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1 (5 ) :. 2. ( ) : (GSH-Px) SPSS (GR). (1111/93±354/99 GSH-Px GR. (24/62±11/2. (3/16±2/95 (TAC) (SOD). T-test 16 SOD. 2. (1158/53±381/21 (62/33±36/29 (7/17±5/51.(P<0/05) GR GSH-Px : : : : doi / Journal of Diabetes & Metabolic Disorders. 2012;11:3 / : ehsaneh_taheri@yahoo.com : : : 91/03/16 : 91/02/18 : 90/12/14:

2 :.[4] [6] [5] 3 (Polyol) (AGEs) NADPH. NADH.[4] ) NADH (. invivo.[7] ) ( 2 3- Advanced Glycation End Products. 2 (RNS).. 1 (ROS)..[1] α A,C,E Q 10 :..[2]..[2]. α E 1- Reactive Oxygen Speices 2- Reactive Nitrogen Speices.[3]

3 ( 5 ) ( ) BMI. (). ( -) Nyco Card READER II MAN HbA 1 c. AXIS-SHIELD EDTA Test Device. ( ) NycoCord Reader. II ( ). HbA 1 c (RIA). (HOMA-IR) Biosorce mmol/l)] / 22.5) =( : [ (µiu/ml) (SOD) (Randox, No: SD 125) convenient sampling D D A C E. (). 3 ( ) 1500g 10 %0/ C. Seca 725 GmbH & co, Seca (Germany) 0/5 100

4 :. g/dl " ". BSA =. O2 H2O2 SOD 505.[8] 16 SPSS ±.. 2. t-test 52/ ( 85) 47/23 ( 95) 47/4 52/6 47/1 52/ (HOMA-IR).(P<0/05) 11/78 ±8/8µU/ml (13/67± 8/15µU/ml).(P>0/05) 3. 2 (GR). NADPH. NADP + NADPH.[9] 340 GSSG + NADPH NADP + + 2GSH (GSH-Px) (GSH-Px) (GSH) (GSSG). NADPH. NADP [9] H 2 O 2 +2GSH 2H 2 O+GSSH LOOH+2GSH H 2 O+ LOH+GSSH (TAC) ABTS ABTS. - ABTS ABTS

5 ( 5 ) ) ( (P=0/001) () BMI 3. (BMI). BMI =18/9-24/9 ) BMI=25-29/9. 40 BMI=30 ( (n=85) (n=95) 2 P-value 2 0/88 51±13 51±11 () 0/09 73/2±12/9 76/9±13/8 ( ) 0/98 26/2±4/5 26/2±9/3 (Kg/m2) (Mean±SD) ± t : P< 0/05 HOMA-IR HbA 1 c -2 P-value 0/0001 0/0001 0/13 0/0001 (n=85) (n=95) 2 87/69±9/58 4/97±0/55 13/67±8/15 54/66±31/ /89±64/18 7/54±1/93 11/78±8/90 89/45±73/92 (mg/dl) (%) HbA 1 c (µ U/ml) HOMA-IR (Mean±SD) ± t : P< 0/05

6 : -3 2 P-value 0/052 0/31 0/001 0/001 3/22±0/ /53±381/21 3/16±2/95 24/62±11/2 2 3/15±1/ /93±354/99 7/17±5/51 62/33±36/29 (mg/dl)tac ( SOD ( GR ( GSH-PX. (Mean±SD) ± SOD. (Median ± IQR) TAC GR,GRx : t : P< 0/ نرمال اضافه وزن چاق 0 افراد آنترل بيماران ديابتي نوع 2 24/9-18/9 =BMI : 1 29/9-24/9 =BMI : =BMI : ( ) r= -0/31 r= -0/21 ( SOD P= 0/04 P= 0/09 r= -0/09 r= -0/03 GSH-PX P= 0/60 P= 0/81 ( r= -0/23 r= -0/11 ( GR P= 0/08 P= 0/32 r= -0 /02 P= 0/86 r= -0/03 P= 0/78 (mg/dl) TAC :P<0/05

7 ( 5 ) SOD Stefek. SOD SOD.[20 21] Aldibasi ( ) 8-OHdG Cu-Zn- SOD..[22]..[23] Pasaoglu Likidlilid.[10] 20 FPG 140 mg/dl FPG 110mg/dL. GSH.[11] GPx FPG. [16] [14 15] [12 13] [12] [17]. [19] [18].

8 :.[26] 20 Codoñer-Franch [27] 2 BMI. BMI TAC BMI GR, GSH-Px, SOD. SOD. SOD 2. (BMI). [28] TBARS. SOD Hamden. Alloxan Cu +2 Cu/Zn SOD. 90 ) ( SOD. Cu/Zn SOD.[23] [24] [25] DNA Al-Aubaidy hydroxy 2'-deoxy- 8- guanosine (8-OHdG)

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10 : Preventive Effects against Oxidative Stress, Hepatic, Pancreatic and Renal Injury in Alloxan- Induced Diabetes in Rats. J Nutr Sci Vitaminol 2009: 55 (3): Marjane, A. Plasma level of malondialdehyde and activity of antioxidant enzymes in red blood cells of type 2 diabetic patients. Ardebil medical university 2006; 6(2): (Persian). 25. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are Oxidative Stress- Activated Signaling Pathways Mediators of Insulin Resistance and - Cell Dysfunction? Diabetes 2003; 52(1): Al-Aubaidy HA, Jelinek HF. Oxidative DNA damage and obesity in type 2 diabetes mellitus. Eur J Endocrinol June 2011; 164 (1): Pilar Codoñer-Franch, Sara Pons-Morales, Laura Boix-García, Victoria Valls-Bellés V. Oxidant/antioxidant status in obese children compared to pediatric patients with type 1 diabetes mellitus. Pediatr Diabetes 2010; 11(4): Narod SA, Dube MP, Klijn J, Lubinski J, Lynch HT, Ghadirian P, et al. Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 2002; 94(23):

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