R741 A Research on Chinese Medicine Promoting Nerve Regeneration

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1 DOI / j. issn R741 A Research on Chinese Medicine Promoting Nerve Regeneration LI Xin MENG Lingyu College of Basic Medical Sciences Changchun University of Chinese Medicine Changchun Jilin China Abstract Nerve regeneration is neuroscience and clinical research hotspot and difficulty mainly in nerve suture breakage neurotrophic factors tissue engineering stem cells gene therapy to promote nerve regeneration research. Chinese medicine as a treasure of Chinese medicine according to its nerve injury regeneration insights is gradually becoming a hot research to promote nerve regeneration. The current study focused on the compound Chinese medicine single herbs acupuncture and several other key aspects and have achieved good results. The author reviewed the above three aspects of their papers and the recent progress in promoting nerve regeneration that Chinese medicine to promote nerve regeneration has good prospects for development. Key words nerve regeneration medicine acupuncture progress 3 3 MS 2 MS MS MS J J J

2 Bcl - 2 /Bax 12 bfgf NGF AKT /PKB VEGF Flk TGF - β TGF - β AchE 70 HSP70 14 MBP 1 EAE GAP - 43 MAP NF Wang L 23 Yang S 2 H 2 O μg /ml 1 h H 2 O 2 12 h MDA Nogo A Wang L / / - 1 / - 2 / Chen A 4 RN SCI SCI middle cerebral artery occlusion MCAO DPN NSCs MCAO NSCs SDF - 1 L4-6 NR2B 8 DRG pnf - H VEGF %

3 A A AMPK 2 LKB1 A 2. 1 Yang XY 47 NSC BMSC A AGEs enos Yu NSE XY 48 B - 2 MAP ~ 25 mg /kg GFAP 28 Nestin Lin YH 49 B β - B 29 BPRP 30 B BPRP NCAM c - fos 31 NSC NSC NGFmRNA NSC NGF SOD MDA Ca 2 + Caspase ⅡA TanⅡA Cheng CY mmol CA1 L - Ca 2 + mrna Ca mmol μmol /L Rg1 Rg1 SVZ 35 Rg1 NSC Hes1 SVZ 36 Rb1 Rb3 Rg1 54 NSC 37 Rg1 Rb Ma J 39 Rg1 EGb Rg1 Lu ZF 40 Rg1 Cheng B 55 GBE h h Caspase SOD GSH - Px Jahanshahi M 56 NOS MDA 41 MCAO VEGF 42 Zhao L 57 BDNF EGB761 bfgf 43 Smith 58 EGb PC12 NSC 44 GFAP EGb Jeong JB 46 PGC - 1α SIRT3 nnos C C A SALA 59 EGb761

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