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1 A Ellwart Sweeney 6 CANTAB Gorwood WMS 8 38 No dfguorongjuan@ 163. com WCST

2 203 Haider HT WMS WCST P300 DA 17 γ - GA- BA GABA + GABA GABA 5 - HT 18 BDNF MC BDNF C HPA PKC N BDNF - - D - NMDAR Song 19 EAA Ca 2 + BDNF 10 CREB mrna Hinkelmann 11 BD- CAR NF CREB CAR d P - ERK 3 P - ERK 4 P - ERK ERK1 / HT NE 14 Milne 21 fmri 15

3 204 3 H - MRS N - NAA Cr MI NAA /Cr MI /Cr 32 Cole 22 MRI HT NE MRI MRS 23 NAA Burke Young 27 fmri fnirs Ach camp - PKA 29 c - fos PET 31

4 205 J Li J Sun JD Liu Y and memory abilities in rat model of depression J Bao Birthelmer A Stemmelin J Jackisch R of acetylcholine noradrenaline Brain Res Bull Haider S Naqvi F Batool Z J Sci Pharm Douglas KM Porter RJ. Longitudinal assessment of neuropsychological function in major depression J. Aust N Z J Psychiatry Li G Wang LY Shofer JB et al. Temporal Relationship Between Depression and Dementia Findings From a Large Community - Based 15 - Year Follow - up Study J. Arch Gen Psychiatry J J Ellwart T Rinck M Becker ES. Selective memory and memory deficits in depressed inpatients J. Depress Anxiety Sweeney JA Kmiec JA Kupfer DJ. Neuropsychologic impairment inbipolar and unipolar mood disorders on the CANTAB neurocognitive battery J. Biol Psychiatry Gorwood P Corruble E Falissard B et al. Toxic effects of depression on brain function impairment of delayed recall and the cumulative length of depressive disorder in a large sample of depressed outpatients J. Am J Psychiatry J J J Hinkelmann K Muhtz C Dettenborn L et al. Association between cortisol awakening response and memory function in major depression J. Psychol Med et al. Mifepristone repairs alteration of learning. Yao Xue Xue. J. et al. Presynaptic modulation and serotonin release in the hippocampus of aged rats with various levels of memory impairments J. et al. Decreased Hippocampal 5 - HT and DA Levels Following Sub - Chronic Exposure to Noise Stress Impairment in both Spatial and Recognition Memory in Male Rats. γ - J Sun MK Alkon DL. Effects of 4 - methylcatechol on spatial memory and depression J. Neuroreport Song L Che W Min Wei W et al. Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress J. Pharmacol Biochem Behav ERK J Milne AM MacQueen GM Hall GB. Abnormal hippocampal activation in patients with extensive history of major depression an fmri. study J. J Psychiatry Neurosci Cole J Costafreda SG McGuffin P et al. Hippocampal atrophy in first episode depression a meta - analysis of magnetic resonance imaging studies J. J Affect Disord Xi G Hui J Zhang Z et al. Learning and memory alterations are. associated with hippocampal N - acetylaspartate in a rat model of depression as measured by 1H - MRS J. PLoS One e Elizabeth AP. Human emotion and memory interactions of the amygdala and hippocampal complex J. Current Opinion in Neurobiology Burke J McQuoid DR Payne ME et al. Amygdala volume in late - life depression relationship with age of onset J. Am J Geriatr Psychiatry Philip van E Guido van W Guillén F et al. Amygdala responsivity. related to memory of emotionally neutral stimuli constitutes a trait factor for depression J. Neuroimage Young KD Bellgowan PS Bodurka J et al. Behavioral and neurophysiological correlates of autobiographical memory deficits in patients with depression and individuals at high risk for. depression J. JAMA Psychiatry Schecklmann M Dresler T Beck S et al. Reduced prefrontal oxy-

5 206 genation during object and spatial visual working memory in unpolar and bipolar depression J. Psychiatry Res Bilgi MM Ozalay O Ca da EM et al. Small frontal gray matter volume in first - episode depression patients J. Turk Psikiyatri Derg Vasic N Walter H Sambataro F et al. Aberrant functional connectivity of dorsolateral prefrontal and cingulate networks in patients with major depression during working memory processing J. Psychol Med Behnken A Schning S Gerss J et al. Persistent non - verbal memory impairment in remitted major depression - caused by encoding deficits J. J Affect Disord J J J Bremner JD Vythilingam M Vermetten E et al. Effects of antidepressant treatment on neural correlates of emotional and neutral de- 41. clarative verbal memory in depression J. J Affect Disord 2007 J J J J camp - PKA J J c - fos J J J J I

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