Cytokines and Parkinson's Disease

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1 * doi /cpj R965 A Cytokines and Parkinson's Disease XIE Tao DU Guan-hua * Beijing Key Laboratory of Drug Targets Identification and Drug Screening Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China ABSTRACT OBJECTIVE To review the role of cytokines played in Parkinson to direct the treatment of the disease from the prospective of cytokines. METHODS This paper had consulted analysed concluded and summarized research progress of the functions of cytokines in Parkinson's disease. RESULTS AND CONCLUSION Cytokines as inflammatory mediators is involved in Parkinson. Some cytokines can contribute to the progress and development by playing the role of proinflammatory. Others however may play the role of anti-inflammatory to slow down the progress of or as a protective agent to against the disease. KEY WORDS Parkinson's disease dopamine cytokines inflammatory Parkinson's disease 1 2 interleukin IL colony stimulating factor 3 CSF interferon IFN tumor necrosis factor TNF growth factor Lewy 4 T 5 1 IL IL T 8 IL 37 IL IL-1 ~ IL IL-1 IL-1 IL-1α IL- 2013ZX * Tel /Fax dugh@ imm. ac. cn 1773

2 IL IL-1 IL-10 IL T /C 1 IL IL IL-12 3IL-1 T 13 4IL-1β IL-12 IL- α-synuclein 10 Lewy 5 IL-15 IL-1β T IL-15 1β 2 IL-1 IL-10 IL OHDA 10 6-OHDA IL-1β CD4 + T IL- MPTP IL-1 ROS NO 22 inos NO MPTP 10 IL-10 IL-1 MPTP IL MPTP -1 inos IL IL-6 25 IL-18 IL-6 T IL C / A 14 IL-6 Hirsch 2 CSF IL-6 Blum CSF Stypula IL-6 IL-6 α- G-CSF tau 15 M-CSF - α- GM-CSF multi-csf IL-3 IL-6 16 LPS 2. 1 G-CSF IL-6 G-CSF G-CSF IL IL IL-10 G-CSF IL-10 MPTP 13 d 40 μg kg - 1 G-CSF MPTP IL G-CSF 6-OHDA IL G-CSF LPS MPTP IL G-CSF IL OHDA G-CSF Bcl Chin Pharm J 2014 October Vol. 49 No

3 36 3 TNF TNF T 43 BDNF BDNF mrna TNF-α TNF-β Bax PC12 29 G- CSF neurotrophic factors NTF G-CSF PI3K /Akt GM-CSF MPTP 6-OHDA GM-CSF GM-CSF GM-CSF GM- CSF GM-CSF PC12 GM-CSF MPTP 33 GM-CSF brain-derived neurotrophic factor BD GM-CSF NF glial-derived neurotrophic 2 factor GDNF neurturin 42 Bcl-2 Bax 4. 1 BDNF GM-CSF BDNF TNF MPTP 6-OHDA 37 6-OHDA BDNF TNF BDNF trkb NT-3 trkc lenti-dn-tnf 38 lenti- α- DN-TNF Bialecka TNF-308 BDNF 44 TNF-308AA 39 BDNF TNF-α MPTP BDNF TNF-α 4. 2 GDNF IL-1β TNF-α NO GDNF 40 LPS EGCG EGCG TNF-α GDNF BDNF GDNF TNF-α 41 TNF-α GDNF A GDNF GDNF 1 Ras /MAPK PI3K /Akt Ca growth factor BDNF BDNF 2 NTFs /Src SFKs 3GDNF MEK1 /2 ERK1 /2 1775

4 4. 3 Neurturin astrocytes J. Molecular Neurobiol DELEIDI M GASSER T. The role of inflammation in sporadic Neurturin GDNF and familial Parkinson's disease J. Cell Mol Life Sci GDNF 2 9 POTT GODOY M C TARELLI R FERRARI C C et al. Central GFRαs RET GFRαs 4 GFRα1 ~ GFRα4 Neurturin GFRα2 and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson' s disease J. Brain Neurturin GFRα2 Ret Ret 10 KIM H S SUH Y H. Minocycline and neurodegenerative diseases J. Behav Brain Res Ret-Shc-Grb2 11 CORBETT G T ROY A PAHAN K. Gemfibrozil a lipid-lowering drug upregulates IL-1 receptor antagonist in mouse cortical Ras Raf MAPK neurons Implications for neuronal self-defense J. J Immunol LOFRUMENTO D D NICOLARDI G CIANCIULLI A et al. 5 Neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson's-like disease Possible role of SOCS-1 in reducing proinflammatory responses J. Innate Immun WANG X CHEN S MA G et al. Involvement of proinflammatory factors apoptosis caspase-3 activation and Ca disturbance in microglia activation-mediated dopaminergic cell degeneration - J. Mech Ageing Dev HOFMANN K W SCHUH A F S SAUTE J et al. Interleukin- 6 serum levels in patients with Parkinson' s disease J. Neurochem Res BICK R J POINDEXTER B J KOTT M M et al. Cytokines disrupt intracellular patterns of Parkinson' s disease-associated pro- IL-1 teins alpha-synuclein tau and ubiquitin in cultured glial cells IL-10 - J. Brain Res IL-12 IL-15 IL KLEGERIS A GIASSON B I ZHANG H et al. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells J. FASEB J TNF-α BEYNON A L BROWN M R WRIGHT R et al. Ghrelin inhibits LPS-induced release of IL-6 from mouse dopaminergic neurones J. J Neuroinflam CHU K ZHOU X LUO B Y. Cytokine gene polymorphisms and Parkinson's disease A meta-analysis J. Can J Neurol Sci RENTZOS M NIKOLAOU C ANDREADOU E et al. Circulating interleukin-10 and interleukin-12 in Parkinson's disease J. Acta Neurol Scand JOHNSTON L C SU X MAGUIRE-ZEISS K et al. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's REFERENCES 1 SCHAPIRA A H. Mitochondria in the aetiology and pathogenesis of Parkinson's disease J. Lancet Neurol COOKSON M R VAN DER BRUG M. Cell systems and the toxic mechanism s of α-synuclein J. Exp Neurol YACOUBIAN T A STANDAERT D G. Targets for neuroprotection in Parkinson' s disease J. Biochim Biophys Acta FRITSCH T SMYTH K A WALLENDAL M S et al. Parkinson disease Research update and clinical management J. South Med J disease J. Mol Ther XIN J WAINWRIGHT D A MESNARD N A et al. IL-10 within the CNS is necessary for CD4 + T cells to mediate neuroprotection J. Brain Behav Immun KUTER K KOLASIEWICZ W GOLEMBIOWSKA K et al. Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of rats J. Pharmacol Rep SCHWENKGRUB J JONIEC-MACIEJAK I SZNEJDER-PACHO LEK A et al. Effect of human interleukin-10 on the expression of nitric oxide synthases in the MPTP-based model of Parkinson's disease J. Pharmacol Rep PHANI S LOIKE J D PRZEDBORSKI S. Neurodegeneration 24 LI D HE Q LI R et al. Interleukin-10 promoter polymorphisms and inflammation in Parkinson's disease J. Parkinson Relat Disord KHANDELWAL P J HERMAN A M MOUSSA C E. Inflammation in the early stages of neurodegenerative pathology J. J Neuroimmunol in Chinese patients with Parkinson's disease J. Neurosci Lett RENTZOS M ROMBOS A. The role of IL-15 in central nervous system disorders J. Acta Neurol Scand MEUER K PITZER C TEISMANN P et al. Granulocyte-colony 7 NIRANJAN R. The Role of inflammatory and oxidative stress stimulating factor is neuroprotective in a model of Parkinson' s mechanisms in the pathogenesis of Parkinson's disease Focus on disease J. J Neurochem Chin Pharm J 2014 October Vol. 49 No

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