1 3 -β -D- a = b = 1. 5 nm c = 0. 6 nm %

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1 Pharm J Chin PLA Vol. 27 No. 5 Oct R979. 1R DOI /j. issn A β -D 1 Surenjav 2 X 20 a = b = 1. 5 nm c = 0. 6 nm C NMR β -D Zhang % % % 4 α β β -D Tel caohong6699@ sina. com β 7 6 Tomati 8

2 Pharm J Chin PLA Vol. 27 No. 5 Oct DNA ~ GPC GPC T % % GPC 12 Hou 13 Moradali HIV Wang 15 Low β -D DNA Feng 16

3 Pharm J Chin PLA Vol. 27 No. 5 Oct Kupfahl Zhou Ito Murata 24 Drandarska 25 Guo 19 Wang Markova 21 Yamada 26 Yu 27

4 Pharm J Chin PLA Vol. 27 No. 5 Oct zhang 34 H 2 O CO 2 Wang % 32 β -D mg /g mg /g % % % 81% % 89. 7% - 1Zhang YY Xu XJ Zhang LN. Gel formation and low-temperature intramolecular conformation transition of a triple-helical polysaccharide lentinan in waterj. Biopolymers

5 Pharm J Chin PLA Vol. 27 No. 5 Oct Surenjav U Zhang L Xu Xet al. Effects of molecular structure on antitumor activities of 1-> 3-beta-d-glucans from different Lentinus Edodes J. Carbohyd Polym Zhang LN Li XL Xu XJ et al. Correlation between antitumor activitymolecular weightand conformation of lentinan J. Carbohyd Res J blood-stage infection by evoking adaptive immune-responsesj. J Murata T Hatayama I Kakizaki I et al. Lentinan enhances sensitivity of mouse colon 26 tumor to J cis-diamminedichloroplatinum 7. IIand decreases glutathione transferase expressionj. Jpn J J Tomati U Belardinelli M Galli Eet al. NMR characterization of the polysaccharidic fraction from Lentinula edodes grown on olive mill waste waters J. Carbohydr Res GPC J Low SY Hill JE Peccia J. DNA aptamers bind specifically and selectively to 1--> 3-beta-d-glucansJ. Biochem Bioph Res Co J Zhang YY Li SWang XHet al. Advances in lentinanisolationstructurechain conformation and bioactivitiesj. Food Hydrocolloid Hou XJ Chen W. Optimization of extraction process of crude polysaccharides from wild edible BaChu mushroom by response surface methodology J. Carbohyd Polym Moradali MFMostafavi H Ghods Set al. Immunomodulating and anticancer agents in the realm of macromycetes fungi macrofungi J. Int Immunopharmacol Wang XH Zhang LN. Physicochemical properties and antitumor activities for sulfated derivatives of lentinan J. Carbohydr Res Feng YL Li WQ Wu XQ et al. Rapid and efficient microwaveassisted sulfate modification of lentinan and its antioxidant and antiproliferative activities in vitroj. Carbohyd Polym Ito M Baba M Sato A et al. Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus HIVin vitro J. Antiviral Res J Guo ZH Hu YL Wang DY et al. Sulfated modification can enhance the adjuvanticity of lentinan and improve the immune effect of ND vaccine J. Vaccine Wang DY Guo ZH Ma X et al. Effects of sulfated lentinan on cellular infectivity of avian infectious bronchitis virus J. Carbohyd Polym Markova N Kussovski V Drandarska Iet al. Protective activity of Lentinan in experimental tuberculosis J. Int Immunopharmacol Kupfahl C Geginat G Hof H. Lentinan has a stimulatory effect on innate and adaptive immunity against murine Listeria monocytogenes infectionj. Int Immunopharmacol Zhou LD Zhang QH Zhang Y et al. The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria Int Immunopharmacol Cancer Res Drandarska I Kussovski V Nikolaeva S et al. Combined immunomodulating effects of BCG and Lentinan after intranasal application in guinea pigsj. Int Immunopharmacol Yamada J Hamuro J Hatanaka Het al. Alleviation of seasonal allergic symptoms with superfine beta-1 3-glucanA randomized study J. J Allergy Clin Immun Yu ZH LiHua Y Qian Y et al. Effect of Lentinus edodes polysaccharide on oxidative stress immunity activity and oral ulceration of rats stimulated by phenol J. Carbohyd Polym J J X Wang XH Xu XJ Zhang LN. Thermally induced conformation transition of triple-helical lentinan in NaCl aqueous solution J. J Phys Chem B J J J Zhang M Zhang LN Cheung PCKet al. Molecular weight and anti-tumor activity of the water-soluble polysaccharides isolated by hot water and ultrasonic treatment from the sclerotia and mycelia of Pleurotus tuber-regium J. Carbohyd Polym J J