OR 95% CI ~ ~ Relationship between serum ferritin and bone mineral density in 435 healthy women

Μέγεθος: px

Εμφάνιση ξεκινά από τη σελίδα:

Download "OR 95% CI 2. 82 1. 25 ~ 6. 38 2. 04 0. 92 ~ 4. 51. Relationship between serum ferritin and bone mineral density in 435 healthy women"

Ζώπυρος Λαγός
7 χρόνια πριν
Προβολές:

1 DOI /j. issn Huang Xi ~ 80 X Logistic < T < P < T P < P < Logistic OR 95% CI ~ ~ BMI BMI C CRP P < R681 A Relationship between serum ferritin and bone mineral density in 435 healthy women Zhang Lin-lin 1 ZHENG Min-qian 1 XU Xiao-zu 1 DIAO Yong-li 1 GE Nai-hang 1 ZHANG Peng 1 DONG Qi-rong 2 QIAN Zhi-yuan 2 LIN Hua 3 HUANG Xi 4 XU You-jia 2 1. Department of Orthopaedics Yancheng First Peoples' Hospital Yancheng Department of Orthopaedics Second Affiliated Hospital Soochow University Suzhou The Center of Research for Metabolic Bone Disease Affiliated Drum Tower Hospital of Medical School Nanjing University Nanjing China 4. New York University NYU Cancer Institute NYU School of Medcine New York Abstract Objective To study how iron content and BMD alter with age also the relationship between iron BK SZS LCZX New York University NYU Cancer Institute NYU School of Medicine New York xuyoujia@ medmail. com. cn

05 R681 A Relationship between serum ferritin and bone mineral density in 435 healthy women Zhang Lin-lin 1 ZHENG Min-qian 1 XU Xiao-zu 1 DIAO Yong-li 1 GE Nai-hang 1 ZHANG Peng 1 DONG Qi-rong 2 QIAN

2 10 content and BMD. Methods This study induded of 435 women from January 2011 to December 2012 whose serum levers of ferritin Fer were measured and remarked. Bone mineral density BMD in femur and lumbar spine were measured by dual-energy X-ray absorptiometry. We observed serum Fer and BMD was changed with age. Then we categorized subjects into 5 groups according to the level of ferritin and Non-conditional Logistic Regression Analysis was used to evaluate the risk of osteopenia. At last associations between Fer and BMD in all areas were measured by multiple regression analyses and partial correlation. Results The serum Fer level was low and stable in women before the age of 40 gradually increased in women aged rapidly rose in women aged and was remaining steady high after the age of 65. However the BMD was high before the age of 50 rapidly fall in women aged and kept low after the age of 65. The concentration of Fer in the group of osteoporosis was higher than in the group of osteopenia P < and in the normal group P < Also the Fer was higher in the group of osteopenia than in the normal P < In analysis by quintiles after adjusting confounding factors compared with the individuals in the lowest quintile those in the highest quintile were more than twice as likely to suffer osteopenia in femur neck and L 1-4 OR % CI and OR % CI Age weight serum Fer and BMI were associated with BMD using multiple regression analyses. Then adjusting age weight and BMI serum Fer also showed negative correlation with BMD at all regions P < Conclusion The concentration of serum Fer increased and BMD decreased with age. With increasing with the concentrations of Fer the BMD decreased and the risk of osteopenia in creased. Key words ferritin iron overload bone mineral density osteoporosis Li Fer > 500 ng /ml ferritin Fer Fer Fer 15 Fer ~ ng /ml Kim 16 3 C- CRP Fer g /cm 2 Lunar DPX-NP X Fer bone mineral density BMD Ward 435 Fer L 1-4 Fer T T ~ Fer T Fer

Then we categorized subjects into 5 groups according to the level of ferritin and Non-conditional Logistic Regression Analysis was used to evaluate the risk of osteopenia.

3 n = 52 Fer 36 ~ 40 n = ~ 45 n = ~ 50 n = ~ 55 n = ~ 60 1 n = ~ 65 n = ~ 70 n = T Fer n = ± ng /ml Fer ± ng /ml Fer 150 ng /ml ± ng /ml 2 ANOVA Fer % 2 Fer T P < g /cm 2 Fer P = g /cm 2 BMD L 1-4 BMD % Logistic T OR L 1-4 T > % CI ~ L 1-4 L 1-4 T SPSS18. 0 x ± s P < Fer ~ ~ ~ 65 Fig ~ 65 1 Table 1 Fer ng /ml 65 1 Fer Fer Serum ferritin and BMD at femoral neck and lumbar with age Fer BMD L Fer ng /ml BMD x ± s Vaule of serum ferritin and BMD in each age group x ± s BMD g /cm 2 Ward L ± ± ± ± ± ± ~ ± ± ± ± ± ± ~ ± ± ± ± ± ± ~ ± ± ± ± ± ± ~ ± ± ± ± ± ± ~ ± ± ± ± ± ± ~ ± ± ± ± ± ± ~ ± ± ± ± ± ± ± ± ± ± ± ± Fer BMD L

04 L 1-4 L 1-4 T - 2. 5 SPSS18. 0 x ± s P < 0.

4 12 Fig 2 2 Fer Levels of serum ferritin among different bone mass group Fer ~ CRP OR 95% CI 2 BMI Fer CRP Fer Fer BMI BMD 3 BMI CRP Fer BMD Fer Wards L 1 -L 4 BMD P ~ OR < Fer 95% CI ~ L 1-4 BMD 2 Fer Table 2 With increasing serum ferritin the risk of bone loss of the femoral neck and lumbar OR 95% CI Q1 Q2 Q3 Q4 Q5 Fer ng /ml 1. 5 ~ ~ ~ ~ ~ OR 95% CI ~ ~ ~ ~ < OR ~ ~ ~ ~ CRP OR ~ ~ ~ ~ < CRP OR ~ ~ ~ ~ L 1-4 OR 95% CI P Q1 Q2 Q3 Q4 Q5 OR 95% CI ~ ~ ~ ~ < OR ~ ~ ~ ~ CRP OR ~ ~ ~ ~ < CRP OR ~ ~ ~ ~ Fer CRP C- P BMD Table 3 3 BMD Multiple regression analysis to identify determinants of bone mineral density of every part Fer β P β P β P β P < < Wards < < < < < L 1-4 BMD < < < BMD L Fer BMI BMI R 2

39 L 1-4 BMD 2 Fer Table 2 With increasing serum ferritin the risk of bone loss of the femoral neck and lumbar OR 95% CI Q1 Q2 Q3 Q4 Q5 Fer ng /ml 1. 5 ~ 12. 7 12. 8 ~ 25. 1 25. 2 ~ 42. 3 42. 4 ~ 78.

5 13 L ~ Fer Fer Fer 17 Fer Fer Fer apoferritin Fe 3 + Fe 3 + Fer Schnitzler 20 Sadat-Ali 21 Ⅱ Fer Valenti Fer CRP CRP 1 3 Fer Fer 3 Fer Fer 16 Fer 435 iron response element IRE VA Fer Fer 2 Fer Fer Fer ANO- 250 mg ANOVA Fer 18 Kato 18 Fer Fer 43 ng /ml 106 ng /ml Zacharski Fer Fer 50 ~ 70 BMI 50 ~ 70 BMI CRP Fer 50 ~ ~ 69 Fer Fer 40 BMI Fer 41 ~ ~ ~ 65 Fer 65 Fer 50 ~ 65 Ⅰ 65 1 McCord JM. Iron free radicals and oxidative injury J.

ANOVA Fer 18 Kato 18 Fer Fer 43 ng /ml 106 ng /ml Zacharski 19 50 Fer Fer 50 ~ 70 BMI 50 ~ 70 BMI CRP Fer 50 ~ 60 60 ~ 69

6 14 J Nutr S S. 2 Elalfy M Esmat G Matter RM et al. Liver fibrosis in young Egyptian beta-thalassemia major patients relation to hepatitis C virus and compliance with chelation J. Ann Hepatol Ramirez RL Qian J Santambrogio P et al. Relation of cytosolic iron excess to cardiomyopathy of friedreich's ataxia J. Am J Cardiol Kim CH Kim HK Bae SJ et al. Association of elevated serum ferritin concentration with insulin resistance and impaired glucose metabolism in Korean men and women J. Metabolism Nú ez MT Urrutia P Mena N et al. Iron toxicity in neurodegeneration J. Biometals J Li GF Li K Xu YJ et al. Iron homeostasis in osteoporosis and its clinical implications J. Osteoporosis Int Zhao GY Zhao LP He YF et al. A comparison of the biological activities of human osteoblast hfob1. 19 between i- ron excess and iron deficiency J. Biol Trace Elem Res Yang Q Jian J Abramson SB et al. Inhibitory effects of iron on bone morphogenetic protein 2-induced osteoblastogenesis J. J Bone Miner Res fractures a bone histomorphometric study J. Calcif J Tissue Int Tsay J Yang Z Ross FP et al. Bone loss caused by iron overload in a murine model importance of oxidative stress J. Blood Jia P Xu YJ Zhang ZL et al. Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species J. J Orthop Res Vogiatzi MG Macklin EA Fung EB et al. Bone disease in thalassemia a frequent and still unresolved problem J. J Bone Miner Res Guggenbuhl P Deugnier Y Boisdet JF et al. Bone mineral density in men with genetic hemochromatosis and HFE gene mutation J. Osteoporos Int Malcovafi L Ports MG PascuRo C et al. Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria a basis for clinical decision making J. J Clin Oncol Kim BJ Ahn SH Bae SJ et al. Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men a 3-year retrospective longitudinal study J. J Bone Miner Res Montonen J Boeing H Steffen A. Body iron stores and risk of type 2 diabetes results from the European Prospec-. yive Investigation into Cancer and Nutrition EPIC -Potsdam study J. Diabetologia Kato I Dnistrian AM Schwartz M et al. Risk of iron o- verload among middle-aged women J. Int J Vitam Nutr Res Zacharski LR Ornstein DL Woloshin S et al. Association of age sex and race with body iron stores in adults analysis of NHANES III data J. Am Heart J Schnitzler CM Schnaid E MacPhail AP et al. Ascorbic acid deficiency iron overload and alcohol abuse underlie the severe osteoporosis in black african patients with hip 21 Sadat-Ali M Sultan O Al-Turki H et al. Does high serum iron level induce low bone mass in sickle cell anemia J. Biometals Valenti L Varenna M Fracanzani AL et al. Association between iron overload and osteoporosis in patients with hereditary hemochromatosis J. Osteoporos Int

4 Kim CH Kim HK Bae SJ et al. Association of elevated serum ferritin concentration with insulin resistance and impaired glucose metabolism in Korean men and women J. Metabolism 2011 60 414-420.

Σχετικά έγγραφα

Chin J Osteoporos April 2011 Vol 17 No. 4 Published online www. wanfangdate. com. cn doi / j. issn

Chin J Osteoporos April 2011 Vol 17 No. 4 Published online www. wanfangdate. com. cn doi / j. issn 312 Published online www. wanfangdate. com. cn doi 10. 3969 / j. issn. 1006-7108. 2011. 04. 007 R681 A 1006-7108 2011 04-0312-05 fat mass lean mass 414 1020 Hologic Delphi A X fat mass lean mass 1 2 Lean