFG 1 ) 2 AF (AFB 2,AFG 2 ) desaturase 2 AF 1 AF (16) VA demethylsterigmatocystin (DMST) VB dihydrodemethylsterigmatocystin (DHDMST) VA demethylsterigmatocystin (DMST) VA DMST VA DMST AF ver-1, ordb, hypx AF VA 50) 52) VA DMST 3 vera 53) VB DHDMST AF 2) (17) DMST sterigmatocystin (ST) DHDMST dihydrosterigmatocystin (DHST) DMST DHDMST 2 OH 6- OH 7-OH, S-adenosylmethionine O-methyltransferase I 6-OH ST DHST 54), 55) O- Methyltransferase I 90 kda K m 1 2 M 100 mm 55) AF O-Methyltransferase I dmta 56) (18) ST O-methylsterigmatocystin (OMST) DHST dihydro-o-methylsterigmatocystin (DHOMST) ST DHST 7-OH S-adenosylmethionine O-methyltransferase II OMST DHOMST O-Methyltransferase II DMST DHDMST 7-OH 6-OH 7-OH 55) O-Methyltransferase II omta 57) (19) OMST 11-hydroxy-O-methylsterigmatocystin (HOMST) DHOMST dihydro- 11-hydroxy-O-methylsterigmatocystin (DHHOMST) orda OrdA P450 OMST AFB 1 58) 60) orda OMST DHOMST 4 AF OrdA G-AF OMST AF OrdA OMST AFB hydroxy-o-methylsterigmatocystin (HOMST) 61), 62) OMST HOMST, OMST dihydro DHOMST DHHOMST OrdA
8 142 (20) (24), (25) HOMST AFB 1 DHHOMST AFB 2 HOMST AFB 1 DHHOMST AFB 2 OrdA 61), 62) aryl ring cleavage, demethylation, dehydration, decarboxylation OrdA (20) (24), (26) (29) HOMST AFG 1 DHHOMST AFG 2 HOMST DHHOMST AFB 1,AFB 2 AFG 1,AFG 2 HOMST feeding AFB 1 AFG 1 DHH- OMST AFB 2 AFG 2 62) HOMST AFG 1 AFB 1 cypa G-AF B-AF CypA 63) HOMST AFG 1 HOMST AFG ) OrdA CypA (29) NADA AFG 1 DHNADA AFG 2 nada G-AF NADA 64) NADA 360 AFG 1 NadA NAD(P)H NADA AFG 1 NADA dihydro DHNADA AFG 2 NadA G-AF HOMST AFG 1 NadA 64) HOMST AFG 1 6. AF NADPH acetyl CoA 1 AF 10 NADPH NAD 1 S-adenosylmethionine (SAM) 2 Vol. 52, No. 3 malonyl CoA SAM NADPH AF AF AF YES 20 5 AF NADPH NADPH AF AF AF AF AF AF AF nor-1 31) esta 41) AF vrda AF 44) vrda AflR AF AF vrda VONE AF VOROL 37) AF AF AF AF AF AF AF NA AVN OMT-I 1 cyclase 2 AF
9 June AF 7. A. parasiticus AFB 1,AFB 2,AFG 1,AFG 2 A. flavus B-AF (AFB 1,AFB 2 ) AF A. flavus AF kb G-AF cypa cypa Aspergillus flavus G-AF 63) B-AF G-AF HOMST AFB 1 OrdA HOMST AFG 1 OrdA 2 G-AF AF 4 AF AFM 1 AFM 2 AF M-AF AF M-AF 8. AF AF A. oryzae A. sojae AF 23), 24), 65) A. parasiticus A. flavus A. nomius, A. pseudotamarii, A. bombycis, A. ochraceoroseus, A. australis AF AF 66) A. nidulans A. versicolor 20 AF (ST) A. nidulans ST ST AF ST ST 67), 68) ST AF Mycosphaerella pini, A. fumigatus, Coccidioides immitis AF 19) A. versicolor E. hetherothallica AF AVR HAVN AF 3), 69), 70) AF 71) AF AF AF AF 9. AF AF AF AF ST OMST DHOMST AFG 1 NADA 64) AF AF 72), 73) AF feeding M AF aflt 74) 10. AF ph AF AF aflr AflR binuclear zinc cluster (Zn(II)2Cys6) DNA AF 53) aflr aflj 75) aflr camp Ca G 76) A. nidulans VeA LaeA A. flavus A. parasiticus AF
10 144 Vol. 52, No. 3 77) AF AF AF 9) Achromobacter xylosoxidans cyclo (A-leucyl-Aprolyl) AF cyclo (A-leucyl-A-prolyl) aflr 11) AF AF X 51 AF AF AF AF AF AF AF AflR AflR AF AflR AF AF 1) , p ) Bennett, J. W., Klich, M. Mycotoxins. Clin. Microbiol. Rev., 16, (2003). 3) Cole, R. J., Cox, R. H. Handbook of Toxic Fungal Metabolites. Academic Press, New York, ) Kumagai, S. The fate of aflatoxin B 1 in animals. Mycotoxins, 60, 7 16 (2010). 5) Bull. Natl. Inst. Health Sci., 124, (2006). 6) B1, B2, G1 G2 05/dl/s k 0001.pdf 7) Robens, J. The costs of mycotoxin management to the USA: Management of aflatoxins in the United States. http: //www. apsnet. org/ online/ feature/ mycotoxin/top.html (2001). 8) Cotty, P. J. Influence of field application of an atoxigenic strain of Aspergillus flavus on the population of A. flavus infecting cotton bolls and on the aflatoxin content of cottonseed. Phytopathology, 84, (1994). 9) Ono, M., Sakuda, S., Suzuki, A., Isogai, A. Aflastatin A, a novel inhibitor of aflatoxin production by aflatoxigenic fungi. J. Antibiot., 50, (1997). 10) Hua, S. S., Baker J. L., Flores-Espiritu, M. Interactions of saprophytic yeasts with a nor mutant of Aspergillus flavus. Appl. Environ. Microbiol., 65, (1999). 11) Yan, P.-S., Song Y., Sakuno, E., Nakajima H., Nakagawa H., Yabe K. Cyclo (A-leucyl-A-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus. Appl. Environ. Microbiol., 70, (2004). 12) Yabe, K., Yan, P.-S., Song, Y., Ichinomiya, M., Nakagawa, H., Shima, Y., Ando, Y., Sakuno, E. Nakajima, H. Isolation of microorganisms and substances inhibitory to aflatoxin production. Food Addit. Contam., Part A, 25, (2008). 13) Manabe, M., Tsuruta, O. Geographical distribution of aflatoxin-producing fungi in Southeast Asia. JARQ, 12, (1978). 14) Saito, M., Okazaki, H., Tanaka, K., Kushiro, M. Distribution of Aspergillus flavus and A. parasiticus in field soils from Ibaraki and Chiba Prefectures. Rep. Nat l. Food Res. Inst., 72, (2008). 15) Trail, F., Mahanti, N., Rarick, M., Mehigh, R., Liang, S. H., Zhou, R., Linz, J. E. Physical and transcriptional map of an aflatoxin gene cluster in Aspergillus parasiticus and functional disruption of a gene involved early in the aflatoxin pathway. Appl. Environ. Microbiol., 61, (1995). 16) Yabe, K., Nakajima, H. Enzyme reactions and genes in aflatoxin biosynthesis. Appl. Microbiol. Biotechnol., 64, (2004). 17) Yu, J., Chang, P. K., Ehrlich, K. C., Cary, J. W., Bhatnagar, D., Cleveland, T. E., Payne, G. A., Linz, J. E., Woloshuk, C. P., Bennett, J. W. Clustered pathway genes in aflatoxin biosynthesis. Appl. Environ. Microbiol., 70, (2004). 18) Aspergillus flavus and aflatoxin. 19) Ehrlich, K. C. Predicted roles of the uncharacterized clustered genes in aflatoxin biosynthesis. Toxins, 1, (2009).
11 June ) Payne, G. A., Nystrom, G. J., Bhatnagar, D., Cleveland, T. E., Woloshuk, C. P. Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus. Appl. Environ. Microbiol., 59, (1993). 21) Smith, C. A., Woloshuk, C. P., Robertson, D., Payne, G. A. Silencing of the aflatoxin gene cluster in a diploid strain of Aspergillus flavus is suppressed by ectopic aflr expression. Genetics, 176, (2007). 22) Dogan: 23) Machida, M. et al. Genome sequencing and analysis of Aspergillus oryzae. Nature, 438, (2005). 24) Tominaga, M., Lee, Y.-H., Hayashi, R., Suzuki, Y., Yamada, O., Sakamoto, K., Gotoh, K., Akita, O. Molecular analysis of an inactive aflatoxin biosynthesis gene cluster in Aspergillus oryzae RIB strains. Appl. Environ. Microbiol., 72, (2006). 25) Matsushima, K., K. Yashiro, Matsushima, K. Yashiro, K. Hanya, Y. Abe, K. Yabe, K. Hamasaki, T. Absence of aflatoxin biosynthesis in koji mold (Aspergillus sojae). Appl. Microbiol., Biotech., 55, (2001). 26) Mahanti, N., Bhatnagar D., Cary, J. W., Joubran, J., Linz, J. E. Structure and function of fas-1a, a gene encoding a putative fatty acid synthase directly involved in aflatoxin biosynthesis in Aspergillus parasiticus. Appl. Environ. Microbiol., 62, (1996). 27) Townsend, C. A., Christensen, S. B., Trautwein, K. Hexanoate as a starter unit in polyketide synthesis. J. Am. Chem. Soc., 106, (1984). 28) Feng, G. H., Leonard, T. J. Characterization of the polyketide synthase gene (pksl) required for aflatoxin biosynthesis in Aspergillus parasiticus. J. Bacteriol., 177, (1995). 29) Chang, P. K., Cary, J. W., Yu, J., Bhatnagar, D., Cleveland, T. E. Aspergillus parasiticus polyketide synthetase gene, pksa, a homolog of Aspergillus nidulans wa, required for aflatoxin B 1. Mol. Gen. Genet., 248, (1995). 30) Yabe, K., Nakamura, Y., Nakajima, H., Ando, Y., Hamasaki, T. Enzymatic conversion of norsolorinic acid to averufin in aflatoxin biosynthesis. Appl. Environ. Microbiol., 57, (1991). 31) Trail, F., Chang, P. K., Cary, J, Linz, J. Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus. Appl. Environ. Microbiol., 60, (1994). 32) Yabe, K., Matsuyama, Y., Ando, Y., Nakajima, H., Hamasaki, T. Stereochemistry during aflatoxin biosynthesis: Conversion of norsolorinic acid to averufin. Appl. Environ. Microbiol., 59, (1993). 33) Yu, J., Chang, P. K., Cary, J. W., Bhatnagar, D., Cleveland, T. E. avna, a gene encoding a cytochrome P- 450 monooxygenase is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus. Appl. Microbiol. Biotechnol., 63, (1997). 34) Chang, P. K., Yu, J., Ehrlich, K. C., Boue, S. M., Montalbano, B. G., Bhatnagar, D., Cleveland, T. E. The aflatoxin biosynthesis gene adha in Aspergillus parasiticus is involved in conversion of 5 -hydroxyaverantin to averufin. Appl. Environ. Microbiol., 66, (2000). 35) Sakuno, E., Yabe, K., Nakajima, H. Involvement of two cytosolic enzymes and a novel intermediate, 5 oxoaverantin, in the pathway from 5 -hydroxyaverantin to averufin in aflatoxin biosynthesis. Appl. Environ. Microbiol., 69, (2003). 36) Sakuno, E., Wen, Y., Hatabayashi, H., Arai, H., Aoki, C., Yabe, K., Nakajima, H. Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis. Appl. Environ. Microbiol., 71, (2005). 37) Yabe, K., Chihaya, N., Hamamatsu, S., Sakuno, E., Hamasaki, T., Nakajima, H., Bennett, J. W. Enzymatic conversion of averufin to hydroxyversicolorone and elucidation of a novel metabolic grid involved in aflatoxin biosynthesis. Appl. Environ. Microbiol., 69, (2003). 38) Yu, J., Woloshuk, C. P., Bhatnagar, D., Cleveland, T. E. Cloning and characterization of avfa and omtb genes involved in aflatoxin biosynthesis in three Aspergillus species. Gene, 248, (2000). 39) Wen, Y., Hatabayashi, H., Arai, H., Kitamoto, H. K., Yabe, K. Function of the cypx and moxy genes in aflatoxin biosynthesis in Aspergillus parasiticus. Appl. Environ. Microbiol., 71, (2005). 40) Miyamoto, M., Matsumoto, J., Iwaya, T., Itagaki, E. Bacterial steroid monooxygenase catalyzing the Baeyer Villiger oxidation of C21-ketosteroids from Rhodococcus rhodochrous: The isolation and characterization. Biochim. Biophys. Acta, 1251, (1995). 41) Chang, P. K., Yabe, K., Yu, J. The Aspergillus parasiticus esta-encoded esterase converts versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol in aflatoxin biosynthesis. Appl. Environ. Microbiol., 70, (2004). 42) Bennett, J. W., Lee, L. S., Cucullu, A. F. E#ect of dichlorvos on aflatoxin and versicolorin A production in Aspergillus parasiticus. Bot. Gaz., 137, (1976). 43) Yabe, K., Ando, Y., Hamasaki, T. A metabolic grid among versiconal hemiacetal acetate, versiconol acetate, versiconol and versiconal during aflatoxin biosynthesis. J. Gen. Microbiol., 137, (1991). 44) Shima, Y., Shiina, M., Shinozawa, T., Ito, Y., Nakajima, H., Adachi, Y., Yabe, K. Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrda gene outside the aflatoxin gene cluster. Fungal. Genetics and Biology, 46, (2009). 45) McGuire, S. M., Silva, J. C., Casillas, E. G., Townsend, C. A. Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodi#erentiating cyclization in aflatoxin biosynthesis essential to DNA interaction. Biochemistry, 35, (1996). 46) Silva, J. C., Minto, R. E., Barry, III C. E., Holland, K. A., Townsend, C. A. Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus: Expression of the aflatoxin B 1 biosynthetic clus-
12 146 Vol. 52, No. 3 ter. J. Biol. Chem., 271, (1996). 47) Yabe, K., Hamasaki, T. Stereochemistry during aflatoxin biosynthesis: cyclase reaction in the conversion of versiconal to versicolorin B and racemization of versiconal hemiacetal acetate. Appl. Environ. Microbiol., 59, (1993). 48) Yabe, K., Ando, Y., Hamasaki, T. Desaturase activity in the branching step between aflatoxins B 1 and G 1 and aflatoxins B 2 and G 2. Agric. Biol. Chem., 55, (1991). 49) Bhatnagar, D., Ehrlich, K. C., Cleveland, T. E. Molecular genetic analysis and regulation of aflatoxin biosynthesis. Appl. Microbiol. Biotechnol., 61, (2003). 50) Skory, C. D., Chang, P. K., Cary, J., Linz, J. E. Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis. Appl. Environ. Microbiol., 58, (1992). 51) Ehrlich, K. C., Montalbano, B., Boue, S. M., Bhatnagar, D. An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin A to sterigmatocystin. Appl. Environ-Microbiol., 71, (2005). 52) Cary, J. W., Ehrlich, K. C., Bland, J. M., Montalbano, B. G. The aflatoxin biosynthesis cluster gene, aflx, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin. Appl. Environ. Microbiol., 72, (2006). 53) Yu, J., Bhatnagar, D., Cleveland, T. E. Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus. FEBS Lett., 564, (2004). 54) Yabe, K., Ando, Y., Hashimoto, J., Hamasaki, T. Two distinct O-methyltransferases in aflatoxin biosynthesis. Appl. Environ. Microbiol., 55, (1989). 55) Yabe, K., Matsushima, K. I., Koyama, T., Hamasaki, T. Purification and characterization of O-methyltransferase I involved in conversion of demethylsterigmatocystin to sterigmatocystin and of dihydrodemethylsterigmatocystin to dihydrosterigmatocystin during aflatoxin biosynthesis. Appl. Environ. Microbiol., 64, (1998). 56) Motomura, M., Chihaya, N., Shinozawa, T., Hamasaki, T., Yabe, K. Cloning and characterization of the O- methyltransferase I gene (dmta) from Aspergillus parasiticus associated with the conversion of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigatocystin in aflatoxin biosynthesis. Appl. Environ. Microbiol., 65, (1999). 57) Yu, J., Cary, J. W., Bhatnagar, D., Cleveland, T. E., Keller, N. P., Chu, F. S. Cloning and characterization of a cdna from Aspergillus parasiticus encoding an O- methyltransferase involved in aflatoxin biosynthesis. Appl. Environ. Microbiol., 59, (1993). 58) Prieto, R., Woloshuk, C. P. ord 1, an oxidoreductase gene responsible for conversion of O-methylsterigmatocystin to aflatoxin in Aspergillus flavus. Appl. Environ. Microbiol., 63, (1997). 59) Yu, J., Chang, P. K., Ehrlich, K. C., Cary, J. W., Montalbano, B., Dyer, J. M., Bhatnagar, D., Cleveland, T. E. Characterization of the critical amino acids of an Aspergillus parasiticus cytochrome P-450 monooxygenase encoded by orda that is involved in the biosynthesis of aflatoxins B 1,G 1,B 2, and G 2. Appl. Environ. Microbiol., 64, (1998). 60) Yabe, K., Nakamura, M., Hamasaki, T. Enzymatic formation of G-group aflatoxins and biosynthetic relationship between G- and B-group aflatoxins. Appl. Environ. Microbiol., 65, (1999). 61) Udwary, D. W., Casillas, L. K., Townsend, C. A. Synthesis of 11 -hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis. J. Am. Chem. Soc., 124, (2002). 62) Zeng, H., Hatabayashi, H., Nakagawa, H., Cai, J., Suzuki, R., Sakuno, E., Tanaka, T., Ito, Y., Ehrlich, K. C., Nakajima, H., Yabe, K. Conversion of 11-hydroxy- O-methylsterigmatocystin to aflatoxin G 1 in Aspergillus parasiticus. Appl. Microbiol. Biotechnol., 90, (2011). 63) Ehrlich, K. C., Chang, P. K., Yu, J., Cotty, P. J. Aflatoxin biosynthesis cluster gene cypa is required for G aflatoxin formation. Appl. Environ. Microbiol., 70, (2004). 64) Cai, J., Zeng, H., Shima, Y., Hatabayashi, H., Nakagawa, H., Ito, Y., Adachi, Y., Nakajima, H., Yabe, K. Involvement of the nada gene in formation of G-group aflatoxins in Aspergillus parasiticus. Fungal Genet. Biol., 45, (2008). 65) Kusumoto, K., Nagata, Y., Ohta, H. Directed deletions in the aflatoxin biosynthesis gene homolog cluster of Aspergillus oryzae. Curr. Genet., 37, (2000). 66) Schmidt-Heydt, M., Häckel, S., Rüfer, C. E., Geisen, R. A strain of Fusarium kyushuense is able to produce aflatoxin B 1 and G 1 Mycotox. Res., 25, (2009). 67) Brown, D. W., Yu, J. H., Kelkar, H. S., Fernandes, M., Nesbitt, T. C., Keller, N. P., Adams, T. H., Leonard, T. J. Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proc. Natl. Acad. Sci. U.S.A., 93, (1996). 68) Keller, N. P., Hohn, T. M. Metabolic pathway gene clusters in filamentous fungi. Fungal Genet. Biol., 21, (1997). 69) Hamasaki, T., Hatsuda, Y., Terashima, N., Renbutsu, M. Studies on the metabolites of Aspergillus versicolor (Vuillemin) Tiraboshi. Part V. Isolation and structure of three new metabolites, versicolorins A, B and C. Agric. Biol. Chem., 31, (1967). 70) Aucamp, P. J., Holzapfel, C. W. Polyhydroxyanthraquinones from Aspergillus versicolor, Aspergillus nidulans and Bipolaris sp.: Their significance in relation to biogenetic theories on aflatoxin B 1. J. S. Afr. Chem. Inst., 23, (1970). 71) Sakuno, E., Kameyama, M., Nakajima, H., Yabe, K. Purification and gene cloning of a dehydrogenase from Lactobacillus brevis that catalyzes a reaction involved
13 June in aflatoxin biosynthesis. Biosci. Biotechnol. Biochem. 72, (2008). 72) Chanda, A., Roze, L. V., Kang, S., Artymovich, K. A., Hicks, G. R., Raikhel, N. V., Calvo, A. M., Linz, J. E. A key role for vesicles in fungal secondary metabolism. Proc. Natl. Acad. Sci. U.S.A., 106, (2009). 73) Roze, L. V., Chanda, A., Linz, J. E. Compartmentalization and molecular tra$c in secondary metabolism: A new understanding of established cellular processes. Fungal Genet. Biol., 48, (2011). 74) Chang, P. K., Yu, J., Yu, J.-H. aflt, a MFS transporterencoding gene located in the aflatoxin gene cluster, does not have a significant role in aflatoxin secretion. Fungal Genet. Biol., 41, (2004). 75) Meyers, D. M., O Brian, G., Du, W. L., Bhatnagar, E., Payne, G. A. Characterization of aflj, a gene required for conversion of pathway intermediates to aflatoxin. Appl. Environ. Microbiol., 64, (1998). 76) Shwab, E. K., Keller, N. P. Regulation of secondary metabolite production in filamentous ascomycetes. Micol. Res., 112, (2008). 77) Amaike, S., Keller, N. P. Distinct roles for VeA and LaeA in development and pathogenesis of Aspergillus flavus. Eukaryotic Cell, 2009, (2009).
Fungal Population and Distribution of Aflatoxigenic Fungi in Commercial Almond Powder Products
90 Vol. 48, No. 4 18 12 8 1 1 2 1, Fungal Population and Distribution of Aflatoxigenic Fungi in Commercial Almond Powder Products Tomoko K:C?D 1,Yuka IH=>9: 1,Koji ADN6B6 2 and Masakatsu I8=>CD: 1, 1 Tokyo
Trace gas emissions from soil ecosystems and their implications in the atmospheric environment
J. Jpn. Soc. Soil Phys. No. 3., p.,+ -+,**- * Trace gas emissions from soil ecosystems and their implications in the atmospheric environment Kazuyuki YAGI* * National Institute for Agro-Environmental Science,
Acknowledgements... 3 Contents... I Figures... VII Tables... IX Abbreviations... X
I Acknowledgements... 3... I Figures... VII Tables... IX Abbreviations... X Amino acids... XII Nucleobases... XII 1 Introduction... 1 1.1 Polyketides and non-ribosomal peptides... 1 1.2 Polyketide synthases...
Electrolyzed-Reduced Water as Artificial Hot Spring Water
/-,**- + +/ 0 +, - + + +, - + +. ++,3 +/. +. Electrolyzed-Reduced Water as Artificial Hot Spring Water Shoichi OKOUCHI +, Daisuke TAKEZAKI +, Hideyuki OHNAMI +, Yuhkoh AGISHI,, Yasuo KANROJI -, and Shigeo
Optimization of fermentation process for achieving high product concentration high yield and high productivity
1128 CHEMICAL INDUSTRY AND ENGINEERING PROGRESS 2006 25 10 ( 214036) (1) (2) (3) (4) (5) TQ 92 A 1000 6613 2006 10 1128 06 Optimization of fermentation process for achieving high product concentration
40,000 Roberts camphor 20 Artemisia annua artemisinin. Taxus brevifolia Jennewein & Croteau 2001 astaxanthin. Misawa H.
651-2241 1-1-1 KNC Development of efficient functional analysis of plant terpene biosynthetic genes: mainly of sesquiterpene biosynthetic genes Key words: cytochrome P450; pathway engineering; sesquiterpene
+, - functional food, nutraceutical , Food for Specified Health Uses (FoSHU) in future Makoto SHIMIZU, ,*+*
-*,* +32. Food for Specified Health Uses (FoSHU) in future Makoto SHIMIZU, +, - - - 1 (+ -) functional food, nutraceutical +33+ +33-,,*+* / 3**,**1 1,***,**3 in vitro + + + (.), + MBP g A +, A Ca Ca a
Nguyen Hien Trang* **
152 Nippon Shokuhin Kagaku Kogaku Kaishi Vol.., No.., +,+3 (,**1) 10 Nguyen Hien Trang* ** * Department of Food Science and Technology, Hue University of Agriculture and Forestry ** Properties of "Shishibishio
E#ects of Drying on Bacterial Activity and Iron Formation in Acid Sulfate Soils
J. Jpn. Soc. Soil Phys. No. 3+, p..3 /1,**, * ** ** E#ects of Drying on Bacterial Activity and Iron Formation in Acid Sulfate Soils Kaoru UENO*, Tadashi ADACHI** and Hajime NARIOKA** * The Graduate School
[11].,, , 316 6, ,., 15.5%, 9.8%, 2006., IDF,, ,500, 2,830.,, ,200.,,, β, [12]. 90% 2,,,,, [13-15].,, [13,
![[11].,, , 316 6, ,., 15.5%, 9.8%, 2006., IDF,, ,500, 2,830.,, ,200.,,, β, [12]. 90% 2,,,,, [13-15].,, [13,](/thumbs/89/98694254.jpg "[11].,, , 316 6, ,., 15.5%, 9.8%, 2006., IDF,, ,500, 2,830.,, ,200.,,, β, [12]. 90% 2,,,,, [13-15].,, [13,")
in vitro αα In Vitro α-glucosidase and α-amylase Inhibitory Effects of Herbal Tea Leaves from Yacon (Smallanthus sonchifolius) 1, 1, 1, 2, 1, 2, 3, 1, 2, 1, 2, 1, 2, 1, 2 1, 2, *, 1 2, 3 Yuto Ueda 1, Shintaro
,35 , 96 %, China Academic Journal Electronic Publishing House. All rights reserved. CHINA BIOTECHNOLOGY ( )
23 9 CHINA BIOTECHNOLOGY 2003 9 3 ( 310014),,, : C 40 H 52 O 2, 56419 [1 ], 1950,,, [2 ], [3 5 ] 1984 FDAΠWHO,,,, 96 %, [1 ] 1,,, 210, :2003204203 :2003207208 3 :stxp108 @yahoo. com. cn (,, 2 24,4 2 ),,,,
Science of Sericulture
Science of Sericulture 2012 38 1 0065-0069 ISSN 0257-4799 CN 32-1115 /S E-mail CYKE@ chinajournal. net. cn 215123 25 0 ~ 24 h GSH GSSG GSH + 2GSSG GSH /GSSG S- GST TPX 23% GR 57% GSH TPX GST GSSG 61% GSH
Mechanism of the Inactivation of Microorganisms by Non-thermal Process
1 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No.+, +/ (,**2) 1 Mechanism of the Inactivation of Microorganisms by Non-thermal Process Soichi Furukawa Department of Food Science and Technology, College
High mobility group 1 HMG1
Vol. 29, pp.705 ~ 711, 2001 High mobility group 1 HMG1 13 12 20 anti-neutrophil cytoplasmic antibodies, ANCA ANCA 1982 Davies 1980 1 high mobility group HMG1 HMG2 30 kd high mobility group HMGHMG HMG1
Antimicrobial Ability of Limonene, a Natural and Active Monoterpene
2010,32 (1) :24 28 http :/ / xuebao. jlau. edu. cn Journal of Jilin Agricultural University E2mail : jlndxb @vip. sina. com Ξ,,,, ΞΞ, 200062 : : 320 mg/ L,; ph 4 9, ; 80, 100,121 : : ; ; : TS20213 : A
Mouse Gene 2.0 ST Array Shn3. Runx2 Shn3. Runx2 Shn3 Runx2. adult. (Schnurri, Shn)3/Hivep3. Runx2 Shn/Hivep. ST2 BMP-2 Shn3
adult (Schnurri, Shn)3/Hivep3 Runx2 Shn/Hivep Shn3 Shn3 Shn3 Shn3 Shn1 Shn2 Shn3 gain-of-function loss-of-function Shn3 in vivo mimic MC3T3-E1 ST-2 ATDC5 C3H10T1/2 ALP RT-PCR alcian blue RT-PCR Affymetrix
ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΓΕΩΤΕΧΝΙΚΩΝ ΕΠΙΣΤΗΜΩΝ ΚΑΙ ΔΙΑΧΕΙΡΗΣΗΣ ΠΕΡΙΒΑΛΛΟΝΤΟΣ. Πτυχιακή εργασία
ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΚΥΠΡΟΥ ΣΧΟΛΗ ΓΕΩΤΕΧΝΙΚΩΝ ΕΠΙΣΤΗΜΩΝ ΚΑΙ ΔΙΑΧΕΙΡΗΣΗΣ ΠΕΡΙΒΑΛΛΟΝΤΟΣ Πτυχιακή εργασία ΠΑΡΑΓΩΓΗ ΦΟΥΜΟΝΙΣΙΝΩΝ ΣΤΟΥΣ ΜΑΥΡΟΥΣ ΑΣΠΕΡΓΙΛΛΟΥΣ Λία Μάρκου Λεμεσός 2016 i ii ΤΕΧΝΟΛΟΓΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ
Νόσος Parkinson-Νέοι ορίζοντες Ξηροµερήσιου Γεωργία Νευρολόγος-Μέλος ερευνητικής οµάδας Νευρογενετικής Αίτια της νόσου Parkinson Περιβαλλοντικοί παράγοντες Γενετικοί παράγοντες Γενετική βλάβη (παθογόνα
Daedaleopsis tricolor
26 4 565~569 2007 Mycosystema Daedaleopsis tricolor 1 434025 2 100101 HPLC 31-34- -8-4- (2- )-8-4- -5,8-3 2 Q939.5 A 1672-6472 2007 04-0565-0569 The antifungal components from Daedaleopsis tricolor XIANG
ACTA SCIENTIAE CIRCUMSTANTIAE. 16S rrna PNAN5 ( Rhodococcus sp. strain PNAN5). 20. ( Institute of Microbiology, Chinese Academy of Sciences,
24 3 2004 5 ACTA SCIENTIAE CIRCUMSTANTIAE Vol. 24,No. 3 May,2004 :025322468 (2004) 0320482205 :X523 :A PNAN5 ( Rhodococcus sp. strain PNAN5),,, 3 (, 100080) :, 16S rrna PNAN5 ( Rhodococcus sp. strain PNAN5).
Abstract... I. Zusammenfassung... II. 1 Aim of the work Introduction Short overview of Chinese hamster ovary cell lines...
III Contents I II III Abstract... I Zusammenfassung... II Contents... III 1 Aim of the work... 1 2 Introduction... 2 2.1 Short overview of Chinese hamster ovary cell lines... 2 2.2 Unspecific mutations:
!#$!"&#"!%. & ) # / $-..,.!.,.-...!., %!30&.., -.
!#$!"&#"!%. & ) 21. 2018 129 # 664.788/ 664.668.9 22 1 2 $..,.!.,....!., +!....,!"8.., %!30&..,.!"## «,!! $» (% ). +. 1.) 1010 81 ) (8) 1. 1 2 ( 1 2 ), &2, 1 ()), 11. 19992016. 2 2 3. & 0 101 1 20132016.
Review article Ανασκόπηση
: 38-47 ΠΕΡΙΟΔΙΚΟ ΤΗΣ EΛΛHNIKHΣ KTHNΙΑΤΡΙΚΗΣ ETAIPΕIAΣ 2011, 62(1): 38-47 Review article Ανασκόπηση Aflatoxin effects on animals health and milk composition of the ruminants Kourousekos G. D., DVM, PhD
Identification of Fish Species using DNA Method
5 * * * Identification of Fish Species using DNA Method Yuumi KAWASHIMA*, Takayuki KATAYAMA* and Yukihiko YAMAZAKI* *Central Customs Laboratory, Ministry of Finance 6-3-5, Kashiwanoha, Kashiwa, Chiba 277-0882,
Chalkou I. C. [PROJECT] Ανάθεση εργασιών.
![Chalkou I. C. [PROJECT] Ανάθεση εργασιών.](/thumbs/29/13219375.jpg "Chalkou I. C. [PROJECT] Ανάθεση εργασιών.")
Πληροφορική της Υγείας 2014 Chalkou I. C. [PROJECT] Ανάθεση εργασιών. Περιεχόμενα 1. Ομάδα ΣΤ... 3 1.1 ΜΑΡΚΟΠΟΥΛΟΥ- ΣΠΥΡΟΠΟΥΛΟΥ -ΚΩΝΣΤΑΝΤΟΠΟΥΛΟΥ... 3 1.2 ΜΑΡΚΟΣ- ΚΟΥΤΣΟΠΟΥΛΟΣ ΑΥΓΕΡΗ - ΜΠΟΥΖΑΛΑ... 3 1.3
Curran et al.,**. Davies et al ,**, ,***,**/
* + *, * - *. * / + Curran et al.,**. Davies et al. +332 +332,**,,***,**/, +333 ++ Daisuke Hattori, Tanaka Kenzo, Kazuo Okamura Irino, Ikuo Ninomiya, Katsutoshi Sakurai : Rehabilitation of the Tropical
(Glycoside Hydrolase, GH) (1) α-n (NagBb) (Hyp) β-l- (HypBA2) β-l- (HypBA1) HypBA2. SeMet-SAD. (2) Bifidobacterium bifidum, B. longum, B. B.
(Glycoside Hydrolase, GH) (1) B α- (AgaBb) α-n (NagBb) (Hyp) β-β-l- (HypBA2) β-l- (HypBA1) B (2) Bifidobacterium bifidum, B. longum, B. breve B. bifidum B. bifidum (3)β-L- β-l- EC 3.2.1.187 EC 3.2.1.185
ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ ΣΤΡΑΤΗΓΙΚΕΣ ΜΕΙΩΣΗΣ ΚΑΙ ΕΞΑΛΕΙΨΗΣ ΤΩΝ ΜΥΚΟΤΟΞΙΝΩΝ ΣΤΑ ΤΡΟΦΙΜΑ
ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΚΑΛΑΜΑΤΑΣ ΣΧΟΛΗ ΤΕΧΝΟΛΟΓΙΑΣ ΓΕΩΠΟΝΙΑΣ ΤΜΗΜΑ ΤΕΧΝΟΛΟΓΙΑΣ ΓΕΩΡΓΙΚΩΝ ΠΡΟΪΟΝΤΩΝ ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ ΣΤΡΑΤΗΓΙΚΕΣ ΜΕΙΩΣΗΣ ΚΑΙ ΕΞΑΛΕΙΨΗΣ ΤΩΝ ΜΥΚΟΤΟΞΙΝΩΝ ΣΤΑ ΤΡΟΦΙΜΑ Σπουδαστής: Πισσάνος
abs acces acces Sample test results. Actual results may vary. Antioxidants B-Vitamins Minerals Order Today At Results Overview
Order Today At www.accesalabs. Antioxidants B-Vitamins Minerals Vitamin C Pyridoxine - Biotin Vitamin A / Carotenoids Vitamin E / Tocopher α-lipoic A Co T ami B1 cer R bo a n - B2 N acin - B3 Results Overview
Studies on the Binding Mechanism of Several Antibiotics and Human Serum Albumin
2005 63 Vol. 63, 2005 23, 2169 2173 ACTA CHIMICA SINICA No. 23, 2169 2173 a,b a a a *,a ( a 130012) ( b 133002), 26 K A 1.98 10 4, 1.01 10 3, 1.38 10 3, 5.97 10 4 7.15 10 4 L mol 1, n 1.16, 0.86, 1.19,
A summation formula ramified with hypergeometric function and involving recurrence relation
South Asian Journal of Mathematics 017, Vol. 7 ( 1): 1 4 www.sajm-online.com ISSN 51-151 RESEARCH ARTICLE A summation formula ramified with hypergeometric function and involving recurrence relation Salahuddin
,**+ Seiichi Ohta : Soils of Humid Tropical Forests in Southeast Asia Their Characteristics and Changes with Forest Degradation
FAO +331 +33* +33/ +32* +-**, ha,**+ Seiichi Ohta : Soils of Humid Tropical Forests in Southeast AsiaTheir Characteristics and Changes with Forest Degradation 2 No. /-,**, U.S. Soil Taxonomy FAO 12,, 0.
Evaluation of Resistance to Scab in Pear Germplasms
2012 13 4 571-576 Journal of Plant Genetic Resources / 125100 197 Evaluation of Resistance to Scab in Pear Germplasms DONG Xing-guangTIAN Lu-mingCAO Yu-fen Research Institute of PomologyChinese Academy
Original Article. Corynebacterium. (
> >>?> @ >> @ 88 82 > ??> Corynebacterium glutamicum?> ddh @E @? > > > > 4 4 3 2 @ < < >? < @>>? > < >>> < 7 6 5 @?? > < @? >? < > @> > @ @ >@ < > >>?> @ >>
Inhibition of mushroom tyrosinase by flavonoid from Sorbus tianschanica Ruper in Xinjiang
13 4 2015 7 Chinese Journal of Bioprocess Engineering Vol. 13 No. 4 Jul. 2015 doi 10. 3969 /j. issn. 1672-3678. 2015. 04. 012 1 2 2 2 2 1. 830054 2. 361005 L- 50% IC 50 0. 27 mg /ml K I - K IS 0. 218 0.
EM Baum-Welch. Step by Step the Baum-Welch Algorithm and its Application 2. HMM Baum-Welch. Baum-Welch. Baum-Welch Baum-Welch.
Baum-Welch Step by Step the Baum-Welch Algorithm and its Application Jin ichi MURAKAMI EM EM EM Baum-Welch Baum-Welch Baum-Welch Baum-Welch, EM 1. EM 2. HMM EM (Expectationmaximization algorithm) 1 3.
Influence of Flow Rate on Nitrate Removal in Flow Process
J. Jpn. Soc. Soil Phys. No. 33, p.1-2-,**/, ******* Influence of Flow Rate on Nitrate Removal in Flow Process Toshio TABUCHI*, Hisao KURODA**, Akiko IKENOBE** and Mayumi HIRANO** * Former professor of
Το Βιολογικό Ρολόι: Θεµελιώδης Ρυθµιστής της Φυσιολογίας των Οργανισµών
Ιούλιος 2005 Το Βιολογικό Ρολόι: Θεµελιώδης Ρυθµιστής της Φυσιολογίας των Οργανισµών ρ. Α. Προµπονά Εργαστήριο Ρύθµισης της Μεταγραφής από το Βιολογικό Ρολόι Κιρκαδικό Ρολόι Ρυθµοί µε περίοδο ~ 24 ωρών
Emulsifying Properties of Egg Yolk as a Function of Diacylglycerol Oil
354 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /-, No.0, -/.-0* (,**0) 38 * * Emulsifying Properties of Egg Yolk as a Function of Diacylglycerol Oil Tomoko Kawakami, Kyoko Ohashi* and Atsuko Shimada Graduate
Ινσουλίνη και καρδιά. Ηλιάδης Φώτης Λέκτορας Α.Π.Θ.
Ινσουλίνη και καρδιά Ηλιάδης Φώτης Λέκτορας Α.Π.Θ. Επίδραση ινσουλίνης στο ήπαρ, στους μυς και στον λιπώδη ιστό : Διατήρηση ευγλυκαιμίας Nature 2001;414:799 806 Ινσουλίνη? Λειτουργικότητα Μορφολογία Βιωσιμότητα
8Q5SAC) 8Q5SAC UV2Vis 8500 ( ) ; PHS23C ) ;721 ( ) :1 4. ;8Q5SAC : molπl ;Britton2Robinson Q5SAC BSA Britton2Robinson,
31 2003 8 (FENXI HUAXUE) 8 Chinese Journal of Analytical Chemistry 976 980 22( 82 252 272 )21,82 23,62 3 (, 510631) 22(82 252 272 )21,82 23,62 (BSA), 8Q5SAC BSA 298K, 35 40 6. 1 10 5 LΠmol 8Q5SAC, ph =
Apr Vol.26 No.2. Pure and Applied Mathematics O157.5 A (2010) (d(u)d(v)) α, 1, (1969-),,.
2010 4 26 2 Pure and Applied Matheatics Apr. 2010 Vol.26 No.2 Randić 1, 2 (1., 352100; 2., 361005) G Randić 0 R α (G) = v V (G) d(v)α, d(v) G v,α. R α,, R α. ; Randić ; O157.5 A 1008-5513(2010)02-0339-06
; +302 ; +313; +320,.
1.,,*+, - +./ +/2 +, -. ; +, - +* cm : Key words: snow-water content, surface soil, snow type, water permeability, water retention +,**. +,,**/.. +30- +302 ; +302 ; +313; +320,. + *+, *2// + -.*, **. **+.,
* ** *** *** Jun S HIMADA*, Kyoko O HSUMI**, Kazuhiko O HBA*** and Atsushi M ARUYAMA***
J. Jpn. Soc. Soil Phys. No. +*2, p. +3,2,**2 * ** *** *** Influence Area of Stem Flow on a Soil of Deciduous Forest Floor by Electric Resistivity Survey and the Evaluation of Groundwater Recharge through
The pathway of the ozonation of 2,4,62trichlorophenol in aqueous solution
25 12 2005 12 Acta Scientiae Circumstantiae Vol. 25,No. 12 Dec., 2005,. 2,4,62 [J ].,2005,25 (12) :1619-1623 PI Yunzheng, WANGJianglong. The pathway of the ozonation of 2,4,62trichlorophenol in aqueous
New Cytotoxic Constituents from the Red Sea Soft Coral Nephthea sp.
SUPPLEMENTARY MATERIAL New Cytotoxic Constituents from the Red Sea Soft Coral Nephthea sp. Mohamed-Elamir F. Hegazy a,*, Amira M. Gamal-Eldeen b, Tarik A. Mohamed a, Montaser A. Alhammady c, Abuzeid A.
Μελέτη της έκφρασης του ογκοκατασταλτικού γονιδίου Cyld στον καρκίνο του μαστού
Σχολή Θετικών Επιστημών Τμήμα Βιολογίας Πρόγραμμα Μεταπτυχιακών Σπουδών Κατεύθυνση: Εφαρμοσμένη γενετική και βιοτεχνολογία ΜΕΤΑΠΤΥΧΙΑΚΗ ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ Μελέτη της έκφρασης του ογκοκατασταλτικού γονιδίου
Reaction of a Platinum Electrode for the Measurement of Redox Potential of Paddy Soil
J. Jpn. Soc. Soil Phys. No. +*0, p.- +*,**1 Eh * ** Reaction of a Platinum Electrode for the Measurement of Redox Potential of Paddy Soil Daisuke MURAKAMI* and Tatsuaki KASUBUCHI** * The United Graduate
GS3. A liner offset equation of the volumetric water content that capacitance type GS3 soil moisture sensor measured
J. Jpn. Soc. Soil Phys. No. 130, p.19 25 (2015) GS3 1 2 A liner offset equation of the volumetric water content that capacitance type GS3 soil moisture sensor measured Shoichi MITSUISHI 1 and Masaru MIZOGUCHI
JOURNAL OF MICROBIOLOGY May 2011 Vol. 31 No. 3. PCR bp BCCP. pet-28a Escherichia coli BL21 DE3 Ni-NTA
6 2011 5 31 3 JOURNAL OF MICROBIOLOGY May 2011 Vol. 31 No. 3 A ACC CT * 430070 PCR A ACC 2 42 ~ 147 bp 315 ~ 677 bp 6 801 bp A 3 BC BCCP CT CT pet-28a Escherichia coli BL21 DE3 Ni-NTA CT 1. 8 mg /ml ACC
Studies on purification and characteristics of glycosyltransferase from an engineering strain
DOI:10.16774/j.cnki.issn.1674-2214.2015.02.001 2015 2 4 44 2,, (, 310014) : pet28b-valg BL21(DE3), 10~40 C ph 5~11,, ph 30 C 8.0 1 mmol/l Ca 2+ Mg 2+ Mn 2+ Co 2+, Cu 2+ Zn 2+, 8 μmol/l 2 μmol/l A, K mb
ΕΘΝΙΚΟ ΜΕΤΣΟΒΙΟ ΠΟΛΥΤΕΧΝΕΙΟ
ΕΘΝΙΚΟ ΜΕΤΣΟΒΙΟ ΠΟΛΥΤΕΧΝΕΙΟ ΣΧΟΛΗ ΗΛΕΚΤΡΟΛΟΓΩΝ ΜΗΧΑΝΙΚΩΝ ΚΑΙ ΜΗΧΑΝΙΚΩΝ ΥΠΟΛΟΓΙΣΤΩΝ ΤΟΜΕΑΣ ΤΕΧΝΟΛΟΓΙΑΣ ΠΛΗΡΟΦΟΡΙΚΗΣ ΚΑΙ ΥΠΟΛΟΓΙΣΤΩΝ Σύστημα Διαχείρισης Διαχρονικών Δεδομένων για Γονίδια ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ
Electronic Supplementary Information DFT Characterization on the Mechanism of Water Splitting Catalyzed by Single-Ru-substituted Polyoxometalates
Electronic Supplementary Information DFT Characterization on the Mechanism of Water Splitting Catalyzed by Single-Ru-substituted Polyoxometalates Zhong-Ling Lang, Guo-Chun Yang, Na-Na Ma, Shi-Zheng Wen,
Βιογραφικό Σηµείωµα Ιωάννη Χαραλαµπόπουλου
ΠΡΟΣΩΠΙΚΑ ΣΤΟΙΧΕΙΑ Επώνυµο : Χαραλαµπόπουλος Όνοµα : Ιωάννης Πατρώνυµο : Νικόλαος Τόπος γεννήσεως: : Πετρούπολη Αττικής Διεύθυνση Εργασίας : Εργαστήριο Φαρµακολογίας Ιατρική Σχολή Πανεπιστηµίου Κρήτης
Correction of chromatic aberration for human eyes with diffractive-refractive hybrid elements
5 5 2012 10 Chinese Optics Vol. 5 No. 5 Oct. 2012 1674-2915 2012 05-0525-06 - * 100190-14 - - 14. 51 μm 81. 4 μm - 1. 64 μm / O436. 1 TH703 A doi 10. 3788 /CO. 20120505. 0525 Correction of chromatic aberration
The toxicity of three chitin synthesis inhibitors to Calliptamus italicus Othoptera Acridoidea
2011 48 4 909 914 * 1 2** 2 2 2 2 2*** 1. 110161 2. 100081 026000 3 Calliptamus italicus L. 3 LC 50 LC 90 1. 34 14. 17 mg / L LC 50 LC 90 2. 09 45. 22 mg / L 50 mg / L 14 d 87% 100% 50 mg / L 50% The toxicity
( ) , ) , ; kg 1) 80 % kg. Vol. 28,No. 1 Jan.,2006 RESOURCES SCIENCE : (2006) ,2 ,,,, ; ;
28 1 2006 1 RESOURCES SCIENCE Vol. 28 No. 1 Jan. 2006 :1007-7588(2006) 01-0002 - 07 20 1 1 2 (11 100101 ; 21 101149) : 1978 1978 2001 ; 2010 ; ; ; : ; ; 24718kg 1) 1990 26211kg 260kg 1995 2001 238kg( 1)
Mean bond enthalpy Standard enthalpy of formation Bond N H N N N N H O O O
Q1. (a) Explain the meaning of the terms mean bond enthalpy and standard enthalpy of formation. Mean bond enthalpy... Standard enthalpy of formation... (5) (b) Some mean bond enthalpies are given below.
LUO, Hong2Qun LIU, Shao2Pu Ξ LI, Nian2Bing
2003 61 3, 435 439 ACTA CHIMICA SINICA Vol 61, 2003 No 3, 435 439 2 ΞΞ ( 400715), 2, 2, 2, 3/ 2 2,, 2,, Ne w Methods for the Determination of the Inclusion Constant between Procaine Hydrochloride and 2Cyclodextrin
Shiraia sp. Slf14 III
39 4 Vol 39 No 4 2015 7 Journal of Jiangxi Normal University Natural Science Jul 2015 1000-5862 2015 04-0430-05 Shiraia sp Slf14 III 1 1 2 1 1 1 2* 1 330022 2 330013 Polyketide synthase PKS Shiraia sp
Nucleotide Sequence of Cloned cd NA for alpha Subunit of Goat Follicle Stimulating Hormone
ISSN 100727626 CN 1123870ΠQ 2002 12 Chinese Journal of Biochemistry and Molecular Biology 18 (6) :693 697 cdna, 3, (, 150030) RNA, cdna cdna PCR, 380 bp cdna pmd2182t2verctor 3,,, 96 %, 95 %,, 74 %, 95
19 Ενδοκρινολόγος. Φάρµακα που στοχεύουν το β- κύτταρο ΕΥΡΥΔΙΚΗ ΠΑΠΑΔΟΠΟΥΛΟΥ ΕΙΣΑΓΩΓΗ ΜΗΧΑΝΙΣΜΟΣ ΔΡΑΣΗΣ
Φάρµακα που στοχεύουν το β- κύτταρο ΕΥΡΥΔΙΚΗ ΠΑΠΑΔΟΠΟΥΛΟΥ 19 Ενδοκρινολόγος ΕΙΣΑΓΩΓΗ Οι σουλφονυλουρίες είναι η πρώτη κατηγορία υπογλυκαιμικών φαρμάκων που χορηγήθηκαν για την αντιμετώπιση του διαβήτη
Development of a Tiltmeter with a XY Magnetic Detector (Part +)
No. 2 +0,/,**, Technical Research Report, Earthquake Research Institute, University of Tokyo, No. 2, pp.+0,/,,**,. XY * * ** *** **** ***** Development of a Tiltmeter with a XY Magnetic Detector (Part
,,, (J ECFA) DNA, (enzyme preparations) ,,, CHINESE JOURNAL OF FOOD HYGIENE
(, 100021) :, FAOΠWHO (J ECFA), : ; ; Regulations of enzyme preparations used in foods in some countries and international organizations in the world Luo Xueyun (National institute for Nutrition and Food
P Ë ³μ,.. μ μ³μ²μ,.. ŠμÎ μ,.. μ μ,.. Š μ. ˆ œ ˆ Š Œˆ ŠˆŒ ƒ Œ Ÿ ˆŸ Š ˆ ˆ -ˆ ˆŠ
P9-2008-102.. Ë ³μ,.. μ μ³μ²μ,.. ŠμÎ μ,.. μ μ,.. Š μ ˆ œ ˆ Š Œˆ ŠˆŒ ƒ Œ Ÿ ˆŸ Š ˆ ˆ -ˆ ˆŠ Ë ³μ... P9-2008-102 ˆ μ²ó μ Ô± μ³ Î ± ³ μ³ ²Ö μ²êî Ö Êα μ μ - ÉμÎ ± μ²êî É ÒÌ Ê ±μ ÒÌ Êαμ 48 Ö ²Ö É Ö μ μ ±²ÕÎ
Available online at shd.org.rs/jscs/
J. Serb. Chem. Soc. 78 (1) S1 S8 (2013) Supplementary material SUPPLEMENTARY MATERIAL TO Metal complexes of N'-[2-hydroxy-5-(phenyldiazenyl)- benzylidene]isonicotinohydrazide. Synthesis, spectroscopic
Anti-inflammatory, Anti-cancer and Anti-diabetic Properties of Sterols and Polyphenols in Vegetables and Fruits
614 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /0, No. +,, 0+. 0+3 (,**3) 8 Anti-inflammatory, Anti-cancer and Anti-diabetic Properties of Sterols and Polyphenols in Vegetables and Fruits Masuko Kobori
ΔΗΜΟΚΡΙΤΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΡΑΚΗΣ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΑΓΩΓΗΣ
ΔΗΜΟΚΡΙΤΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΡΑΚΗΣ ΣΧΟΛΗ ΕΠΙΣΤΗΜΩΝ ΑΓΩΓΗΣ ΤΜΗΜΑ ΕΠΙΣΤΗΜΩΝ ΕΚΠΑΙΔΕΥΣΗΣ ΣΤΗΝ ΠΡΟΣΧΟΛΙΚΗ ΗΛΙΚΙΑ ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ Διαπολιτισμική Εκπαίδευση και Θρησκευτική Ετερότητα: εθνικές και θρησκευτικές
1(a) moat. moat. moat. 1(b) moving magnetic feature
High Altitude Observatory, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307 3000, USA e-mail: kubo@ucar.edu 1. km km 1 2 100 1) 2. 1(a) moat moat 1(a) moat 1(b) moat moat moat
Resurvey of Possible Seismic Fissures in the Old-Edo River in Tokyo
Bull. Earthq. Res. Inst. Univ. Tokyo Vol. 2.,**3 pp.,,3,.* * +, -. +, -. Resurvey of Possible Seismic Fissures in the Old-Edo River in Tokyo Kunihiko Shimazaki *, Tsuyoshi Haraguchi, Takeo Ishibe +, -.
c Key words: cultivation of blood, two-sets blood culture, detection rate of germ Vol. 18 No
2008 245 2 1) 1) 2) 3) 4) 1) 1) 1) 1) 1), 2) 1) 2) 3) / 4) 20 3 24 20 8 18 2001 2 2 2004 2 59.0 2002 1 2004 12 3 2 22.1 1 14.0 (CNS), Bacillus c 2 p 0.01 2 1 31.3 41.9 21.4 1 2 80 CNS 2 1 74.3 2 Key words:
X,60. Umiel,, Griesbach,, China Academic Journal Electronic Publishing House. All rights reserved ,Vol. 22,No.
2002,Vol. 22,No. 2 3 ( 100101 ),,,,,,, ( ), 60 Co 1 111,,,, [1 ],,,,,, Umiel,,,, 11312, [2 ] Griesbach,,, F 2 [3 ] DNA 112,,, 2,, -, [4 ] 3 :,,, 113 11311 X,60 80, :,,,, ;,,, 81 ,,,,, [1 ],,, : [5 8 ]
J. of Math. (PRC) Banach, , X = N(T ) R(T + ), Y = R(T ) N(T + ). Vol. 37 ( 2017 ) No. 5
Vol. 37 ( 2017 ) No. 5 J. of Math. (PRC) 1,2, 1, 1 (1., 225002) (2., 225009) :. I +AT +, T + = T + (I +AT + ) 1, T +. Banach Hilbert Moore-Penrose.. : ; ; Moore-Penrose ; ; MR(2010) : 47L05; 46A32 : O177.2
ER-Tree (Extended R*-Tree)
1-9825/22/13(4)768-6 22 Journal of Software Vol13, No4 1, 1, 2, 1 1, 1 (, 2327) 2 (, 3127) E-mail xhzhou@ustceducn,,,,,,, 1, TP311 A,,,, Elias s Rivest,Cleary Arya Mount [1] O(2 d ) Arya Mount [1] Friedman,Bentley
1.6 Other Intramolecular Decarboxylative Coupling Reactions Decarboxylative Coupling Reaction of Allyl Carboxylates
Contents Part I New Carbon Carbon Coupling Reactions Based on Decarboxylation 1 Transition Metal-Catalyzed Decarboxylation and Decarboxylative Cross-Couplings... 3 1.1 Introduction... 3 1.2 Metal-Catalyzed
Αξιοποίηση Φυσικών Αντιοξειδωτικών στην Εκτροφή των Αγροτικών
Ζώων για Παραγωγή Προϊόντων Ποιότητας» 1 Αξιοποίηση Φυσικών Αντιοξειδωτικών στην Εκτροφή των Αγροτικών Ζώων για Παραγωγή Προϊόντων Ποιότητας Γεωπονικό Πανεπιστήμιο Αθηνών Εργαστήριο Ζωοτεχνίας MIS 380231
Progress in breeding techniques of ornamental plants
2003,32(2):64-68. 650091 S603.6 A 1009-7791(2003)02-0064-05 Progress in breeding techniques of ornamental plants LIU Xiao-li, LIU Fei-hu (College of Life Science, Yunnan University, Kunming 650091, Yunnan
Study on AgrobacteriunΟmediated transformation of tobacco plant with rol C gene
2001, 24 (1) : 2529 Journal of Nanjing Agricultural University rolc (, 210095) :, rolc ( Nicotiana tabacum ), GUS, PCR Southern rolc,, rolc : ; ; rolc ; : S572103513 : A : 1000Ο2030 (2001) 01Ο0025Ο05 Study
The 6 th National Biotechnology Congress of Iran Aug, 2009, Milad Tower Conference Hall, Tehran-Iran
388 22-24 **2 * (parisa.aghagolzade.golzade@gmail.com)( fatemeh.zamansani@gmail.com) 2 (ebrahimie@shirazu.ac.ir). - ATPase. ATP ca 2+ / H + - Antiporter. H + ca 2+ ATP.. F test Feature selection.. β-strand
ΒΙΟΛΟΓΟΣ, ΔΙΑΤΡΟΦΟΛΟΓΟΣ ΕΡΓΑΣΤΗΡΙΟ ΠΕΙΡΑΜΑΤΙΚΗΣ ΧΕΙΡΟΥΡΓΙΚΗΣ & ΧΕΙΡΟΥΡΓΙΚΗΣ ΕΡΕΥΝΗΣ «Ν.Σ. ΧΡΗΣΤΕΑΣ», Ιατρική Σχολή, ΕΚΠΑ
& ΒΙΟΛΟΓΟΣ, ΔΙΑΤΡΟΦΟΛΟΓΟΣ ΕΡΓΑΣΤΗΡΙΟ ΠΕΙΡΑΜΑΤΙΚΗΣ ΧΕΙΡΟΥΡΓΙΚΗΣ & ΧΕΙΡΟΥΡΓΙΚΗΣ ΕΡΕΥΝΗΣ «Ν.Σ. ΧΡΗΣΤΕΑΣ», Ιατρική Σχολή, ΕΚΠΑ Πολυγονιδιακές Ασθένειες Πολυγονιδιακές = οι παθήσεις που οφείλονται σε µεταλλάξεις
Research on Economics and Management
36 5 2015 5 Research on Economics and Management Vol. 36 No. 5 May 2015 490 490 F323. 9 A DOI:10.13502/j.cnki.issn1000-7636.2015.05.007 1000-7636 2015 05-0052 - 10 2008 836 70% 1. 2 2010 1 2 3 2015-03
«ΑΓΡΟΤΟΥΡΙΣΜΟΣ ΚΑΙ ΤΟΠΙΚΗ ΑΝΑΠΤΥΞΗ: Ο ΡΟΛΟΣ ΤΩΝ ΝΕΩΝ ΤΕΧΝΟΛΟΓΙΩΝ ΣΤΗΝ ΠΡΟΩΘΗΣΗ ΤΩΝ ΓΥΝΑΙΚΕΙΩΝ ΣΥΝΕΤΑΙΡΙΣΜΩΝ»
I ΑΡΙΣΤΟΤΕΛΕΙΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΘΕΣΣΑΛΟΝΙΚΗΣ ΣΧΟΛΗ ΝΟΜΙΚΩΝ ΟΙΚΟΝΟΜΙΚΩΝ ΚΑΙ ΠΟΛΙΤΙΚΩΝ ΕΠΙΣΤΗΜΩΝ ΤΜΗΜΑ ΟΙΚΟΝΟΜΙΚΩΝ ΕΠΙΣΤΗΜΩΝ ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ ΣΤΗΝ «ΔΙΟΙΚΗΣΗ ΚΑΙ ΟΙΚΟΝΟΜΙΑ» ΚΑΤΕΥΘΥΝΣΗ: ΟΙΚΟΝΟΜΙΚΗ
BL21 (D E3)2p E T28a ( + )2bgl 2
28 2 2009 3 Journal of Food Science and Biotechnology 28 No. 2 Vol. Mar. 2009 :167321689 (2009) 0220250206 BL21 (D E3)2p E T28a ( + )2bgl 2,, 3, (, 214122) : 2E. coli BL21 (DE3)2p ET28a ( + )2bgl LB, p
TGFp FSH INH INH
(210095) E-mail ( genlinwang@hotmail.com) - -(Strept Avidin-Biotin-Peroxidase Complex SABC), 1 32,, 1 inhibin INH α 32 000 TGFp FSH FSH [1] INHα Sertoli Noguchi 1997 [2] Meunier et al.1988 [3] INH INH
ADVANCED STRUCTURAL MECHANICS
VSB TECHNICAL UNIVERSITY OF OSTRAVA FACULTY OF CIVIL ENGINEERING ADVANCED STRUCTURAL MECHANICS Lecture 1 Jiří Brožovský Office: LP H 406/3 Phone: 597 321 321 E-mail: jiri.brozovsky@vsb.cz WWW: http://fast10.vsb.cz/brozovsky/
Development of a Seismic Data Analysis System for a Short-term Training for Researchers from Developing Countries
No. 2 3+/,**, Technical Research Report, Earthquake Research Institute, University of Tokyo, No. 2, pp.3+/,,**,. * * Development of a Seismic Data Analysis System for a Short-term Training for Researchers
Quantitative chemical analyses of rocks with X-ray fluorescence analyzer: major and trace elements in ultrabasic rocks
98 Scientific Note X : Quantitative chemical analyses of rocks with X-ray fluorescence analyzer: major and trace elements in ultrabasic rocks Kimiko Seno and Yoichi Motoyoshi,**- +, +, ;,**. -,/ Abstract:
, Litrrow. Maxwell. Helmholtz Fredholm, . 40 Maystre [4 ], Goray [5 ], Kleemann [6 ] PACC: 4210, 4110H
![, Litrrow. Maxwell. Helmholtz Fredholm, . 40 Maystre [4 ], Goray [5 ], Kleemann [6 ] PACC: 4210, 4110H](/thumbs/88/115525025.jpg ", Litrrow. Maxwell. Helmholtz Fredholm, . 40 Maystre [4 ], Goray [5 ], Kleemann [6 ] PACC: 4210, 4110H")
57 6 2008 6 100023290Π2008Π57 (06) Π3486208 ACTA PHYSICA SINICA Vol. 57,No. 6,June,2008 ν 2008 Chin. Phys. Soc. 3 1) 2) 1) g 1) (, 130033) 2) (, 100049) (2007 9 11 ;2007 11 14 ),Littrow,,.,., Litrrow.
Free Radical Initiated Coupling Reaction of Alcohols and. Alkynes: not C-O but C-C Bond Formation. Context. General information 2. Typical procedure 2
Free Radical Initiated Coupling Reaction of Alcohols and Alkynes: not C-O but C-C Bond Formation Zhongquan Liu,* Liang Sun, Jianguo Wang, Jie Han, Yankai Zhao, Bo Zhou Institute of Organic Chemistry, Gannan
Μέτρηση της Ρυθµικής Ικανότητας σε Μαθητές Γυµνασίου που Ασχολούνται µε Αθλητικές ραστηριότητες Συνοδευµένες ή Όχι από Μουσική
Ερευνητική Αναζητήσεις στη Φυσική Αγωγή & τον Αθλητισµό τόµος 3 (1), 22 28 ηµοσιεύτηκε: 11 Φεβρουαρίου 2005 Inquiries in Sport & Physical Education Volume 3 (1), 22-28 Released: February 11, 2005 www.hape.gr/emag.asp
coronary heart disease CHD 40% [1] atherosclero- sis AS 52.27±5.3 2~6. / polycyclic aromatic hydrocarbons PAHs
![coronary heart disease CHD 40% [1] atherosclero- sis AS 52.27±5.3 2~6. / polycyclic aromatic hydrocarbons PAHs](/thumbs/91/107201748.jpg "coronary heart disease CHD 40% [1] atherosclero- sis AS 52.27±5.3 2~6. / polycyclic aromatic hydrocarbons PAHs")
140 1674-6309 2017 02-0140-04 1 2 1 AhR rs2066853-205 190 - AS-PCR AhR rs2066853 AhR rs2066853 χ 2 AhR rs2066853 OR 95%CI AhR rs2066853 AA AG GG χ 2 =6.48 P
ΒΙΟΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ Ν.Κ. ΜΟΣΧΟΝΑ (Νοεμβριος 2013)
ΒΙΟΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ Ν.Κ. ΜΟΣΧΟΝΑ (Νοεμβριος 2013) 1. ΑΤΟΜΙΚΑ ΣΤΟΙΧΕΙΑ Όνομα: Νικόλαος Κ. Μοσχονάς Ημερομηνία Γεννήσεως: 21 Νοεμβρίου 1952 Οικογενειακή Κατάσταση: Έγγαμος, δύο παιδία 2. ΣΠΟΥΔΕΣ 1979-1981:
Ίδρυμα Τεχνολογίας & Έρευνας (ΙΤΕ)
Ίδρυμα Τεχνολογίας & Έρευνας (ΙΤΕ) Ινστιτούτο Μοριακής Βιολογίας & Βιοτεχνολογίας (IMBB) Ηράκλειο, Κρήτη Σύντομη Ιστορία του ΙΜΒΒ Ιδρύθηκε το 1983 Ένα από τα Ινστιτούτα του Ερευνητικού Κέντρου Κρήτης (ΕΚΕΚ)
Supporting information. Influence of Aerosol Acidity on the Chemical Composition of Secondary Organic Aerosol from β caryophyllene
Supporting information Influence of Aerosol Acidity on the Chemical Composition of Secondary Organic Aerosol from β caryophyllene M. N. Chan 1, J. D. Surratt 2,*, A. W. H. Chan 2,**, K. Schilling 2, J.
Accumulation of Soil Arsenic by Panax notoginseng and Its Associated Health Risk
32 3 2011 3 ENVIRONMENTAL SCIENCE Vol 32 No 3 Mar 2011 1 1 1 2 1 100101 2 663000 Panax notoginseng Burk F H Chen 6 9 ~ 242 0 mg kg - 1 48% 2 mg kg - 1 24% 81% 14% 57% 44% 100 mg kg - 1 ADI > > > > FAO
Evolution of Novel Studies on Thermofluid Dynamics with Combustion
MEMOIRS OF SHONAN INSTITUTE OF TECHNOLOGY Vol. 42, No. 1, 2008 * Evolution of Novel Studies on Thermofluid Dynamics with Combustion Hiroyuki SATO* This paper mentions the recent development of combustion
Œ.. ² μ,.. Œ ²μ, ƒ.. μ ±μ,. Ô Ô ², Œ.. ƒê Éμ, Œ.. Œ ² μ *
6-2008-5 Œ.. ² μ,.. Œ ²μ, ƒ.. μ ±μ,. Ô Ô ², Œ.. ƒê Éμ, Œ.. Œ ² μ * ˆ ˆ ˆˆ U(VI) ˆ ˆ ˆ ˆ Š ˆ ² μ Ê ² μì ³ Ö *, μ -, μ² Ö ² μ Œ... 6-2008-5 ˆ ² μ μ Í U(VI) μî μ μ Ì ² Ð μ ±É ÒÌ μéìμ μ ˆ ² μ μ Í Ö U(VI) μî
Prey-Taxis Holling-Tanner
Vol. 28 ( 2018 ) No. 1 J. of Math. (PRC) Prey-Taxis Holling-Tanner, (, 730070) : prey-taxis Holling-Tanner.,,.. : Holling-Tanner ; prey-taxis; ; MR(2010) : 35B32; 35B36 : O175.26 : A : 0255-7797(2018)01-0140-07
Comparison of Evapotranspiration between Indigenous Vegetation and Invading Vegetation in a Bog
J. Jpn. Soc. Soil Phys. No. +*-, p.-3.1,**0 ** * *** Comparison of Evapotranspiration between Indigenous Vegetation and Invading Vegetation in a Bog Toshiki FUJIMOTO*, Ippei IIYAMA*, Mai SAKAI*, Osamu
Introduction to Bioinformatics
Introduction to Bioinformatics 260.602.01 September 2, 2005 Jonathan Pevsner, Ph.D. pevsner@jhmi.edu bioinformatics medical informatics Tool-users public health informatics databases algorithms Tool-makers