CAO Yin-fang DING Hai-tao

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1 * CEA CA199 CA125 CA153 RNA microrna Exosomes R737.9 A DOI: /j.cnki.issn x X THE PROGRESS OF BIOMARKERS IN BREAST CANCER CAO Yin-fang DING Hai-tao Inner Mongolia People`S Hospital Hohhot China Abstract Breast cancer which was associated with lots of risk factors including environmental factors and personal lifestyle plays an important role in female health.previous studies have demonstrated that the combined application of tumor markers such as CEA CA199 CA125 and CA153 are useful for the early diagnosis and prognosis however the disadvantage for both the sensitively and specificity of the application exists.the further development of new tumor markers can provide clues for early diagnosis and prognosis which is valuably.this study has a systematic review and focus on new tumor markers which can provide the further understanding of micrornas and Exosomes. Key words breast cancer early diagnosis tumor marker biology prognosis breast cancer BC 1 3% nmgyy2302@ 163.com

2 478 Journal Of Inner Mongolia Medical University Oct.2017 Vol.39 No.5 CA125 6 CA125 1 CA125 CEA CA CA huaman epidermal CA199-2 HER-2 growth facter-2 HER-2 LPA FER HER-2 17q12 ~ 21 HER carcinoembryonic antigen CEA CEA HER-2 2 CEA lysophosphatidic acid LPA LPA CEA G CEA LPA CEA CEA 8 LPA LPA FER carbohydrate antigen153 CA153 CA153 FER CA153 CA153 H 4 30% ~ 50% CA153 80% L CA153 FER 11 CA TSGF carbohydrate antigen125 CA125 8 HER-2 FER TSGF TSGF CA125 CA125 TSGF

3 Bcl-2 p53 TSGF 18 mir RNA microrna 3 Exosomes RNA RNA 20 ~ 25 nucleotides NT mrna3 RNA 20 RNA mir- 155 mir - 19a mir - 181b mir - 24 mir - 34a mir-210 mir s mir- 148b mir p mir mir - 21 mir s 14 25% HER2 2.2 mir-10b mir-105 mir-34a P- mir ZO-1 1d 16 mir ANGPT2 mir - 10b RNA G1 G HER B -3B - Ex3-2B mir mir-200 mir-125b mir-15 mir-203 AdVHER2 210 mir-801 mir - 16 mir - 125b HER2 T

4 480 Journal Of Inner Mongolia Medical University Oct.2017 Vol.39 No mir-16 5.Cea CA 19-9 CA242 CA 72-4 TNF-α IL-6 TGF-β J M Chen MY Gao WW Xu YH et al.the significance of her 2 gene detection in breast cancer diagnosis and treatment 4 J.Modern Oncology Alsalloom AA.An update of biochemical markers of hepatocellular caicinoma J.Int J Health Sci Qassim Carroll PR Parsons JK Andriole G et al. Prostata cancer early detection Version featured updates to the nccn guidelines J. J Natl Compr Canc Netw J Chen JP Yan Y Wang XY et al. Muci - positive ciuculating tumor crlls and muci protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer J.Chin J Cancer Wu QB Sun GP.Expression of cox-2and her-2in colorectal cancer and their correlation J. World J Gastroen- terol ER PR her- 2 Ki67 J exosmme mirna J Chen WQ Zheng RS Baade PD et al.cancer statistics in china 2015 J. CA CANCER J CLIN J J CA153 cea CA125 cy- 16 Lin X Lo C Wong T et al. Noncoding rnas in human fra211 J. saliva as potential disease biomarkers J. Front Genet Lee JS Park S Park JM et al. Elevated levelsof preoperative CA 15-3and cea serum levels haveindependently poor prognostic significance in breast cancer J. Ann Oncol Bahrami A Mortazavizadeh MR Yazdi MF et al. Serial tumor markers serum carcinoembryonic antigenand cancer antigen 15-3assays in detecting symptomaticmetastasis in breast cancer patients J.East MediterrHealth J CA153 CA125 her-2 J Zhou W Fong MY Min Y et al. Cancer - secreted mir - 105destroysvascular endothelial barriers to promote metastasis J.Cancer Cell Sochor M Basova P Pesta M et al.oncogenic micrornas mir-155 Mir-19a Mir-181b And mir- 24enable monitoring of early breast cancer in serum J.BMC Cancer Roth C Rack B Müller V et al. Circulating micrornas as bloodbased marks for ppatients with primary and metastatic breast cancer J.Breast Cancer Res

5 Li Y Zheng Q Bao C et al.circular RNA is enriched and stable in exosomes a promising biomarker for cancer diagnosis J.Cell Res KesSLEr T Erdmann J Vilne B et al.serum microrna- 1233is a specific biomarker for diagnosing acute pulmonary embolism J.J Transl Med Yu DD Wu Y Shen HY et al.exosome in development Metastasis and drug resistance of breast cancer J. Cancer Sci Jang JY Lee JK Jeon YK et al. Exosome derived form epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor - associated macrophage infiltration and M 2 polarization J. BMC Cancer Bronte F Bronte G Fanale D et al. Hepatomirnoma the proposal of a new network of targets for diagnosis Prognosis and therapy in hepatocellular carcinoma J. Crit Rev Oncol Hematol Yang N Ekanem NR Sakyi CA et al.hepatocellular carcinoma and micorna new perspectives on therapeutics and diagnostics J.Adv Drug Deliv Rev Amr KS Ezzat WM Elhosary YA et al.the potential role of mirnas 21 and199 - a in early diagnosis of hepatocellular carcinoma J.Gene