HCG TSH TSH. ATA gestational transient hyperthyroidism GTH Graves 20% ~ 40% 11 GD 30% ~ 40% % ~ 1. 0% 5

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1 Keywords pregnancy hyperthroidism ATA R C The American Thyroid Association ATA hyperthyroidism thyrotoxicosis FT 4 10 FT 3 HCG 3 HCG 1 TSH α HCG 0. 1% ~ 0. 2% 2 TSH % ~ 0. 4% 3 ATA gestational transient hyperthyroidism GTH Graves 1% ~ 3% 4 20% ~ 40% 11 GD 30% ~ 40% % ~ 1. 0% 5 FGR ATA 0. 4 ~ 4. 0 mu /L ~ 0. 2 mu /L 1. 0 mu chendunjin@ hotmail. com 9 TBG TBG 10% TSH TSH TSH TSH

2 562 TT 3 TT 4 1 / FT 3 FT 4 FT 3 FT 4 FT 3 FT 4 5% ~ 10% HCG TSH TSH 0. 1 mu /L 1 /3 10% ~ 30% 12 GTH TSH TBG Graves 3 GTH Graves TSH ATA 1 TSH HCG TSH < 0. 1 mu /L FT 4 TT 3 T 4 TRAb T 3 16 TSH B-USPSTF 2 11 I-USP- ATA 1 STF 3 3 D-USPSTF TSH B-USPSTF 2 3 TSH mu /L 0. 1 ~ 3. 1 GTH GTH 2. 5 mu /L ~ 3. 0 mu /L ~ 3. 0 mu /L I-USPSTF 3 FT 4 HCG - FT 4 TT 4 TSH - LC-MS-MS A-USP- STF 4 LC-MS-MS FT 4 GTH GTH FT 4 ATA 1 GTH TSH I-USPSTF A-USPSTF 2 ATD 5 FT 4 FT 4 GTH D-USPSTF 3 FT 4 GTH HCG B-USPSTF HCG GD GTH 3. 2 Graves 1 14 TSH Graves Graves /min TSH < 0. 1 mu /L FT 3 FT 4 TBG TT 4 TT 3 GD HCG FT 4 TSH T 4 T 3 TRAb 95% 99% T 4 T 3 TSAb Graves ATA Ⅲ 5'- 1 GD GD TG 20 ~ 24 TRAb B-USPSTF 2 TRAb 3

3 563 I-USPSTF GD TRAb 1% ~ 2% 5% 0. 1% ~ 0. 5% 0. 1% ~ 1% GD TRAb TRAb TRAb ATD GD GD TRAb TRAb 22 ~ ~ 26 TRAb ATD GTH 3 ~ 4 d 7 ~ 10 d ATD ATD 3. 3 GD BMR 13 BMR MMI PTU 10% BMR 20% ~ 30% > 30% ~ 60% 60% 4 ATD ATA 3 PTU MMI I PTU 3 MMI I-USPSTF PTU MMI 6 PTU MMI PTU 1 ~ 2 h ATD ATD GD 6-7 PTU 2 TRAb 3 MMI PTU 20 4 Graves I 25% ~ 50% PTU MMI ATD ATD 7 1% ~ 5% ATD FDA ATD D ATD ATD MMI 6 ~ 8 h PTU MMI 7 MMI FGR PTU MMI MMI ATD ATD PTU PTU MMI % ~ 6% 1% ~ 5% 2 PTU TRAb 22 ~ 26 MMI TRAb 22 ~ 26 MMI MMI PTU 22 ~ 26 TRAb TRAb 22 ~ 26 ATD TRAb 22 ~ 26 TRAb 22 ~ 26 PTU MMI 10 1 ~ mg PTU 10 mg MMI ATD PTU MMI ATD

4 564 TSH 14 90% ~ 95% 0. 6% ~ ATD 9. 8% 22 PTU 50 ~ 150 mg 50 ~ 300 mg 2 ~ 3 /d MMI 5 ~ 15 mg 1 /d ATA ATD 2 ~ 6 FT 4 TSH FT 4 A-USPSTF B-USPSTF 4 TSH FT 4 4 TSH 6 ~ 8 FT 4 TSH 4. 5% ~ 5. 5% 23 TSH TSH ATD TRAb 5 ATD TRAb 5. 1 ATA ATD A-USPSTF ATA ATD I-USPSTF 1 FT 4 ATD FT 4 ATD FT 4 ATD 1 /3 ATD ATA MMI 20 ~ 30 mg /d 5. 2 PTU300 mg /d ATD FGR A-USPSTF ATD MMI PTU ATD 1 PTU MMI ATA ATD 10% ~ 20% 75% 24 LT 4 D-USPSTF 2 ~ 4 h ATD ATD ATD 21 ATD LT 4 LT 4 ATD ATA I ATD

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