Comparative transcriptome analysis of peripheral blood mononuclear cells in

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1 Comparative transcriptome analysis of peripheral blood mononuclear cells in hepatitis B-related acute-on-chronic liver failure Qian Zhou, Wenchao Ding, Longyan Jiang, Jiaojiao Xin, Tianzhou Wu, Dongyan Shi, Jing Jiang, Hongcui Cao, Lanjuan Li, Jun Li Contents Supplemental Table S1. Supplemental Table S2. Supplemental Table S4. Supplemental Table S5.

2 Supplemental Table S1. The clinical characteristics of the patients in the sequencing group. Patients Age Sex ALB ALT AST TB Sodium HBV-DNA (years) (F/M) (g/l) (U/L) (U/L) Cr (μmol/l) INR (μmol/l) (μmol/l) log10(iu/ml) MELD Healthy-1 26 F NA 5.64 Healthy-2 28 F NA 6.84 Healthy-3 29 F NA NA NA Healthy-4 42 M NA NA NA CHB-1 51 M CHB-2 41 M CHB-3 39 M CHB-4 32 M ACLF-1 48 M ACLF-2 54 M ACLF-3 28 M ACLF-4 34 M

3 Supplemental Table S2. The clinical characteristics of the patients in the validation group. Patients Age ALB ALT AST TB Cr Sodium HBV-DNA Sex (F/M) (years) (g/l) (U/L) (U/L) INR (μmol/l) (μmol/l) (μmol/l) log10(iu/ml) MELD Healthy-5 34 M NA NA NA NA Healthy-6 30 F NA NA NA Healthy-7 27 F NA NA NA Healthy-8 27 F NA NA NA Healthy-9 31 F NA NA NA Healthy M NA NA NA Healthy F NA NA NA NA NA Healthy F NA NA NA Healthy F NA NA NA Healthy M NA NA NA Healthy M NA NA NA Healthy M NA NA NA Healthy F NA NA NA Healthy F NA NA NA Healthy M NA NA NA Healthy M NA NA NA Healthy M NA NA NA Healthy M NA NA NA NA NA Healthy M NA NA NA NA NA Healthy F NA NA NA CHB-5 65 F CHB-6 69 F CHB-7 48 M

4 CHB-8 41 M CHB-9 40 M CHB F CHB M CHB F CHB F CHB M CHB M CHB M CHB F CHB F CHB M CHB M CHB M CHB F CHB M CHB M HBV-ACLF-5 60 F HBV-ACLF-6 30 M HBV-ACLF-7 41 M NA HBV-ACLF-8 47 M HBV-ACLF-9 47 M HBV-ACLF M HBV-ACLF M HBV-ACLF M HBV-ACLF M HBV-ACLF F HBV-ACLF F

5 HBV-ACLF M HBV-ACLF M NA HBV-ACLF M HBV-ACLF F HBV-ACLF M HBV-ACLF M HBV-ACLF M HBV-ACLF M HBV-ACLF M

6 Supplemental Table S3. List of the 2381 differentially expressed genes. Gene ID Gene short name Locus XLOC_ CICP27 1: XLOC_ ISG15 1: XLOC_ PRKCZ 1: XLOC_ SKI 1: XLOC_ PLCH2 1: XLOC_ VAMP3 1: XLOC_ NMNAT1,RP11-807G9.2 1: XLOC_ RBP7 1: XLOC_ PGD 1: XLOC_ UBIAD1 1: XLOC_ FBXO44 1: XLOC_ DRAXIN 1: XLOC_ TNFRSF8 1: XLOC_ MIR7846,TNFRSF1B 1: XLOC_ PADI4 1: XLOC_ OTUD3 1: XLOC_ CDA 1: XLOC_ NBPF3 1: XLOC_ ALPL 1: XLOC_ ZBTB40 1: XLOC_ RCAN3 1: XLOC_ CLIC4 1: XLOC_ : XLOC_ LDLRAP1 1: XLOC_ MAN1C1 1: XLOC_ SYTL1 1: XLOC_ FGR 1: XLOC_ RNU6-1245P,STX12 1: XLOC_ THEMIS2 1: XLOC_ : XLOC_ EPB41 1: XLOC_ SERINC2 1: XLOC_ LCK 1: XLOC_ AGO4 1: XLOC_ MIR6732,ZC3H12A 1: XLOC_ EXO5 1: XLOC_ PPIH,RP5-994D16.3 1: XLOC_ BTBD19,PLK3 1: XLOC_ FAAHP1 1: XLOC_ GPX7 1: XLOC_ PODN 1: XLOC_ C1orf177,DHCR24 1: XLOC_ LEPR,LEPROT 1: XLOC_ PDE4B 1: XLOC_ TCTEX1D1 1: XLOC_ IL12RB2 1: XLOC_ GADD45A 1: XLOC_ PTGFR 1:

7 XLOC_ PRKACB 1: XLOC_ CDC14A 1: XLOC_ RP4-575N6.5,S1PR1 1: XLOC_ GPSM2 1: XLOC_ CELSR2 1: XLOC_ CYB561D1 1: XLOC_ GSTM1,GSTM2,GSTM4 1: XLOC_ SLC22A15 1: XLOC_ CD2 1: XLOC_ LINC : XLOC_ FCGR1B 1: XLOC_ FCGR1C,RP5-998N21.4 1: XLOC_ LINC00869,PPIAL4C,RP11-353N4.6 1: XLOC_ FCGR1A 1: XLOC_ SNX27 1: XLOC_ AL : XLOC_ S100A9 1: XLOC_ ATP8B2 1: XLOC_ IL6R 1: XLOC_ ZBTB7B 1: XLOC_ SEMA4A 1: XLOC_ RP11-71G12.1 1: XLOC_ : XLOC_ CD1D 1: XLOC_ MNDA 1: XLOC_ FCER1A 1: XLOC_ FCRL6 1: XLOC_ SLAMF7 1: XLOC_ FCER1G,MIR5187,NDUFS2,TOMM 40L 1: XLOC_ FCGR2A,FCGR2B,FCGR2C,HSPA6,HSPA7,RP11-25K21.6 1: XLOC_ ATF6 1: XLOC_ C1orf226,NOS1AP,RP11-565P22.6 1: XLOC_ UAP1 1: XLOC_ CD247 1: XLOC_ XCL1 1: XLOC_ FASLG 1: XLOC_ QSOX1 1: XLOC_ NPL 1: XLOC_ LAMC1 1: XLOC_ RGL1 1: XLOC_ C1orf21 1: XLOC_ PLA2G4A 1: XLOC_ RGS18 1: XLOC_ RGS1 1: XLOC_ RGS2 1: XLOC_ GPR25 1: XLOC_ C1orf106 1: XLOC_ LGR6 1:

8 XLOC_ PPFIA4 1: XLOC_ BTG2 1: XLOC_ ATP2B4 1: XLOC_ LAX1 1: XLOC_ SOX13 1: XLOC_ SRGAP2 1: XLOC_ PFKFB2 1: XLOC_ CD55 1: XLOC_ CR1 1: XLOC_ G0S2 1: XLOC_ TRAF3IP3 1: XLOC_ ATF3 1: XLOC_ Mar 1: XLOC_ HLX 1: XLOC_ DEGS1 1: XLOC_ H3F3A 1: XLOC_ ARF1,MIR3620 1: XLOC_ OBSCN 1: XLOC_ FTH1P2 1: XLOC_ RHOU 1: XLOC_ CNST 1: XLOC_ SCCPDH 1: XLOC_ NLRP3 1: XLOC_ LYPD8 1: XLOC_ HES4 1: XLOC_ GPR153 1: XLOC_ PLEKHG5,TNFRSF25 1: XLOC_ SLC2A5 1: XLOC_ DHRS3 1: XLOC_ ARHGEF19 1: XLOC_ PADI2 1: XLOC_ PADI4 1: XLOC_ ALDH4A1,IFFO2,RP13-279N23.2,T AS1R2 1: XLOC_ ECE1 1: XLOC_ NBPF2P 1: XLOC_ TCEA3 1: XLOC_ E2F2 1: XLOC_ RUNX3 1: XLOC_ : XLOC_ PAFAH2 1: XLOC_ ZNF683 1: XLOC_ AHDC1 1: XLOC_ FGR 1: XLOC_ LAPTM5 1: XLOC_ SDC3 1: XLOC_ LCK 1: XLOC_ RNF19B 1: XLOC_ A3GALT2,PHC2 1: XLOC_ CLSPN 1:

9 XLOC_ COL8A2 1: XLOC_ CSF3R,MRPS15 1: XLOC_ MTF1,YRDC 1: XLOC_ HPCAL4 1: XLOC_ RIMS3 1: XLOC_ CITED4 1: XLOC_ : XLOC_ SLC2A1 1: XLOC_ SPATA6 1: XLOC_ ORC1 1: XLOC_ ECHDC2 1: XLOC_ SLC1A7 1: XLOC_ SSBP3 1: XLOC_ TTC22 1: XLOC_ JUN 1: XLOC_ JAK1 1: XLOC_ GNG5 1: XLOC_ CTBS 1: XLOC_ MIR7856,ODF2L 1: XLOC_ GBP5 1: XLOC_ TGFBR3 1: XLOC_ EVI5 1: XLOC_ ARHGAP29 1: XLOC_ RPL7P9 1: XLOC_ DPYD 1: XLOC_ SLC25A24 1: XLOC_ PSRC1 1: XLOC_ SORT1 1: XLOC_ AMIGO1 1: XLOC_ KCNA3 1: XLOC_ PPM1J,RHOC,RP11-426L : XLOC_ BCL2L15 1: XLOC_ CD2 1: XLOC_ FTH1P22 1: XLOC_ ZNF697 1: XLOC_ NOTCH2,RP5-1042I8.7 1: XLOC_ OTUD7B 1: XLOC_ CTSS 1: XLOC_ LINGO4,RORC 1: XLOC_ THEM4 1: XLOC_ S100A11 1: XLOC_ IVL 1: XLOC_ S100A12 1: XLOC_ S100A8 1: XLOC_ S100A6 1: XLOC_ RAB13 1: XLOC_ PBXIP1 1: XLOC_ GBA 1: XLOC_ RIT1 1: XLOC_ IQGAP3 1:

10 XLOC_ ARHGEF11 1: XLOC_ FCRL5 1: XLOC_ FCRL3 1: XLOC_ FCRL6 1: XLOC_ IGSF8 1: XLOC_ SLAMF6 1: XLOC_ SLAMF1 1: XLOC_ SH2D1B 1: XLOC_ GPA33 1: XLOC_ CD247 1: XLOC_ CREG1 1: XLOC_ XCL2 1: XLOC_ F5 1: XLOC_ KIFAP3 1: XLOC_ RP11-568K15.1,RP4-798P15.3,SEC1 6B 1: XLOC_ GLUL 1: XLOC_ NCF2 1: XLOC_ ARPC5 1: XLOC_ COLGALT2 1: XLOC_ EDEM3 1: XLOC_ PTGS2 1: XLOC_ : XLOC_ KIF21B 1: XLOC_ ARL8A 1: XLOC_ ADIPOR1 1: XLOC_ CHI3L1 1: XLOC_ CHIT1 1: XLOC_ ETNK2 1: XLOC_ RAB29 1: XLOC_ SLC41A1 1: XLOC_ IL10 1: XLOC_ FAIM3 1: XLOC_ PLXNA2 1: XLOC_ SLC30A1 1: XLOC_ LPGAT1 1: XLOC_ TLR5 1: XLOC_ LBR 1: XLOC_ RP11-285F7.2,TMEM63A 1: XLOC_ PARP1 1: XLOC_ ITPKB 1: XLOC_ : XLOC_ PCNXL2,RP5-862P8.3 1: XLOC_ LYST 1: XLOC_ CHRM3-AS2 1: XLOC_ CEP170 1: XLOC_ ZNF692 1: XLOC_ : XLOC_ : XLOC_ :

11 XLOC_ ZMYND11 10: XLOC_ AKR1C1,AKR1C3,RP11-499O7.4 10: XLOC_ PFKFB3 10: XLOC_ PRKCQ-AS1,RP11-554I8.1 10: XLOC_ GATA3 10: XLOC_ ECHDC3 10: XLOC_ OPTN 10: XLOC_ VIM 10: XLOC_ PLXDC2 10: XLOC_ MSRB2 10: XLOC_ OTUD1 10: XLOC_ APBB1IP 10: XLOC_ MAP3K8 10: XLOC_ HNRNPA1P32 10: XLOC_ ZEB1 10: XLOC_ CSGALNACT2 10: XLOC_ ALOX5 10: XLOC_ : XLOC_ ASAH2B 10: XLOC_ UBE2D1 10: XLOC_ CDK1 10: XLOC_ ZNF365 10: XLOC_ : XLOC_ SRGN 10: XLOC_ HKDC1 10: XLOC_ TSPAN15 10: XLOC_ C10orf35 10: XLOC_ COL13A1 10: XLOC_ DDIT4 10: XLOC_ MCU 10: XLOC_ PLAU 10: XLOC_ ADK,MRPL35P3 10: XLOC_ KAT6B 10: XLOC_ SAMD8 10: XLOC_ C10orf11 10: XLOC_ PPIF 10: XLOC_ CDHR1 10: XLOC_ CCSER2 10: XLOC_ LIPN 10: XLOC_ CEP55 10: XLOC_ TBC1D12 10: XLOC_ C10orf131,CC2D2B,ENTPD1,RP11-248J23.6,RP11-248J23.7,RP11-429G 10: ,RP11-690P14.4 XLOC_ FRAT1 10: XLOC_ GOLGA7B 10: XLOC_ SCD 10: XLOC_ ELOVL3 10: XLOC_ GSTO1,GSTO2 10: XLOC_ SHOC2 10:

12 XLOC_ ENO4 10: XLOC_ GRK5 10: XLOC_ PLEKHA1 10: XLOC_ PTPRE,RP11-4C : XLOC_ VENTX 10: XLOC_ CYP2E1,MTG1,PAOX,RP11-108K1 4.8,SCART1 10: XLOC_ DIP2C 10: XLOC_ GDI2 10: XLOC_ PRKCQ 10: XLOC_ SFMBT2 10: XLOC_ NMT2 10: XLOC_ FAM171A1 10: XLOC_ ST8SIA6 10: XLOC_ MPP7 10: XLOC_ SVILP1 10: XLOC_ KIF5B 10: XLOC_ NAMPTP1 10: XLOC_ RP11-258F22.1,ZNF248 10: XLOC_ NCOA4 10: XLOC_ ANTXRLP1 10: XLOC_ C10orf128 10: XLOC_ SGMS1 10: XLOC_ IPMK 10: XLOC_ CCDC6 10: XLOC_ ANK3 10: XLOC_ RTKN2 10: XLOC_ EGR2 10: XLOC_ AIFM2,TYSND1 10: XLOC_ PRF1 10: XLOC_ PSAP 10: XLOC_ SPOCK2 10: XLOC_ MICU1 10: XLOC_ ZNF503 10: XLOC_ DLG5 10: XLOC_ ANKRD22 10: XLOC_ CPEB3 10: XLOC_ MYOF 10: XLOC_ ALDH18A1 10: XLOC_ PIK3AP1 10: XLOC_ FRAT2 10: XLOC_ DNMBP 10: XLOC_ CHUK,ERLIN1 10: XLOC_ FBXW4 10: XLOC_ NT5C2 10: XLOC_ COL17A1,MIR936 10: XLOC_ ITPRIP 10: XLOC_ ABLIM1 10: XLOC_ ENO4,KIAA : XLOC_ PRDX3 10:

13 XLOC_ CHST15 10: XLOC_ MKI67 10: XLOC_ : XLOC_ : XLOC_ : XLOC_ : XLOC_ ATHL1,RP11-326C3.2 11: XLOC_ IFITM1,IFITM2,RP11-326C3.10,RP C3.11,RP11-326C3.12,RP : C3.15 XLOC_ SIGIRR 11: XLOC_ RASSF7,RP11-496I9.1 11: XLOC_ TALDO1 11: XLOC_ AC ,LSP1,hsa-mir : XLOC_ TNNT3 11: XLOC_ CD81 11: XLOC_ OR52L2P 11: XLOC_ GVINP1 11: XLOC_ SWAP70 11: XLOC_ ADM 11: XLOC_ AMPD3 11: XLOC_ FAR1 11: XLOC_ LDHA 11: XLOC_ PRRG4 11: XLOC_ CAT 11: XLOC_ CD44 11: XLOC_ LDLRAD3 11: XLOC_ PRR5L 11: XLOC_ CD82 11: XLOC_ SPI1 11: XLOC_ PTPRJ 11: XLOC_ OR10Y1P,STX3 11: XLOC_ MS4A3 11: XLOC_ MS4A4A 11: XLOC_ MS4A14,MS4A6E,MS4A7 11: XLOC_ CD6 11: XLOC_ CD5 11: XLOC_ LGALS12 11: XLOC_ RARRES3 11: XLOC_ RTN3 11: XLOC_ NAA40 11: XLOC_ SLC22A20 11: XLOC_ CTSW 11: XLOC_ RAD9A,TBC1D10C 11: XLOC_ ALDH3B1 11: XLOC_ FOLR3 11: XLOC_ INPPL1 11: XLOC_ P2RY2,RP11-800A3.4 11: XLOC_ RELT,RP11-809N8.4 11: XLOC_ PLEKHB1 11:

14 XLOC_ RPS3,SNORD15A 11: XLOC_ SERPINH1 11: XLOC_ DGAT2 11: XLOC_ ACER3 11: XLOC_ CAPN5 11: XLOC_ MYO7A 11: XLOC_ RPS28P7 11: XLOC_ : XLOC_ PRSS23 11: XLOC_ SLC36A4 11: XLOC_ FUT4,PIWIL4,RP11-867G2.4 11: XLOC_ RP11-60C6.5,SRSF8 11: XLOC_ ENDOD1 11: XLOC_ RAB39A 11: XLOC_ ZC3H12C 11: XLOC_ NCAM1 11: XLOC_ ZBTB16 11: XLOC_ AP ,PAFAH1B2,SIDT2,TA GLN 11: XLOC_ RP11-728F : XLOC_ : XLOC_ CD3E 11: XLOC_ CD3G 11: XLOC_ TMEM25,TTC36 11: XLOC_ VWA5A 11: XLOC_ ROBO3 11: XLOC_ SLC37A2 11: XLOC_ APLP2 11: XLOC_ ST14 11: XLOC_ GLB1L2 11: XLOC_ ANO9,SIGIRR 11: XLOC_ CTSD,IFITM10,KRTAP5-4,RP K3.1 11: XLOC_ CDKN1C 11: XLOC_ OSBPL5 11: XLOC_ RHOG 11: XLOC_ PRKCDBP 11: XLOC_ APBB1 11: XLOC_ DCHS1 11: XLOC_ CYB5R2 11: XLOC_ DENND5A 11: XLOC_ RP11-1H15.1,SBF2 11: XLOC_ RP11-351I : XLOC_ MTRNR2L8,RNF141 11: XLOC_ MRVI1 11: XLOC_ DKK3 11: XLOC_ RP11-21L19.1,RRAS2 11: XLOC_ E2F8 11: XLOC_ LMO2 11: XLOC_ TP53I11 11:

15 XLOC_ MYBPC3 11: XLOC_ RP11-750H9.5,SPI1 11: XLOC_ PRG2,RP11-872D17.8,SLC43A3 11: XLOC_ SLC43A1 11: XLOC_ MPEG1 11: XLOC_ TCN1 11: XLOC_ AP ,MS4A6A 11: XLOC_ MIR6503,MS4A4E 11: XLOC_ FTH1 11: XLOC_ MEN1 11: XLOC_ CDC42BPG 11: XLOC_ LTBP3 11: XLOC_ AP5B1 11: XLOC_ FOSL1 11: XLOC_ CD248 11: XLOC_ SLC29A2 11: XLOC_ CTSF 11: XLOC_ CORO1B,PTPRCAP 11: XLOC_ UNC93B1,UNC93B5 11: XLOC_ CPT1A 11: XLOC_ KCNE3 11: XLOC_ PAK1 11: XLOC_ GAB2 11: XLOC_ PRCP 11: XLOC_ SYTL2 11: XLOC_ PICALM 11: XLOC_ ME3 11: XLOC_ SLC36A4 11: XLOC_ SMCO4 11: XLOC_ RP11-680H : XLOC_ MMP8 11: XLOC_ PDGFD 11: XLOC_ RP11-693N9.2 11: XLOC_ CARD16,CARD17,CASP1 11: XLOC_ KDELC2 11: XLOC_ USP28 11: XLOC_ RP11-109L : XLOC_ FXYD2,FXYD6,FXYD6-FXYD2 11: XLOC_ CD3D 11: XLOC_ BCL9L 11: XLOC_ HYOU1 11: XLOC_ HSPA8,SNORD14C,SNORD14D 11: XLOC_ FEZ1 11: XLOC_ : XLOC_ ETS1 11: XLOC_ B3GAT1 11: XLOC_ : XLOC_ : XLOC_ CCND2 12: XLOC_ LTBR,RP1-102E :

16 XLOC_ GAPDH 12: XLOC_ LAG3 12: XLOC_ C12orf57,RNU7-1 12: XLOC_ CLEC4A,FAM66C,ZNF705A 12: XLOC_ CLEC6A 12: XLOC_ CLEC4D 12: XLOC_ A2MP1,KRT17P8,LINC00987,RP11-118B22.4,RP11-436I9.6 12: XLOC_ RP11-726G1.1 12: XLOC_ CLEC2D,GOT2P3,RP11-705C15.2,R P11-705C15.3,RP11-705C15.5,RP11-12: L1.1 XLOC_ KLRF1 12: XLOC_ CLEC7A 12: XLOC_ TMEM52B 12: XLOC_ KLRD1 12: XLOC_ RP11-277P : XLOC_ RP11-291B : XLOC_ ETV6 12: XLOC_ HTR7P1,RP11-377D9.3 12: XLOC_ PTPRO 12: XLOC_ MGST1 12: XLOC_ PLEKHA5 12: XLOC_ SSPN 12: XLOC_ FAR2 12: XLOC_ FGD4 12: XLOC_ LRRK2 12: XLOC_ METTL7A 12: XLOC_ ACVRL1 12: XLOC_ ACVR1B 12: XLOC_ GRASP 12: XLOC_ NR4A1 12: XLOC_ SOAT2 12: XLOC_ ESPL1 12: XLOC_ SP1 12: XLOC_ CDK2,DGKA 12: XLOC_ COQ10A 12: XLOC_ LRP1 12: XLOC_ DTX3 12: XLOC_ ARHGEF25 12: XLOC_ MSRB3 12: XLOC_ IRAK3,MIR : XLOC_ DYRK2 12: XLOC_ LYZ 12: XLOC_ : XLOC_ ATXN7L3B 12: XLOC_ GLIPR1 12: XLOC_ TMTC2 12: XLOC_ SOCS2 12: XLOC_ PLXNC1 12:

17 XLOC_ APAF1 12: XLOC_ DRAM1 12: XLOC_ KIAA : XLOC_ TMEM263 12: XLOC_ UNG 12: XLOC_ SH2B3 12: XLOC_ ACAD10,ALDH2,RP11-162P : XLOC_ RPH3A 12: XLOC_ SDSL 12: XLOC_ CCDC64 12: XLOC_ P2RX7,RP11-340F : XLOC_ CAMKK2 12: XLOC_ ORAI1 12: XLOC_ TCTN2 12: XLOC_ GLT1D1 12: XLOC_ FBXL14 12: XLOC_ TNFRSF1A 12: XLOC_ LPAR5 12: XLOC_ C1R,C1RL 12: XLOC_ CD163,CD163L1 12: XLOC_ CLEC4C 12: XLOC_ SLC2A3 12: XLOC_ C3AR1 12: XLOC_ CLEC4E,RP11-561P : XLOC_ KLRB1 12: XLOC_ CLEC7A 12: XLOC_ OLR1 12: XLOC_ KLRC1,KLRC2,KLRC3,KLRC4,KL RC4-KLRK1,KLRK1,NKG2-E,RP11 12: P12.9 XLOC_ STYK1 12: XLOC_ YBX3 12: XLOC_ MANSC1 12: XLOC_ PLBD1 12: XLOC_ LDHB 12: XLOC_ BCAT1 12: XLOC_ KRAS 12: XLOC_ TMTC1 12: XLOC_ PKP2 12: XLOC_ CPNE8 12: XLOC_ ABCD2,AC ,KIF21A 12: XLOC_ NELL2 12: XLOC_ SLC38A1 12: XLOC_ PCED1B-AS1 12: XLOC_ VDR 12: XLOC_ WNT10B 12: XLOC_ RHEBL1 12: XLOC_ NCKAP5L 12: XLOC_ LIMA1 12: XLOC_ KRT72,KRT73 12:

18 XLOC_ ITGB7 12: XLOC_ GPR84 12: XLOC_ TESPA1 12: XLOC_ CD63 12: XLOC_ AGAP2 12: XLOC_ GNS 12: XLOC_ AC ,RBMS1P1,RP11-335I : XLOC_ RP11-81H14.1,RP11-81H : XLOC_ LIN7A 12: XLOC_ DUSP6 12: XLOC_ RP11-887P2.3 12: XLOC_ NTN4 12: XLOC_ LTA4H 12: XLOC_ SLC9A7P1 12: XLOC_ RP11-135F9.3,UHRF1BP1L 12: XLOC_ NT5DC3,RP11-341G : XLOC_ CKAP4 12: XLOC_ MTERF2 12: XLOC_ CRY1 12: XLOC_ CMKLR1 12: XLOC_ CORO1C 12: XLOC_ TRPV4 12: XLOC_ GLTP 12: XLOC_ ANAPC7,ARPC3,RP11-478C : XLOC_ HVCN1 12: XLOC_ TESC 12: XLOC_ WSB2 12: XLOC_ GCN1L1 12: XLOC_ CAMKK2 12: XLOC_ CLIP1 12: XLOC_ RILPL2 12: XLOC_ LINC : XLOC_ RNU6-1017P 12: XLOC_ : XLOC_ C1QTNF9,RP11-307N16.6,SPATA1 3 13: XLOC_ PABPC3 13: XLOC_ NUPL1 13: XLOC_ ALOX5AP 13: XLOC_ KL 13: XLOC_ LACC1 13: XLOC_ ARL11 13: XLOC_ HNRNPA1L2,MRPS31P4,RP11-78J : XLOC_ OLFM4 13: XLOC_ KLF5 13: XLOC_ LINC00381,LINC00402,RPL21P108 13: XLOC_ AC : XLOC_ DNAJC3 13:

19 XLOC_ TM9SF2 13: XLOC_ RP11-153I24.4,TNFSF13B 13: XLOC_ IRS2 13: XLOC_ ATP11A 13: XLOC_ MCF2L 13: XLOC_ TMCO3 13: XLOC_ : XLOC_ ZDHHC20 13: XLOC_ SACS 13: XLOC_ MTMR6 13: XLOC_ FLT3 13: XLOC_ SLC7A1 13: XLOC_ LCP1 13: XLOC_ KIAA0226L,LINC00563,PPP1R2P4 13: XLOC_ DLEU2,MIR15A,MIR : XLOC_ PCDH9 13: XLOC_ DACH1 13: XLOC_ KLF12 13: XLOC_ TBC1D4 13: XLOC_ AC ,KCTD12 13: XLOC_ DOCK9 13: XLOC_ CCR12P 13: XLOC_ IRS2 13: XLOC_ RAB20 13: XLOC_ CARS2 13: XLOC_ LINC00565,RASA3 13: XLOC_ : XLOC_ : XLOC_ : XLOC_ RP11-203M5.6 14: XLOC_ ANG,RNASE4 14: XLOC_ RNASE6,RP11-219E7.1 14: XLOC_ RNASE3 14: XLOC_ RP11-84C : XLOC_ RNASE2 14: XLOC_ ARHGEF40 14: XLOC_ TRAV1-1 14: XLOC_ TRAV8-2,TRAV8-3 14: XLOC_ TRAV : XLOC_ TRAV : XLOC_ TRAV : XLOC_ TRAV9-2 14: XLOC_ TRAV : XLOC_ TRAV16 14: XLOC_ TRAV17 14: XLOC_ TRAV19 14: XLOC_ TRDV1 14: XLOC_ TRAV24 14: XLOC_ TRAV25 14: XLOC_ TRAV :

20 XLOC_ TRAV27 14: XLOC_ TRAV29DV5 14: XLOC_ AE ,TRAC,TRAJ21,TRAJ2 3,TRAJ29,TRAJ32,TRAJ39,TRAJ54, TRAV38-2DV8,TRDC,TRDD3,TRD 14: J1,TRDJ2,TRDJ3,TRDJ4,TRDV2 XLOC_ RP11-104E : XLOC_ LGALS3 14: XLOC_ PELI2 14: XLOC_ FLJ22447,PRKCH,RP11-47I : XLOC_ HIF1A,RP11-618G20.1,SNAPC1 14: XLOC_ SYNE2 14: XLOC_ PLEKHG3 14: XLOC_ SIPA1L1 14: XLOC_ PSEN1 14: XLOC_ FOS 14: XLOC_ JDP2 14: XLOC_ FLVCR2,IFT43,TTLL5 14: XLOC_ CTD-2341M : XLOC_ SLC24A4 14: XLOC_ CTD-2506J : XLOC_ RP11-204N : XLOC_ EVL 14: XLOC_ : XLOC_ RCOR1 14: XLOC_ TDRD9 14: XLOC_ CRIP2 14: XLOC_ TMEM121 14: XLOC_ MIR6717,NDRG2 14: XLOC_ SALL2 14: XLOC_ OR10G2 14: XLOC_ SLC7A7 14: XLOC_ AJUBA,HAUS4,MIR4707,RP I3.5 14: XLOC_ CDH24 14: XLOC_ CEBPE 14: XLOC_ CTSG 14: XLOC_ GZMH 14: XLOC_ GZMB 14: XLOC_ SPTSSA 14: XLOC_ BAZ1A 14: XLOC_ NFKBIA 14: XLOC_ RPL32P29,RPS29 14: XLOC_ PYGL 14: XLOC_ ERO1L 14: XLOC_ CNIH1 14: XLOC_ GMFB 14: XLOC_ DLGAP5 14: XLOC_ WDR89 14: XLOC_ ZFP36L1 14:

21 XLOC_ ACTN1,HMGN1P3 14: XLOC_ NUMB,RP1-240K6.3,RP4-647C : XLOC_ PNMA1 14: XLOC_ LTBP2,MIR4709,NPC2 14: XLOC_ TMED8 14: XLOC_ SPTLC2 14: XLOC_ GPR68 14: XLOC_ CCDC88C 14: XLOC_ CATSPERB,TC2N 14: XLOC_ FBLN5 14: XLOC_ DDX24 14: XLOC_ SERPINA1 14: XLOC_ CLMN,CTD-2240H : XLOC_ LINC : XLOC_ BCL11B 14: XLOC_ : XLOC_ WARS 14: XLOC_ CDC42BPB 14: XLOC_ CKB 14: XLOC_ PPP1R13B 14: XLOC_ : XLOC_ IGHV : XLOC_ : XLOC_ : XLOC_ : XLOC_ RP11-603B : XLOC_ WHAMMP3 15: XLOC_ NIPA1,RP11-566K : XLOC_ MKRN3 15: XLOC_ PWAR5,PWAR6,RP11-701H24.7,SN HG14,SNORD107,SNORD115-13,S NORD115-26,SNORD115-46,SNOR D115-7,SNORD116,SNORD116-20, 15: SNORD116-22,SNORD116-3,SNOR D116-4,SNORD116-5,SNORD64,SN RPN,SNURF XLOC_ WHAMMP2 15: XLOC_ APBA2 15: XLOC_ HMGN2P5 15: XLOC_ GOLGA8B 15: XLOC_ THBS1 15: XLOC_ BAHD1 15: XLOC_ CASC5 15: XLOC_ SPINT1 15: XLOC_ CHP1 15: XLOC_ NUSAP1 15: XLOC_ BLOC1S6,HMGN2P46,RP11-96O20.4,SQRDL 15: XLOC_ AQP9 15: XLOC_ RPS3AP6 15:

22 XLOC_ LACTB 15: XLOC_ USP3 15: XLOC_ AC ,ANKDD1A,PLEKHO2 15: XLOC_ SMAD3 15: XLOC_ KIF23 15: XLOC_ SCAMP5 15: XLOC_ C15orf39 15: XLOC_ ST20-AS1 15: XLOC_ BCL2A1 15: XLOC_ IL16 15: XLOC_ ABHD2 15: XLOC_ LINC : XLOC_ ANPEP 15: XLOC_ IQGAP1 15: XLOC_ FURIN 15: XLOC_ FES,MAN2A2 15: XLOC_ SLCO3A1 15: XLOC_ ARRDC4 15: XLOC_ CYFIP1 15: XLOC_ ATP10A 15: XLOC_ LPCAT4 15: XLOC_ GOLGA8A 15: XLOC_ RASGRP1 15: XLOC_ CTD-2033D15.1,CTD-2033D : XLOC_ BMF 15: XLOC_ LTK 15: XLOC_ FBN1 15: XLOC_ ATP8B4 15: XLOC_ DMXL2 15: XLOC_ GNB5 15: XLOC_ PIGBOS1,RAB27A 15: XLOC_ CCPG1,DYX1C1,DYX1C1-CCPG1, MIR628 15: XLOC_ NEDD4 15: XLOC_ ALDH1A2 15: XLOC_ AQP9 15: XLOC_ BNIP2 15: XLOC_ : XLOC_ ANXA2 15: XLOC_ RORA,uc_338 15: XLOC_ : XLOC_ DAPK2 15: XLOC_ FAM96A 15: XLOC_ OAZ2 15: XLOC_ UACA 15: XLOC_ PKM 15: XLOC_ ADPGK 15: XLOC_ NPTN 15: XLOC_ IMP3 15: XLOC_ CTSH 15:

23 XLOC_ RASGRF1 15: XLOC_ BCL2A1 15: XLOC_ AC ,GOLGA2P10 15: XLOC_ SEC11A 15: XLOC_ HAPLN3 15: XLOC_ MFGE8 15: XLOC_ ANPEP 15: XLOC_ CHSY1 15: XLOC_ TARSL2 15: XLOC_ : XLOC_ HBA2 16: XLOC_ CACNA1H 16: XLOC_ TMEM204 16: XLOC_ LA16c-380H5.5 16: XLOC_ MMP25 16: XLOC_ IL32,RNU1-125P,RNU1-22P 16: XLOC_ HMOX2 16: XLOC_ C16orf72,RP11-473I1.9 16: XLOC_ CTD-2349B8.1,ITPRIPL2,SYT17 16: XLOC_ METTL9 16: XLOC_ PRKCB 16: XLOC_ IL4R 16: XLOC_ IL21R 16: XLOC_ SBK1 16: XLOC_ APOBR 16: XLOC_ LAT,RP11-264B17.3,SPNS1 16: XLOC_ AC ,QPRT,SPN 16: XLOC_ ALDOA 16: XLOC_ ITGAL 16: XLOC_ ITGAM 16: XLOC_ ITGAX 16: XLOC_ RBL2 16: XLOC_ LPCAT2,RP11-212I : XLOC_ CPNE2 16: XLOC_ GPR114,HMGB3P32 16: XLOC_ GPR56 16: XLOC_ GPR97 16: XLOC_ NDRG4 16: XLOC_ LINC : XLOC_ PDP2,RP11-61A14.2,RP11-61A : XLOC_ NOL3 16: XLOC_ RLTPR 16: XLOC_ PLA2G15 16: XLOC_ HP,HPR 16: XLOC_ ATP2C2 16: XLOC_ CRISPLD2 16: XLOC_ KIAA : XLOC_ ZFPM1 16: XLOC_ : XLOC_ CDT1 16:

24 XLOC_ VPS9D1-AS1,ZNF276 16: XLOC_ AC ,FAM157C 16: XLOC_ AXIN1 16: XLOC_ RAB11FIP3 16: XLOC_ MSRB1 16: XLOC_ ABCA3 16: XLOC_ PRSS30P 16: XLOC_ PKMYT1 16: XLOC_ RP11-473M : XLOC_ MEFV 16: XLOC_ NLRC3 16: XLOC_ RP11-461A8.4,TRAP1 16: XLOC_ CDIP1 16: XLOC_ CPPED1 16: XLOC_ IGSF6 16: XLOC_ SBK1 16: XLOC_ RP11-297C4.6,SEPT1 16: XLOC_ PYCARD 16: XLOC_ HMGN2P41 16: XLOC_ RP11-44F14.1,RP11-44F : XLOC_ CES1 16: XLOC_ CCDC102A 16: XLOC_ GPR114 16: XLOC_ GPR56 16: XLOC_ NAE1 16: XLOC_ ATP6V0D1 16: XLOC_ MLKL 16: XLOC_ CDYL2 16: XLOC_ COTL1 16: XLOC_ KLHDC4,RP11-278A : XLOC_ P2RX1 17: XLOC_ SPNS2 17: XLOC_ ARRB2 17: XLOC_ ASGR2 17: XLOC_ RPL7AP64 17: XLOC_ NLGN2 17: XLOC_ CD68,EIF4A1,MPDU1,SENP3,SEN P3-EIF4A1,SNORA48,SNORA67,S NORD10,TNFSF12,TNFSF12-TNFS 17: F13,TNFSF13 XLOC_ KDM6B,TMEM88 17: XLOC_ CHD3 17: XLOC_ HS3ST3B1 17: XLOC_ CCDC144A,NOS2P4,RP11-219A15. 1,RP11-219A15.2,RP11-219A15.4,U 17: SP32P1 XLOC_ KRT16P4,LGALS9C 17: XLOC_ CCDC144CP,SPECC1,USP32P3 17: XLOC_ RP11-173M1.7,RP11-173M1.8,WSB 1 17:

25 XLOC_ CPD 17: XLOC_ ADAP2,RN7SL138P,RNF135,RP11-848P1.3 17: XLOC_ RHOT1 17: XLOC_ SLFN5 17: XLOC_ AC ,RDM1 17: XLOC_ DUSP14 17: XLOC_ CISD3,CTB-58E17.1,MLLT6 17: XLOC_ ERBB2 17: XLOC_ IKZF3 17: XLOC_ THRA 17: XLOC_ RARA 17: XLOC_ : XLOC_ ATP6V0A1,MIR5010,RP11-400F : XLOC_ GRN 17: XLOC_ TBX21 17: XLOC_ ABCC3 17: XLOC_ PCTP 17: XLOC_ NOG 17: XLOC_ SCPEP1 17: XLOC_ DYNLL2,RP11-159D : XLOC_ YPEL2 17: XLOC_ CLTC,VMP1 17: XLOC_ CA4 17: XLOC_ MILR1 17: XLOC_ RGS9 17: XLOC_ ARSG,PRKAR1A,RP11-120M : XLOC_ KCNJ2 17: XLOC_ RPL38 17: XLOC_ KIF19 17: XLOC_ MIR3615,RAB37,SLC9A3R1 17: XLOC_ LLGL2,TSEN54 17: XLOC_ SCARNA16,SEC14L1,SNHG20 17: XLOC_ SEPT9 17: XLOC_ TMC8 17: XLOC_ SYNGR2 17: XLOC_ BIRC5 17: XLOC_ GAA 17: XLOC_ RPTOR 17: XLOC_ MIR6787,RP13-516M14.10,RP M14.8,SLC16A3 17: XLOC_ RP E : XLOC_ DOC2B 17: XLOC_ FAM101B 17: XLOC_ YWHAE 17: XLOC_ CRK 17: XLOC_ SLC43A2 17: XLOC_ RILP,SCARF1 17: XLOC_ MIR22,MIR22HG 17:

26 XLOC_ RP11-147K16.3,SPATA22,TRPV3 17: XLOC_ CAMKK1,P2RX1 17: XLOC_ PELP1 17: XLOC_ CXCL16,RP11-314A : XLOC_ SCIMP 17: XLOC_ ASGR2,CLEC10A 17: XLOC_ ZBTB4 17: XLOC_ AURKB 17: XLOC_ GAS7 17: XLOC_ PMP22 17: XLOC_ TBC1D27,TNFRSF13B 17: XLOC_ CCDC144B,CTD-2303H24.2,FAM1 06A,USP32P2 17: XLOC_ FOXO3B,RP11-815I9.3,RP11-815I9. 4,TBC1D28,ZNF286B 17: XLOC_ RAB34 17: XLOC_ CTD-2370N5.3,EVI2A,EVI2B 17: XLOC_ RP M14.5,RP11-686D22.10,S LFN12L,SLFN13,TOMM20P2 17: XLOC_ HEATR9 17: XLOC_ CCL5 17: XLOC_ SYNRG 17: XLOC_ PLXDC1 17: XLOC_ IKZF3,RP11-94L : XLOC_ GSDMB,ORMDL3 17: XLOC_ TOP2A 17: XLOC_ CCR7 17: XLOC_ KRT23 17: XLOC_ JUP 17: XLOC_ LEPREL4 17: XLOC_ STAT3 17: XLOC_ LINC : XLOC_ VAT1 17: XLOC_ BRCA1 17: XLOC_ DUSP3 17: XLOC_ WNT3 17: XLOC_ TBX21 17: XLOC_ OSBPL7 17: XLOC_ SKAP1 17: XLOC_ LRRC59 17: XLOC_ MIR3614,TRIM25 17: XLOC_ CUEDC1 17: XLOC_ MPO 17: XLOC_ CYB561,RP11-269G : XLOC_ ICAM2 17: XLOC_ TEX2 17: XLOC_ PECAM1 17: XLOC_ AXIN2,CEP112,CTD-2535L : XLOC_ FAM20A 17: XLOC_ ABCA6,ABCA9 17:

27 XLOC_ CDC42EP4 17: XLOC_ CD300LB 17: XLOC_ CD300C 17: XLOC_ GRB2 17: XLOC_ TRIM65 17: XLOC_ ACOX1 17: XLOC_ SOCS3 17: XLOC_ CTD-2357A8.3 17: XLOC_ CYTH1 17: XLOC_ USP36 17: XLOC_ KIAA1731NL,TIMP2 17: XLOC_ BAIAP2-AS1 17: XLOC_ AATK 17: XLOC_ LINC : XLOC_ RP B8.4 17: XLOC_ : XLOC_ RAB40B 17: XLOC_ : XLOC_ : XLOC_ : XLOC_ EMILIN2,RP11-737O : XLOC_ RAB31 18: XLOC_ VAPA 18: XLOC_ IMPA2 18: XLOC_ ANKRD20A5P,CYP4F35P,RHOT1P 1,RP11-757O6.1,RP11-757O6.6 18: XLOC_ RIOK3 18: XLOC_ MAPRE2 18: XLOC_ SIGLEC15 18: XLOC_ CTIF,MIR : XLOC_ RAB27B 18: XLOC_ PMAIP1 18: XLOC_ SERPINB10,SERPINB2 18: XLOC_ HMSD,SERPINB8 18: XLOC_ TSHZ1 18: XLOC_ KCNG2 18: XLOC_ ENOSF1 18: XLOC_ YES1 18: XLOC_ ZBTB14 18: XLOC_ EPB41L3 18: XLOC_ RP11-973H7.1,RP11-973H7.4 18: XLOC_ RP11-535A5.1 18: XLOC_ DSC2 18: XLOC_ PSTPIP2 18: XLOC_ LOXHD1 18: XLOC_ SMAD7 18: XLOC_ MEX3C 18: XLOC_ BCL2 18: XLOC_ CD226,DOK6,RP11-543H : XLOC_ ZNF516 18:

28 XLOC_ GZMM 19: XLOC_ : XLOC_ FSTL3 19: XLOC_ AZU1 19: XLOC_ PRTN3 19: XLOC_ ELANE 19: XLOC_ ARID3A 19: XLOC_ MIDN 19: XLOC_ GADD45B 19: XLOC_ GNA15 19: XLOC_ AC ,TJP3 19: XLOC_ MATK 19: XLOC_ FSD1 19: XLOC_ SEMA6B 19: XLOC_ TNFSF9 19: XLOC_ EMR1 19: XLOC_ RETN 19: XLOC_ CTD-3214H19.16,MCEMP1,TRAPP C5 19: XLOC_ CTC-325H20.2,ZNF177,ZNF559,ZN F559-ZNF177 19: XLOC_ ICAM1 19: XLOC_ QTRT1 19: XLOC_ C19orf38 19: XLOC_ ZNF788 19: XLOC_ JUNB 19: XLOC_ CYP4F22 19: XLOC_ CYP4F3,CYP4F8 19: XLOC_ COLGALT1 19: XLOC_ RPL18A,SNORA68 19: XLOC_ IFI30,PIK3R2 19: XLOC_ LSM4 19: XLOC_ SLC25A42 19: XLOC_ PLEKHF1 19: XLOC_ URI1 19: XLOC_ ZNF507 19: XLOC_ DPY19L3 19: XLOC_ ZNF181 19: XLOC_ ZNF30 19: XLOC_ FFAR2 19: XLOC_ HAUS5 19: XLOC_ LRFN3 19: XLOC_ ZNF420 19: XLOC_ HKR1 19: XLOC_ ZFP36 19: XLOC_ LTBP4 19: XLOC_ AC : XLOC_ CEACAM3 19: XLOC_ ZNF574 19: XLOC_ CD177 19:

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