Who identified endometriosis Fertility and Sterility Special. Cullen adenomyoma. Irving and. site less common site rare site common site

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1 131 Who identified endometriosis Fertility and Sterility Special Contribution Thomas S. Cullen Jonhs Hopkins Cullen adenomyoma adenomyoma endometriosis John A. Sampson Irving and Clement common siteless common siterare site common site polypoid endometriosis

2 132 Common site Less common site Rare site S polypoid endometriosis polypoid endometriosis adenomyotic nodules epithelial mesenchymal transition : EMT EMT Deepinfiltrating endometriosis EMT EMA CD, Ki

3 133 porous diaphragm syndrome porous diaphragm syndrome Shih and Kurman Type I Type II Type PTENβcateninKras Kathleen R. Cho PIK Pten signaling pathway Wntβcatenin signaling pathway CreLox P PTEN APC Dinulescu et al CreLox P Kras BRAF KRAS Type KRAS LOHPTEN βcatenin KRAS MI ARIDA ARIDA KRAS MI TGFβ RII Type p HERneu AKT p p LOH : loss of heterozygosity, MI : microsatelite instability

4 134 PTEN ARIDA Takeuchi et al ARIDA BAFα ARIDA PTEN, ARIDAp PTEN ARIDA p PTEN ARIDA p Ueda et al PTEN ARIDA ARIDAp p

5 135 debulking surgery IVFET debulking surgery GnRH Debulking surgery UAE MRI FUS PDT debulking surgery

6 136 GnRH EP Ocs GnRH GnRH EP PG Gn E Gn Gn P GnRH Gn NSAIDs

7 137 EMT EGFFGF βtgfβ αtnfα EMT E EMT in vitro In vitro EMT MET Department of Pathology, University of Michigan, U.S.A. Kathleen R. ChoProfessor

8 138 Benagiano G et al. Who identified endometriosis? Fertil Steril Cullen TS. Adenomyoma of the uterus. Philaderphia : Saunders WB Cullen TS. The distribution of adenomyomata containing uterine mucosa. Arch Surg Sampson JA. Inguinal endometriosis. Am J Obstet Gynecol Irving JA et al. Disease of the peritoneum. In : Kurman RJ, Ellenson LH, Ronnett BM eds. Blaunstein s Pathology of the Female Genital Tract, th ed, New York: Springer-Verlag Polypoid endometriosis S polypoid endometriosis FUJI Infertility&MenopauseNewssuppl Saito F et al. Twisted ovarian tumor causing progressive hemothorax: a case report of porous diaphragm syndrome. Gynecol Obstet Invest Shih IM et al. Ovarian tumorigenesis : a proposed model based on morphologic and molecular genetic analysis. Am J Pathol Wu R et al. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PIK/Pten signaling pathways. Cancer Cell Dinulescu DM et al. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nature Med Jones S et al. Frequent mutation of chromatin remodeling gene ARIDA in ovarian clear cell carcinoma. Science Wiegand KC et al. ARIDA mutation in endometriosis-associated ovarian carcinomas. N Engl J Med Takeuchi T et al. Chromosomal mapping and expression of the human B gene. Gene Ueda Y et al. Retrospective analysis of ovarian endometriosis during pregnancy. Fertil Steril ART Pafumi CA et al. Adenomyosis and uterus rupture during labor. Zhonghua Yi Xue Za Zhi Taipei Nakamura M et al. Scanning electron-microscopic and immunohistochemical studies of pelvic endometriosis. Hum Reprod Nisolle M et al. Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertil Steril Ohtake H et al. A novel in vitro experimental model for pelvic endometriosis : the three-dimensional culture of the human ovarian surface epithelial cells in collagen gel system with the human ovarian surface epithelial cells. Fertil Steril Arima Y et al. Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res EMT Takahashi E et al. Tumor necrosis factor-α regulates transforming growth factor-β-dependent epithelial-mesenchymal transition by promoting hyaluronan CD moesin interaction. J Biol Chem

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