Feedback Regulation of Adipocytokines in Proliferation and Differentiation of Adipocyte

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1 ISSN CN / Q http / / cjbmb bjmu edu cn Chinese Journal of Biochemistry and Molecular Biology ~ 217 * R589 2 Feedback Regulation of Adipocytokines in Proliferation and Differentiation of Adipocyte ZHOU Yan-Lan CHI Yu-Jing GUAN You-Fei YANG Ji-Chun * Department of Physiology and Pathophysiology Peking University Diabetes Center Peking University Health Science Center Beijing China Abstract Obesity has been demonstrated to be a causal factor of insulin resistance type 2 diabetes hypertension hyperlipidemia coronary heart disease and other metabolic diseases Obesity is generally indicated by abnormal increased number and mass of adipocytes leading to excessive deposition of lipids The proliferation and differentiation of preadipocyte is regulated by many factors including hormones nutrients and adipocytokines which are referred to the cytokines secreted by adipose tissues In animal models and a majority of patients with obesity abnormal profile of adipocytokines in the circulation and adipose tissues can be observed in association with the development and progression of obesity In the present paper the regulatory role of several important adipocytokines in adipocyte proliferation and differentiation are summarized and discussed Key words adipocytokines obesity adipocyte proliferation and differentiation No No * Tel yangj@ bjmu edu cn Received November Accepted January Supported by National Natural Science Foundation of China No No * Corresponding author yangj@ bjmu edu cn

2 3 213 TNFα α Leptin Resistin TNF-α α TNF- Adiponectin Visfatin Chemerin TNF-α 1 α 2 α TNF-α Leptin 1994 TNF-α TNF-α TNF-α 9 TNF-α 2 10 TNF-α 2 TNF-α 1 TNF-α 2 3T3-L1 TNF-α TNF-α 1 3 TNF-α C / EBPδ PPARγ Leptin 4 Chae 5 LPL LPL JNK NF-kB TNF-α JNK SP γ PGC-1a IkkB 2 UCP2 3 UCP3 NF-kB SP TNF-α 12 IkkB NF-kB TNF-α PPARγ CEB-α PPAR-γ TNF-α NF-kB TNF-α 13 3T3-L1 GPDH 3T3-L1 TNF-α 3T3-L1 10 nmol / L ADRP perilipin ADRP 3T3-L1 14 Leptin PI3K / mtor perilipin 15 6 TNF-α Qian 7 TNF-α TNF-α Caspase-3 TNF-α T3-L1

3 Kim 17 COS 3T3- L1 Pref-1 C / EBPα 3T3-F442A PPAR-γ ap-2 FAS 80% Pref-1 C / EBPα 3T3-L1 Gong T3-L Fukuhara 23 sirna 3T3-L cdna Gu 19 3T3-L1 Visfatin Visfatin B pre-b-cell colonyenhancing factor PBEF 24 Nampt 25 Visfatin PBEF Nampt Fu 21 3T3- L1 3T3-L1 3 Resistin Bauche 22 COS Visfatin Fukuhara 23 Visfatin CD36 PPARγ C / EBPα FAS 20 3T3-L1 3T3- F442A 4 Visfatin LPL PPARγ ap2 FAS Adiponectin 26 Visfatin 10

4 3 215 Chemerin-Chemerin Chemerin Chemerin Ca 2 + ERK1 / 6 Chemerin 2 Chemerin Chemerin 2007 ERK1 /2 4 d Chemerin CHEMERIN CHEMERIN PPARγ 27 Chemerin-Chemerin Chemerin 3T3-L1 3 d 28 Muruganandan 29 Chemerin mrna 8 d Chemerin Chemerin mrna CHEMERIN Chemerin-Chemerin Chemerin RNAi Chemerin 3T3-L1 7 8 d Chemerin / Chemerin Chemerin 8 d Leptin Perilipin FAS GLUL4 HSL Resistin Visfatin Chemerin Adiponectin Chemerin PPARγ Adiponectin Fig 1 The feedback regulatory role of adipocytokines in the proliferation and differentiation of adipocyte In overnutrient conditions the disturbed balance in pro-differential and anti-differential adipocytokines play crucial roles in the development and progression of obesity

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