1043 NJA National Journal of Andrology Zhonghua Nan Ke Xue Za Zhi 2011 17 11 1043-1049 http / /www. androl. cn R698 A 1009-3591 2011 11-1043-07 1 1. 1 1. 1. 1 premature ejaculation PE 1-3 PE / PE PE PE PE 7 1. 1. 3 8 PE PE 1 ~ 2 min PE PE PE PE PE 4-5 1. 1. 2 PE 1. 1. 3. 1 PE PE 1 2 / 3 4 90% 30 ~ 60 s 5 PE Ⅳ- diagnostic and statistical manual of mental disorders IV-Text revision DSM- IV -TR PE 6 international society for sexual medicine ISSM PE 1 min PE 1 4 1. 1. 3. 2 PE 1 2PE 3PE 4 5
1044 1. 1. 3. 3 PE PE PE 15 1 2 PE quality of life QoL 3 1. 1. 3. 4 PE PE / 3 1 PE 16-17 PE 2 IELT 3 IELT 4 QoL erectile dysfunction ED PE 1 4 PE PE 3 1 IELT PE PE PE 2 3 1. IELT IELT IELT IELT / 2. 3. 4. 1 = IELT 2 = 3 = 4 = 2 18 3. 1 PE PE IELT 19-20 IELT PE IELT 21 IELT 2. 1 PE IELT PE 2% ~ 5% PE 80% 80% 22 PE 3-4 IELT PE 20% ~ 30% 9 0 = 4 = PE 0 = 4 = 2. 2 4 PE patient-reported outcome PRO 10-11 PE 5-12 5-96% / 5- IELT PE PE 3. 2 PE PROs 18 PE PE PE PE 2. 3 PE PE 3. 2. 1 premature ejaculation diagnostic tool PEDT 13-14 PE 23-24 3. 2. 2 Arabic index of premature
1045 ejaculation AIPE 3. 2. 3 2 3. 3 PE 25 PE PE premature ejaculation profile PEP 26 Peyronie index of premature ejaculation IPE 27 male sexual health 29 questionnaire ejaculatory dysfunction MSHQ-EjD 28 3. 4 PE 3 2 CIPE 1 2 3 4 5 1. 2. 3. 4. > 3 min 4 ~ 5 min 6 ~ 10 min < 30 s 1 min 2 min 3 min 11 ~ 20 min > 21 min 5. 6. 7. 8. 9. 10. CIPE = 3 PE PE IELT 1a A IELT IELT 2a B PROs PE PROs 3 C PE PE ED 3 C 3 C 4 SSRIs 3 PE PE 5 selective serotonin reuptake inhibitors SSRIs 4 PE PE 1 PE PE 4. 1 / PE 4. 1. 1 PE SSRIs 4. 1. 2 1-2 PE start-stop 30 2
1046 1 ~ 2 1 ~ 2 3 SSRIs 50% ~ 60% 31-32 2 ~ 3 41 33-34 4. 2 ED 4. 3. 1 SSRIs SSRIs 4. 2. 1 - - SSRIs 5% 20 ~ 30 min 4. 3. 2 SSRIs SSRIs PE Tmax 1. 5 h TEMPE 35 PE 7. 5 mg + 2. 5 mg 1 958 TEMPE 42 1 min 4. 9 min 30 60 mg 1 ~ 3 h 0. 9 min 1. 6 min P < 0. 01 TEMPE 5 ~ 10 min ED 36-37 6 ~ 12 PE 30 mg 60 mg 0. 9 min 1. 75 min 2. 78 min 3. 32 min 30 mg 60 mg 4. 2. 2 SS SS 9 51% 58% 1 h 30 mg SS 60 mg 8. 7% 20. 1% 3. 9% 6. 8% 38-39 0. 2 g SS 5. 9% 6. 8% 3. 0% 6. 2% IELT 1. 37 min 10. 92 min 32% 2. 45 min 18. 5% 2 SS 5-43 95% PE 4. 3 5 SSRIs 7- PE SSRIs 67. 1% IELT SD 3. 7 SSRIs IELT 2. 6 ~ 4. 3 vs 0. 77 1. 8 min 30 60 mg 40 13. 2 PE 2 Cochrane SSRIs 36. 3% 44. 5% vs 15% IELT 4. 4 5 45 20 ~ 40 mg 5 25 ~ 200 mg 10 ~ 60 mg PDE - 5 PE 25 ~ 50 mg SSRIs 46-49
1047 4. 5 α PE 57 50 58 PE 51-52 5- PE 53-55 4. 6 56 4. 7 PE 4 PE 1 4 PE ED 2a B PE 3 C PE 1a A SSRIs PE SSRIs pm 1a A SSRIs 7 PE 1a A SSRIs off-line 1b A PDE5 2B C 1b A 3 C 1 * PE * Lue et al. 2004 49 IELT = PE = ED = SSRIs = 5-
1048 Behav 2003 32 3 261-270. 16 Sharlip I. Diagnosis and treatment of premature ejaculation The physician's perspective. J Sex Med 2005 2 suppl 2N 103-109. 17 Shabsigh R. Diagnosing premature ejaculation A review. J Sex Med 2006 3 suppl 4N 318-323. 1 Waldinger MD Schweitzer DH. Changing paradigms from an historical DSM-III and DSM-IV view towards an evidence based definition of premature ejaculation. Part I Validity of DSM-IV-TR. J Sex Med 2006 3 4 682-692. 2 Waldinger MD Schweitzer DH. Changing paradigms from an historical DSM-III and DSM-IV view towards an evidence based definition of premature ejaculation. Part II Proposals for DSM-V and ICD-11. J Sex Med 2006 3 4 693-705. 3 Waldinger MD. The need for a revival of psychoanalytic investigations into premature ejaculation. J Mens Health Gend 2006 3 390-396. 4 Waldinger MD. Premature ejaculation State of the art. Urol Clin North Am 2007 34 4 591-599. 5 Waldinger MD. Premature ejaculation Different pathophysiologies and etiologies determine its treatment. J Sex Marital Ther 2008 34 1 1-13. 6 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th Ed. Text Revision. Washington D. C. American Psychiatric Publishing Inc 2000. 7 McMahon CG Althof SE Waldinger MD et al. An evidencebased definition of lifelong premature ejaculation Report of the International Society for Sexual Medicine ISSM ad hoc committee for the definition of premature ejaculation. J Sex Med 2008 5 7 1590-1606. 8 Godpodinoff ML. Premature ejaculation Clinical subgroups and etiology. J Sex Marital Ther 1989 15 2 130-134. 9 St. Lawrence JS Madakasira S. Evaluation and treatment of premature ejaculation A critical review. Int J Psychiatr Med 1992 22 77-97. 10 Waldinger MD Schweitzer DH. The use of old and recent DSM definitions of premature ejaculation in observational studies A contribution to the present debate for a new classification of PE in the DSM-V. J Sex Med 2008 5 5 1079-1087. 11 Waldinger MD Hengeveld MW Zwinderman AH et al. An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation. Intern J Psychiatry Clin Pract 1998 2 287-293. 12 Waldinger MD. The neurobiological approach to premature ejaculation. J Urol 2002 168 6 2359-2367. 13 Rowland D Perelman M Althof S et al. Self-reported premature ejaculation and aspects of sexual functioning and satisfaction. J Sex Med 2004 1 2 225-232. 14 Rowland DL Patrick DL Rothman M et al. The psychological burden of premature ejaculation. J Urol 2007 177 3 1065-1070. 15 Byers ES Grenier G. Premature or rapid ejaculation Heterosexual couples' perceptions of men's ejaculatory behavior. Arch Sex 18 Althof SE Symonds T. Patient reported outcomes used in the assessment of premature ejaculation. Urol Clin North Am 2007 34 4 581-589 vii. 19 Giuliano F Patrick DL Porst H et al. Premature Ejaculation Results from a five-country European observational study. Eur Urol 2008 53 5 1048-1057. 20 Patrick DL Althof SE Pryor JL et al. Premature ejaculation An observational study of men and their partners. J Sex Med 2005 2 3 358-367. 21 Patrick DL Rowland D Rothman M. Interrelationships among measures of premature ejaculation The central role of perceived control. J Sex Med 2007 4 3 780-788. 22 Rosen RC McMahon CG Niederberger C et al. Correlates to the clinical diagnosis of premature ejaculation Results from a large observational study of men and their partners. J Urol 2007 177 3 1059-1064. 23 Symonds T Perelman M Althof S et al. Further evidence of the reliability and validity of the premature ejaculation diagnostic tool. Int J Impot Res 2007 19 5 521-525. 24 Symonds T Perelman MA Althof S et al. Development and validation of a premature ejaculation diagnostic tool. Eur Urol 2007 52 2 565-573. 25 Arafa M Shamloul R. Development and evaluation of the Arabic Index of Premature Ejaculation AIPE. J Sex Med 2007 4 6 1750-1756. 26 Patrick DL Althof SE Pryor JL et al. Premature ejaculation An observational study of men and their partners. J Sex Med 2005 2 3 358-367. 27 Althof S Rosen R Symonds T et al. Development and validation of a new questionnaire to assess sexual satisfaction control and distress associated with premature ejaculation. J Sex Med 2006 3 3 465-475. 28 Rosen RC Catania JA Althof SE et al. Development and validation of four-item version of Male Sexual Health Questionnaire to assess ejaculatory dysfunction. Urology 2007 69 5 805-809. 29 Shabsigh R. Diagnosing premature ejaculation A review. J Sex Med 2006 3 4 318-323. 30 Semans JH. Premature ejaculation A new approach. South Med J 1956 49 4 353-358. 31 Grenier G Byers ES. Rapid ejaculation A review of concep-tual etiological and treatment issues. Arch Sex Behav 1995 24 4 447-472. 32 Metz ME Pryor JL Nesvacil LJ et al. Premature ejaculation A psychophysiological review. 1 3-23. J Sex Marital Ther 1997 23 33 De Amicis LA Goldberg DC LoPiccolo J et al. Clinical follow-
1049 up of couples treated for sexual dysfunction. Arch Sex Behav 1985 14 6 467-489. 34 Hawton K Catalan J Martin P et al. Long-term outcome of sex therapy. Behav Res Ther 1986 24 4 665-675. 35 Henry R Morales A Wyllie MG. TEMPE Topical eutectic-like mixture for premature ejaculation. Expert Opin Drug Deliv 2008 5 2 251-261. 36 Dinsmore WW Hackett G Goldmeier D et al. Topical eutectic mixture for premature ejaculation TEMPE A novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int 2007 99 2 369-375. 37 Henry R Morales A. Topical lidocaine-prilocaine spray for the treatment of premature ejaculation A proof of concept study. Int J Impot Res 2003 15 4 277-281. 38 Xin ZC Choi YD Seong DH et al. Sensory evoked potential and effect of SS-cream in premature ejaculation. Yonsei Med J 1995 36 5 397-401. 39 Xin ZC Choi YD Lee WH et al. Penile vibratory threshold changes with various doses of SS-cream in patients with primary premature ejaculation. Yonsei Med J 2000 41 1 29-33. 40. 5- Urol 1995 28 2 126-30.. 53 Safarinejad MR Hosseini SY. Safety and efficacy of tramadol in 2009 15 3 248-255. the treatment of premature ejaculation A double-blind placebocontrolled fixed-dose randomized study. J Clin Psychopharma- Huang XK Lu YP Luo SW et al. Zhonghua Nan Ke Xue Za Zhi 2009 15 3 248-255. col 2006 26 1 27-31. 41 Waldinger MD. Premature ejaculation Definition and drug treatment. Drugs 2007 67 4 547-568. 42.. Med 2008 5 1 188-193. 2001 7 2 97-98. Dai JC Li LG. Zhonghua Nan Ke Xue 2001 7 2 97-98. 43 Pryor JL Althof SE Steidle C et al. Dapoxetine Study Group. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation An integrated analysis of two double-blind randomised controlled trials. Lancet 2006 368 9539 929-937. 44 Shabsigh R Patrick DL Rowland DL et al. Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation Results from phase III trials with dapoxetine. BJU Int 2008 102 7 824-828. 45. 57... 2005 11 7 520-522. Zhang XS Wang YX Huang XY et al. Zhonghua Nan Ke Xue Za Zhi 2005 11 7 520-522. 46 Chen J Keren-Paz G Bar-Yosef Y et al. The role of phosphodiesterase type 5 inhibitors in the management of premature ejaculation A critical analysis of basic science and clinical data. Eur Urol 2007 52 5 1331-1339. 47 McMahon CG McMahon CN Leow LJ et al. Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature e- jaculation A systematic review. BJU Int 2006 98 2 259-272. 48 Wang WF Minhas S Ralph DJ. Phosphodiesterase 5 inhibitors in the treatment of premature ejaculation. Int J Androl 2006 29 5 503-509. 49. 2004 10 5 366-367. Tang WH Ma LL Zhao LM et al. Zhonghua Nan Ke Xue 2004 10 5 366-367. 50 Hsieh JT Chang HC Law HS et al. In vivo evaluation of serotonergic agents and alpha-adrenergic blockers on premature ejaculation by inhibiting the seminal vesicle pressure response to electrical nerve stimulation. Br J Urol 1998 82 2 237-240. 51 Basar MM Yilmaz E Ferhat M et al. Terazosin in the treatment of premature ejaculation A short-term follow-up. Int Urol Nephrol 2005 37 4 773-777. 52 Cavallini G. Alpha-1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy. Eur 54 Salem EA Wilson SK Bissada NK et al. Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex 55.. 2011 17 6 538-541. Xiiong GG Wu FH Chen SH et al. Zhonghua Nan Ke Xue Za Zhi 2011 17 6 538-541. 56. 128. 2005 11 10 789-791. Zhang CY Zhang HF Guo J et al. Zhonghua Nan Ke Xue Za Zhi 2005 11 10 789-791. 2003 9 3 227-228. Mao XM Zheng SB Sei AY. Zhonghua Nan Ke Xue 2003 9 3 227-228. 58.. 2006 12 3 225-227. Zhang SJ Zhao YM Zheng SG et al. Zhonghua Nan Ke Xue Za Zhi 2006 12 3 225-227. 2011-09-26 2011-10-08