- ( ). C-reactive protein 5* 4 4 3 2 1 C-reactive protein () :.. ) polypill 2 Polypill : -79 ( (%64) 448 50 FBS <126 mg/dl WBC <12000 per µl <1/3 mg/dl high sensitivity (hs). 1386 1385..(P=0/001) [0/9 (0/4 2) mg/l] [1/3 (0/7 2/6) mg/l] (IQR) : (P=0/009) (P=0/002) (P=0/001) (P=0/006) (P=0/001) (P=0/042) (P=0/007) HDL. log. :. : -1-2 -3-4 -5 : 82415300 : 09123216695 : 14117 : : * pourshams@ams.ac.ir 88/7/27 : 88/7/12 : 88/3/25:
... C-reactive protein : 90 20 polypill. 2/5 81. 12/5 79 55 79 50 Polypill 1617. 1386 1385 ( 675 942) 872 (OTC) 1-12.. 10 mg/dl WBC 12000 per µl Cr 1/3 mg/dl FBS 126. 700 4 2 (kg) (BMI). high. (m) sensitivity (hs) ( ) mg/l. intra- and interassay coefficients of variation. 1/7 2/6 hs LDL HDL 1- Over-The-Counter 2- Body Mass Index C-. reactive protein ()..[1]. IL6.[2 3] ATPIII 3 HDL.[4].[5].. Polypill. Polypill 2 polypill ).[6].(
91 ( ). 252 (%64) 448 700 1. (%36) SD ±.. 59/5 ± 7/1 log (1 ) (IQR). mg/l 1/0 (0/5 2/3) mg/l 1/3 (0/7 2/6) mg/l %3 0/9 (0/4 2).( P = 0/001).(2 ) 10 mg/dl 3. log 4. log log (P = 0/04) 6 5.(P = 0/77). log stepwise. HDL.(7 ) ( ) intra- and. interassay coefficients of variation 1/6 1/5 1/1 1/6 1/29 0/6 LDL 1/8 0/8 HDL 2/21 1/19 1/74 HbA 1 C. 2/73. BMI (Interquartile range, IQR) SD ± LDL.. BMI LDL (chi-square) Mann-Withney U. t-test log. log Pearson stepwise. z- SPSS.. 16 test (SPSS Inc., Chicago, IL). P <0/05
... C-reactive protein : 92 n = 252 1 n = 448 60/6 ± 5/9 58/9 ± 7/ 6 *() ± SD 27 /0(23/7 30/2) 24/9(22/3 27/7) *(Kg/m 2 )(IQR) BMI 93/1±13/2 91/4 ± 11/ 7 (cm)sd ± 1/0 ± 0/9 ± 0/ 1 * 96 ± 10 96 ± 10 (mg/dl)sd ± FBS 127 (94 181) 119 (87 168) *( mg/dl)(iqr) TG 177 (99 141) 107 (88 126) *( mg/dl)(iqr) LDL 49 ± 11 42 ± 10 *(mg/dl)sd ± HDL 212 ± 51 190 ± 45 *(mg/dl)sd ± 8/5 ± 1/0 5/5 ± 0/ 9 *(%)SD ± HbA 1 C 4/8 ± 1/1 5/5 ± 1/ 2 *(mg/dl)sd ± 129 ± 18 129 ± 18 (mmhg)sd ± 70 ± 10 80 ± 11 *(mmhg)sd ± 1 /3(0/7 2/6) 0/9(0/4 2/0) *( mg/l)(iqr) % 2/4 % 17 (%) * Mann Whitney U T. 75 25 :IQR :SD.(P < 0/05) P * Frequency (n) (mg/dl) ( n= 691) -1
93 ( ). 97 9/4 14 10/2 10/4 10/4 11/7 6/4 9/3 90 4/3 5/3 4/7 4/6 4/7 5/9 3/0 4/9 n (%) 352(50/9) 219(31/7) 120(17/4) 691(100) 2 75 1/8 2/3 2/2 2/0 2/4 2/9 2/2 2/6 50 0/9 0/9 1/0 0/9 1/1 1/5 1/1 1/3 25 0/4 0/6 0/4 0/4 0/6 0/8 0/8 0/7 10 0/2 0/3 0/3 0/3 0/2 0/3 0/6 0/3 3 0/2 271 105 66 442 131 89 29 249 () 50-59 60 69 70 55 59 60 69 70 3 n (%) 105(42/4) 104(41/6) 40(16) 249(100) n (%) 247(55/9) 119(26) 80(18/1) 442(100) * mg/l1 < * mg/l3 1 mg/l 3 >. P * 4 r (p) 0/09(0/018) 6(0/0001) 7(0/0001) 6(0001) 3(0/001) 1(0/002) -3(0/001) 5(0/001) 2(0/004) 4(0/0001) 7(0/0001) 5(0/0001) 0/06() r (p) 0/06(0/2) 4(0/02) 2(0/06) 1(0/07) 5(0/01) 0(0/09) -4(0/01) 8(0/003) 0/09(9) 0/26(0/0001) 0/25(0/0001) 0/09() 0/02(0/66) r (p) 0/08(0/07) 5(0/001) 9(0/0001) 9(0/0001) 0/091(0/05) 1(0/01) -7(0/0001) 1(0/02) 1(0/02) 0/08(0/08) 9(0/0001) 9(0/0001) 0(0/04) BMI TG HDL LDL HbA 1 C FBS
... C-reactive protein : 94 (mg/l) (95%CI) (95%CI) 1/3 ( 1/0-1/7) 1/1 (0/9 1/3) 1/5 (1/2 1/8) 1/1(0/9 1/3) 4/4 (1/1 1/6) 1/1 (0/9 1/3) 1/7 (1/4 2/1) 1/0 (0/9 1/2) 1/4 (1/2 1/7) 1/1 (0/9 1/3) 5 (cm 88< ) *( 150 mg/dl) (< 50 mg/dl) HDL *(FBS 100 mg/dl) *( 130/85 mmhg ).(P < 0/05) P * (mg/l) (95%CI) - 6 (95%CI) 1/4 (1/1 1/7) 0/9 (0/8 1/0) 1/1 (0/9 1/3) 0/9 (0/8 1/0) 1/2 (1/0 1/5) 0/8 (0/7 0/9) 1/3 (1/1 1/5) 0/9 (0/8 1/0) 1/2 (1/0 1/4) 0/8 (0/7 1/0) *(cm 102< ) ( 150 mg/dl) *(< 40 mg/dl) HDL *(FBS 100 mg/dl) *( 130/85 mmhg ).(P < 0/05) P *
95 ( ). stepwise 7 β 53 52 33-28 05 0/213 79. 12000 WBC..[14 13] LDL [15] HDL [16].[14]. 25.[9 8] 50-79.. BMI * * * *HDL * *FBS *.(P < 0/05) P *...[7-10] [11 8] LDL BMI LDL.. ICAM-1 Selectin CD40L CD40 VCAM-1.[12] 10 %3.[9 7] %5
... C-reactive protein : 96.......[17]. HDL HDL LDL.[18] LDL. 1..[19]..[12]. 2 PAI-1 IL6.[20] HDL...[21] 1- Foam cell 2- Plasminogen activator inhibitor
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