Extrapulmonary manifestations of Mycoplasma pneumoniae infection

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1 JOURNAL OF TONGJI UNIVERSITY MEDICAL SCIENCE Vol. 33 No. 4 Aug doi /j. issn MP R A Extrapulmonary manifestations of Mycoplasma pneumoniae infection LI Cheng-mei YIN Shao-jun Dept. of Gereology Tenth People's Hospital Tongji University Shanghai China Abstract The pathogenesis of Mycoplasma pneumoniae MP is inclined to the two mechanisms of epithelial cell adhesion and immunological which immune dysregulation may play an important role in the pathogenicity of extra-pulmonary damage of M P. The manifestations of its extra-pulmonary usually involves multiple systems. including nervous system cardiovascular system urinary system. skin tissue immune system damage muscle and joint damage. Extra-pulmonary damage of MP should be paid attention in clinical w ork. mycoplasma pneumoniae MP 1 MP MP MP Ⅰ T 45% ~ 48. 8% % 35. 7% 21. 4% 12. 5% 1. 8% 37. 5% MP galaxyli0418@ hotmail. com. yinshaojun2010@ yahoo. com. cn

2 4 MP 1. 1 MP MP MP B IgM IgG Th 1 /Th 2 MP Th 1 Th 2 IgM MP 1 MP 3 ~ 4 2 ~ MP MP MP MP 2. 1 MP MP 4-7 MP MP - 8 MP MP 7% 8. 3% 9 70% MP MP MP MP IgM IgG siga IgA MP IgM IgA 15% ~ 20% MP IgG MP MP IgM IgA MP cerebrospinal fluid MP CSF MD CSF-MP-IgM MP MP CSF 10 T B NK T MP CSF MP MP Lionadi 11 2 MP GC 121

3 MP 17 MP MP MP Ⅱ ST-T ALT 6 creatine kinase MB isoenzyme CK-MB lactic dehydrogenase LDH 2. 6 MP MP MP MP MP 19 MP MP 2. 7% Stevens-Jonson S-JS 3 ~ MP MD IgG albumin ALB β 2 β 2 -microglobulin β 2 -M MP 2. 7 MP MP IgG CD4 + CD4 /CD8 IgM CD MP CD4 + MP MP B MP MP 2. 4 MP MP MP MP Coomb's MP Coomb's % MP 2. 99% MP 2. 8 MP 14 MP MP disseminated intravascular coagulation MP 18 MP DIC MP MP ALT MP 122

4 4 3 MP MP MP MP X MP MP 22 ctn-i MP Zhang B Chen ZM. Changes in clinical manifestation of mycoplasma pneumonia pneumonia in children older 4 MP than 3 years during in Hangzhou J. Zhonghua Er Ke Za Zhi MP MP 3 Kashyap S Sarkar M. Mycoplasma pneumonia MP Clinical features and management J. Lung India Yang J Hooper WC Phillips DJ et al. Cytokines in DIC MP Mycoplasma pneumoniae infections J. Cytokine MP-IgM Growth Factor Reviews MP-IgG Waites KB Talkingt on DF. Mycoplasma pneumoniae and its role as a human pathogen J. Clin Mictcbiol MP Rev Yang J Hooer WC Phillips DJ et al. Cytokines in community acquiredpneumonia CAP CAP ~ 50 MP 32. 8% 27. 8% 50 5 MP 1 Smith LG. Mycoplasma pneumonia and its complications J. Infect Dis Clin North Am Myceplasma pneumoniae infections J. Cytokine Growth Factor Rev Martire B Foci C Cassano N et al. Persisten B-cell lymphopenia multiorgan disease and erythema multiforme caused by mycoplasma pneumoniae infection J. PedialrDerrmatol Beskind DI Kein SM. Chorcoathctotic movement disorder in a boy with mycoplasma pneumonia encephalitic J. Anm Emerg Med MP 17 J MP 10 Lee KY. Pediatric respiratory in fections by Mycoplasma pneumoniae J. Expert Rev Anti Infect Ther Leonaidi S Pavone P Rotolo N et al. Stroke in two 123

5 33 children with Mycoplasma pneumoniae infection A causal or casual relationship J. Pediatr Infect Dis J Mitsugi N Takashi H Harumitsu. Cardiac thrombus associated with mycoplasma pneumonia infection J. Interactive cardiovascular and thoracic Surgery Bogomolov BP Mol'kova TN Deviatkin Av. Cardiovascular system condition in respiratory mycoplasmosis J. Klin Med Mosk MP of P1 and 16S rrna genes by nested PCR for detection J Chrussanthopoulos C Eboriadou M Montik K et al. Fatal disseminated intravascular coagulation caused by Mycoplasma pneumoniae J. Pediatr Infect Dis J Joo CU Kim JS Han YM. Mycoplasma pneumoniae induced popliteal artery thrombosis treated with urokinase J. Postgrad Med J J J Joo HC Young SK Bok KK. A case of acute hepatitis with Mycoplasma pneumonia infection and transient depression of multiple coagulation factors J. Yonsei Medical Journal Orlandini Dega H Dubertretl. Cutaneous vaculitis revealing a mycoplasma pneumoniae infection J. Press Med Pt J Nour M Trabelsi A Maatouk N et al. Amplification of Mycoplasma pneumoniae in paediatric patients J. Pathol Biol Paris I J J

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