Epidemiology, Evidence, and Basic Research of Diabetes Mellitus

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Κλωθώ Βιτάλη
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1 ( ) JOURNAL OF SUN YAT-SEN UNIVERSITY(MEDICAL SCIENCES) Vol.31 No.2 Mar (, ) :,,, (WHO-IDF) ; ; ;, Journal of Diabetes Investigation ; 20 2, wjianp@mail.sysu.edu.cn :,, 2, : ; ; ; ; : R349 : A : (2010) Epidemiology, Evidence, and Basic Research of Diabetes Mellitus WENG Jian-ping (Guangdong Research Center of Diabetes Mellitus Institute of Diabetes Mellitus of Sun Yat-sen University The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou , China) Abstract: The prevalence of diabetes is increasing dramatically and what is more serious is that the age of onset of diabetes in population is much younger than that of before. The author has carried out a series of research in diabetes, which mainly focused on epidemiology of diabetes mellitus and molecular genetics, early diagnosis and treatment of type 2 diabetes. This article aims to raise the attention of diabetes and promote the individual diagnosis and therapy of diabetes. Key words: diabetes mellitus; epidemiology; molecular genetics diagnosis; therapy [J SUN Yat-sen Univ(Med Sci),2010,31(2): ;'179] ,2010 ), 9.6%,, 6.09 [1] 15, , 14 7, ( NEJM, : : ( );(C ); 973 (2006C503902); ( ); ( ); (2006A );(2006B ); (2KM05001S); (Roche& NOVO); (2005Z1-E0041); 5010 ( )

2 [5] 44.0%, 23.0 ~ 24.9, 1998 kg / m %,25.0 ~ 29.9kg / m 2 8.9%, , 90%73% kg / m 2 1.3%,, 2 (HbAlc) 50 ~ 59 40, [2] 35.0%( )36.7%(, ),,, 1.3, 2, 1 1.1,2004, 10 [6], ( ) (TG),8 753, 8.3%, 6.8%,, (IGR) 4.9% 433,2003,, 27.9%,49.9%, IGR, 194 [3],(41.8% ), 152 (43.2% ), : 244 (67.6% ), 11.46%, 5.17%, 16.35%, TG 25.59%,, 4.72%, 18.84%, ,,,439 6 ~ ( 129, 115, ( ), [4] 195 ) 20 ~ %,, 10.8%, ; IGR 20.9% 10.4%; 17.2%, 15.9% IGR 17.9%1.6% 1.2,,,,,IGR, ( ) 1997 ( 3.5%), 2, ,5 ~ ~ 49, 50 ~ 59 60,, ,20 ~ 39,,,, ,

3 168 ( ) %, MODY, 2, MODY, MODY 1 ~ 5,, MODY4 IPF1 P239Q,,, ( 2 ) [11], 2, MODY 1 ~ 5, [12], MODY 2006 GCK E339K,, [13] 2, [ ],GCK E339K,2, (ATP) B MODY2 2, MODY,, 2 2,, [7], 2.2,,, 2.1 trnaleu (UUR) 3243A G (Maturity-onset diabetes of the young, MODY),, 6 MODY :MODY1 / -4α, (Hepatic nuclear factor-4α,hnf-4α),mody2 / (Glucokinase, GCK),MODY3 / [15-17] 1α(HNF-1α),MODY4 / 1 (insulin promoter factor 1, IPF1),MODY5 /, DNA, 1β(HNF-1β),MODY6 / DNA, 1(NeuroD1 / BETA2) MODY, MODY, 60, MODY trnaleu (UUR) 3243A G,,, 90 MODY, MODY ( MODY5, MODY2) 2,IPF1 P239Q [14] DNA,, 1997 ~ 2000 LUND DNA, MODY, MODY4 MODY5 trnaleu [8-10], (UUR) 3243A G C

4 2. 169, DNA, B 2005,, ( ),, 2.4 [18] 2.3 A, ) MODY,,, ( A ), ( ),, 2004, A, , LMNA ; 14, 2000, LMNA, lamin A / C,,10 ( miu / L) 3 : ( ) lamina / C (R1174W,CGG TGG) [19] A laminopathy LMNA,, lamin A C prelamin A / lamina : 5,, β, lamin A,lamin C A, [21],,,, lamin C, lamin 4, 2004, 12 ( (laminopathy), C,,, R1174W,CGG TGG,,, [20] -,, 2 ;,, B

5 170 ( ) 31, 2 ;,,,, , 2 [26], B B,,, HbAlc B,,,, 2,, 2,2, 3.2,, 2, ,, , 2 SD, 2 (CSII), 2,2 CSII,2 [23],, B, [23] [28] CSII 1,, (47.1%),, [29-30], B, NFκB ;, [24] 2,, ( ; ) (, ), [31] ; B [25],,,, 9 B, 2004, C57B6 / J [27], 2,

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7 178 ( ) 31 [29] ES-cell-like state [J]. RNA, 2008, 14 (10): Cadigan KM, Nusse R. Wnt signaling: a common [35] 351(7): Jamieson CH, Ailles LE, Dylla SJ, et al. Granulocytemacrophage progenitors as candidate leukemic stem [30] [31] [32] [33] [34] theme in animal development [J]. Genes Dev, 1997, 11(24): baron M. An overview of the Notch signalling pathway [J]. Semin Cell Dev Biol, 2003, 14(2): Nozoe T, Takahashi I, Baba H, et al. Relationship between intracellular localization of p34cdc2 protein and differentiation of esophageal squamous cell carcinoma [J]. J Cancer Res Clin Oncol, 2005, 131 (3): Walkley CR, Olsen GH, Dworkin S, et al. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency [J]. Cell, 2007, 129(6): Mantovani A. Cancer: Inflaming metastasis [J]. Nature, 2009, 457(7225): Jamieson CH, Ailles LE, Dylla SJ, et al. Granulocytemacrophage progenitors as candidate leukemic stem [36] [37] [38] [39] cells in blast-crisis CML [J]. N Engl J Med, 2004, 351(7): Fan X, Matsui W, Khaki L, et al. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors [J]. Cancer Res, 2006, 66(15): Jin L, Hope KJ, Zhai Q, et al. Targeting of CD44 eradicates human acute myeloid leukemic stem cells [J]. Nat Med, 2006, 12(10): Kawashima K, Nagura E, Kato Y, et al. Treatment of adult acute promyelocytic leukemia during the period of [J]. Rinsho Ketsueki, 1984, 25 (2): Calabrese C, Poppleton H, Kocak M, et al. A perivascular niche for brain tumor stem cells [J]. Cancer Cell, 2007, 11(1): (, ) cells in blast-crisis CML [J]. N Engl J Med, 2004,!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! ( 171 from page 171) [25] [26] [27] [28] Xu W, Li YB, Deng WP, et al. Remission of hyperglycemia following intensive insulin therapy in newly diagnosed type 2 diabetic patients: a long term follow-up study [J]. Chin Med J, 2009, 122 (21): Weng JP, Li Y, Xu W, et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial [J]. Lancet, 2008, 371(9626): diet, streptozotocin-treated diabetic rats [J]. Acta Diabetologia, 2008, 45(3): ,,,. decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular [J].,2009,36(10): triglyceride accumulation after insulin therapy in highfat-diet Bi Y, Sun WP, Chen X, et al. Effect of early insulin therapy on nuclear factor kappab and cytokine gene and streptozotocin-induced diabetic rats Metabolism, 2009, 58(6): [J]. expressions in the liver and skeletal muscle of high-fat (, ) [29] [30] [31],,. -KB [J].,2009,48(1):17-22.,,. κb [J].,2008,88(46): Yan Bi, Mengyin Cai, Hua Liang, et al. Increased carnitine palmitoyl transferase 1 expression and

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