+33. BRCA+ +33/ BRCA, BRCA, RAD/+ DNA ORF

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1 33 0* ---2,*++ /+2, DNA * 1,0, BRC repeats C +33 BRCA+ +33/,*, BRCA+ cdna ++ kb +*, -+ bp DNA ORF -,0 NM _**+**00/ BRCA+ cdna 02 /2 p/- RB+ APC 2* +-,**, +1 cdna + / kb +,*,* bp ORF --3 NM_ **+**-*- ORF DNA ,, DNA 1 +0, -+/,+,, DNA

2 34 0*,*++ + a : BRC repeats NLS C b : c : 02 /2 +**, mrna,** ng RNA RT-PCR BRC repeats C - BRC repeats repeats repeat repeat ++ repeats, PELLEGRINI 2 BRC repeats repeat +, BRC repeat BRC repeat BRC repeat BRC + ) BRC +/-, Valine DSB Isoleucine V DNA +/-, I BRC RAD /+ Mammalian two-hybrid assay / 1 V+/-, F BRC +*

3 35 - a : BRC repeats BRC repeats b +* Gal-Screen Applied Biosystems b : C DBD : GAL -DNA TA : GAL repeat : BRC repeat RAD /+ : C-term : C emp : / a UCSF-Chimera http : //wwwcglucsfedu/chimera/ V+/-, I M,+* contact DNA, + V+/-, F clash Mammalian V+/-, I BRC repeat two-hybrid / b, c, d, e BRC repeat

4 36 0*,*++ BRC repeats a : BRC repeats BRC repeats - b : BRC repeat BRC repeat -,*++ DNA

5 37 / BRC BRC a : BRC BRC + - b : BRC BRC : RAD /+ : RAD /+ : M,+* : BRC : V +-,, K+/-- E, A+/-/ T, D+/1E F +/,, F+/0 V+/-, I V+/-, F c, d, e : V +/-,, I +/-,, F+/-, contact clash

6 38 0*,*++ +* O CHIAI, K, Y OSHIKAWA, Y, Y OSHIMATSU, K, O ONUMA, T, T OMIOKA, Y, T AKEDA, E, A RIKAWA, J, M OMINOKI, K, O MI, T, H ASHIZUME, K and M ORIMATSU, M (,*++ a) Valine +/-, of human BRC repeat plays an important role in the interaction between and RAD /+ FEBS Lett, /2/, O CHIAI, K, Y OSHIKAWA, Y, O ONUMA, T, T OMIOKA, Y, H ASHIZUME, K and M ORIMATSU, M (,*++ b) Interactions between canine and full length or truncated BRC repeats Vet J, in press +, P ELLEGRINI, L, Y U, D S, L O, T, A NAND, S, L EE, M, B LUNDELL, T L and V ENKITARAMAN, A R (,**,) Insights into DNA recombination from the structure of a - complex Nature,,*,,21,3- + C HEN, C F, C HEN, P L, Z HONG, Q, S HARP, Z D and +- R ANDALL, T C, B ELL, K A, R EBANE, B A, R UBIN, S L EE, W H ( +333) Expression of BRC repeats in C and B OYD, J ( +332) Germline mutations of the breast cancer cells disrupts the -Rad/+ BRCA+ and genes in a breast and ovaricomplex and leads to radiation hypersensitivity an cancer patient Gynecol Oncol, 1*, -, - and loss of G(,)/M checkpoint control J Biol + R ICHARDSON, C, S TARK, J M, O MMUNDSEN, M and Chem,,1, -,3-+ -,3-/ J ASIN, M (,**) Rad/+ overexpression promotes, D ORN, C R, T AYLOR, D O, F RYE, F L and H IBBARD, alternative double-strand break repair pathways H H ( +302) Survey of animal neoplasms in Alaand genome instability Oncogene,,-, /0 //- meda and Contra Costa Counties, California I +/ R IVERA, P, M ELIN, M, B IAGI, T, F ALL, T, H AGGSTROM, Methodology and description of cases J Natl J, LINDBLAD-T OH, K and VON E ULER, H (,**3) Mam- Cancer Inst, *,,3/ -*/ mary tumor development in dogs is associated - H SU, W L, H UANG, Y H, C HANG, T J, W ONG, M L with BRCA+ and BRCA, Cancer Res, 03, 211* and C HANG, S C (,*+*) Single nucleotide varia- 211 tion in exon ++ of canine in healthy and +0 R UTTEMAN, G R, C ORNELISSE, C J, D IJKSHOORN, N cancerous mammary tissue Vet J, +2, -/+ -/0 J, P OORTMAN, J and M ISDORP, W ( +322) Flow M IKI, Y, S WENSEN, J, SHATTUCK-E IDENS, D, cytometric analysis of DNA ploidy in canine F UTREAL, P A, H ARSHMAN, K, T AVTIGIAN, S, L IU, mammary tumors Cancer Res, 2, Q, C OCHRAN, C, B ENNETT, L M, D ING, W and et al +1 T AKATA, M, T ACHIIRI, S, F UJIMORI, A, T HOMPSON, L ( +33 ) A strong candidate for the breast and H, M IKI, Y, H IRAOKA, M, T AKEDA, S and Y AMAZOE, ovarian cancer susceptibility gene BRCA + Science,,00, 001+ M (,**,) Conserved domains in the chicken homologue of BRCA, Oncogene,,+, ++-* ++- / M OE, L (,**+) Population-based incidence of +2 T AYLOR, G N, S HABESTARI, L, W ILLIAMS, J, M AYS, mammary tumours in some dog breeds J C W, A NGUS, W and M CFARLAND, S ( +310) Mam- Reprod Fertil Suppl, /1, -3 - mary neoplasia in a closed beagle colony Cancer 0 M OULTON, J E, T AYLOR, D O, D ORN, C R and Res, -0,,1*,1- A NDERSEN, A C ( +31* ) Canine mammary tumors +3 W ONG, A K, P ERO, R, O RMONDE, P A, T AVTIGIAN, S Pathol Vet, 1,,23-,* V and B ARTEL, P L ( +331 ) interacts with 1 M OYNAHAN, M E and J ASIN, M (,*+*) Mitotic the evolutionarily conserved BRC motifs in the homologous recombination maintains genomic human breast cancer susceptibility gene brca, stability and suppresses tumorigenesis Nat Rev J Biol Chem,,1,, Mol Cell Biol, ++, +30,*1,* W OOSTER, R, B IGNELL, G, L ANCASTER, J, S WIFT, S, 2 O CHIAI, K, M ORIMATSU, M, T OMIZAWA, N and S EAL, S, M ANGION, J, C OLLINS, N, G REGORY, S, S YUTO, B (,**+) Cloning and sequencing full G UMBS, C and M ICKLEM, G ( +33/ ) Identification of length of canine Brca, and Rad/+ cdna J Vet the breast cancer susceptibility gene BRCA, Med Sci, 0-, ++*- ++*2 Nature, -12, 12313, 3 O CHIAI, K, M ORIMATSU, M, Y OSHIKAWA, Y, S YUTO,,+ Y OSHIKAWA, Y, M ORIMATSU, M, O CHIAI, K, N AGANO, B and H ASHIZUME, K (,**) IBrca, C-terminus M, T OMIOKA, Y, S ASAKI, N, H ASHIZUME, K and interacts with Rad/+ and contributes to nuclear I WANAGA, T (,**2) Novel variations and loss of focus formation in double-strand repair of DNA heterozygosity of identified in a dog with Biomed Res,,/,,03,1/ mammary tumors Am J Vet Res, 03, +-,- +-,2

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