Ιωάννης Ντούπης MD, PhD

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1 Ιωάννης Ντούπης MD, PhD Βιογραφικό Σημείωμα Γενικά Στοιχεία Ονοματεπώνυμο : Ιωάννης Ντούπης Διεύθυνση Εργασίας: Ιατρικό Παλαιού Φαλήρου, Αρεως 36 Π Φάληρο, Ιατρείο : Θεσσαλονίκης 3, Νίκαια Ναυτικό Νοσοκομείο Αθηνών john.doupis@joslin.harvard.edu τηλ κινητό : Τόπος Γέννησης : Αθήνα Ημερομηνία γέννησης : 23 Ιανουαρίου 1972 Σπουδές Σταδιοδρομία ο Δημοτικό Σχολείο Νίκαιας ο Γυμνάσιο και 2 ο Λύκειο Νικαίας Στρατιωτική Ιατρική Σχολή Θεσσαλονίκης ΑΠΘ Διδακτορική Διατριβή - Ιατρική Σχολή ΕΚΠΑ Μεταδιδακτορικό Ιατρική Σχολή Χάρβαρντ Βοστώνη ΗΠΑ Μεταπτυχιακή εκπαίδευση : 2001 Άσκηση ειδικότητος Παθολογίας, Ναυτικό Νοσοκομείο Αθηνών

2 Άσκηση ειδικότητος Παθολογίας, Α Προπαιδευτική Παθολογική Κλινική Νοσοκομείο Λαϊκό 2007 Μεταπτυχιακή Εκπαίδευση στη Βιοστατιστική, Brigham and Women s Hospital, Boston MA Μεταπτυχιακή Εκπαίδευση στο Διαβήτη, Joslin Diabetes Center, Harvard Medical School, Boston MA, USA 2008 Μεταπτυχιακή Εκπαίδευση στη διατροφή : The Science of Human Nutrition Harvard School of Public Health, Boston MA, USA Άλλες Μεταπτυχιακές εκπαιδευτικές Δραστηριότητες Κυκλική εκπαίδευση στο Ναυτικό Νοσοκομείο Αθηνών Μεταπτυχιακή εκπαίδευση σε θέματα Ναυτικής Ιατρικής, Ναυτικό Νοσοκομείο Αθηνών 1998 Αdvanced Trauma Life Support, (ATLS), Καποδιστριακό Πανεπιστήμιο Αθηνών 1998 Advanced Cardiopulmonary Resuscitation, (CPR), Ναυτικό Νοσοκομείο Αθηνών 1998 Μεταπτυχιακό στην Καταδυτική και υπερβαρική Ιατρική Ναυτικό Νοσοκομείο Αθηνών 2000 & 2001 Μεταπτυχιακή σειρά μαθημάτων στο Διαβήτη, Ελληνική διαβητολογική εταιρία 2001 Μεταπτυχιακή σειρά μαθημάτων στην Αρτ Υπέρταση, Ελληνική εταιρία υπέρτασης Θέσεις σε Νοσηλευτικά και Πανεπιστημιακά ιδρύματα Ημεδαπής και αλλοδαπής : 2005 Επιστημονικός Συνεργάτης Διαβητολογικού Κέντρου Α Προπαιδευτικής Παθολογικής Κλινικής Πανεπιστημίου Αθηνών. Νοσοκομείο «Λαϊκό» 2005 Διευθυντής Παθολογικού Τμήματος Ναυτικού Νοσοκομείου Σαλαμίνος Διευθυντής Παθολογικής Κλινικής, Στρατιωτικού Νοσοκομείου Αργυροκάστρου Επιστημονικός Συνεργάτης Κλινικής Joslin, Joslin Diabetes Center, Harvard Medical

3 Scholl, Boston MA Επιστημονικός Συνεργάτης Κλινικής Beth Israel Foot Center, Harvard Medical Scholl, Boston MA Επιστημονικός Συνεργάτης, Νοσοκομείου Brigham and Womans, Harvard Medical Scholl, Boston MA 2008 Διευθυντής Παθολογικού Τμήματος Ναυτικού Νοσοκομείου Σαλαμίνος Μέλος Ιατρικών Εταιριών: 1997 Ιατρικός Σύλλογος Πειραια 2002 Ελληνική Διαβητολογική εταιρία 2003 Diabetes and Nutrition Study Group 2003 Ελληνική εταιρία μελέτης παχυσαρκίας 2004 European Association for the study of Diabetes 2004 American Diabetes Association Βραβεία και Διακρίσεις : ο βραβείο πτυχιακής διατριβής, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης ο βραβείο ερευνητικής εργασίας, 8 ο Πανελλήνιο Διαβητολογικό συνέδριο ο βραβείο ερευνητικής εργασίας, 7 ο Πολυθεματικό Συνέδριο Ναυτικού Νοσοκομείου ο βραβείο ερευνητικής εργασίας, 9 ο Πανελλήνιο Διαβητολογικό συνέδριο ο βραβείο ερευνητικής εργασίας, 24 ο Diabetes and Nutrition Study Group Congress, Salerno, Italy 2007 Hellenic Harvard Association Academic year Award

4 Registered Reviewer σε Ιατρικά Περιοδικά 1. Diabetes Care 2. Advances in Therapy 3. Wounds 4. Diabetologia 5. Current Medicinal Chemistry 6. EndocrinologyandDiabetes 7. Experimental Neurology 8. Expert Review of ClinPharmacology 9. Journal of Applied Physiology 10. Journal of RehabilitationMedicine 11. Journal of Zhejiang University 12. Metabolism 13. Rural and Remote health 14. Current Diabetes Reviews 15. Expert Opinion On Drug Safety 16. Journal of diabetes and its complications 17. Journal of Vascular Research 18. Medical Science Monnitor 19. Recent Patents on Endocrine Metabolic and Immune Drug Discovery 20. Vascular Medicine Μέλος Editorial Board Ιατρικών Περιοδικών Wounds Advances in Theraphy Συμμετοχή Σε πολυκεντρικές Μελέτες ΝΝ (Detemir) Navigator

5 Παρούσα Ερευνητική Δραστηριότητα Μελέτη συσχέτισης της αντίστασης στην ινσουλίνη σε σχέση με το κάπνισμα και τον υπογοναδισμό σε νέους άνδρες ηλικίας 18 με 25 ετών. (Ναυτικό Νοσοκομείο Σαλαμίνας) Συσχέτιση του πάχους ενδοθηλίου καρωτίδων με κλασσικούς παράγοντες κίνδυνου για καρδιαγγειακή νόσο. (Ναυτικό Νοσοκομείο Σαλαμίνας) Growth factors and Diabetic ulcer healing (Beth Israel Deaconess Foot Center) Diabetes Heart and air pollution study (Joslin Diabetes Center) Byetta study (Joslin Diabetes Center) Arterial Stifness Study (Joslin Diabetes Center) Διδακτική Δραστηριότητα Διδασκαλία Ιατρών Πολεμικών Πλοίων σε θέματα επείγουσας Ιατρικής (2005) Διδασκαλία φοιτητών 4 ου και 5 ου έτους Ιατρικής Σχολής Πανεπιστημίου Αθηνών σε θέματα Παθολογίας (2005) Επίβλεψη διδακτορικών διατριβών σε 3 μεταπτυχιακούς φοιτητές για 2 έτη ( ) Διδασκαλία φοιτητών Ιατρικής Σχολής Χάρβαρντ σε θέματα Σακχαρώδους Διαβήτη ( ) Συγγραφικό Έργο Διδακτορική Διατριβή Η οξεία επίδραση της υπερομοκυστεϊναιμιας μετά από λήψη μεθειονίνης στο ενδοθήλιο ασθενών με διαβήτη τύπου 2»

6 Συγγραφή κεφαλαίων σε Ιατρικά βιβλία Doupis J, Schramm JC, Veves A. Diabetes and Exercise (Humana Press) Chapter: Endothelial Dysfunction, Inflamation and Exercise in Diabetes. Didangellos T, Doupis J, Veves A. Painfull Diabetic Neuropathy. Clinical Aspects (Under press) Doupis J, Didangellos T, Veves A Oxidative stress in Human Diabetes and Possible Interventions (Under press) Δημοσιεύσεις σε Ελληνικά και διεθνή Ιατρικά περιοδικά Kokkinos A,Tentolouris N, Kyriaki D, Doupis J, Tsigos C, Raptis S A, Katsilambros N. Differential effects of high-fat and high-carbohydrate content isoenergetic meals on plasma active ghrelin concentrations in lean and obese women. Iatrikos Typos 2003; 266 Nikou GC, Toumbanakis I, Kirlagitsis S, Madonakis N, Karamvakalis, Doupis J, Kastanakis M. Carcinoid Tumors of the Appendix: Characteristics, Diagnosis and Treatment, Digestive Oncology 2003; 3:84-88 Psallas M, Petrikkos G, Toskas A, Stephanou J, Doupis J, Katsilambros N. Streptococcal toxic shock syndrome. An interesting case. Iatriki 2004; 86:75-78 Tentolouris N, Kokkinos A, Tsigos C, Kyriaki D, Doupis J, Raptis SA, Katsilambros N. Differential effects of high-fat and high-carbohydrate content isoenergetic meals on plasma active ghrelin concentrations in lean and obese women. Horm Metab Res 2004; 36: Pavlatos S, Psallas M, Makrilakis K, Doupis J, Stathi C, Nikolakopoulou E, Katsilambros N. Acute respiratory distress syndrome due to miliary tuberculosis in a patient with rheumatoid arthritis under corticosteroid therapy. Eur J Intern Med 2004; 15:62-64 Psallas M, Tentolouris N, Kokkinos A, Doupis J, Katsilambros N. Cardiac Autonomic Neuropathy. (Review) Journal of Military Medicine 2006:40;1-12 Kokkinos A, Tentolouris N, Kyriakaki E, Argyrakopoulou G, Doupis J, Psallas M, Kyriaki D, Katsilambros N. Differentiation in the short- and long-term effects of smoking on plasma total ghrelin concentrations between male nonsmokers and habitual smokers. Metabolism Apr;56(4):523-7 Doupis J, Tentolouris N, Mastrokostopoulos A, Kokkinos A, Doupis C, Zdrava A, Kafantogias A. Prevalence of type 2 diabetes in the southwest Albanian adult population. Rural Remote Health Apr- Jun;7(2):744. Epub 2007 Jun 25 Doupis J,Grigoropoulou P, Voulgari C, Stylianou A, Georga A, Thomakos T, Xiromeritis K, Koliaki C, Katsilambros N, Tentolouris N High Rates of Comorbid Conditions in Patients With Type 2 Diabetes and Foot Ulcers. Wounds May 2008 Vol. 20, No. 5 :

7 Doupis J, Veves A. Antioxidants, Diabetes, and Endothelial Dysfunction U S endocrine Disease 2007: Doupis J, Veves A. Classification, Diagnosis, and Treatment of Diabetic Foot Ulcers. WOUNDS 2008;20(5): Doupis J, Veves A. DPP4 inhibitors: a new approach in diabetes treatment. Adv Ther Jul;25(7): Review. Argyrakopoulou G, Doupis J. DPP4 inhibitors: from sitagliptin monotherapy to the new alogliptinpioglitazone combination therapy. Adv Ther Mar;26(3): Doupis J, Lyons TE, Wu S, Gnardellis C, Dinh T, Veves A. Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy. J Clin Endocrinol Metab Jun;94(6): Yeh SY, Doupis J, Rahangdale S, Horr S, Malhotra A, Veves A. Total serum bilirubin does not affect vascular reactivity in patients with diabetes. Vasc Med May;14(2): Doupis J, Dimosthenopoulos C, Diamanti K, Perrea D, Katsilambros N, Makrilakis K. Metabolic syndrome and Mediterranean dietary pattern in a sample of young, male, Greek navy recruits. Nutr Metab Cardiovasc Dis Jul;19(6):e7-8 Dinh T, Doupis J, Lyons TE, Kuchibhotla S, Julliard W, Gnardellis C, Rosenblum BI, Wang X, Giurini JM, Greenman RL, Veves A. Foot muscle energy reserves in diabetic patients without and with clinical peripheral neuropathy. Diabetes Care Aug;32(8): Doupis J, Stavrianos C, Saltiki K, Mantzou E, Mastrokostopoulos A, Philippou G, Alevizaki M. Thyroid volume, selenium levels and nutritional habits in a rural region in Albania. Hormones (Athens) Oct- Dec;8(4): Doupis J, Didangellos T, Veves A. Stochastic Resonance - a method to reverse sensory loss? The Pain Practitioner Doupis J, Eleftheriadou I, Kokkinos A, Perrea D, Pavlatos S, Gonis A, Katsilambros N, Tentolouris N. Acute hyperhomocysteinemia impairs endothelium function in subjects with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes Jul;118(7): Epub 2010 Mar 3 Doupis J, Rahangdale S, Gnardellis C, Pena SE, Malhotra A, Veves A. Effects of Diabetes and Obesity on Vascular Reactivity, Inflammatory Cytokines and Growth Factors. Obesity (Silver Spring) Sep 9

8 Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus Koliaki C, Doupis J Diabetes Ther May; 2(2): Published online 2011 February 28. doi: /s Δημοσιεύσεις σε Supplement ιατρικών περιοδικών Doupis J, Tentolouris N, Perrea D, Zacharopoulou O, Kyriaki D, Katsilambros N. Acute methionineinduced hyperhomocysteinaemia causes endothelial dysfunction in patients with type 2 diabetes. Diabetes June 2003;52 Suppl 1:A Doupis J, Tentolouris N, Perrea D, Kyriaki D, Pavlatos S, Katsilambros N. Acute hyperhomocysteinaemia activates cardiac sympathetic nervous system in patients with type 2 diabetes. Diabetes June 2003;52 Suppl 1:A Pavlatos S, Tentolouris N, Tsigos C, Doupis J, Tsapogas P, Raptis SA, Katsilambros N. Meal-induced thermogenesis and substrate oxidation is not different between lean and obese women after a protein-rich and a fat-rich meal. Diabetes Metabolism 2003; 29 Suppl: A1926 Doupis J, Tentolouris N, Perrea D, Pavlatos S, Kyriaki D, Makrilakis K, Katsilambros N. Acute hyperhomocysteinaemia causes endothelial dysfunction in patients with type 2 diabetes. Diabetologia 2003;40 Suppl 2: A1204 Pavlatos S, Makrilakis C, Psallas M, Stathi C, Doupis J, Nikolakopoulou E, Katsilambros N. Acute respiratory distress syndrome due to miliary tuberculosis in a patient with rheumatoid arthritis under corticosteroid therapy. Nosocomial Annals 2003 ; 65 Suppl.: A176. Kokkinos A, Tentolouris N, Kyriaki D, Doupis J, Tsigos C, Raptis S, Katsilambros N. Different effects of high-fat and high-carbohydrate isoenergetic meals on plasma active ghrelin concentrations in lean and obese women. Nosocomial Annals 2003; 65 Suppl 1: A71 Toumbanakis C, Kyriaki D, Kitsou E, Kokkinos A, Karamvakalis N, Doupis J, Nikou GC. Chromogranin- A: A specific tumor marker for the follow-up of patients with metastatic carcinoid tumors. Comparison of different neuroedocrine tumor markers. Annals of Gastroenterology 2003;16 Suppl 1:86 Kyriaki D, Toumpanakis C, Kitsou E, Georgiou A, Doupis I, Kokkinos A, Karamvakalis N, Nikou GK. Chromogranin-A: A specific tumor marker for the follow-up of patients with metastatic carcinoid tumors: Comparison of different neuroendocrine tumor markers. World journal of Nuclear Medicine Jan 2004;3 Suppl 1:S93 Doupis J, Tentolouris N, Pavlatos S, Zacharopoulou O, Perrea D, Kyriaki D, Katsilambros N. Effect of acute methionine-induced hyperhomocysteinaemia on the aortic wave reflection in patients with type 2 diabetes. Diabetes 2004;52 Suppl 2:A712-P

9 Tsiombanidis I, Tentolouris N, Hatzis G, Manolakopoulos S, Tzourmakliotis D, Psallas M, Doupis J, Vafiadi E, Katsilambros N. Study of the autonomic nervous system function in patients with hepatic cirrhosis. Annals of Greek Internal Medicine 2004, Suppl : A526. Doupis J, Tentolouris N, Perrea D, Pavlatos S, Zacharopoulou O, Liatis S, Tsokos N, Kitsou E, Katsilambros N. Effect of acute hyperhomocysteinaemia on QT interval in patients with type 2 diabetes. Diabetologia 2004; 47 Suppl. 1: A1207 Zacharopoulou O, Tentolouris N, Athanaselis S, Doupis J, Stilianou A, Psallas M, Cokkinos D, Katsilambros N. Effects of coffee intake on QT interval in subjects with type 2 diabetes. Diabetologia 2004; 47 Suppl. 1: A1196 Zacharopoulou O, Tentolouris N, Athanaselis S, Doupis J, Stilianou A, Psallas M, Kokkinos D, Katsilambros N. Effects of coffee intake on QT interval in subjects with Type 2 diabetes. Nosocomial Annals 2004; 66 Suppl.1 : A153. Pavlatos S, Kokkinos A, Tentolouris N, Kyriaki D, Diakoumopoulou E, Doupis J, Katsilambros N. Changes in plasma total ghrelin levels after high-protein and high-fat isoenergetic meals in lean and obese women Diabetologia 2005; 48 Suppl. 1: A222 Tentolouris N,Kokkinos A,Tsigos C,Kyriaki D,Doupis J,Raptis SA,Katsilambros N. Changes of active Ghrelin plasma levels after tow separate meals, one rich in fat and one rich in carbohydrates. Obesity Reviews 2005 ;6 Suppl 1: A023 N. Tentolouris, A. Kokkinos, C. Tsigos, E. Koukou, M. Grammatikou, J. Doupis, SA Raptis, N. Katsilambros. Meal-induced thermogenesis and macronutrient oxidation are not different between lean and obese women after two different isoenergetic meals, one rich in fat and one rich in protein.. Obesity Reviews 2005; Suppl 1: A023 Doupis J, Lyons T, Dinh T, Veves A. Microvascular Reactivity in Painful and Painless Peripheral Diabetic Neuropathy. ADA 6-10 June 2008 San Francisco CA Van Bergen A, Cohen LA, Doupis J, Gibson H, Gold RD, Horton E, Comparison of Two Methods of Assessing Macrovascular Disease in Type 2 Diabetes. Diabetes June 2008 Supplement Knegt C, Doupis J, Gibson H, Cohen LA Horton SE Effects of a Mixed Meal on Endothelial Function and Arterial Stiffness in Type 2 Diabetes. Diabetes June 2008 Supplement Doupis J, Tentolouris N, Mastrokostopoulos A, Kokkinos A, Doupis C, Zdrava A, Kafantogias A. Prevalence of type 2 Diabetes in a sample of adult population in Southwest Albania. Diabetes June 2008 Supplement Dinh T, DPM, Doupis J, Lyons T, Kuchibhotla S, Julliard W, Gnardellis C, Rosenblum B, Wang X, Giurini J, Greenman R, Veves A. Foot Muscle Energy Reserves Are Reduced In Diabetic Patients without And With Peripheral Neuropathy. Diabetes June 2009 Supplement 1A-884.

10 Ανακοινώσεις σε Ελληνικά και διεθνή Ιατρικά συνέδρια Doupis J, Apostolopoulos K, Pliakas G. Orthopaedic emergencies during Christmas holidays. Abstract, 3 rd Pan-Hellenic Medical Congress of Medical Students, March 1993, Thessalonica, Greece Kabaroudis A, Gerasimidis T, Vougiouklis N, Aslanidis S, Doupis J. Vascular manifestations of Behcet s disease. Abstract, 3 rd Hellenic-Italian Congress of Vascular Surgery, 27 June 2 July 1997, Halkidiki, Greece Vasiliadis I, Spanos A, Antoniou A, Stogioglou A, Doupis J, Skiadas I. The contribution of transoesophageal ultrasonography in the prognosis of endocarditis. Polycentric Study Abstract, 17 th Medical Congress of Greek Armed Forces, November 1998, Thessalonica, Greece Spanos A, Stogioglou A, Doupis J, Skiadas I, Antoniou A, Papaioannou S, Vasiliadis I. The contribution of angiocardiography in the diagnosis of coronary heart disease and its treatment. Are there any differences between men and women? Abstract, 17 th Medical Congress of Greek Armed Forces, November 1998, Thessalonica, Greece Pliakas G, Aggelaki M, Chatzaki D, Dimitroulia E, Psallas M, Doupis J, Spanakis N, Tsakris A, Legakis NI. Herpes simplex viral meningoencephalitis diagnosis using nested-pcr. Abstract, 1 st National Congress of Clinical Microbiology,30 January February 2003, Athens, Greece Pavlatos S, Tentolouris N, Doupis J, Tsigos C, Raptis SA, Katsilambros N. Meal-induced thermogenesis is not different between lean and obese women. Abstract, 1 st Balkan Congress on Obesity, 6-9 February 2003, Athens, Greece Doupis J, Tentolouris N, Perrea D, Pavlatos S, Zacharopoulou O, Katsilambros N. Acute hyperhomocysteinemia causes endothelial dysfunction in patients with type 2 diabetes. Abstract, 7 th Naval Medical Congress, 28 February 2003, Athens, Greece Doupis J, Tentolouris N, Perrea D, Kyriaki D, Pavlatos S, Psallas M, Katsilambros N. Acute hyperhomocysteinaemia activates cardiac sympathetic nervous system in patients with type 2 diabetes. Abstract, 8 th Pan-Hellenic Congress on Diabetes, March 2003, Athens, Greece Doupis J, Tentolouris N, Perrea D, Zacharopoulou O, Kyriaki D, Pavlatos S, Katsilambros N. Acute hyperhomocysteinemia causes endothelial dysfunction in patients with type 2 diabetes. Abstract, 8 th Pan- Hellenic Congress on Diabetes, March 2003, Athens, Greece Pavlatos S, Tentolouris N, Tsigos C, Doupis J, Tsapogas P, Pentea S, Raptis SA, Katsilambros N. Mealinduced thermogenesis is not different between lean and obese women. Abstract, 8 th Pan-Hellenic Congress on Diabetes, March 2003, Athens, Greece Doulgerakis D, Moyssakis I, Tentolouris N, Stamatiadis D, Doupis J, Kokkinos A, Pantazopoulos N, Stathakis C, Voteas B, Katsilambros N. The function of the left heart ventricle in patients with renal failure: correlation with body mass index. Abstract, 29 th Annual Pan-Hellenic Medical Congress, May 2003, Athens, Greece

11 Doupis J, Tentolouris N, Perrea D, Kyriaki D, Pavlatos S, Katsilambros N. Acute hyperhomocysteinaemia activates cardiac sympathetic nervous system in patients with type 2 diabetes. Abstract, American Diabetes Association 63 rd Scientific Sessions,13-17 June 2003, New Orleans, USA Doupis J, Tentolouris N, Perrea D, Zacharopoulou O, Kyriaki D, Katsilambros N. Acute methionineinduced hyperhomocysteinaemia causes endothelial dysfunction in patients with type 2 diabetes. Abstract, American Diabetes Association 63 rd Scientific Sessions, June 2003, New Orleans, USA Ioannidis I, Doupis J, Katsilambros N. Diabetes and Alcohol : A review of the recent literature. Is there any impact on our dietary guidelines? Abstract, 21 st International Symposium on Diabetes and Nutrition, June 2003, Brugge, Belgium Doupis J, Tentolouris N, Perrea D, Pavlatos S, Kyriaki D, Makrilakis K, Katsilambros N. Acute hyperhomocysteinaemia causes endothelial dysfunction in patients with type 2 diabetes. Abstract, 18 th International Diabetes Federation Congress, August 2003, Paris, France Pavlatos S, Tentolouris N, Tsigos C, Doupis J, Tsapogas P, Raptis SA, Katsilambros N. Meal-induced thermogenesis and substrate oxidation is not different between lean and obese women after a protein-rich and a fat-rich meal. Abstract, 18 th International Diabetes Federation Congress, August 2003, Paris, France Toumbanakis C, Kyriaki D, Kitsou E, Kokkinos A, Karamvakalis N, Doupis J, Nikou GC. Chromogranin- A: A specific tumor marker for the follow-up of patients with metastatic carcinoid tumors. Comparison of different neuroedocrine tumor markers. Abstract, 23 rd Hellenic Congress of Gastroenterology, 1-5 October 2003, Athens, Greece Doupis J, Tentolouris N, Zacharopoulou O, Pavlatos S, Nikolakopoulos E, Katsilambros N. Factors that are correlated with endothelial function in patients with type 2 diabetes. Abstract, 9 th Pan-Hellenic Congress of Internal Medicine, 6-11 October 2003, Athens, Greece Soulantikas K, Doupis J, Terzis T. Prevalence of hearing impairment among the technical staff of Salamina Naval Base. Abstract, 12 th Pan-Hellenic Congress of Ear, Nose and Throat Medicine, 8-12 October 2003, Thessalonica, Greece Kyriaki D, Toumpanakis C, Kitsou E, Georgiou A, Doupis I, Kokkinos A, Karamvakalis N, Nikou GK. Chromogranin-A: A specific tumor marker for the follow-up of patients with metastatic carcinoid tumors: Comparison of different neuroendocrine tumor markers. Abstract, International Symposium on Nuclear Oncology January 2004, Porto Alegre, Brazil Liatis S, Doupis J, Tentolouris N, Perrea D, Zacharopoulou O, Katsilambros N. Effect of acutely-induced hyperhomocysteinaemia on aortic pulse waveform in patients with type 2 diabetes. 39 th Annual Meeting of the European Diabetes Epidemiology Group, April 2004, Salerno, Italy Doupis J, Tentolouris N, Pavlatos S, Zacharopoulou O, Perrea D, Kyriaki D, Katsilambros N. Effect of acute methionine-induced hyperhomocysteinaemia on the aortic wave reflection in patients with type 2 diabetes. Abstract, American Diabetes Association 64 th Scientific Sessions, 4-8 June 2004, Orlando, Florida, USA

12 Makrilakis K, Panagiotakis DB, Dimosthenopoulos C, Ioannidis I, Chrysohoou C, Doupis J, Pitsavos C, Katsilambros N. Low-to-moderate filtered coffee drinking attenuates the likelihood of acute coronary syndromes in diabetic subjects: the CARDIO 2000 II Study. Abstract, 22 nd International Symposium on Diabetes and Nutrition, 1-3 July 2004, Sastaholm, Sweden Doupis J, Tentolouris N, Perrea D, Pavlatos S, Zacharopoulou O, Liatis S, Tsokos N, Kitsou E, Katsilambros N. Effect of acute hyperhomocysteinaemia on QT interval in patients with type 2 diabetes. Abstract, 40 th Annual Meeting of the European Association for the Study of Diabetes, 5-9 September 2004, Munich, Germany Zacharopoulou O, Tentolouris N, Athanaselis S, Doupis J, Stilianou A, Psallas M, Cokkinos D, Katsilambros N. Effects of coffee intake on QT interval in subjects with type 2 diabetes. Abstract, 40 th Annual Meeting of the European Association for the Study of Diabetes, 5-9 September 2004, Munich, Germany Pavlatos S, Kokkinos A, Tentolouris N, Kyriaki D, Diakoumopoulou E, Doupis J, Katsilambros N. Differences in plasma total ghrelin concentrations after consumption of high-protein and high-fat content isoenergetic meals in lean and obese individuals. Abstract, 9 th Pan-Hellenic Congress on Diabetes, March 2005, Rhodes, Greece Papazafeiropoulou A, Moyssakis I, Perrea D, Tentolouris N, Skrapari I, Zacharopoulou O, Doupis J, Voteas B, Katsilambros N. Association of aortic distensibility with classic and novel risk factors in patients with type 2 diabetes. Abstract, 9 th Pan-Hellenic Congress on Diabetes, March 2005 Rhodes, Greece Tentolouris N, Kokkinos A,Tsigos C,Kyriaki D,Doupis J,Raptis SA,Katsilambros N. Changes of active Ghrelin plasma levels after tow separate meals, one rich in fat and one rich in carbohydrates. Abstract,2 nd Scientific Congress of Medical School, May 2005, Athens, Greece Tentolouris N, Kokkinos A, Tsigos C, Koukou E, Grammatikou M, Doupis J, Raptis SA, Katsilambros N. Meal-induced thermogenesis and macronutriend oxidation are not different between lean and obese woman after two separate isoenergetic meals, one rich in fat and one rich in carbohydrates. Abstract,14 th European Congress on Obesity,1-4 June 2005,Athens,Greece S. Pavlatos, A. Kokkinos, N. Tentolouris, D. Kyriaki, E. Diakoumopoulou, J. Doupis, N. Katsilambros Changes in plasma total ghrelin levels after high-protein and high-fat isoenergetic meals in lean and obese women 41 st EASD Annual Meeting Athens, Greece, September 2005 Doupis J, Mastrokostopoulos A, Doukas A, Kafantogias A. Incidence of common risk factors for cardiovascular disease, in South-west Albanian population. 2 nd Greek-Albanian medical military congress. May , Gyrocaster, Albania. Doupis J, Mastrokostopoulos A, Doukas A, Kafantogias A. Incidence of type 2 Diabetes in South-west Albanian population. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece. Mastrokostopoulos A, Doupis J, Doukas A, Kafantogias A. Incidence of Metabolic Syndrome in South- West Albanian adult population. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece.

13 Doupis J, Mastrokostopoulos A, Patsidiotis M, Kobolaki M, Voyajaki Th, Doukas A, Kafantogias A. Incidence of Impaired Fasting blood Glucose and Dyslipidaemia in South-West Albanian adult population. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece. Doupis J, Mastrokostopoulos A, Tentolouris N, Kokkinos A, Doukas A, Kafantogias A. Correlation between fasting blood glucose levels and presence of Carotid atherosclerosis in non diabetic subjects. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece. Mastrokostopoulos A, Doupis J, Doukas A, Kafantogias A. Correlation between Carotid endothelium thickness and common risk factors for cardiovascular disease, in Albanian outpatients of the cardiological clinic. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece. Mastrokostopoulos A, Doupis J, Kokkinos A, Doukas A, Kafantogias A. Correlation between Carotid endothelium thickness and body exercise in Albanian outpatients of the cardiological clinic. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece. Mastrokostopoulos A, Doupis J, Doukas A, Kafantogias A. Correlation between Carotid atherosclerosis and blood pressure in Albanian outpatients of the cardiological clinic. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece. Mastrokostopoulos A, Doupis J, Doukas A, Papadopoulos V, Kafantogias A. Correlation between Cardiothoracic index and body mass index in Albanian outpatients of the cardiological clinic. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece. Mastrokostopoulos A, Doupis J, Kokkinos A, Doukas A, Kafantogias A. Alcohol consumption and carotid endothelium thickness in South-west Albanian population. 10th Congress of Balkan Military Medical Committee June 2006, Athens, Greece. Dimosthenopoulos C, Makrilakis K, Doupis J, Diamanti K, Perrea D, Tsiamalos P, Metaxas Y, Zografos T.A, Tsipis D.A, Katsilambros N Disappointing adherence to the Mediterranean dietary pattern of a sample of young Greek Navy recruits. 23 nd International Symposium on Diabetes and Nutrition, 29 June -3 July 2006, Salerno, Italy Doupis J, Makrilakis K, Dimosthenopoulos C, Perrea D, Tsiamalos P, Diamanti K, Metaxas Y, Zografos T.A, Tsipis D.A, Katsilambros N Metabolic syndrome and Mediterranean dietary pattern in a sample of young Greek Navy recruits. 23 nd International Symposium on Diabetes and Nutrition, 29 June -3 July 2006, Salerno, Italy Kokkinos A, Tentolouris N, Kyriakaki E, Argyrakopoulou G, Doupis J, Kyriaki D, Katsilambros N. Chronic and acute effects of smoking on plasma total ghrelin concentrations in male non-smokers and habitual smokers. 10 th International Congress on Obesity 3-6 Sept 2006 Sydney, Australia. Makrilakis K, Doupis J, Dimosthenopoulos C,, Diamanti K, Perrea D Katsilambros N. Metabolic syndrome and Mediterranean dietary pattern in a sample of young Greek Navy recruits. 6 th Pan-Hellenic congress on Obesity September 2006.

14 Kokkinos A, Tentolouris N, Kyriakaki E, Argyrakopoulou G, Doupis J, Psallas M, Tentolouris N, Kyriaki D, Katsilambros N. Chronic and acute effects of smoking on plasma total ghrelin concentrations in male non-smokers and habitual smokers. 6 th Pan-Hellenic congress on Obesity September Makrilakis K, Doupis J, Dimosthenopoulos C, Perrea D, Diamanti K, Raptis SA, Katsilambros NL. The influence of the Mediterranean diet on the development of the Metabolic Syndrome in a sample of young Greek Navy recruits. 1 st World Congress on Controversies on Diabetes, Obesity and Hypertension (CODHy), October 26-29, 2006, Berlin, Germany. Oikonomou K, Doupis J, Mastrokostopoulos A, Mouhasiris C, Komninos C, Kafantogias A. The mission of the military Hospital of Gyrocaster. Achievements and statistical data st Hellenic Medical Military Congress, November 2006, Thessalonica, Greece. Mastrokostopoulos A, Doupis J, Doukas A, Kafantogias A. Correlation between Carotid endothelium thickness and common risk factors for cardiovascular disease, in Albanian outpatients of the cardiological clinic. 21 st Hellenic Medical Military Congress, November 2006, Thessalonica, Greece. Makrilakis K, Doupis J, Dimosthenopoulos C, Perrea D, Diamanti K, Katsilambros NL. The influence of the Mediterranean diet on the development of the Metabolic Syndrome in a sample of young Greek Navy recruits. 15 th European Congress on Obesity, April 22-25, 2007, Budapest, Hungary. Doupis J, Tentolouris N, Mastrokostopoulos A, Kokkinos A, Doupis C, Zdrava A, Kafantogias A. Prevalence of type 2 Diabetes in a sample of adult population in Southwest Albania. ADA June 2007, Chicago IL J. Doupis, E. Mantzou, A. Mastrokostopoulos, K. Saltiki, C. Stavrianos, M. Alevizaki Association of thyroid volume with nutritional habits in southwestern Albania. 32 nd annual meeting of the European thyroid association September 1st - 5 th, 2007 Leipzig, Germany Dinh T, DPM, Doupis J, Greenman R, Lima C, Giurini J, Gnardellis C Khaodhiar L Lyons T, Veves A Role of Vascular Reactivity and Inflammation in the Development and Healing of Diabetic Foot Ulceration AHA New Orleans Nov New Orleans. Doupis J, Stavrianos C, Mantzou E, Mastrokostopoulos A, Saltiki K, Alevizaki M. Thyroid volume, selenium levels and nutritional habits in outhwestern Albania. 35 th Hellenic congress of Endocrinology and Metabolism March Van Bergen A, Cohen LA, Doupis J, Gibson H, Gold RD, Horton E, Comparison of Two Methods of Assessing Macrovascular Disease in Type 2 Diabetes. ADA 6-10 June 2008 San Francisco CA Knegt C, Doupis J, Gibson H, Cohen LA Horton SE Effects of a Mixed Meal on Endothelial Function and Arterial Stiffness in Type 2 Diabetes. ADA 6-10 June 2008 San Francisco CA

15 Doupis J, Lyons T, Dinh T, Veves A. Microvascular Reactivity in Painful and Painless Peripheral Diabetic Neuropathy. ADA 6-10 June 2008 San Francisco CA Doupis J, Lyons T, Dinh T, Veves A. Microvascular Reactivity in Painful and Painless Peripheral Diabetic Neuropathy. Neurodiab 2008 San Francisco CA Doupis J, Saltiki K,Mantzou E, Mastrokostopoulos A, Stavrianos C, Alevizaki M. Thyroid volume, selenium levels and nutritional habits in outhwestern Albania. European Congress of Endocrinology 2008 Berlin, Germany May 2008 Doupis J, Lyons T, Dinh T, Veves Microvascular reactivity in painful and painless peripheral diabetic neuropathy EASD, Rome, 7-11 September Dinh T, DPM, Doupis J, Lyons T, Kuchibhotla S, Julliard W, Gnardellis C, Rosenblum B, Wang X, Giurini J, Greenman R, Veves A. Foot Muscle Energy Reserves Are Reduced In Diabetic Patients without And With Peripheral Neuropathy. ADA 6-10 June 2009 New Orleans LA. Doupis J, Tentolouris N, Mastrokostopoulos A, Kokkinos A, Doupis C, Kafadogias A. Prevalence of type 2 Diabetes in a sample of adult population in Southwest Albania. 45 th meeting of the Eutopean Epidemiology Group, Porto Heli May Dinh T, Doupis J, Gnardellis C, Lyons T, Kafanas A, Veves A. Role of Neuropeptides and Inflammation in the Development and Healing of Diabetic Foot Ulceration. 70 th ADA Orlando FL USA. Doupis J, Rahangdale S, Gnardellis C, Pena SE, Malhotra A,Veves A. Effects of Diabetes and Obesity on Vascular Reactivity, Inflammatory Cytokines and Growth Factors. 70 th ADA Orlando FL USA. Voulgari C, Koliaki C, Doupis J, Katsilambros N, Tentolouris N. The Smoking Profile And Its Relationship To Diabetic Complications In A Greek Type 2 Diabetes Sample. Idof Oct, Athens Greece.

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