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Ἀρχιμήδης Γεωργιάδης
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1 Ch in J Pancreato l, M arch 2004, V o l. 4, N o. 1 5 (severe acute pancreatitis, SA P), SA P 32,, 4 : (N S) (tetrandrine, T et) (ch inese m edicine qing yi tang, CM Q ) T et + CM Q 12 h, 6 h,, 5% (0. 5 m lgkg ) SA P, 1 h N S N S, 1 h 6 h 12 h 24 h 48 h 72 h 96 h,, (96 h) 96, N S, SA P 96 h ( 1 h ) (P < ), (P < 0. 01) (P > 0. 05), (P < P < ) N S SA P,, : (1),,,, (2), Effects of tetrandr ine, Qingy i Tang on blood levels of gastr in and m otilin in p igs with severe acute pancreatitiṡ L I Y ong 2Y u, GA O Z han2f eng, DU I D an2h ua, L I L i2j uan, W E I Y u, CH EN X iao2 Y an, L IU J ia2y un. D ep artm ent of P athop hy siology, M ed ical Colleg e, T ongj i U niversity, S hang hai , Ch ina Corresp ond ing au thor: L I Y ong 2Y u, E 2m ail: y ongy u li@hotm ail. com Abstract Objective To investigate the effects of tetrandrine, Ch inese m edicine Q ingyi T ang (CM Q ) on gastro intestinal ho rmones in m iniature p igs w ith severe acute pancreatitis(sa P) induced by sodium deoxycho late. M ethods 32 Guizhou m iniature p igs w ere divided random ly into four group s (n= 8), including con tro l group, tetrandrine group, CM Q group, and tetrandrine associating CM Q group. A ll experim ental anim als w ere fasted overnigh t w ithout access to w ater fo r six hours befo re operation, and then po rtal vein and vena cava paracentesis w as perfo rm ed w ith sterile technique. SA P model w as induced by injecting 5% sodium deoxycho late (0. 5 m lgkg w eigh t) into the pancreatic duct at a con stan t p ressu re. O ne hou r after the operation, saline, CM Q, tetrandrine o r CM Q associating tetrandrine w as adm in istered acco rdingly by in travenou s drip o r by gastric catheterization. A t p re2model, and 1 h, 6 h, 12 h, 24 h, 48 h, 72 h and 96 h after inducem ent of SA P, blood w as draw n from all p igs via the po rtal vein and vena cava at the sam e tim e. T he Serum levels of gastrin and : (N o ) : , ( ) ( ) :, E2m ail: yongyuli@ho tm ail. com

2 Ch in J Pancreato l, M arch 2004, V o l. 4, N o. 1 p lasm a levels of mo tilin w ere tested by radio imm unoassay. T he mo rtality of the p igs in different group s w as reco rded. Results Compared w ith N S group, tetrandrine and CM Q reduced the mo rtality significantly (P < o r P < 0. 01), and attenuated the increase of gastrin level and the decrease of mo tilin level bo th in the po rtal vein and vena cava. T he effect of tetrandrine w as sim ilar to that of CM Q (P > 0. 05). T he effect of their association w as mo re significant than that of the o ther group s (P < o r P < 0. 01). A lso, the patho logic mo rpho logy in the pancreas and duodenum imp roved in tetrandrine and CM Q group ṡ Conclusion s T he results of th is study show ed that tetrandrine and CM Q offered good therapeutic effects on p ig SA P induced by sodium deoxycho late. T he m echanism sm igh t be related to their m ulti functions on the stressed body by decreasing the h igher gastrin level to p revent the stress u lcer, and by increasing the low er m o tilin level, thu s accelerating in testinal peristalsis and drainage of po isonous substances to p revent ileus and endo toxem ia in SA P. Key words T etrandrine Pancreatitis M o tilin Gastrins Q ingyi T ang ( severe acu te pancreatitis, SA P ) (m u ltip le o rgan dysfunction syndrom e, M OD S),,, SA P : (1) 12 h, 6 h, 3% (35 m ggkg ) (ch inese m edicine qing yi tang, CM Q ) (T et), (cen tral venou s catheteri2 [ 122 SA P ] zation set) (A RRow ) 12 cm SA P,,, CM Q T et, (3),,,,,, (4) 1. : (12 2) ( ) ] ( ) 32, ( ) kg, 2. : SA P, SA P 4 : g 1 h, (N S) g (CM Q ) N S : (0. 5 m lgkg g (T et) g ), (5 m lgkg ) (CM Q + T et) 2. :, CM Q (5 m lgkg ) T et : ( ) (, : ), CM Q + T et : g (CM Q ), T et, CM Q, 12 h, : 25 g 25 g 40 g 25 g 25 g 25 g 40 g ( ) 15 g ( ), 1 h 6 h 12 h 24 h 48 h 72 h 96 h 4 m l, 2 m l (3 500 rgm in), 2 D PC GAM BYT 2CR Χ ( D PC ), [ 3 1. : ],, (2), (80 cm H 2O, 1 cm H 2O = kpa) 5% (015 m lgkg ) SA P (5) [ ( ) kj gkg CM Q :, 30 m ggm l T et (0. 5 m lgkg ), 3. : (p re2m odel, PM ), m l (30 Λl) ED TA (30 Λl)

3 Ch in J Pancreato l, M arch 2004, V o l. 4, N o. 1 7, 4 (3 500 rgm in),,, D PC GAM BYT 2CR Χ (96 h) 96, 10%,, H E, 4. :,, SPSS W indow s, F isher, ς 2 x θ s, t, P < 0105, P < SA P 96 h 1, (96 h), N S 50%, (P < P < 0. 05),, SA P, 2 1 SA P 96 h 96 h (% ) g N S g CM Q g T et g CM Q + T et :, 3 P < 0. 05, 33 P < N S (P < 0. 01) T et T et CM Q SA P CM Q (P < P < 0. 05), CM Q (P > 0. 05) T et 1 2, SA P 6 h, N S CM Q SA P,, 24 h, 1. : N S :,, 96 h,, (P < 0. 01), ( 1h ), N S (P <, CM Q + T et 0101) (P > 0105), : CM Q T et SA P, 1 T et CM Q SA P 3 4, SA P 1 h, N S,, 96 h, ( 1 h )

4 Ch in J Pancreato l, M arch 2004, V o l. 4, N o ,,, ( 5) : N S :,, CM Q + T et :, ( 6), SA P,,,,, [ 4 ], SA P TN F2Α, [ 5 ],,,,,,,, (T et),,, T et,,, T et 2. : : N S : T et,,, PLA 2 CM Q + [ 6 T et : ], PA F IL 21 TXA 2 A : N S :,, B: CM Q + T et :,,, 5 SA P (H E 200)

5 Ch in J Pancreato l, M arch 2004, V o l. 4, N o. 1 9 A : N S :,, B: CM Q + T et :, 6 SA P (H E 100) TN F,,,, [ 7 ] [ 2 ], T et PLA 2, PLA 2,, SA P TN F2Α,,,, SA P, SA P,,,,, 1999, 116: ,,,. SA P., 2002, 22 (, SA P 6 h, ) : ,,, 2001, 10: SA P [ 8 ] SA P,, SA P : (1), (2),, (3),, 1 W o jcik iew icz RJ, E rnst SA, Yule D İ Secretagogues cause ubiquitination and dow n2regulation of ino sito l 1, 4, 52trispho sp2 hate recep to rs in rat pancreatic acinar cells. Gastroentero logy, 3,,,.., 1999, 16: ,,,.. 5,,,.., 1999, 19: L ake2bakaar G, L yubsky S. Do se2dependent effect of continuous subcutaneous verapam il infusion on experim ental acute pancreatitis in m ice. D ig D is Sci, 1995, 40: ,,. A 2., 1995, 11: ,,,.., 2003, 4: ( : ) ( : )

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