Progress on Chemical Constituents Pharmacological Effects and Clinical Applications from Broussonetia papyrifera

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1 * R A Progress on Chemical Constituents Pharmacological Effects and Clinical Applications from Broussonetia papyrifera ZHU Kai-mei LIU Jian-nan GU Sheng-jiu * ZHAO Lei College of Pharmacy Guilin Medical Univercity Guilin China Abstract Broussonetia papyrifera distributes many place in china the resource are very rich. With the development of science scholars more concerned about the development and use of the broussonetia. Found not just good pulp materials keeping materials also has very important clinical value of medicinal. To object described chemical constituents the clinical application of pharmacology research are for broussonetia of Chinese herbal medicines as a valuable reference for research and development. Key words Broussonetia papyritera chemical constituents pharmacological clinical Broussonetia papyrifera L1 vent Moreceae 1 Broussonetia 2 20 m glzkm@ 163. com Sephadex LH-20 * E- mail gushengjiu@ 163. com 8 apigenin 1 198

2 cosmosiin 2 vitexin 3 PTB-1B luteolin 4-7-O-β-D- luteolin-7-o-β-dglucopyranoside methoxycoumarin 6 scopoletin 7 1-hentriacontanol 8 Lee uralenol 4 oussochalcone A 5 7 ODS Sephadex LH quercetin 2 13 dihydroquercetin 3 butei-4-methyl ester 4 14 liquiritigenin 5 peroxide 2 D- D-galacitol 3 sulfuretin 4 liriodendrin 5 graveolone % 10 Sephadex LH-20 kazinol B dihydroxy-3 -prenyflavan 3-3-methylbut-2-enyl trihydroxyflavane ESI- MS NMR 2 S d dihydroxy-4 -methoxyflavan 1 ergosterol ~ g ml % dimethylallyl -5-3-methylbut pentahy droxyflavone oussochalcone A 5 3 uralenol dimethylallyl -5-3-methylbut-2-enyl tetrahydroxyflanvonol pentahydroxyflavone 11 kazinol B 7 4 -dihydroxy-3 -prenyflavan methylbut-2-enyl trihydroxyflavane % % % % PTB-1B PTB-1B 2006 Neel PTB-1B OH PTB-1B DPPH Fe 3 + PEPCK % G-6-P PTB-1B FBH FBH H 2 O 2 PTB-1B AMPK 12 enyl tetrahy droxyflanvonol methylbut-2- enyl trihy droxyflavane PTP-1B % Fe

3 TFBP UVA TFBP 96 UVA MDA 3 SOD GSH-Px 24 1 kg 273 mg 25 D BPAE BPF BPAE SOD GSH-Px BPF BPF NO MDA BPAE CaCl BPAE BPF 2. 5 BPF 2 26 Lin Chun-nan h 3 1 g ml - 1 brousochalcone A broussoaruone A kazinol A broussflavonol F 3 brousochalconea MTT μg L % % 50 μg L - 1 MTT 20% 30% 100 μg L % 60% LPO SOD TC TG HDL 3 1 g ml d Dongho lee LPO SOD broussonina tetrahydroxy-3- TC TG geranylflavone isogemichacone 3 - γ- hydroxymethyl - E -γmethylally tet rahydroxychalcone -11 -O-coumarate HDL HDL SOD 2S dihydroxy-2-1-hydroxy-1-methyllethyl dihydrofuro CaCl 2 CaCl 2 LPO TC TG 2 3-H flavanone demethyl moracin e HBV-DNA NF-κB

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