The Interaction between ERS and MicroRNAs in Tumor

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1 ISSN CN / Q http / / cjbmb bjmu edu cn Chinese Journal of Biochemistry and Molecular Biology ~ 988 ERS MicroRNAs * MicroRNAs RNAs micrornas micrornas RNA Q28 R73 The Interaction between ERS and MicroRNAs in Tumor JIA Xiao-Ting HE Zhi-Min * Affiliated Tumor Hospital of Guangzhou Medical University Guangzhou China Abstract Endoplasmic reticulum ER is the organelle which is important for polypeptide posttranslational modification and for achieving their correct mature folding conformation There are kinds of external factors such as heat shock virus infections and hypoxia which disrupt the function of ER leading to unfolded proteins or misfolded proteins to accumulate in ER lumen The accumulation of these proteins in lumen of the ER triggers a cell stress response were called endoplasmic reticulum stress ERS MicroRNAs are small noncoding RNAs which play important roles in posttranscriptional gene regulation An increasing evidence shows that there is a close relationship between ERS and microrna They interact with each other and take part in many physiology processes together This review summarized the relationship between tumor and the interaction of ERS with micrornas to understand the regulation mechanisms of tumorigenesis in-depth and also to provide new strategies for tumor therapy Key words endoplasmic reticulum stress ERS unfolded protein response UPR micrornas tumor expression regulation ERS 2 Ca 2 + tunicamycin 3-5 micrornas thapsigargin dithiothreitol endoplasmic reticulum stress ERS 1 * Tel unfolded protein response UPR ER-associated degradation ERAD micrornas hezhimin2005@ yahoo com Received July Accepted September * Corresponding auther Tel hezhimin2005@ yahoo com

2 11 ERS MicroRNAs ERS ERS - C57 / B6 ERS Western CP 6 7 PERK IRE1 ERS ERS UPR CP 19 ERS 8 ERS 2 MicroRNAs ERS 9 10 ERS MicroRNAs RNA Ⅱ Pol Ⅱ ERS pri-micrornas microprocessor 70 nt 16 Ryoo UPR pre-micrornas Dicer 22 nt micrornas ERS micrornas pre-micrornas micrornas micrornas * 21 micrornas micrornas * RNA RNA-induced silencing ERS mrna 3'UTR mrna GRP78 78 kd mrna glucose-regulated protein GRP78 / Bip 22 MicroRNAs ERS Pten phosphatase and tensin homolog deleted on chromosome ten human hepatocellular cancer HCC mir-221 / GRP78 Pten 222 HCC ERS Pten AKT mir-221 /222 HCC GRP78 mir-221 /222 ERS GRP78 AKT mir-221 /222 GRP78 GRP mir-221 /222 ERS HCC ERS calreticulin calumenin 1 ERP29 SET tetrakis mir-122 tetrahydropyrane copper I hexafluorophosphate CP CP 26S micrornas pre-micrornas micrornas complex RISC mir-122 HCC GRP78 CHOP 23 mir-122 CP CP 4 cyclindependent kinase 4 CDK4 26S

3 ATP 10 26S proteasome non-atpase regulatory subunit 10 PSMD10 thapsigargin HepG2 6 h mir-22 mir ATF6 mir-455 PERK NF-kB mir-455 calreticulin XBP1 Calr Calr XBP1 microrna UPR human trabecular meshwork cells HTM 5 Li 26 mir-204 tunicamycin 34 XBP1 mir-214 PCR ERS mir-214 UPR 34 ERS ATF4 GRP94 BIP CHOP mir mir-204 UPR activating transcription factor 4 NFR2 nuclear UPR factor erythroid-2-related factor 2 mir- 106b-25 Bim Bim UPR 27 3 ERS micrornas 4 ERS micrornas DNA RNAi mouse micrornas embryonic fibroblasts MEFs CHOP 37 mir-708 GRP78 ERS 2 /3 CHOP mir-708 H4 4 mir-708 GRP78 38 GRP78 28 HEK293 trnas trnas ERS trna micrornas mir GRP78 mir-131 mir mir-205 epigallocatechin gallate EGCG GRP78 3 mir ERS 41 GRP78 XBP1 mir-346 GRP78 LPS mir-346 GRP78 Btk HSV-tk herpes simplex virus-thymidine kinase TNF-α mir PERK 42 ERS NF-κB mir-30c-2 * 5 BCL9 BCL9 ERS ATF6 33 ERS UPR UPR NF-κB mir-199a /214 NF-κB XBP1 mir ERS micrornas 32 ERS ERS micrornas

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