(IMOS) EMRC EMRC (IDF) (NCEP) HDL. mg/dl WHO HOMA-IR. mg/dl

HTML
DOWNLOAD

Μέγεθος: px

Εμφάνιση ξεκινά από τη σελίδα:

Download "(IMOS) EMRC EMRC (IDF) (NCEP) HDL. mg/dl WHO HOMA-IR. mg/dl"

Σωστράτη Μακρή
6 χρόνια πριν
Προβολές:

1 (4 ) D * D. 2 D :.. D. 646 : (PTH) D %29) % 8/3 646 : D. %72/3 D.( %4/6.(P=0/03) D.(P=0/00) D D :. D D : - : emrc@tums.ac.ir : : : 89/02/25 : 89/0/5 : 88/0/05:

2 ... D : (IMOS) ( ).[9] EMRC. -80 EMRC. 7 TG. D 6 5 HDL TC.. 8 mg/dl ADA.[20] 2 WHO.[2]. 2 BMI>30 kg/m 2 HOMA-IR >0/85 >0/9 mg/dl 35 HDL TG 50mg/dl mg/dl 3- Iranian multi-center osteoporosis study 4- Endocrinology and Metabolism Research Center 5- Total cholesterol 6- High density lipoprotein 7- Triglyceride 8- American Diabetes Association 39 -.[] [2] %27/46-33/7 2 (IDF) (NCEP) %39/ %34/6.[2 3] 60..[3-5] [6-0] D [8 3 4] [ 8-5] D. [ 6].[7-9] D National Cholesterol Education Program 2- International Diabetes Federation

3 385 (4 ) %8/3.( %4/6 %29/4) %53/ % 70.(2 ). ) 3/33 30/92±8 nmol/l09 ±2/45 nmol/l 25(OH) D 32/57±2/69nmol/l D.( %73/) %72/3 (35 nmol/l ).( %72 D WHO. 3 D D.(P=0/00) D 40.(P=0/05) D 40 ) 40 P=0/03 40.(P=0/04 40 D (P=0/05) 40. D 40 D P=0/002 : ).(P=0/04 P=0/02 D.(P=0/00) D.(P=0/03) 40/90 mmhg. 20 mcg/min D3-25) D IDS (England, Immunodiagnostic Systems Limited) 2 3. %5/49 %8/ 2-25 D3-25 ) nmol/l 34/9nmol/L.[9] ( mmHg SPSS JNC VII 90 mmhg.[22]. 3. Chi-Square D.. 0/05 % WHO WHO. 2 - Coefficient of variation 2- Inter-assay 3- Intra-assay

4 ... D : ( n=60) ( n=486) 47±4 40± 5 50± 3 ( ) 26/6±4/8 24/8± 4 27/4±4/ 9 (kg/m2) 94/8±2/5 95/5±/ 5 94/3±3/ 3 (cm) 07/8±9/4 06/3±8/ 3 09/±0/ 2 (cm) 0/8±0 0/8± 0 0/8± 0 04/9±9/9 07/5±23/ 3 04±8/ 7 (mg/dl) 64±0 76± 32 60± 89 (mg/dl) 4/9±4/6 32/6±9/ 7 44/9±4/ 6 (mg/dl) HDL 3/3±2/4 32/5±2/ 6 30/9± 8 (nmol/l) D. ±. : WHO -2 ( n=60) % 33/9 35/ 6 % 57/3 70 % 45/8 62/ 9 % 3/8 0/ 6 ( n=486) % 33/ % 53/ % 39/ % 4/ % 3 % % 7 % 8.. : D WHO -3 ( n= 486) (n= 486) D % 47/4 %29/2 %39/9 %6/7 %4/8 %24/2 %28/2 %9/5 % 45/6 %26 %2 %0/ %20 %4/3 %4/3 %5/3 % 67/7 %52/2 %47/6 %34/8 %30 %24/2 %29/9 %28/6 % 2/ %8 %20/7 %6/3 %6/7 %5/3 %2 %4/. * :

5 387 (4 ) D.[2] D D.[ ] D D [3 30] β.[3 3] D [32] Pittas 2 ng/ml ) D CI=0/23-/27)0/54 (0-23 ng/ml (%95 [ ] - 2. D D.[ 2 25]. [25] NHANES D.[8 33] D D. [9] D. D D. [23 24] []. 40 D D..[6 25] 26 [9] Scragg 3 D D % %30).(P<0/00.[26] D.[-5] D D D [4] D Boucher D 34 [3]. D. Chiu D

6 ... D : Eckel RH, Grundy SM, Zimmet PZ, The metabolic syndrome. Lancet 2005; 365: Azizi F, Salehi P, Etemadi A, Zahedi-Asl S, Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study. Diabetes Res Clin Pract 2003; 6: Ford ES, Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the US. Diabetes Care 2005; 28: Azadbakht L, Mirmiran P, Esmaillzadeh A, Azizi F, Dairy consumption is inversely associated with the prevalence of the metabolic syndrome in Tehranian adults. Am J Clin Nutr 2005; 82: Fakhrzadeh H, Ebrahimpour P, Nouri M, Pourebrahim R Heshmat R Shoushtarizadeh P Larijani B, Evaluation of prevalence of the metabolic syndrome in inhabitants of Tehran university of medical sciences population lab. Iranian Journal of Diabetes & Lipid Disorders, 2004; 3 (Suppl ): Isaia G, Giorgino R, Adami S, High prevalence of hypovitaminosis D in female type 2 diabetic population (Letter). Diabetes Care 200; 24: Pietschmann P, Schernthaner G, Woloszczuk W, Serum osteocalcin levels in diabetes mellitus: analysis of the type of diabetes and microvascular complications. Diabetologia 988; 3: Scragg R, Sowers M, Bell C, Serum 25- hydroxyvitamin D, diabetes, and ethnicity in the third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27: Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E, Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose. D. D. D. D Ĥ tolerance and diabetes mellitus. Diabetes Res Clin Pract 995; 27: Maghbooli Z, Hossein-Nezhad A, Shafaei AR, Karimi F, Madani FS, Larijani B, Vitamin D status in mothers and their newborns in Iran. BMC Pregnancy and Childbirth 2007; 7: -6.. Chiu KC, Chu A, Go VL, Saad MF, Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004; 79: Baynes KC, Boucher BJ, Feskens EJ, Kromhout D, Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 997; 40: Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ, Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia 995; 38: Lind L, Hanni A, Lithell H, Hvarfner A, Sorensen OH, Ljunghall S, Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men. Am J Hypertens 995; 8: Ortlepp JR, Metrikat J, Albrecht M, Korff A, Hanrath P, Hoffmann R, The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men. Diabet Med 2003; 20: Boucher BJ, Inadequate vitamin D status: does it contribute to the disorders comprising syndrome X? Br J Nutr 998; 79: Larijani B, Moayyeri A, Keshtkar AA, Hossein-Nezhad A, Soltani A, Bahrami A, Omrani GH, Rajabian R, Nabipour I, Peak bone mass of Iranian population: the Iranian Multicenter Osteoporosis Study. J Clin Densitom 2006; 9: Maghbooli Z, Hossein-Nezhad A, Shafaei AR, Karimi F, Larijani B, Correlation between vitamin D3 deficiency and insulin resistance in

7 389 (4 ) pregnancy. Diabetes Metab Res Rev 2008; 24: Hashemipour S, Larijani B, Adibi H, Sedaghat M, Pajouhi M, Bastan-Hagh MH, Soltani A, Javadi E, Shafaei AR, Baradar-Jalili R, Hossein- Nezhad A, The status of biochemical parameters in varying degrees of vitamin D deficiency. J Bone Miner Metab 2006; 24: American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 2004; 27(Suppl ): S5-S0. 2. Alberti KG, Zimmet PZ, Definition, diagnosis and classification of diabetes mellitus and its complications. Part : diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 998; 5: Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JTJr, Roccella EJ, Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. The seventh report of the Joint National Committee on prevention detection, evaluation and treatment of high blood pressure for the National High Blood Pressure Education Program Coordinating Committee. JAMA 2003; 289: Zemel MB, Hang S, Greer B, Dirienzo D, Zemel PC, Regulation of adiposity by dietary calcium. FASEB J 2000; 4: Frankel BJ, Heldt AM, Grodsky GM, Vitamin D deficiency inhibits pancreatic secretion of insulin. Science 980; 209: Ford ES, Ajani UA, McGuire LC, Liu S, Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care 2005; 28: Reaven GM, Banting, Lecture 988: Role of insulin resistance in human disease. Diabetes 988; 37: Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R, The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003; 57: Lind L, Pollare T, Hvarfner A, Lithell H, Sorensen OH, Ljunghall S, Long-term treatment with active vitamin D (alphacalcidol) in middle-aged men with impaired glucose tolerance. Effects on insulin secretion and sensitivity, glucose tolerance and blood pressure. Diabetes Res 989; : Tanaka Y, Seino Y, Ishida M, Yamaoka K, Yabuuchi H, Ishida H, Seino S, Seino Y, Imura H, Effect of vitamind3on the pancreatic secretion of insulin and somatostatin. Acta Endocrinol (Copenh) 984; 05: Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 200; 285: Holick MF, Vitamin D. the underappreciated D- lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes 2002; 9: Pittas AG, Lau J, Hu F, Dawson-hughes B, The Role of Vitamin D and Calcium in type 2 diabetes. A systematic Review and Meta- Analysis. J Clin Endocrin Metab 2007; 92: Parikh SJ, Edelman M, Uwaifo GI., Freedman RJ, Semega-Janneh M, Reynolds J, Yanovski JA, The relationship between obesity and serum,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004; 89:96-99.

Σχετικά έγγραφα

ΠΑΡΟΥΣΙΑΣΕΙΣ ΠΑΙΔΙΑΤΡΙΚΩΝ ΠΕΡΙΠΤΩΣΕΩΝ. Μεταβολικό Σύνδρομο. Νεδελκοπούλου Ναταλία Τριανταφύλλου Παναγιώτα

ΠΑΡΟΥΣΙΑΣΕΙΣ ΠΑΙΔΙΑΤΡΙΚΩΝ ΠΕΡΙΠΤΩΣΕΩΝ 9 Μεταβολικό Σύνδρομο Νεδελκοπούλου Ναταλία Τριανταφύλλου Παναγιώτα Εισαγωγή Το Μεταβολικό Σύνδρομο (ΜΣ) αποτελεί ένα οργανικό σύνδρομο που χαρακτηρίζεται από την