M R I. ( 11 C2F lun itrazepam ) China Academic Journal Electronic Publishing House. All rights reserved.

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1 Journal of Iso topes V o l. 13N o. 4 N ov (, ) :,,, : ; ; ; : R 817 : A : (2000) X2CT [ 1 M R I ],, PET SPECT,,, ( ) ( ), ; ; L angley,,, 52 [ 2 (BZ) ] (1) : 1979 Eckelm an [ 3 ], Com ar [ 4 ] 11 C ( 11 C2F lun itrazepam ), (2) : 1982, : ; : : (1956), ( ),,,

2 W agner [ 5 ] 11 C2N 2m ethyl2sp iperone ( 11 C 2N 2 2, 11 C2NM SP) D 2 PET, (PD ) (EP) [ 69 ] [ 10 (3) : 1996 ] 99 T c m (DA T ) 99 T c m 2TRODA T 21, (DA ), 1996, (RRA ) (RA ) 20, (ECT ) PET, M R I X2CT PET,,,,,, ; PET ; PET,,, SPECT ; PET, [ 11 ], I2IL IS, 123 I2IBZM, 123 I2Β2C IT, 99 T c m 2TRODA T F2dopa, 11 C2NM SP, 11 C2raclop ride, 11 C2d 2th reo2m P, 11 C2Β2C IT 123 I2IQNB 11 C2nico tine, 11 C2QNB 123 I2iom azenil 11 C2flum azenil I222ketanserin, 123 I2Β2C IT 76 B r222ketanserin, 11 C2Β2C IT 123 I2mo rph ine, 123 I2o2IA 2D PN, 131 I2D PN 11 C2D PN, 11 C2CFN 2 ( 500 ) (SPECT, SPECT gpet, PET ),

3 4 : %, %, 21, FDA 18 F2dopa, 11 C2NM SP 11 C2raclop ride ( ),, ( 2Α2 ), Χ2 gbz, 3 H 2018 BZ, BZ 131 [ 12, 13 I2018 ] [ 14, 15 ] D I2IBZP, 131 I2IBZP SPECT D 1, 60 m in 120 m in % ID g - 1 [ 16 ] 131 I2IBZM M PT P (PD ) SPECT PD D 2, PD D 2, PD PD PD [ 17 ] 42 2N 2( ) ( 125 I2A IBZM ), 125 I2A IBZM, 125 I2A IBZM D 2 [ 18, ] 125 I2IBZM Scatchard K d= nm o lgl, B m ax= fm o lgl IBZM D 2 (7Α2o2IA 2D PN ), (K i= Λm o lg L ) M u sach io L ever T afan i [ 1922 SPECT ] 123 I2 [ 23 ] [ 24 C IT DA T, PD ] 123 I2iom azen il [ 25, M R I ] PD D 2, PD [ 26 DA, PD D 2 ] 99 T c m 2 TRODA T 21, 120 m in % ID g , PET, 10, 70, 4, SC I 3, 51, 13,

4 D 1, D 2 DA T ( ) M ( ) N ( ) GABA PBZ NM DA 52H T 1 A, B, C, 52H T 2, 3 52H T T (52 ) Λ,, ϑ PD, HD ( ) PD, PD, EP ( ) EP, g PD EP,,, 311, D 2 PD PD HD PD,,,,,, (PD ) PD, ( ) PD, X2CT M R I, D 2 18 F 11 C2NM SP 11 C2 raclop ride D 2 PD ( )D 2,, HD ( ) D 2, L 2, PD g PET 11 C2 NM SP D 2, IBZM SPECT D 2, PD D 2, PD, PD, [ 9, 27 D 2 ] D 2 PD ( IBZM ) PD ( ),, [ 28 PD PD ] 123 I2 IBZM SPECT,,,, [ 29 ] D 2, D 2, D 2, D 2

5 4 : 231 DA T, 99 T c m 2TRODA T 21 Β2C IT DA T DA T, PDL aih inen 9 PD 3 11 C2Β2C IT, PD 11 C2Β2C IT, 11 C2Β2C IT Seibyl 15 PD I2Β2C IT SPECT DA T, PD 55 %, 15 PD 14 PD,, 15 PD 1 NDR ( ), 123 I2Β2C IT SPECT DA T PD PD, [ 30, 31 ] DA T,, 99 T c m 2TRODA T C2d 2th reo2m ethylphen idate ( 11 C2d 2 2, 11 C2d 2th reo2m P) 11 C2 123 I2Β2C IT DA T (K i= nm o lgl ) DA T [ 3234 PD ],,, [ 33 DA T m RNA ], DA T PD C 123 I2QNB 11 C2n ico tin (AD ), M 2, 11 C2 n ico tin,, AD [ 3537 ] 313 EP, [ 24, M R I ] 123 I2iom azen ily, [ 38 EP ] g, 123 I222ketan serin 123 I2Β2C IT SPECT 52, C italop ram [ ] 315 [ 40,, ] PET g 11 C2D PN 11 C2carfen tan il SEPCT g 123 I2D PN 123 I2o2IA 2D PN [ 41, 42, EP ] [ 43 ] PET 11 C2carfen tan il M ethadon (, 1018 nggd) M ethadon, M ethadon

6 ,,,, 21,, (pm o l), : (1), (SDA ),,, (2),,, (3) 123 I,, SPECT, 123 I, 111 In 11 C 18 F 76 B r PET SPECT PET SPECT gpet, 18 F 99 T c m, 99 T c m (4) X2CT M R I SPECT PET (Fu sion), (SPM ),,, (5),,,,, (6) SDA,,,,,,, : [ 1 ]. [J ]., 1997, 17: 197. [ 2 ]. [J ]. [ ], 1998, 22: [ 3 ]Eckelm an W C, Reba RC, Gibson RE, et al. Recep to r B inding Radio tracers: a C lass of Po tential Radiopharm aceuticals [J ]. J N uclm ed, 1979, 20: [ 4 ]Com ar D, M azi re M, Codo t JM, et al. V isualization of 11 C2flum itrazepan D isp lacem ent in the B rain of L ive Baboon [J ]. N ature, 1979, 280: [ 5 ]W agner HN, Burns HD, D annals RF, et al. Im aging DA Recep to rs in the H um an B rain by PET [J ]. Science, 1983, 221:

7 4 : 233 [ 6 ]Granett ES, F irnau G, N ahm ias C, et al. Dopam ine V isualized in the Basal Ganglia of L iving M an [J ]. N ature, 1983, 305: [ 7 ]Jones A KP, L uth ra SK, M aziere B, et al. Regional Cerebral Op io id Recep to r Studies W ith [ 11 C ] dip reno rph ine in N o rm al V o lunteers[j ]. J N euro science M ethods, 1988, 23: [8 ]W einberger DR, Gibson R, Coppo la R, et al. T he D istribution of Cerebral M uscarinic A cetylcho line Recep to rs in V ivo in Patients W ith D em entia[j ]. A rch N euro l, 1991, 48: [ 9 ]Seibyl JP, W oods SW, Zoghbi SS, et al. D ynam ic SPECT Im aging of Dopam ine D 2 Recep to rs in H um an SubjectsW ith Iodine21232IBZM [J ]. J N uclm ed, 1992, 33: [ 10 ]Kung H F, Kim HJ, KungM P, et al. Im aging of Dopam ine T ranspo rters in H um ans w ith 99 T c m 2TRODA T 21[J ]. Eur J N uclm ed, 1996, 23: [ 11 ]V erhoeff N PL G. Pharm aco logical Imp lications fo r N euro recep to r Im aging [J ]. Eur J N ucl M ed, 1991, 18: [ 12 ],. 018 [J ]., 1989, 9: [ 13 ],,,. [J ]., 1992, 12: [ 14 ],,. D 1 2IBZP [J ]., 1991, 11: [ 15 ],,,. 131 I2IBZP D 1 [J ]., 1989, 212 (Supp l) : [ 16 ],,,. D 2 2 SPECT [J ]., 1991, 11: [ 17 ],,,. 125 I2A IBZM [J ]., 1996, 16: [ 18 ],,,. D 2 IBZM [J ]., 1996, 16: [ 19 ]W ang RF, T afani JAM, Bergon M, et al. Synthesis and Characterization of 7Α2o2iodoallyl D ip reno rph ine : A N ew L igand fo r Po tential SPECT Im aging of Op io id Recep to rs[j ]. J L abeled Compds Radiopharm aco l, 1995, 36: [ 20 ], T afani JAM, Bergon M,. 7Α2o2IA 2D PN [J ]., 1997, 17: [21 ] W ang RF, T afani JAM, F rances B, et al. Evaluation of [ I2125 ] 7Α2o2iodoallyl D ip reno rph ine as a N ew Po tential SPECT Op io id Recep to r Im aging A gent[j ]. N uclm ed B io l, 1997, 24: [ 22 ],, T afani JAM,. 7Α2o2 3 IA 2D PN : [J ]., 1998, 30: [ 23 ], Eveline D, R iccabona G. 123 I2Β2C IT SPECT [J ]., 1998, 18: [ 24 ],,,. 123 I2iom azenil SPECT [J ]., 1998, 18: [ 25 ],. D 2 [J ]., 1999, 19: [ 26 ],,,. 99 T c m 2TRODA T 21 [J ]., 1999, 19: [ 27 ]Ich ise M, Ballinger JR. SPECT Im aging of Dopam ine Recep to rs[j ]. J N uclm ed, 1996, 37: [ 28 ]Toyam a H, Ich ise M, Ballinger JR, et al. Dopam ine D 2 Recep to r SPECT Im aging: Basic in V ivo Characteristics and C linical A pp lications of 123 I2IBZM in H um an [J ]. A nn N uclm ed, 1993, 7: [29 ] H erber WW, Reijs A EM, Kw ekkeboom DJ, et al. In V ivo Im aging of P ituitary T umo rs U sing a Radio labelled

8 Dopam ine D 2 Recep to r Radio ligand[j ]. C linical Endocrino logy, 1996, 45: [ 30 ] Seibyl JP, M arek KL, Q uinlan D, et al. D ecreased Single2pho ton Em ission Tomograph ic 123 I2beta2C IT 2striatal U p take Co rrelates W ith Symp tom Severity in Park inson s D isease[j ]. A nn N euro l, 1995, 38: [ 31 ]Ish ikaw a T, D haw an V, Kazum ata K, et al. Comparative N igro striatal Dopam inergic Im aging w ith Iodine21232ΒC IT 2 FPgSPECT and F luo rine2182fdo PA gpet [J ]. J N uclm ed, 1996, 37: [ 32 ]Kung M P, Stevenson DA, P lo ssl K, et al. [ 99 T c m ]TRODA T 21: a N ovel T echnetium 299m Comp lex as a Dopam ine T ranspo rter Im aging A gent[j ]. Eur J N uclm ed, 1997, 24: [ 33 ]V o lkow ND, D ing YS, Fow leer JS, et al. [ 11 C ]2d2T hero2m ethylphenidate: a N ew PET L igand fo r the Dopam ine T ranspo rteṙ Iİ Study of in the H um an B rain[j ]. J N uclm ed, 1995, 36: [ 34 ]Boo ij J, H abraken BA, Bergm ans P, et al. Im aging of Dopam ine T ranspo rters W ith Iodine21232FP2C IT SPECT in H ealthy Contro ls and Patients W ith Park inson s D isease[j ]. J N uclm ed, 1998, 39: [ 35 ]Kuh l D E, M ino sh im a S, Fessler JA, et al. In V ivo M app ing of Cho linergic T erm inals in N o rm al A ging, A lzheim er s D isease, and Park inson s D isease[j ]. A nn N euro l, 1996, 40: [ 36 ]Iyo M, N am ba H, Fukush i K, et al. M easurem ent of A cetylcho linesterase by Po sitron Em ission Tomography in the B rains of H ealthy Contro ls and Patients w ith A lzheim er s D isease[j ]. L ancet, 1997, 349: [ 37 ]Sh ino toh H, N am ba H, Yam aguch im, et al. Po sitron Em ission Tomography M easurem ent of A cetylcho linesterase A ctivity Reveals D ifferential Lo ss of A scending Cho linergic System s in Parkinson s D isease and P rogressive Sup ranuclear Palsy[J ]. A nn N euro l, 1999, 46: [ 38 ] Schubiger PA, H asler PH, Beer2W oh lfah rt H, et al. Evaluation of a M ulticentre Study W ith Iom azenil2a Benzodiazep ine Recep to r L igand[j ]. N uclm ed Comm un, 1991, 12: [ 39 ]D haenen H, Bo ssuyt A, M ertens J, et al. SPECT Im aging of Sero tonin 2 Recep to rs in D ep ression [J ]. P sych iatry Research N euro im aging, 1993, 45: [ 40 ]A tcheson R, L ansect D G. U p take on Op io id Recep to rs[j ]. B J A naesthesia, 1994, 73: [ 41 ]F ro st JJ, M ayberg H S, Sadzo t B, et al. Comparison of [ 11 C ]dip reno rph ine and [ 11 C ]carfentanil B inding to Op iate Recep to rs in H um ans by Po sitron Em ission Tomography[J ]. J Cereb B lood F low M etab, 1990, 10: [ 42 ]F isher RS, F ro st JJ. Ep ilep sy[j ]. J N uclm ed, 1991; 32: [43 ] T afani JAM, L azo rthes Y, D anet B, et al. H um an B rain and Sp inal Co rd Scans A fter Intracerebroventricular A dm inistration of 123 I2mo rph ine[j ]. N uclm ed B io l, 1989, 18: Presen t Situa tion of the Study on Cen tra l Neurotran sm itter and Receptor Imag ing W ang Rong2fu (D ep artm ent of N uclear M ed icine, P ek ing U niversity F irst H osp ital, B eij ing , Ch ina) Abstract: T he develop ing h isto ry and the p resen t situation of the study on neu ro tran sm itter and recep to r im aging are retro spected and summ arized b riefly. T he clin ical app lication and investigation of cen tral neu ro tran sm itter and recep to r im aging is m ain ly in troduced. M eanw h ile, the p relim inary exp lo ration fo r enhancing recep to r studies and facing a variou s p rob lem s in ou r coun try in fu tu re is discu ssed. Key words: neu ro tran sm itter; recep to r; ligand; im aging