Chinese Bulletin of Life Sciences. Mitofusin 2. Roles of Mitofusin on the pathogenesis, prevention and cure of insulin resistance

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1 Chinese Bulletin of Life Sciences Vol. 20, No. 4 Aug., (2008) Mitofusin ; Mitofusin 2 Mitofusin Mitofusin Q44 Q244 A Roles of Mitofusin on the pathogenesis, prevention and cure of insulin resistance QI Zheng-tang 1,2,DING Shu-zhe 2 *,HE Jie 1 (1 Department of Physical Education, Hengyang Normal University, Hengyang , China; 2 College of Physical Education and Health, East China Normal University, Shanghai , China) Abstract: Mitofusin was a key regulator of mitochondrial fusion and closely related to insulin resistance and type 2 diabetes. Roles of Mitofusin on the pathogenesis, prevention and cure of insulin resistance were summarized in the review. Key words: Mitofusin mitochondrial fusion insulin resistance [1] Rizzuto [2] [3] [4] mtdna mtdna [5] [6] (ROS) ( ) * szding@tyxx.ecnu.edu.cn

2 600 Dynamin( ) Mitofusin(Mfn) [7] 1 Mitofusin GTPase Mfn1 Mfn2 [8] N GTPase Mfn1 Mfn2 7 HR1 HR2 [9] Mfn1 Mfn2 60% (Docking) Mfn1 Mfn1 GTPase OPA1(optic atrophy 1) [10] Mfn2 Mfn1 Mfn1 Mfn2 GTPase [11] Mfn1/2 N GTP C HR2 (coiled-coil ) Mfn1/2 Mfn1/2 coiled-coil [12] GTP [13] OPA1 sirna OPA1 [14] OPA1 GTP Margaret Mfn2 (Mfn2 RasG12V ) Mfn2 GTP Mfn2 GTP Mfn2 GTPase Staurosporine Bax Mfn2 Mfn2 Bax c Mfn2 Mfn2 GTPase Mfn2 [15] Mfn2 Mfn2 Ras [16] Mfn2 Florence [17] SNARE D (mitopld) mitopld Mfn [18] 2 Mitofusin (insulin resistance) ( ) 2 mtdna 2 [19] Lowell Shulman [20] (MRS) 2 Mitofusin 2.1 Mitofusin [21] Fzo1A/B Fzo1A/B Fzo1A/B Mfn1/2 Fzo1A/B c Bax/Bak Mfn Drp1 [22]

3 Mitofusin Mitofusin ROS Mfn2 [15] ROS Mfn2 ROS ROS Mfn2 ROS ROS Mitofusin ROS Time-lapse [23] 2 ROS Mitofusin ROS 2.3 Mitofusin [1] Mfn2 [24] Mfn2 [25] Mfn2 Mfn2 TNFα/IL-6 Mfn2 [26] Mfn2 [27] Mfn2 3 PCG-1α Mfn2 PGC-1α (PPARs) PPARγ PGC-1α PGC-1α 2 [28] PGC-1α Mfn1/2 OPA1 Drp1 Fis1 PGC-1α Mfn2 Mfn2 PGC-1α Mfn2 PGC-1α Mfn2 PGC-1α PGC-1α Mfn2-413/-398 ERRα( ) Mfn2 PGC- 1α Mfn2 PGC-1α mrna PGC-1α ERRα Mfn2 2 [29] Pawlikowska [30] Mfn2 PI3K Mfn2 [30] PGC-1α-Mfn2 PGC-1α Mfn2 2 PGC-1α Mfn2 [31] Mfn2 [32] PGC-1α GLUT4 [33] PGC-1α Mfn2 PGC-1α Mfn2 [26] PGC-1α Mfn2 [34] PGC-1α mrna Mfn2 [35] Zucker 2 Mfn2 mrna [1] PGC-1α G482S 2 [36] 2 PGC-1α PGC-1α 2 PGC-1α [37]

4 602 PGC-1α 2 [38] Mitofusin PCG-1α 2 PGC-1α- Mfn2 4 Mitofusin 2 II I Mitofusin Mitofusin Mfn2 ( β3- ) [29] Mfn2 2 24h Mfn1 Mfn2 mrna PGC-1α ERRα Mfn1 Mfn2 COXIV mrna 24h PGC-1α ERRα mrna 2h PGC-1α/ERRα Mfn1/Mfn2 Mfn2 PGC-1α/ERRα PGC-1α [39] Mfn2 PGC- 1α mrna Mfn2 PCG-1α ERRα [40] PGC-1α 1 PGC-1α/NRF-1, 2 PGC-1α/Mfn2

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