Peptide Synthesis. GeneCust Europe. GeneCust Europe

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1 GeneCust Europe Laboratoire de Biotechnologie du Luxembourg S.A. 6 rue Dominique Lang L-3505 Dudelange Luxembourg Tél. : Fax : info@genecust.com Web : Peptide Synthesis GeneCust Europe

2 Peptide Synthesis Leading Supplier GeneCust is Your Provider for High Quality Custom Peptides. With highly skilled and committed personnel and the best lab equipment, we are able to synthesize almost all kinds of peptides to meet your biggest needs. Using state-of-the-art solid phase technology (FMOC-chemistry) synthesis is performed with fully-automated synthesizers.to guarantee highest quality, your peptides are purified and analyzed by HPLC (if requested) and checked by mass spectrometry analysis. Quantities from 2 mg up to kg. Widest range of purification levels on the market. Crude and desalted peptides for high-throughput screening (e.g. preliminary screening) >70%: antigens for antibody production >75%: ligands for affinity purification, in enzyme substrate studies, epitope mapping >80%: Peptide blocking studies (non-quantitative),protein electrophoresis applications >85%: immunological applications, polyclonal antibody production and non sensitive screening, peptide arrays >90%: SAR studies, bioassays >95%: In vitro bioassays such as ELISA, enzymology, biological activity >98%: Structural studies such as Crystallography, NMR or sensitive bioassays. >99%: cgmp peptides for drug studies, peptides industry such as cosmetics Competitive Prices Price per amino acid Amount Crude Desalted >70% >75% >80% >85% >90% >95% >98% >99% Min. fee mg 2,77 3,47 4,85 5,55 6,24 6,94 8,32 9,71 12,49 14,76 5 mg 3,12 3,82 5,55 6,17 7,28 8,46 10,12 10,68 15,19 16,13 10 mg 3,47 4,30 6,59 7,28 8,46 9,57 11,24 12,35 17,41 18,56 15 mg 3,68 4,51 7,28 8,19 9,44 10,68 12,70 14,08 19,98 21,30 20 mg 3,82 4,72 8,11 9,02 10,40 11,79 14,08 15,74 22,47 23,83 25 mg 4,10 4,99 8,81 9,84 11,24 12,70 15,19 17,13 23,93 25,82 30 mg 4,30 5,34 9,64 10,68 12,14 13,46 16,30 18,45 25,31 27,94 40 mg 4,72 5,55 10,40 11,58 13,24 14,91 17,41 19,64 27,26 29,52 50 mg 4,99 5,97 11,10 12,35 14,36 16,30 18,51 20,81 29,20 31, mg 6,17 7,07 14,71 16,30 18,51 20,81 25,31 28,09 39,32 42, mg 7,84 9,02 20,25 22,47 24,69 26,98 32,60 36,55 54,52 55, mg 10,68 12,35 27,81 30,93 34,05 37,11 43,28 49,45 73,04 74,22 1 g 16,86 19,56 43,83 48,69 53,47 58,33 69,99 77,82 116,59 116,92 2 g 24,02 27,78 62,19 69,18 75,99 82,81 99,30 110,41 165,25 198,76 3 g 31,08 35,96 80,49 89,53 98,35 107,15 128,49 142,88 213,84 257,22 4 g 38,14 44,12 98,78 109,87 120,69 131,51 157,70 175,35 262,45 315,67 5 g 42,38 49,02 109,75 122,08 134,10 146,12 175,22 194,83 291,61 350,75

3 Modifications A Modification 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg A1 Acetylation (N-Terminal) Free Free Free Free Free Free Free Free Free Free A2 Fmoc(N-Terminal) Free Free Free Free Free Free Free Free Free Free A3 Amidation (C-Terminal) Free Free Free Free Free Free Free Free Free Free A4 Z (CBZ) (N-Terminal) 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa A5 Bz (N-Terminal) 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa A6 Acetylation {Lys(Ac)} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A7 Br-Ac- {N terminal)} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A8 Formylation (N-Terminal) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A9 Fatty acid (N-Terminal) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A10 Myristic acid (N-Terminal) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A11 Palmytolyl (N-Terminal) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A12 {Cys(Cam)} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A13 {Cys(Acm)} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A14 {Cys(tBu)} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 A15 {Lys(Dnp)} 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 A16 {Lys(Dde)} 1aa+204 1aa+238 1aa+272 1aa+306 1aa+340 1aa+374 1aa+442 1aa+510 1aa+578 1aa+646 A17 {Lys(Alloc)} 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 A18 {Lys(Me)} 1aa+272 1aa+306 1aa+340 1aa+374 1aa+425 1aa+510 1aa+595 1aa+680 1aa+765 1aa+850 A19 {Lys(Me2)} 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 A20 {Lys(Me3)} 1aa+272 1aa+306 1aa+340 1aa+374 1aa+425 1aa+510 1aa+595 1aa+680 1aa+765 1aa+850 A21 {Ser(octanoic acid)} 1aa+315 1aa+340 1aa+374 1aa+408 1aa+425 1aa+510 1aa+595 1aa+680 1aa+765 1aa+850 A22 Suc (N-Terminal) 1aa+19 1aa+21 1aa+22 1aa+24 1aa+26 1aa+31 1aa+36 1aa+41 1aa+46 1aa+51 A23 pna (C-Terminal) 1aa+136 1aa+145 1aa+153 1aa+162 1aa+170 1aa+204 1aa+238 1aa+272 1aa+306 1aa+340

4 A24 AMC ( C-Terminal) 1aa+179 1aa+187 1aa+196 1aa+204 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 A27 Cysteamide ( C-Terminal) 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 A28 {HPP},3-(p- Hydroxyphenyl)propionic Acid (N-Terminal) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B Special amino acid 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg B1 {D-2-Me-Trp} 1aa+323 1aa+374 1aa+425 1aa+476 1aa+544 1aa+646 1aa+765 1aa+884 1aa+986 1aa+1088 B2 {D-Ile} 1aa+51 1aa+68 1aa+85 1aa+102 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 B3 {D-Orn} 1aa+51 1aa+68 1aa+85 1aa+102 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 B4 {D-Gln} 1aa+51 1aa+68 1aa+85 1aa+102 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 B5 {D-Cit} 1aa+51 1aa+68 1aa+85 1aa+102 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 B6 {Dab} 1aa+51 1aa+68 1aa+85 1aa+102 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 B7 {Dap} 1aa+51 1aa+68 1aa+85 1aa+102 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 B8 {D-Beta-Asp} 1aa+51 1aa+68 1aa+85 1aa+102 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 B9 {D-Gama-Glu} 1aa+51 1aa+68 1aa+85 1aa+102 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 B10 {D-Arg} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B11 {D-Cys} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B12 {D-Asp} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B13 {D-Asn} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B14 {D-Glu} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B15 {D-Ser} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B16 {D-His} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B17 {D-Tyr} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B18 {D-Thr} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B19 {D-Trp} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B20 {D-Lys} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B21 {Orn} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B22 {Abu} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B23 {Aib} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B24 {Nva} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B25 {Nle} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B26 {Cit} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B27 {Hse} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170

5 Special amino acid 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg B29 {D-Pen} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B30 {Mpa} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B31 {Cha} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B32 {D-Cha} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B33 {Chg} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B34 {D-Chg} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B35 {D-1-Nal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B36 {L-1-Nal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B37 {D-2-Nal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B38 {L-2-Nal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B39 {D-2-Pal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B40 {L-2-Pal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B41 {D-3-Pal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B42 {L-3-Pal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B43 {D-4-Pal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B44 {L-4-Pal} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B45 {D-4-Cl-Phe} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B46 {L-4-Cl-Phe} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B47 {D-4-F-Phe} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B48 {L-4-F-Phe} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B49 {D-4-NO2-Phe} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B50 {L-4-NO2-Phe} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B51 {D-4-I-Phe} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B52 {L-4-I-Phe} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B53 {Beta-Asp} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B54 {Gama-Glu} 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B55 {D-Ala} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B56 {D-Leu} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B57 {D-Met} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B58 {D-Pro} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B59 {D-Phe} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B60 {D-Val} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B61 {pglu} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B62 {Hyp} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B63 {Phg} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B64 {Sar} 1aa+29 1aa+33 1aa+36 1aa+39 1aa+43 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 B65 {Mini-PEG} 1aa+51 1aa+60 1aa+68 1aa+77 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 B66 {Ahx Linker}, Acp 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa 1aa

6 C N-Methyl amino acid 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg C1 {N-Me-Ala} 1aa+221 1aa+238 1aa+272 1aa+306 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 C2 {N-Me-Phe} 1aa+221 1aa+238 1aa+272 1aa+306 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 C3 {N-Me-Leu} 1aa+221 1aa+238 1aa+272 1aa+306 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 C4 {N-Me-Ile} 1aa+221 1aa+238 1aa+272 1aa+306 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 C5 {N-Me-Val} 1aa+221 1aa+238 1aa+272 1aa+306 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 C6 {N-Me-Met} 1aa+221 1aa+238 1aa+272 1aa+306 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 C7 {N-Me-Nle} 1aa+221 1aa+238 1aa+272 1aa+306 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 C8 {N-Me-Nva} 1aa+221 1aa+238 1aa+272 1aa+306 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 C9 {N-Me-Ser} 1aa+442 1aa+476 1aa+544 1aa+612 1aa+680 1aa+760 1aa+952 1aa aa aa+1360 C10 {N-Me-Tyr} 1aa+442 1aa+476 1aa+544 1aa+612 1aa+680 1aa+760 1aa+952 1aa aa aa+1360 C11 {N-Me-Thr} 1aa+442 1aa+476 1aa+544 1aa+612 1aa+680 1aa+760 1aa+952 1aa aa aa+1360 C12 {N-Me-Asp} 1aa+442 1aa+476 1aa+544 1aa+612 1aa+680 1aa+760 1aa+952 1aa aa aa+1360 C13 {N-Me-Glu} 1aa+442 1aa+476 1aa+544 1aa+612 1aa+680 1aa+760 1aa+952 1aa aa aa+1360 D Phosphorylation 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg D1 {pser} 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 D2 {ptyr} 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 D3 {pthr} 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 D4 Di-sites in sequence 2aa+408 2aa+459 2aa+510 2aa+561 2aa+638 2aa+765 2aa+893 2aa aa aa+1275 D5 Tri-sites in sequence 3aa+476 3aa+918 3aa aa aa aa aa aa aa aa+2550 E 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg Fluorescence/Dye Labeling E1 Biotin (N-Terminal) E2 Biotin-LC (N-Terminal) E3 3-Indolylacetic acid E4 FITC (N-Terminal) E5 FITC-LC (N-Terminal) E6 5-FAM (N-Terminal) E7 5-FAM-LC (N-Terminal) E8 Dansyl (N-Terminal) E9 Dansyl-LC (N-Terminal) E10 MCA (N-Terminal) E11 TMR (N-Terminal) E12 Lys(Biotin) (internal) 1aa+272 1aa+289 1aa+306 1aa+323 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 E13 Lys(Biotin) (C Terminal) 1aa+272 1aa+289 1aa+306 1aa+323 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680

7 E14 Lys(FITC) (internal) 1aa+340 1aa+374 1aa+425 1aa+476 1aa+510 1aa+612 1aa+714 1aa+816 1aa+918 1aa+1020 E15 Lys(FITC) (C Terminal) 1aa+340 1aa+374 1aa+425 1aa+476 1aa+510 1aa+612 1aa+714 1aa+816 1aa+918 1aa+1020 E16 Lys(5-FAM) (internal) 1aa+340 1aa+374 1aa+425 1aa+476 1aa+510 1aa+612 1aa+714 1aa+816 1aa+918 1aa+1020 E17 Lys(5-FAM) (C Terminal) 1aa+340 1aa+374 1aa+425 1aa+476 1aa+510 1aa+612 1aa+714 1aa+816 1aa+918 1aa+1020 E18 Lys(Dansyl) (internal) 1aa+340 1aa+374 1aa+425 1aa+476 1aa+510 1aa+612 1aa+714 1aa+816 1aa+918 1aa+1020 E19 Lys(Dansyl) (C Terminal) 1aa+340 1aa+374 1aa+425 1aa+476 1aa+510 1aa+612 1aa+714 1aa+816 1aa+918 1aa+1020 E20 Lys(TMR) (internal) 1aa+553 1aa+595 1aa+629 1aa+663 1aa+714 1aa+850 1aa aa aa aa+1428 E21 Lys(TMR) (C Terminal) 1aa+553 1aa+595 1aa+629 1aa+663 1aa+714 1aa+850 1aa aa aa aa+1428 E22 EDBiotin (C Terminal) 1aa+340 1aa+374 1aa+425 1aa+476 1aa+510 1aa+612 1aa+714 1aa+816 1aa+918 1aa+1020 E23 EDDnp (C Terminal) 1aa+340 1aa+374 1aa+425 1aa+476 1aa+510 1aa+612 1aa+714 1aa+816 1aa+918 1aa+1020 F Cyclic peptide 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg F1 Mono Disulfide bridge F2 Double Disulfide bridge F3 Triple Disulfide bridge F4 Amide cyclic (end) F5 Amide cyclic (Side chain) G Quenched fluorescent peptide 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg G1 Abz/ Tyr (3-NO2) G2 Abz G3 Tyr (3-NO2) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 G4 Glu(EDANS)-NH2 2aa+264 2aa+272 2aa+289 2aa+306 2aa+323 2aa+391 2aa+459 2aa+527 2aa+595 2aa+646 G5 DABCYL G6 DABCYL/Glu(EDANS)- NH H Carrier Complex 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg H3 KLH-Peptide enquiry enquiry enquiry enquiry enquiry H4 BSA-Peptide I Ia C Terminal Modification 1-9mg 10-19mg 20-29mg 30-39mg 40-49mg mg mg mg mg C terminal ended amino acids: Ala, Gly, Met, Leu, Ile, Phe, Pro, Val Ia1 -OMe (C-terminal) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 Ia2 -OEt (C-terminal) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170

8 Ia3 -OBzl (C-terminal) 1aa+43 1aa+51 1aa+60 1aa+68 1aa+85 1aa+102 1aa+119 1aa+136 1aa+153 1aa+170 Ia4 -OtBu (C-terminal) 1aa+85 1aa+102 1aa+119 1aa+136 1aa+170 1aa+204 1aa+238 1aa+272 1aa+306 1aa+340 Ia5 -TBzl (C-terminal) 1aa+85 1aa+102 1aa+119 1aa+136 1aa+170 1aa+204 1aa+238 1aa+272 1aa+306 1aa+340 Ia6 -NHMe (C-terminal) 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 Ia7 -NHEt (C-terminal) 1aa+136 1aa+153 1aa+170 1aa+187 1aa+213 1aa+255 1aa+298 1aa+340 1aa+383 1aa+425 Ia8 -NHisopen (C-terminal) 1aa+204 1aa+230 1aa+255 1aa+281 1aa+315 1aa+374 1aa+442 1aa+510 1aa+578 1aa+638 Ib C terminal ended amino acids: Lys, Gln, Asn, Cys, His, Arg, Ser, Thr, Tyr, Trp Ib1 -OMe (C-terminal) 1aa+65 1aa+77 1aa+99 1aa+111 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 Ib2 -OEt (C-terminal) 1aa+65 1aa+77 1aa+99 1aa+111 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 Ib3 -OBzl (C-terminal) 1aa+65 1aa+77 1aa+99 1aa+111 1aa+128 1aa+153 1aa+179 1aa+204 1aa+230 1aa+255 Ib4 -OtBu (C-terminal) 1aa+128 1aa+153 1aa+179 1aa+204 1aa+255 1aa+272 1aa+357 1aa+408 1aa+459 1aa+510 Ib5 -TBzl (C-terminal) 1aa+128 1aa+153 1aa+179 1aa+204 1aa+255 1aa+272 1aa+357 1aa+408 1aa+459 1aa+510 Ib6 -NHMe (C-terminal) 1aa+204 1aa+230 1aa+255 1aa+281 1aa+315 1aa+383 1aa+442 1aa+510 1aa+578 1aa+638 Ib7 -NHEt (C-terminal) 1aa+204 1aa+230 1aa+255 1aa+281 1aa+315 1aa+383 1aa+442 1aa+510 1aa+578 1aa+638 Ib8 -NHisopen (C-terminal) 1aa+306 1aa+340 1aa+383 1aa+425 1aa+493 1aa+561 1aa+663 1aa+765 1aa+867 1aa+884 Ic C terminal ended amino acids: Asp, Glu Ic1 -OMe (C-terminal) 1aa+85 1aa+102 1aa+119 1aa+136 1aa+170 1aa+204 1aa+238 1aa+272 1aa+306 1aa+340 Ic2 -OEt (C-terminal) 1aa+85 1aa+102 1aa+119 1aa+136 1aa+170 1aa+204 1aa+238 1aa+272 1aa+306 1aa+340 Ic3 -OBzl (C-terminal) 1aa+85 1aa+102 1aa+119 1aa+136 1aa+170 1aa+204 1aa+238 1aa+272 1aa+306 1aa+340 Ic4 -OtBu (C-terminal) 1aa+170 1aa+204 1aa+238 1aa+272 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 Ic5 -TBzl (C-terminal) 1aa+170 1aa+204 1aa+238 1aa+272 1aa+340 1aa+408 1aa+476 1aa+544 1aa+612 1aa+680 Ic6 -NHMe (C-terminal) 1aa+272 1aa+306 1aa+340 1aa+380 1aa+425 1aa+510 1aa+595 1aa+680 1aa+765 1aa+850 Ic7 -NHEt (C-terminal) 1aa+272 1aa+306 1aa+340 1aa+380 1aa+425 1aa+510 1aa+595 1aa+680 1aa+765 1aa+850 Ic8 -NHisopen (C-terminal) 1aa+408 1aa+459 1aa+510 1aa+561 1aa+629 1aa+748 1aa+884 1aa aa aa+1275 J Aliquoting 1 /vial L M N O Amino Acid Analysis (AAA) N elemental Analysis Solubility test Microbial analysis for minimum 4 mg of peptide 102 (we will use around 4 mg peptide) Free for HPLC solubility test with solvents like MeOH, acetonitrile, TFA, : 12 / peptide (water / DMSO) P Q Water content (Karl Fischer) Acetate Content (HIPC) 85 for quantities >5 g 85 (we will use around 10 mg peptide) R S Maldi-Tof MS 34 Endotoxin analysis 340 for quantities >5 g

9 Storage of freeze-dried peptides Peptides are generally preserved at -20 C, which allows conservation over several years. Before opening, leave a few moments the bottle at ambient temperature in order to avoid the problems of condensation, then close again this last immediately after taking away in order to ensure the best conservation of peptide. Peptides containing of Gln and Asn are likely of deamination and must be stored with -70 C. Peptides containing Gln at end N can become cyclic in pyroglutamate in diluted acid conditions. For peptides sensitive to oxidation: containing Cysteines, Methionines or Tryptophans. Use deaerated water (splashing of nitrogen, helium or argon). They must be stored in a freeze-dried state or -70 C if they must be in solution. Avoid a setting in basic solution or in the DMSO for peptides containing of Cysteines or Methionines (Thiol oxidation). Peptides dissolution Finding the ideal peptide solubility for a given research process is a serious challenge since improper solubilization can result in loss of peptide or failure of the experiment. The steps outlined below provides you with a method to perform a solubility test for determining the best solvent for a synthetic peptide. It is best to test it by dissolving a minute amount of peptide, rather than the entire sample. As a general rule, peptides should first be dissolved in distilled, sterile water, particularly peptides of fewer than five residues. For individual peptides, conditions are chosen for optimum solubility based on the given peptide sequence. Before dissolving your peptide, please read the recommendations below and perform a solubility test : - Assign a value of -1 to each acidic residue. The acidic residues are Asp (D), Glu (E), and the C-terminal -COOH. Assign a value of +1 to each basic residue. The basic residues are Arg (R), Lys (K), His (H), and the N-terminal -NH2. Calculate the overall charge of the peptide. - If the overall charge of the peptide is positive, try to dissolve the peptide in water. If the peptide cannot be dissolved, try 10% to 30% acetic acid solution. If the peptide still does not dissolve, add TFA (< 50 μl) to solubilize the peptide and dilute to the desired concentration. - If the overall charge of the peptide is negative, try to dissolve the peptide in water. If the peptide does not dissolve, add NH4OH (< 50 μl) and dilute to the desired concentration. If the peptide contains Cys, then do not use basic solutions to dissolve it. Try the method listed below. - If the overall charge of the peptide is zero, you need to add some organic solvents. At first, try to add some acetonitrile, methanol, or isopropanol. For very hydrophobic peptides, try dissolving the peptide in a very small amount of DMSO, and dilute with water to the desired concentration. For Cys-containing peptides, use DMF instead of DMSO. For peptides that tend to aggregate, add 6 M guanidine HCl or 8 M urea, and then proceed with the necessary dilutions. Note: 1. It is recommended that the concentration of the stock solution be around 1-2 mg of peptide per ml of solution. This is dilute enough to minimize the potential precipitation of the peptides during storage, but concentrated enough to take relatively small volumes (< 100 μl) of aliquots for the assay, and therefore minimizing the effect of the solvents initially used for solubilization. 2. Lyophilized peptides can be stored long-term at -20 C and are stable for more than 1 year. Once in solution we recommend that you aliquot them into tubes and store at -20 C. It is recommended that peptides containing methionine, cysteine, or tryptophan residues be stored in oxygen-1aaatmosphere to avoid oxidation. 3. This guideline is used for catalog peptides whose solubility conditions are not listed.

10 How to order Request a quote by at info@genecust.com. Give us following informations : Sequence Quantity Purity Modifications Download Peptide Synthesis Order Form on Order Form at info@genecust.com Or send it by fax at Sales Conditions - An extra cost could be charged if the peptide is difficult to synthetize or to purify. - The peptidic sequence is garanteed - Each standard peptide is delivered with its electrospray mass spectrum coupled to HPLC - The sequence is kept with strict confidentiality. - The standard delivery period is about 2-3 weeks. We plan 4 weeks for long peptides (> 40 AA), and for quantities above 50 mg purified peptides. - All peptides sold by GeneCust are designed for research usage only. - All peptide orderings are honoured if accepted by GeneCust. If the peptide is difficult to synthetize or to purify, Gene- Cust reserve the right to cancel the order or to produce a product with lower quality. The re-synthesis of the compound will be charged at GeneCust expenses. The price will be reduced if the quantity or the quality of the peptide is lower than those written on the order form; the price will be calculated according to our price list. Once the order is done, we consider that the customer accepts that all the peptides prepared with a variation of 5% versus the purity and/or quantity values expected will be automatically shipped and invoiced at the recalculated price.

11 Thank you for your time. 6 rue Dominique Lang, L-3505 Dudelange, Luxembourg, info@genecust.com