436 2013 27 5 1 2 1 1 1 2 CFAEs 22 CFAEs CFAEs CFAEs CFAEs CFAEs CFAEs DOI 10. 7695 /zgxzqb201305016 2013-10 - 10 10 05 http / /www. cnki. net /kcms /detail /42. 1421. R. 20131010. 1005. 015. html R541. 7 + 5 R454. 1 R331. 3 + 8 A 1007-2659 2013 05-0436 -05 The frequency and distribution of complex fractionated atrial electrograms in a canine model of atrial fibrillation induced by local electrical stimulation. LIU Peng 1 GUO Ji-hong 2 ZHANG Zhen 1 LI Jiao 1 LIU Hou-guang 1 ZHANG Hai-cheng 2. 1 Department of Cardiovascular Medicine China Meitan General Hospital Beijing 100028 China 2 Department of Cardiology People's Hospital Peking University Beijing 100044 China Corresponding author LIU Peng E-mail liupeng1037@ sohu. com Abstract Objective To investigate the frequency and distribution of complex fractionated atrial electrograms CFAEs in a canine model of atrial fibrillation AF induced by local electrical stimulation at different sites in the atria and 4 pulmonary veins PVs. Methods In 22 mongrel dogs the cervical vagal trunks were isolated bilaterally and decentralized. Local burst stimulation S 1 S 1 = 80 ms impulse duration 0. 5 ms and programmed stimulation were performed to right appendage RAA left appendage LAA and different sites of 4 PVs. AF inducibility and CFAEs were determined at each site in the baseline state and during bilateral cervical vagal nerve stimulation VNS 12. 5 Hz impulse duration 0. 5 ms stimulation voltage 5-8 V. Results The sites of local electrical stimulation initiating AF were not at the same location as those of the CFAEs. CFAEs were observed more frequently at RAA LAA and the proximal portions of 4 PVs during AF. The prevalence of CFAEs was higher during VNS. Conclusion It is more common to map CFAEs at several sites of PVs during AF. VNS increases the frequency of CFAEs. Chinese Journal of Cardiac Pacing and Electrophysiology 2013 27 5 436-440 Key words Cardiology Atrial fibrillation Pulmonary vein Complex fractionated atrial electrograms Vagal nerve Electrophysiology 1 CFAEs CFAEs CFAEs 1 100028 2 100044 1965 - E-mail liupeng1037@ sohu. com 2 3 CFAEs 29% CFAEs
437 CFAEs 1. 7 4 1 1 RAA LAA 1. 1 22 Burst S 1 S 1 80 15 ~ 23 kg 3 ms 2 0. 5 ms 5% 20 mg /kg 3 30 s 2 5% 12. 5 2. 5 mg kg - 1 h - 1 Hz 0. 5 ms 5 ~ 8 V KTH-3 > 2 s 4 ~ 6 L /min Burst 10 ml /kg 0 ~ 2 Kpa 5 > 500 / 1. 2 4 ~ 5 1. 8 CFAEs 10 s 6 CFAEs CFAEs 7 1 2 2 50 ms 2 1. 3 120 ms < 50 ms 1. 9 5 min 1. 4 1. 10 10% 50 ms 1. 5 2 7F 2. 1 22 2 RV 5F 3 2 mm 5 mm Bard 1 2 RAA LAA LSPV LIPV RSPV RIPV 14 Burst 3 1 ~ 2 32 GY-6328 42 1 ~ 2 2 ~ 3 2. 2 CFAEs 3 ~ 4 Burst 30 ~ 500 Hz 1. 6 1 CFAEs RAA LAA PSA Biotronik CFAEs 0. 5 ms 10 CFAEs 1 ~ 20 / 2 1 2 LSPV LSPV LSPVp DF-5A 6 LSPVp CFAEs 2 S 1 S 1 300 ms S 1 S 2 = 200 ms LSPV 7-10 ms RAA LAA 0. 5 ms 2 CFAEs 1 CFAEs CFAEs RAA LAA LSPVp LSPVm LSPVd LIPVp LIPVm LIPVd RSPVp RSPVm RSPVd RIPVp RIPVm RIPVd 7 4 4 2 6 2 4 0 7 0 4 1 10 2 3 0 6 2 6 1 4 0 5 1 3 0 1 0 18 10 12 5 15 11 11 4 12 8 13 6 16 10 8 4 16 9 14 8 12 4 14 8 10 4 8 3 p = m = d =
438 2013 27 5 1 LIPVp CFAEs RAA 2 RAA CFAEs LSPVp LSPVm LSPVd LIPVd A P 121 95% CFAEs 1 CFAEs 91% Oral 2 CFAEs CFAEs Nademanee CFAEs 1 3 33% 13 2. 3 CFAEs CFAEs 57% 3 44% 2 3 CFAEs 1 3 CFAEs CFAEs Nademanee 6 CFAEs CFAEs CFAEs
439 3 LIPVp S 1 S 2 300 /120 ms LSPVp LIPVp RIPVp RIPVm CFAEs CFAEs CFAEs CFAEs CFAEs 8 CFAEs 9 GP 15 10 11 CFAEs 12 10 CFAEs 16 GP 13 CFAEs GP CFAES CFAEs 14 CFAEs 6 1 CFAEs 2
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