Anti-inflammatory, Anti-cancer and Anti-diabetic Properties of Sterols and Polyphenols in Vegetables and Fruits

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1 614 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /0, No. +,, (,**3) 8 Anti-inflammatory, Anti-cancer and Anti-diabetic Properties of Sterols and Polyphenols in Vegetables and Fruits Masuko Kobori National Food Research Institute, National Agriculture and Food Research Organization, + +, Kannondai, Tsukuba, Ibaraki -*/ 20., +.3,21 Hyzsozigus marmoreus Phliota nameko 0 HL0* HL0* Sarcodon aspratus +. HL0* ergosterol peroxide / a, 2 a-epidioxy-,, + E-ergosta- 0,,, -diene--b-ol 3++, Lentinus edodes Len- 3++, -dehydroergosterol pertinan Corolus versicolor oxide / a 2 a-epidioxy-,, E-ergosta- 0, 3 ++,,-trien- 12 PSK polysaccharide-k bo - b-ol + b-glucan Biological Response Modifiers, BRM ergosterol + / D, in vitro 3++, HL0* 3++, -*/ 20.,, + +, Corresponding author kobori@a# rc.go.jp,

2 9 : A 3, ++ B 3 C, 3++, in vitro HT,3 HT,3 2 HL0*, +* HT,3 3 DNA 3++, Momordica HL0*,. charantia L. WST , momordicosides K L, Momordicine 3, ++ WI-2 a a-eleostearic acid, ( 3 Z, ++ E, +-E)- 3, ++, +--Octadecatrienoic acid 3 STAT-+ HL0* RAW, lipopolysaccharide, LPS,. TNFa HL0* 3

616 /0 +,,**3 +, 10 - HL0* pericarp placenta seeds,. DNA,,-/2 ++ 3 + +/ +0 ao +/, +0 -dihydroxy a-eleostearic acid. ++ +, +, +- +. DNA Streptozotocin STZ ++ +-.

3 616 /0 +,,**3 +, 10 - HL0* pericarp placenta seeds,. DNA,,-/ / +0 ao +/, +0 -dihydroxy a-eleostearic acid. ++ +, +, DNA Streptozotocin STZ /, +0 a ao HL0* HT,3 HT,3 in vivo HT,3 RAW,0.. 1 LPS -,** DNA RAW,0.. 1 LPS 0/ DNA / LPS NF-kB MAP P LPS NF-kB MAP in vitro +- STZ. BALBc + -a-linolenoyl lysophosphatidylcholine (LPC),,,-a-linolenoyl LPC, + -lynoleoyl LPC,-linoleoyl LPC 0 LPS +/ +,

4 11 : 617 / RAW,0.. 1 LPS, ngml Bitter gourd 0 RNA DNA a LPC +, a LPC, + +- LPC -, LPC. TBARS DNA STZ / C/1BL0 */., +/ 1 */. Cdkn+ a Cdkn+ a STZ. Cdkn+ a SGLT Cdkn+ a +/ STZ,

5 618 /0 +,,**3 +, 12 1 STZ STZ 0./ Welch s one-way ANOVA, P**/. control ; STZ ; STZ STZ Quer *+. ; *+. STZ STZ Quer */. ; */. STZ +/ 2 STZ 2 TBARS *+. */. +0 STZ SGLT

6 13 : 619 Y., Kasuga, Y., Matsuzawa, T., Ikekawa, T., Sasaki, S. and Tsugane, S., Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan. Nutr. Cancer,.0, (,**-). 1 Takei, T., Yoshida, M., Ohnishi-Kameyama, M. and Kobori, M., Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.) S. Ito. Biosci. Biotech. Biochem., 03,,+,,+/ (,**/). 2 Kobori, M., Yoshida, M., Ohnishi-Kameyama, M., Takei, T. and Shinmoto, H., / a, 2 a-epidioxy-,, E-ergosta- 0, 3 ( ++ ),,,-trien--b-ol from an edible mushroom suppresses growth of HL0* leukemia and HT,3 colon adenocarcinoma cells. Biol. Pharm. Bull.,,3, 1// 1/0 (,**0). 3 Kobori, M., Yoshida, M., Ohnishi-Kameyama, M. and Shinmoto, H., Ergosterol peroxide from an edible mushroom suppresses inflammatory responces in RAW,0.. 1 macrophages and growth of HT,3 colon adenocarcinoma cells. Br. J. Pharmacol., /*,,*3,+3 (,**1). +* Grover, J.K. and Yadav, S.P., Pharmacological actions and potential uses of Momordica charantia : a review. J. Enthopharmacol., 3-, +,- +-, (,**.). ++ /-.*2.+/,**0 +, Kobori, M., Ohnishi-Kameyama, M., Akimoto, Y., Yukizaki, C. and Yoshida, M., Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J. Agric. Food Chem., /0, +*/+/ +*/,* (,**2). +- Kobori, M., Nakayama, H., Fukushima, K., Ohnishi- Kameyama, M., Ono, H., Fukushima, T., Akimoto, Y., Masumoto, S., Yukizaki, C., Hoshi, Y., Deguchi, T. and + Takei, T., Yoshida, M., O-Kameyama, M. and Kobori, M., Yoshida, M., Bitter gourd suppresses lipopolysaccharide- Ergosterol peroxide, an apoptosis-inducing component induced inflammatory responses. J. Agric. Food Chem., isolated from Sarcodon aspratus (Berk.) S. Ito. Biosci. /0,.**..*++ (,**2). Biotech. Biochem., 03,,+,,+/ (,**/). +. K. Nagai, K., Takahashi, Y., Mikami, I., T. Fukushima, T.,, Oike H. and Kobori M., Fisetin suppresses mast cell activation induced by interaction with activated T cell.3,/*,/0,**, membranes. Br. J. Pharmacol., +/2, 3*13+3 (,**3). - Katsube, N., Iwashita, K., Tsushida, T., Yamaki, K. and +/ Kobori, M., Masumoto, S., Akimoto, Y., Takahashi, Y., Kobori, M., Induction of apoptosis in cancer cells by Dietary quercetin alleviates diabetic symptoms and Bilberry (Vaccinium myrtillus) and the anthocyanins. J. reduces streptozotocin-induced disturbance of hepatic Agric. Food. Chem., /+, 021/ (,**-). gene expression in mice. Mol. Nutr. Food Res., /-, 2/3. 20/ (,**3). +0 Masumoto, S., Akimoto, Y., Oike, H. and Kobori, M.,.3 /+3 /,0,**, Dietary phloridzin reduces blood glucose levels and / Kidd, P.M., The use of mushroom glucans and pro- reverses Sglt+ expression in the small intestine in teoglycans in cancer treatment. Altern. Med. Rev., /,. streptozotocin-induced diabetic mice. J. Agric. Food,1 (,***). Chem., /1,.0/+.0/0 (,**3). 0 Hara, M., Hanaoka, T., Kobayashi, M., Otani, T., Adachi, H.Y., Montani, A., Natsukawa, S., Shaura, K., Koizumi,,+ 2 +2

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