2016 20 24 Journal of Clinical Medicine in Practice 7 200437 60 2 7 NYHA I ctni BNP LVEF E /A 2 ctni BNP P < 0. 05 P < 0. 05 2 LVEF E /A NYHA P < 0. 05 R 631 A 1672-2353 2016 24-007-04 DOI 10. 7619 /jcmp. 201624002 Effect of shengjiang powder on protection of myocardial injury in patients with sepsis QIAN Fenghua ZHAO Lei SHEN Mengwen WANG Jin XI Yao GUO Jian Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200437 ABSTRACT Objective To observe the clinical effect of shengjiang powder on protection of myocardial injury in patients with sepsis. Methods A total of 60 patients with myocardial injury caused by sepsis toxic heat syndrome were randomly divided into western control group and traditional Chinese and western medicine treatment group. Western medicine control group was given routine treatment of western medicine while traditional Chinese medicine and western medicine treatment group was given western medicine combined with shengjiang powder on the basis of control group. The TCM syndrome score curative effect of TCM syndrome the NYHA grading the levels of troponin I ctni brain natriuretic peptide BNP left ventricular ejection fraction LVEF and the ratio of mitral flow velocity and the expansion of the early peak atrial systolic blood flow velocity E /A were detected and compared before and after treatment. Results After treatment the TCM syndrome score serum ctni and BNP improved significantly in both groups P < 0. 05 and Chinese and western medicine treatment group were significantly better than the western medicine control group P < 0. 05. After treatment the LVEF E /A and NYHA grading improved significantly in both groups P < 0. 05. Conclusion Shengjiang powder combined with routine western medicine therapy can effectively reduce TCM syndrome score in myocardial injury toxic heat flourishing syndrome patients with sepsis improve the curative effect of TCM syndrome and reduce the myocardial damage of patients. KEY WORDS sepsis myocardial injury shengjiang powder 2015-12 - 16 81303101 201440399 E - mail smileqian1975@ qq. com
8 20 MODS 1 1 2 2 3 I 4 ctni BNP 7 d / 1. 2 6 g 3 g 3 g 12 g 1 /d 2 200 ml 1 1. 1 100 ml 2 7 d 2013 6 2015 2 1. 3 62 2002 31 31 2 2 4 0 2 4 6 17 14 66. 26 ± 0 1 2 3 2 8. 89 APACHEⅡ 18. 10 ± 7. 13 7 15 14 65. 48 ± 9. 96 APACHEⅡ 16. 29 ± 5. 11 2 APACHE Ⅱ 2002 P > 0. 05 2012 2 95% I ctni 70% 2 2013 30% 30% 3 - / 100% 2 7 I ctni BNP 2 7 M 1 18 85 LVEF 2 E / A LVEF 2D-simpson LVEF < 50% E /A 3 E /A < 1 NYHA Ⅲ ~ Ⅳ 2 7 4 5 NYHA 6 7 3 ml
24 9-20 20. 65 ± 5. 58 22. 31 ± Beckman Access 5. 33 P = 0. 243 ctni BNP ACU- SON sequoia 512 10. 81 ± 5. 61 8. 59 ± 4. 51 1. 4 SPSS 16. 0-13. 72 ± 3. 58 P < ± 0. 05 t t P < 0. 05 2 P < 0. 05 P > 0. 05 2 P < 0. 05-9. 84 ± 3. 63 1 ctni 1. 89 ± 1. 21 2. 05 ± 1. 14 ng /ml 1 2 n = 31 n = 29 /% /% 12 10 9 71. 0 19 9 1 96. 6 * 10 10 11 64. 5 13 13 3 89. 7 * 14 11 6 80. 6 19 9 1 96. 6 * 11 15 5 83. 9 17 11 1 96. 6 * 7 16 8 74. 2 14 13 2 93. 1 5 14 12 61. 3 13 10 6 79. 3 * 4 12 15 51. 6 7 9 13 55. 2 * 9 8 14 54. 8 13 7 9 69. 0 6 12 13 58. 1 8 10 11 62. 1 * 6 9 16 48. 4 9 6 14 51. 7 * P < 0. 05 P = 0. 588 ctni 0. 81 ± 0. 71 0. 57 ± 0. 56 ng /ml P < 0. 05 ctni - 1. 08 ± 0. 67 ng /ml - 1. 48 ± 0. 73 ng /ml P = 0. 029 BNP 320. 12 ± 157. 83 318. 10 ± 191. 56 pg /ml E /A < 1 E /A 1 P = 0. 965 n = 31 15 48. 4 16 51. 6 BNP 186. 22 ± 6 19. 4 * 25 80. 6 115. 22 126. 80 ± 75. 64 pg /ml n = 29 16 55. 2 13 44. 8 5 17. 2 * 24 82. 8 P < 0. 05 BNP - 191. 30 ± 139. 54 NYHAⅠ 14-133. 90 ± 56. 15 P = 45. 2% NYHAⅡ 17 54. 8% 0. 046 2 LVEF NYHAⅠ 13 44. 8% NYHA 2 2 E /A 3 2 2 LVEF n % LVEF < 50% LVEF 50% n = 31 10 32. 3 21 67. 7 3 9. 7 * 28 90. 3 n = 29 9 31. 0 20 69. 0 * P < 0. 05 3 2 6. 8 * 2 E /A n % 27 93. 2 Ⅱ 16 55. 2% 2 NYHA
10 20 P = 0. 979 NYHAⅠ NYHAⅡ ~ Ⅳ NYHAⅡ NYHA Ⅱ 76. 5% 13 /17 87. 5% 14 /16 2 P = 0. 656 2 3 / 10-13 14 - CI 16 CO 1999 Andrew 25% I ctni BNP 4 - / 6 30 7-9 ctni BNP 1 GALLEY H F. Oxidative stress and mitochondrial dysfunction in sepsis J. Br J Anaesth 2011 107 1 57-63. 19
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